Circulation: Cardiovascular Interventions最新文献

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Pharmaco-Invasive Approach in Older Patients Presenting With ST-Segment-Elevation Myocardial Infarction. 对出现 ST 段抬高型心肌梗死的老年患者采取药物介入治疗方法
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-12-17 DOI: 10.1161/CIRCINTERVENTIONS.124.014890
Adnan Kastrati, Gjin Ndrepepa
{"title":"Pharmaco-Invasive Approach in Older Patients Presenting With ST-Segment-Elevation Myocardial Infarction.","authors":"Adnan Kastrati, Gjin Ndrepepa","doi":"10.1161/CIRCINTERVENTIONS.124.014890","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.014890","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":"17 12","pages":"e014890"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Native Valve and Native Neo-Sinus Remodeling Following Transcatheter Aortic Valve Replacement. 经导管主动脉瓣置换术后的原生瓣膜和原生新窦重构。
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-12-17 DOI: 10.1161/CIRCINTERVENTIONS.124.014379
Joshua Yoon, Hacina Gill, Julius Jelisejevas, Althea Lai, Jaffar M Khan, Geoffrey W Payne, John G Webb, Janarthanan Sathananthan, Michael A Seidman, David Meier, Stephanie L Sellers
{"title":"Native Valve and Native Neo-Sinus Remodeling Following Transcatheter Aortic Valve Replacement.","authors":"Joshua Yoon, Hacina Gill, Julius Jelisejevas, Althea Lai, Jaffar M Khan, Geoffrey W Payne, John G Webb, Janarthanan Sathananthan, Michael A Seidman, David Meier, Stephanie L Sellers","doi":"10.1161/CIRCINTERVENTIONS.124.014379","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.014379","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve replacement (TAVR) pushes aside the diseased native aortic valve and creates a native neo-sinus bordered by the aortic root wall and the displaced native valve. There are limited data on the progression of native valve disease post-TAVR and no previous analysis of the native neo-sinus.</p><p><strong>Methods: </strong>Native aortic valves and native neo-sinus explants obtained post-TAVR were evaluated histologically (hematoxylin and eosin, Movat pentachrome, and Martius Scarlet Blue stains) and by immunohistochemistry (TGF-β1 [transforming growth factor-beta 1], FAP [fibroblast activation protein], and ALP [alkaline phosphatase]) to assess disease mechanisms.</p><p><strong>Results: </strong>Native aortic valves were obtained from 20 patients from 0 to 2583 days (7.08 years) post-TAVR. Native leaflets showed persistent calcific aortic stenosis-like disease activity with positivity for ALP and FAP. Native valve remodeling was observed as changes in architecture evident in explants >1.5 years, which was observed as crumpling of the leaflets. Disease activity was also present in native neo-sinuses with transcatheter heart valve implant durations >1 year with positive staining for TGF-β1, FAP, and ALP. Extensive native neo-sinus remodeling occurred with replacement and filling-in of this space with contiguous extracellular matrix, calcific deposits, and microvessels.</p><p><strong>Conclusions: </strong>Following TAVR, there is ongoing calcific aortic stenosis-like disease with architectural changes to native leaflets and extensive remodeling of the native neo-sinus, evidenced by replacement and contiguous filling-in of the native neo-sinus blood pool space with increasing implant duration. The dynamic nature of these tissues has potential implications for neo-sinus flow, valve degeneration, and re-intervention.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":"17 12","pages":"e014379"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcatheter Aortic Valve Replacement With the Evolut FX Self-Expanding Versus SAPIEN 3 Ultra Resilia Balloon-Expandable Valves. 使用 Evolut FX 自扩张瓣膜与 SAPIEN 3 Ultra Resilia 球囊扩张瓣膜进行经导管主动脉瓣置换术。
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1161/CIRCINTERVENTIONS.124.014696
Ali H Dakroub, Sarah Malik, Stephanie L Sellers, David Meier, Lindsey Hart, William Chung, Matthew Henry, Andrew Berke, George Petrossian, Newell Robinson, David J Cohen, Jaffar M Khan
