Circulation最新文献

{"title":"Early Vascular Aging Determined by 3-Dimensional Aortic Geometry: Genetic Determinants and Clinical Consequences.","authors":"Cameron Beeche,Bingxin Zhao,Hamed Tavolinejad,Bianca Pourmussa,Joonghyun Kim,Jeffrey Duda,James Gee,Walter R Witschey,Julio A Chirinos, ","doi":"10.1161/circulationaha.125.074554","DOIUrl":"https://doi.org/10.1161/circulationaha.125.074554","url":null,"abstract":"BACKGROUNDVascular aging is an important phenotype characterized by structural and geometric remodeling. Some individuals exhibit supernormal vascular aging, associated with improved cardiovascular outcomes; others experience early vascular aging, linked to adverse cardiovascular outcomes. The aorta is the artery that exhibits the most prominent age-related changes; however, the biological mechanisms underlying aortic aging, its genetic architecture, and its relationship with cardiovascular structure, function, and disease states remain poorly understood.METHODSWe developed sex-specific models to quantify aortic age on the basis of aortic geometric phenotypes derived from 3-dimensional tomographic imaging data in 2 large biobanks: the UK Biobank and the Penn Medicine BioBank. Convolutional neural ne2rk-assisted 3-dimensional segmentation of the aorta was performed in 56 104 magnetic resonance imaging scans in the UK Biobank and 6757 computed tomography scans in the Penn Medicine BioBank. Aortic vascular age index (AVAI) was calculated as the difference between the vascular age predicted from geometric phenotypes and the chronological age, expressed as a percent of chronological age. We assessed associations with cardiovascular structure and function using multivariate linear regression and examined the genetic architecture of AVAI through genome-wide association studies, followed by Mendelian randomization to assess causal associations. We also constructed a polygenic risk score for AVAI.RESULTSAVAI displayed numerous associations with cardiac structure and function, including increased left ventricular mass (standardized β=0.144 [95% CI, 0.138, 0.149]; P<0.0001), wall thickness (standardized β=0.061 [95% CI, 0.054, 0.068]; P<0.0001), and left atrial volume maximum (standardized β=0.060 [95% CI, 0.050, 0.069]; P<0.0001). AVAI exhibited high genetic heritability (h2=40.24%). We identified 54 independent genetic loci (P<5×10-8) associated with AVAI, which further exhibited gene-level associations with the fibrillin-1 (FBN1) and elastin (ELN1) genes. Mendelian randomization supported causal associations between AVAI and atrial fibrillation, vascular dementia, aortic aneurysm, and aortic dissection. A polygenic risk score for AVAI was associated with an increased prevalence of atrial fibrillation, hypertension, aortic aneurysm, and aortic dissection.CONCLUSIONSEarly aortic aging is significantly associated with adverse cardiac remodeling and important cardiovascular disease states. AVAI exhibits a polygenic, highly heritable genetic architecture. Mendelian randomization analyses support a causal association between AVAI and cardiovascular diseases, including atrial fibrillation, vascular dementia, aortic aneurysms, and aortic dissection.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"24 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PIEZO1 Overexpression in Hereditary Hemorrhagic Telangiectasia Arteriovenous Malformations.","authors":"Hyojin Park, Sungwoon Lee, Jessica Furtado, Mark Robinson, Richard J Antaya, S Paul Oh, Young-Kwon Hong, Martin A Schwartz, Lawrence H Young, Anne Eichmann","doi":"10.1161/CIRCULATIONAHA.124.073630","DOIUrl":"10.1161/CIRCULATIONAHA.124.073630","url":null,"abstract":"<p><strong>Background: </strong>Hereditary hemorrhagic telangiectasia is an inherited vascular disorder characterized by arteriovenous malformations (AVMs). Loss-of-function variations in activin receptor-like kinase 1 (<i>ALK1</i>) cause type 2 hereditary hemorrhagic telangiectasia, and <i>Alk1</i> knockout mice develop AVMs, along with overactivation of vascular endothelial growth factor receptor 2/phosphoinositide 3-kinase/AKT signaling. The full spectrum of signaling alterations resulting from <i>ALK1</i> variations remains unknown, and more effective and specific inhibitors to combat AVM formation in patients are needed.