{"title":"Transcatheter Aortic Valve Replacement With the Evolut FX Self-Expanding Versus SAPIEN 3 Ultra Resilia Balloon-Expandable Valves.","authors":"Ali H Dakroub, Sarah Malik, Stephanie L Sellers, David Meier, Lindsey Hart, William Chung, Matthew Henry, Andrew Berke, George Petrossian, Newell Robinson, David J Cohen, Jaffar M Khan","doi":"10.1161/CIRCINTERVENTIONS.124.014696","DOIUrl":"10.1161/CIRCINTERVENTIONS.124.014696","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e014696"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacts of Hospital Volume and Patient-Hospital Distances on Outcomes of Older Adults Receiving Percutaneous Microaxial Ventricular Assist Devices for Cardiogenic Shock. 医院容量和患者-医院距离对接受经皮微轴心室辅助装置治疗心源性休克的老年人预后的影响。
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI: 10.1161/CIRCINTERVENTIONS.124.014738
Atsuyuki Watanabe, Yoshihisa Miyamoto, Hiroki A Ueyama, Hiroshi Gotanda, Jacob C Jentzer, Navin K Kapur, Ulrich P Jorde, Yusuke Tsugawa, Toshiki Kuno
{"title":"Impacts of Hospital Volume and Patient-Hospital Distances on Outcomes of Older Adults Receiving Percutaneous Microaxial Ventricular Assist Devices for Cardiogenic Shock.","authors":"Atsuyuki Watanabe, Yoshihisa Miyamoto, Hiroki A Ueyama, Hiroshi Gotanda, Jacob C Jentzer, Navin K Kapur, Ulrich P Jorde, Yusuke Tsugawa, Toshiki Kuno","doi":"10.1161/CIRCINTERVENTIONS.124.014738","DOIUrl":"10.1161/CIRCINTERVENTIONS.124.014738","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous microaxial ventricular assist devices (pVADs) have the potential to reduce mortality of patients with cardiogenic shock (CS). However, the association between the distribution of pVAD-performing centers and outcomes of CS has not been explored.</p><p><strong>Methods: </strong>This observational study included Medicare fee-for-service beneficiaries aged 65 to 99 years treated with pVAD for CS from 2016 to 2020. It examined the associations between patient outcomes and 2 exposure variables: hospitals' procedure volumes of pVAD and patient-hospital distances (in quintiles [Qn]). We developed Cox proportional hazards regression for 180-day mortality and heart failure readmission rates, and multivariable logistic regression for in-hospital outcomes, adjusting for patient demographics, comorbidities, concomitant treatments, and hospital characteristics, including CS volume, teaching status, and the ability to perform extracorporeal membrane oxygenation.</p><p><strong>Results: </strong>A total of 6637 patients with CS underwent pVAD at 1041 hospitals, with the annualized hospital volume ranging widely from 0.3 to 55.6 cases/year. Patients treated at higher-volume centers experienced lower 180-day mortality compared with those treated at lower-volume centers (Qn1=reference; Qn2: adjusted hazard ratio [aHR], 0.88 [95% CI, 0.79-0.97]; Qn3: aHR, 0.88 [95% CI, 0.79-0.98]; Qn4: aHR, 0.88 [95% CI, 0.78-0.99]; Qn5: aHR, 0.84 [95% CI, 0.74-0.95]; <i>P</i> for trend, 0.026), while we found no evidence that patient-hospital distances were associated with mortality (Qn1=reference; Qn2: aHR, 0.99 [95% CI, 0.89-1.09]; Qn3: aHR, 0.94 [95% CI, 0.85-1.04]; Qn4: aHR, 1.01 [95% CI, 0.92-1.11]; Qn5: aHR, 0.91 [95% CI, 0.82-1.01]; <i>P</i> for trend, 0.160). We found no evidence that the hospital volume and patient-hospital distances were associated with in-hospital bleeding, intracranial hemorrhage, or renal replacement therapy initiation.</p><p><strong>Conclusions: </strong>Hospital volume was more strongly associated with mortality than patient-hospital distances, suggesting that rational distribution of pVAD-performing centers while ensuring adequate procedure volumes may optimize patient mortality.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e014738"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive or CT Angiography: Alternative or Complementary Imaging Tools After CABG? 有创血管造影还是 CT 血管造影?CABG 术后的替代或补充成像工具?
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-11-25 DOI: 10.1161/CIRCINTERVENTIONS.124.014838
Carlo Di Mario, Filippo Cademartiri, Alessio Mattesini
{"title":"Invasive or CT Angiography: Alternative or Complementary Imaging Tools After CABG?","authors":"Carlo Di Mario, Filippo Cademartiri, Alessio Mattesini","doi":"10.1161/CIRCINTERVENTIONS.124.014838","DOIUrl":"10.1161/CIRCINTERVENTIONS.124.014838","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e014838"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Birth of a New Entity Post-TAVR: Unveiling Neo-Sinus Formation and Structural Transformations. TAVR术后新实体的诞生:揭开新窦道形成和结构转变的面纱。
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-12-17 DOI: 10.1161/CIRCINTERVENTIONS.124.014891
Giuseppe Tarantini, Luca Nai Fovino
{"title":"Birth of a New Entity Post-TAVR: Unveiling Neo-Sinus Formation and Structural Transformations.","authors":"Giuseppe Tarantini, Luca Nai Fovino","doi":"10.1161/CIRCINTERVENTIONS.124.014891","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.014891","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":"17 12","pages":"e014891"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Baseline Mitral Valve Area With Procedural and Clinical Outcomes of Mitral Transcatheter Edge-to-Edge Repair: Insights From the OCEAN-Mitral Registry. 基线二尖瓣面积与二尖瓣经导管边缘到边缘修复的手术和临床结果的关系:来自ocean -二尖瓣注册的见解。
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-12-17 DOI: 10.1161/CIRCINTERVENTIONS.124.014420
Kazunori Mushiake, Shunsuke Kubo, Sachiyo Ono, Takeshi Maruo, Naoki Nishiura, Kohei Osakada, Kazushige Kadota, Masanori Yamamoto, Mike Saji, Masahiko Asami, Yusuke Enta, Masaki Nakashima, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Yuki Izumi, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Kazuki Mizutani, Toshiaki Otsuka, Kentaro Hayashida
{"title":"Association of Baseline Mitral Valve Area With Procedural and Clinical Outcomes of Mitral Transcatheter Edge-to-Edge Repair: Insights From the OCEAN-Mitral Registry.","authors":"Kazunori Mushiake, Shunsuke Kubo, Sachiyo Ono, Takeshi Maruo, Naoki Nishiura, Kohei Osakada, Kazushige Kadota, Masanori Yamamoto, Mike Saji, Masahiko Asami, Yusuke Enta, Masaki Nakashima, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Yuki Izumi, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Kazuki Mizutani, Toshiaki Otsuka, Kentaro Hayashida","doi":"10.1161/CIRCINTERVENTIONS.124.014420","DOIUrl":"10.1161/CIRCINTERVENTIONS.124.014420","url":null,"abstract":"<p><strong>Background: </strong>A small mitral valve area (MVA) is one of the challenging anatomies for transcatheter edge-to-edge repair (TEER) for mitral regurgitation, but the relationship between baseline MVA and clinical outcomes remains unknown. This study aimed to evaluate the association of baseline MVA with procedural and clinical outcomes in patients undergoing TEER with MitraClip from the OCEAN-Mitral registry (Optimized Catheter Valvular Intervention-Mitral).</p><p><strong>Methods: </strong>A total of 1768 patients undergoing TEER were divided into 3 groups according to baseline MVA: group 1: <4.0 cm<sup>2</sup>, n=358; group 2: 4.0-5.0 cm<sup>2</sup>, n=493; and group 3: ≥5.0 cm<sup>2</sup>, n=917. The primary end point was a composite of all-cause death and heart failure hospitalization within 2 years of TEER and compared between the 3 groups.</p><p><strong>Results: </strong>Patients with smaller MVA had significantly fewer clips implanted and higher postprocedural transmitral mean pressure gradient. There was no significant difference in the acute procedural success rate and postprocedural mitral regurgitation severity between the 3 groups. The incidence of the primary end point was similar in group 1 compared with groups 2 and 3 (35.2% versus 34.5% versus 34.0%; <i>P</i>=0.96) and was also similar in patients with MVA <3.5 cm<sup>2</sup> and those with MVA 3.5 to 4.0 cm<sup>2</sup>. The adjusted risk of MVA <4.0 cm<sup>2</sup> relative to MVA of 4.0 to 5.0 cm<sup>2</sup> and MVA ≥5 cm<sup>2</sup> for the primary end point remained insignificant (hazard ratio, 1.06 [95% CI, 0.79-1.41]; <i>P</i>=0.68; hazard ratio, 0.99 [95% CI, 0.75-1.31]; <i>P</i>=0.96, respectively). At 1 year, no significant difference in the proportion of residual mitral regurgitation 3+/4+ was observed between the 3 groups (7.2% versus 4.4% versus 6.5%; <i>P</i>=0.49).