</p><p><strong>Methods: </strong>Single-cell RNA sequencing of endothelial-specific <i>Alk1</i> knockout mouse retinas and controls was performed. Overexpression of fluid shear stress signaling signatures including the mechanosensitive ion channel PIEZO1 was confirmed in mouse and human type 2 hereditary hemorrhagic telangiectasia lesions. Genetic and pharmacological PIEZO1 inhibition was tested in <i>Alk1</i> knockout mice, along with downstream PIEZO1 signaling.</p><p><strong>Results: </strong>A cluster of <i>Alk1</i> mutant endothelial cells with altered arterio-venous identity overexpressed pathways related to fluid shear stress, hypoxia, inflammation, cell cycle, and vascular endothelial growth factor receptor 2/phosphoinositide 3-kinase/AKT signaling. <i>Piezo1</i> deletion and pharmacological inhibition in <i>Alk1</i>-deficient mice mitigated AVM formation, whereas <i>Piezo1</i> overexpression enhanced AVM formation induced by ALK1 ligand blockade. Mechanistically, PIEZO1 inhibition reduced elevated vascular endothelial growth factor receptor 2/AKT, ERK5-p62-KLF4, endothelial nitric oxide synthase, hypoxia, proliferation, and inflammation in ALK1-deficient endothelium.</p><p><strong>Conclusions: </strong>PIEZO1 expression and signaling are elevated in type 2 hereditary hemorrhagic telangiectasia. PIEZO1 blockade reduces AVM formation and alleviates cellular and molecular hallmarks of ALK1-deficient cells. This finding provides new insights into the mechanistic underpinnings of ALK1-related vascular diseases and identifies potential therapeutic targets to prevent AVMs.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique Role of Intracellular Perinuclear β₁-Adrenergic Receptors in Defining Signaling Compartmentation and Pathological Cardiac Remodeling.","authors":"Moriah Gildart Turcotte, Anne-Maj Samuelsson, Sofia M Possidento, Jinliang Li, Zhuyun Qin, Michael S Kapiloff, Kimberly L Dodge-Kafka","doi":"10.1161/CIRCULATIONAHA.124.072682","DOIUrl":"10.1161/CIRCULATIONAHA.124.072682","url":null,"abstract":"<p><strong>Background: </strong>β-Adrenergic receptors (βARs) are prototypical G protein-coupled receptors that regulate contractility in the normal heart and pathological remodeling in disease. Canonical βAR signaling originates at the plasma membrane, but functional βARs have been localized to intracellular membranes such as the endosome, sarcoplasmic reticulum, Golgi, and nuclear envelope. The functional significance of these intracellular receptors remains unclear, including whether they regulate cellular processes distinct from those regulated by plasma membrane receptors and whether they can be independently targeted for therapeutic benefit.</p><p><strong>Methods: </strong>Live cell imaging of rat and human cardiomyocytes expressing novel compartment-specific modulators of βAR activity and fluorescent biosensors was used to study the compartment-specific βAR regulation of second messengers and to target enzyme activity. Compartmentalized signaling was compared with myocyte gene expression and hypertrophy. Adeno-associated virus gene delivery conferring gain and loss of perinuclear βAR activity was studied in wild-type mice and a mouse model of familial dilated cardiomyopathy.</p><p><strong>Results: </strong>We demonstrate here that intracellular β₁ARs present on Golgi membrane facing the outer nuclear membrane regulate a perinuclear cAMP compartment containing the A-kinase anchoring protein 6β signalosome, conferring selective regulation of perinuclear cAMP-dependent protein kinase activity independently of βARs at the plasma membrane or endosome. The A-kinase anchoring protein 6β compartment is shown to be of nanometer scale and dependent on local restriction of cAMP diffusion. In addition, perinuclear βARs are shown to be sufficient and necessary for activation of the Ca²⁺-dependent calcineurin-nuclear factor of activated T cells pathway and myocyte hypertrophy in vitro. Accordingly, adeno-associated virus 9-based delivery of an outer nuclear membrane-localized pepducin, which selectively activated perinuclear βARs in vitro, induced dilated cardiomyopathy in wild-type mice. Conversely, in vivo delivery of an outer nuclear membrane-localized nanobody, which selectively inhibited perinuclear βARs in vitro, improved cardiac function and inhibited pathological remodeling in a mouse model of familial dilated cardiomyopathy with established disease.