</p><p><strong>Conclusions: </strong>In patients undergoing TEER, a small MVA <4.0 cm<sup>2</sup> may limit the number of clips implanted and increase the transmitral pressure gradient after TEER, but baseline MVA was not associated with mitral regurgitation reduction and clinical outcomes.</p><p><strong>Registration: </strong>URL: https://center6.umin.ac.jp/cgiope n-bin/ctr/ctr_view.cgi?recptno=R000027188; Unique identifier: UMIN000023653.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":"17 12","pages":"e014420"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmaco-Invasive Strategy With Half-Dose Tenecteplase in Patients With STEMI: Prespecified Pooled Analysis of Patients Aged ≥75 Years in STREAM-1 and 2. STEMI 患者使用半剂量替奈普酶的药物介入策略:STREAM-1 和 2 中年龄≥75 岁患者的预设汇总分析。
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-12-17 DOI: 10.1161/CIRCINTERVENTIONS.124.014251
Kevin R Bainey, Robert C Welsh, Yinggan Zheng, Alexandra Arias-Mendoza, Arsen D Ristic, Oleg V Averkov, Yves Lambert, José F Kerr Saraiva, Pablo Sepulveda, Fernando Rosell-Ortiz, John K French, Ljilja B Musić, Tracy Temple, Eric Ly, Kris Bogaerts, Peter R Sinnaeve, Thierry Danays, Cynthia M Westerhout, Frans Van de Werf, Paul W Armstrong
{"title":"Pharmaco-Invasive Strategy With Half-Dose Tenecteplase in Patients With STEMI: Prespecified Pooled Analysis of Patients Aged ≥75 Years in STREAM-1 and 2.","authors":"Kevin R Bainey, Robert C Welsh, Yinggan Zheng, Alexandra Arias-Mendoza, Arsen D Ristic, Oleg V Averkov, Yves Lambert, José F Kerr Saraiva, Pablo Sepulveda, Fernando Rosell-Ortiz, John K French, Ljilja B Musić, Tracy Temple, Eric Ly, Kris Bogaerts, Peter R Sinnaeve, Thierry Danays, Cynthia M Westerhout, Frans Van de Werf, Paul W Armstrong","doi":"10.1161/CIRCINTERVENTIONS.124.014251","DOIUrl":"10.1161/CIRCINTERVENTIONS.124.014251","url":null,"abstract":"<p><strong>Background: </strong>In STREAM-1 (Strategic Reperfusion Early After Myocardial Infarction), excess intracranial hemorrhage occurred in patients aged ≥75 years receiving full-dose tenecteplase as part of a pharmaco-invasive strategy, whereas no further intracranial hemorrhage occurred after halving the tenecteplase dose. In STREAM-2 (Second Strategic Reperfusion Early After Myocardial Infarction), half-dose tenecteplase was an effective and safe pharmaco-invasive strategy in older patients with ST-segment-elevation myocardial infarction presenting within <3 hours, compared with primary percutaneous coronary intervention (PCI). We prespecified evaluating the efficacy and safety of a half-dose versus full-dose pharmaco-invasive strategy and compared the half-dose pharmaco-invasive strategy to primary PCI in patients aged ≥75 years.</p><p><strong>Methods: </strong>We pooled data sets in patients aged ≥75 years from STREAM-1 and STREAM-2 receiving a pharmaco-invasive strategy versus primary PCI. Resolution of ST-segment-elevation after fibrinolysis and angiography was assessed, as was the relative risk of the primary composite of 30-day all-cause death, myocardial infarction, heart failure, and shock, along with bleeding.</p><p><strong>Results: </strong>A total of 390 patients were included: 42 patients were randomized to full-dose pharmaco-invasive treatment, 205 patients to half-dose pharmaco-invasive treatment, and 143 patients to primary PCI. Half-dose versus full-dose pharmaco-invasive treatment resulted in similar proportions of patients achieving ≥50% ST-segment resolution posttenecteplase (63.2% versus 62.6%), with reduced intracranial hemorrhage (7.1% versus 0%, respectively). Half-dose pharmaco-invasive treatment and primary PCI also had similar proportions of patients with ≥50% ST-segment resolution postangiography (77.9% versus 72.4%; <i>P</i>=0.277) and comparable composite end points (23.4% versus 28.0%; relative risk, 0.90 [95% CI, 0.62-1.30]; <i>P</i>=0.567) without occurrence of intracranial hemorrhage.