</p><p><strong>Conclusions: </strong>These results demonstrate that β₁ARs localized to Golgi membranes facing the outer nuclear membrane regulate A-kinase anchoring protein 6β signalosomes required for the induction of pathological cardiac remodeling, defining an intracellular nanocompartment. Proof of concept is provided for a novel therapeutic approach for familial dilated cardiomyopathy, with potential application to other forms of cardiovascular disease.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":""},"PeriodicalIF":35.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centering Diné (Navajo) Voices: Barriers, Facilitators, and Perceptions of Cardiac Care Among Patients With Heart Failure in Rural Navajo Nation.","authors":"Lauren A Eberly, Ada Tennison, Larissa Morgan, Marita Smith, Leah Gray, Matthew Kearney, Benjamin Feliciano, Erica Lindsey, Jacob Manche, Pamela Detsoi-Smiley, Sonya Shin, Maricruz Merino","doi":"10.1161/CIRCULATIONAHA.124.073166","DOIUrl":"10.1161/CIRCULATIONAHA.124.073166","url":null,"abstract":"<p><strong>Background: </strong>The American Indian population in the United States experiences marked cardiovascular health disparities. American Indian patients, particularly those receiving care rurally through the Indian Health Service (IHS), face unique challenges to accessing appropriate cardiovascular care. However, there are no studies in the current era characterizing these challenges from the patient perspective. Therefore, the aim of this study was to characterize the barriers, facilitators, and perceptions of cardiac care among Diné (Navajo) patients with heart failure receiving care through the IHS, as well as to determine patient-designed solutions to improve access to quality cardiovascular care.</p><p><strong>Methods: </strong>We performed semi-structured interviews and surveys of Diné patients (n=30) living with heart failure and receiving care at two IHS sites in rural Navajo Nation. The participants were 27% female and 30% Navajo speaking with a median age of 59 (interquartile range 53, 67) years. Interviews were guided by the Consolidation Framework for Implementation Research to describe patient experiences with receiving cardiac care. Interviews were audio recorded and transcribed for thematic analysis.</p><p><strong>Results: </strong>Several themes emerged reflecting barriers and facilitators to accessing cardiac care, as well as perspectives regarding heart failure care and advanced therapies. Primary barriers included lack of specialists locally, transportation-related and financial barriers to traveling long distances to urban centers for care, complicated IHS referral processes, and mistrust of providers outside of the IHS. Facilitators included trust of local IHS care; community and family support; and exceptional patient and caregiver resiliency and activation. Most patients felt that Traditional Medicine was important for their cardiovascular health and desired more of its integration into Western treatment. There was heterogeneity in cultural beliefs regarding heart transplantation, but the majority felt that it was acceptable if needed. Proposed solutions for improving cardiovascular care included making more services available locally, increased telehealth options, and assistance for social determinants of health, especially access to healthier food and transportation-related costs for referral care.</p><p><strong>Conclusions: </strong>As the first qualitative study of American Indian patients with heart failure in the current era, these results highlight unique care challenges, which can inform community-designed strategies to improve access to care.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"101-112"},"PeriodicalIF":35.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations of Intraoperative Transesophageal Echocardiography During Adult Cardiac Surgery: A Scientific Statement From the American Heart Association.","authors":"Lisa Q Rong, Linda Shore-Lesserson, Kiran Belani, Abimbola Faloye, Enrique Garcia-Sayan, Jennifer Lawton, Timothy Maus, Wanda Miller-Hance, Alina Nicoara, Richard Sheu","doi":"10.1161/CIR.0000000000001342","DOIUrl":"10.1161/CIR.0000000000001342","url":null,"abstract":"<p><p>Intraoperative transesophageal echocardiography is used with increasing frequency in cardiac surgery for monitoring and diagnostic purposes. Recent data have shown the impact of improved outcomes in patients undergoing cardiac surgery and the use of intraoperative transesophageal echocardiography in managing complex surgical decisions. However, specialty society recommendations have not been updated to reflect these trends. This scientific statement reviews the state-of-the-art practice of intraoperative echocardiography, summarizes the association of the use of intraoperative transesophageal echocardiography with enhanced outcomes, and provides specific perioperative and procedural transesophageal echocardiography considerations in the cardiac surgical population.