</p><p><strong>Conclusions: </strong>Comparable efficacy exists between half- and full-dose tenecteplase pharmaco-invasive treatments with improved safety in patients with ST-segment-elevation myocardial infarction aged ≥75 years. Half-dose pharmaco-invasive therapy is a legitimate therapeutic option for elderly patients with ST-segment-elevation myocardial infarction unable to access timely primary PCI.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT00623623. URL: https://www.clinicaltrials.gov; Unique identifier: NCT02777580.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":"17 12","pages":"e014251"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial. 缺血试验中不同应激试验方式下缺血严重程度与冠状动脉疾病的关系
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-12-01 Epub Date: 2024-12-17 DOI: 10.1161/CIRCINTERVENTIONS.123.013743
Harmony R Reynolds, Courtney B Page, Leslee J Shaw, Daniel S Berman, Bernard R Chaitman, Michael H Picard, Raymond Y Kwong, James K Min, Jonathon Leipsic, G B John Mancini, Matthew J Budoff, Cameron J Hague, Roxy Senior, Hanna Szwed, Balram Bhargava, Jelena Celutkiene, Milind Gadkari, Kevin R Bainey, Rolf Doerr, Ruben B Ramos, Peter Ong, Sudhir R Naik, Philippe Gabriel Steg, Kaatje Goetschalckx, Benjamin J W Chow, Marielle Scherrer-Crosbie, Lawrence Phillips, Daniel B Mark, John A Spertus, Karen P Alexander, Sean M O'Brien, William E Boden, Sripal Bangalore, Gregg W Stone, David J Maron, Judith S Hochman
{"title":"Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.","authors":"Harmony R Reynolds, Courtney B Page, Leslee J Shaw, Daniel S Berman, Bernard R Chaitman, Michael H Picard, Raymond Y Kwong, James K Min, Jonathon Leipsic, G B John Mancini, Matthew J Budoff, Cameron J Hague, Roxy Senior, Hanna Szwed, Balram Bhargava, Jelena Celutkiene, Milind Gadkari, Kevin R Bainey, Rolf Doerr, Ruben B Ramos, Peter Ong, Sudhir R Naik, Philippe Gabriel Steg, Kaatje Goetschalckx, Benjamin J W Chow, Marielle Scherrer-Crosbie, Lawrence Phillips, Daniel B Mark, John A Spertus, Karen P Alexander, Sean M O'Brien, William E Boden, Sripal Bangalore, Gregg W Stone, David J Maron, Judith S Hochman","doi":"10.1161/CIRCINTERVENTIONS.123.013743","DOIUrl":"10.1161/CIRCINTERVENTIONS.123.013743","url":null,"abstract":"<p><strong>Background: </strong>The relationship between the extent and severity of stress-induced ischemia and the extent and severity of anatomic coronary artery disease (CAD) in patients with obstructive CAD is multifactorial and includes the intensity of stress achieved, type of testing used, presence and extent of prior infarction, collateral blood flow, plaque characteristics, microvascular disease, coronary vasomotor tone, and genetic factors. Among chronic coronary disease participants with site-determined moderate or severe ischemia, we investigated associations between ischemia severity on stress testing and the extent of CAD on coronary computed tomography angiography.</p><p><strong>Methods: </strong>Clinically indicated stress testing included nuclear imaging, echocardiography, cardiac magnetic resonance imaging, or nonimaging exercise tolerance test. Among those with preserved renal function who underwent coronary computed tomography angiography, we examined relationships between ischemia and CAD by coronary computed tomography angiography, overall, and by stress test modality, regardless of subsequent randomization. Core laboratories categorized ischemia as severe, moderate, mild, or none, while the extent and severity of anatomic CAD were categorized based on the modified Duke prognostic index.