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"129-145"},"PeriodicalIF":35.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Disparities in Long-Term Outcomes After Endovascular Aortic Aneurysm Repair in Black and White Medicare Beneficiaries.","authors":"Abena Appah-Sampong, Christina Marcaccio, Siling Li, Yang Song, Mohamad A Hussain, Robert Yeh, Marc L Schermerhorn, Eric A Secemsky","doi":"10.1161/CIRCULATIONAHA.124.072018","DOIUrl":"10.1161/CIRCULATIONAHA.124.072018","url":null,"abstract":"<p><strong>Background: </strong>Despite reported racial disparities between Black and White adults in short-term outcomes after abdominal aortic aneurysmal intervention, there is a paucity of literature aimed at understanding long-term disparities. The present study aims to characterize racial disparities in long-term outcomes, perioperative outcomes, and health care use after endovascular aortic aneurysm repair.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study from 2011 to 2019 with outcome assessment through 2020. Using a 100% sample of national Medicare data, we identified beneficiaries ≥66 years of age who underwent intact infrarenal endovascular aortic aneurysm repair. The primary outcome was a composite of endovascular or open aortic reintervention, late aneurysm rupture, and all-cause mortality. Secondary outcomes included other reinterventions, perioperative outcomes, and annual rates of health care use.</p><p><strong>Results: </strong>A cohort of 107 636 Black (3.9%) and White (96.1%) beneficiaries was identified. The cumulative incidence of the primary outcome was 72.9% (95% CI, 71.8%-73.9%) in White patients versus 80.0% (95% CI, 76.4-83.0) in Black patients (<i>P</i><0.0001). The adjusted hazard of the primary outcome was not significantly different between Black and White adults (adjusted hazard ratio [HR] 1.04 [95% CI, 0.99-1.09]); however, when death was treated as a competing risk, a significantly higher hazard for the composite outcome was observed for Black patients (subdistribution HR, 1.56 [95% CI, 1.39-1.76]). Components of the primary outcome were also greater among Black compared with White patients. Black patients had higher rates of medical complications in the perioperative period, including acute renal failure (subdistribution HR, 1.18 [95% CI, 1.01-1.38]), dialysis initiation (subdistribution HR, 2.75 [95% CI, 2.03-3.7]), and deep vein thrombosis (subdistribution HR, 1.54 [95% CI, 1.05-2.26]). Black patients had lower rates of vascular office visits after intervention (adjusted rate ratio, 0.96 [95% CI, 0.93-0.99]) but higher rates of emergency department visits (adjusted rate ratio, 1.05 [95% CI, 1.02-1.09]) and hospital readmissions (adjusted rate ratio, 1.13 [95% CI, 1.08-1.18]).</p><p><strong>Conclusions: </strong>Black patients demonstrated increased risk of late aortic-related events after endovascular aortic aneurysm repair after accounting for the competing risk of death and controlling for baseline covariates. Further investigation into structural barriers affecting optimal preoperative medical management and barriers to postoperative health care access is necessary to further elucidate underlying mechanisms for the observed disparities.</p>","PeriodicalId":10331,"journal":{"name":"Circulation","volume":" ","pages":"92-100"},"PeriodicalIF":35.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Vision for Equity in Heart Health.","authors":"Nilay S Shah,Mercedes R Carnethon,Karol Watson","doi":"10.1161/circulationaha.125.075923","DOIUrl":"https://doi.org/10.1161/circulationaha.125.075923","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"29 1","pages":"85-86"},"PeriodicalIF":37.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Promise and Peril of Learning Algorithms and Predictive Models in Clinical Decision Support: Be Careful What You Train For.","authors":"Trejeeve Martyn,Mazen Hanna,Fatima Rodriguez","doi":"10.1161/circulationaha.125.075097","DOIUrl":"https://doi.org/10.1161/circulationaha.125.075097","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"108 1","pages":"89-91"},"PeriodicalIF":37.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Methylation Signatures of Cardiovascular Health Provide Insights Into Diseases.","authors":"Madeleine Carbonneau,Yi Li,Yishu Qu,Yinan Zheng,Alexis C Wood,Mengyao Wang,Chunyu Liu,Tianxiao Huan,Roby Joehanes,Xiuqing Guo,Jie Yao,Kent D Taylor,Russell P Tracy,Peter Durda,Yongmei Liu,W Craig Johnson,Wendy S Post,Tom Blackwell,Jerome I Rotter,Stephen S Rich,Susan Redline,Myriam Fornage,Jun Wang,Hongyan Ning,Lifang Hou,Donald Lloyd-Jones,Kendra Ferrier,Yuan-I Min,April P Carson,Laura M Raffield,Alexander Teumer,Hans J Grabe,Henry Völzke,Matthias Nauck,Marcus Dörr,Arce Domingo-Relloso,Amanda Fretts,Maria Tellez-Plaza,Shelley A Cole,Ana Navas-Acien,Meng Wang,Joanne M Murabito,Nancy L Heard-Costa,Brenton Prescott,Vanessa Xanthakis,Dariush Mozaffarian,Daniel Levy,Jiantao Ma","doi":"10.1161/circulationaha.124.073181","DOIUrl":"https://doi.org/10.1161/circulationaha.124.073181","url":null,"abstract":"BACKGROUNDThe association of overall cardiovascular health (CVH) with changes in DNA methylation (DNAm) has not been well characterized.METHODSWe calculated the American Heart Association's Life's Essential 8 score to reflect CVH in 5 cohorts with diverse backgrounds (mean age 54 years, 55% women, and enrollment year ranging from 1989 to 2012). Epigenome-wide association studies (EWAS) for Life's Essential 8 score were conducted, followed by bioinformatic analyses. DNAm loci significantly associated with Life's Essential 8 score were used to calculate a CVH DNAm score. We examined the association of the CVH DNAm score with incident cardiovascular disease (CVD), cardiovascular disease-specific mortality, and all-cause mortality.RESULTSWe identified 609 cytosine-phosphate-guanines (CpGs) associated with Life's Essential 8 score at false discovery rate<0.05 in the discovery analysis and at Bonferroni-corrected P<0.05 in the multicohort replication stage. Most had low to moderate heterogeneity (414 CpGs [68.0%] with heterogeneity <0.2) in replication analysis. Pathway enrichment analyses and a phenome-wide association study search associated these CpGs with inflammatory or autoimmune phenotypes. We observed enrichment for phenotypes in the Epigenome-Wide Association Study Catalog, with 29-fold enrichment for stroke (P=2.4e-15) and 21-fold for ischemic heart disease (P=7.4e-38). Two-sample Mendelian randomization (MR) analysis showed significant association between 141 CpGs and ten phenotypes (261 CpG-phenotype pairs) at false discovery rate<0.05. For example, hypomethylation at cg20544516 (MIR33B [microRNA 33b] and SREBF1 [sterol regulatory element-binding transcription factor 1]) is associated with a lower risk of stroke (P=8.1e-6). In multivariable prospective analyses, the CVH DNAm score was consistently associated with clinical outcomes across participating cohorts. Per SD increase in the CVH DNAm score, the decrease in risk of incident cardiovascular disease, cardiovascular disease mortality, and all-cause mortality ranged from 19% to 32%, 28% to 40%, and 27% to 45%, respectively.CONCLUSIONSWe identified new DNAm signatures for CVH across diverse cohorts. Our analyses indicate that multiple biological pathways may be relevant to the observed association between CVH and clinical outcomes.","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"693 1","pages":""},"PeriodicalIF":37.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity and Incident Atrial Fibrillation in African Americans: The Jackson Heart Study.","authors":"Jack Tiahnybik,Marielle Siebert,Daisuke Kamimura,Wondwosen Yimer,Yuan-I Min,Kaustuv Bhattacharya,James Floyd,Yi Yang,Susan R Heckbert,Michael E Hall,Adolfo Correa,Takeki Suzuki","doi":"10.1161/circulationaha.124.072893","DOIUrl":"https://doi.org/10.1161/circulationaha.124.072893","url":null,"abstract":"","PeriodicalId":10331,"journal":{"name":"Circulation","volume":"12 1","pages":"126-128"},"PeriodicalIF":37.8,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144630348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}