</p><p><strong>Results: </strong>Among 3601 participants with interpretable stress tests and coronary computed tomography angiography, ischemia severity was weakly associated with CAD extent/severity (r=0.27), with modest variability in strength of association by modality: nuclear (n=1532; r=0.40), echocardiography (n=827; r=0.15), cardiac magnetic resonance imaging (n=108; r=0.31), and exercise tolerance test (n=1134; r=0.18). The extent of infarction on nuclear imaging and echocardiography was weakly associated with CAD extent/severity.</p><p><strong>Conclusions: </strong>Overall, ischemia severity on stress testing showed weak to moderate associations with the anatomic extent of CAD in this cohort with moderate or severe ischemia on local interpretation and controlled symptoms.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT01471522.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":"17 12","pages":"e013743"},"PeriodicalIF":6.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11658795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-Based Differences in Long-Term Outcomes Following Transcatheter Closure of Patent Foramen Ovale for Cryptogenic Stroke. 隐源性中风经导管闭合大孔后的长期疗效的性别差异。
IF 6.1 1区 医学
Circulation: Cardiovascular Interventions Pub Date : 2024-11-01 Epub Date: 2024-11-19 DOI: 10.1161/CIRCINTERVENTIONS.124.014467
Eduardo Flores-Umanzor, Lusine Abrahamyan, Areeba Asghar, Lore Schrutka, Karl Everett, Douglas S Lee, Mark Osten, Lee Benson, Eric Horlick
{"title":"Sex-Based Differences in Long-Term Outcomes Following Transcatheter Closure of Patent Foramen Ovale for Cryptogenic Stroke.","authors":"Eduardo Flores-Umanzor, Lusine Abrahamyan, Areeba Asghar, Lore Schrutka, Karl Everett, Douglas S Lee, Mark Osten, Lee Benson, Eric Horlick","doi":"10.1161/CIRCINTERVENTIONS.124.014467","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.014467","url":null,"abstract":"<p><strong>Background: </strong>Evidence from trials suggests that patent foramen ovale closure is superior to medical therapy alone in reducing stroke recurrence in men but not in women. Evidence from real-world data on the impact of sex on outcomes after patent foramen ovale closure, however, remains scarce. Therefore, the present study aimed to assess sex-based differences in long-term outcomes after transcatheter closure of patent foramen ovale.</p><p><strong>Methods: </strong>This was a single-center, retrospective cohort study enrolling patients who underwent transcatheter patent foramen ovale closure to prevent recurrent cerebrovascular events. Detailed information from medical charts was entered into a clinical registry, which has been linked to population-based administrative health databases in Ontario. Procedural, short, and long-term outcomes have been compared by sex.</p><p><strong>Results: </strong>Of the 783 patients included in the sample, 349 (44.5%) were women and 434 (55.5%) were men. Women were younger and had a higher rate of migraine, while men had a higher prevalence of cardiovascular risk factors. No differences were observed in procedural and 30-day outcomes by sex. At a median follow-up of 14 years, the event rates of recurrent cerebrovascular events, survival, and new-onset atrial fibrillation were not different by sex. In adjusted analysis, men experienced higher rates of pacemaker implantation (hazard ratio, 5.62 [95% CI, 1.57-20.1]).</p><p><strong>Conclusions: </strong>No sex-based differences in recurrent cerebrovascular events, survival, or new-onset atrial fibrillation were observed in this study, suggesting equal benefits for both sexes. Future studies should report outcomes by sex to enhance the reproducibility of our findings and help support guideline development.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":"17 11","pages":"e014467"},"PeriodicalIF":6.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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