Circulation: Cardiovascular Interventions最新文献

{"title":"Optimal Target of Activated Clotting Time During PCI and Outcomes: The OPTIMAL-ACT Trial.","authors":"S Michael Gharacholou, Colleen S Thomas, David O Hodge, Abdallah El Sabbagh, Gary E Lane, Peter M Pollak, Dilip P Pillai, Gretchen Johns, Leslie J Donato, Mandeep Singh","doi":"10.1161/CIRCINTERVENTIONS.125.015291","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.125.015291","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015291"},"PeriodicalIF":6.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Coronary Physiological Indices in Identifying Functionally Significant Myocardial Bridges in ANOCA.","authors":"Hisao Otsuki, Akihiro Yoshida, Vedant Satish Pargaonkar, Kuniaki Takahashi, Yasuhiro Honda, Peter Fitzgerald, Ingela Schnittger, Jennifer A Tremmel","doi":"10.1161/CIRCINTERVENTIONS.124.014824","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.014824","url":null,"abstract":"<p><strong>Background: </strong>A functionally significant myocardial bridge (MB) is an important cause of angina with nonobstructive coronary arteries. However, distinguishing a functionally significant versus incidental MB remains challenging. Resting and hyperemic intracoronary functional indices are available, but no studies have compared their diagnostic performance in MBs.</p><p><strong>Methods: </strong>We prospectively studied 64 patients with angina and nonobstructive coronary arteries, all of whom had an MB confirmed by intravascular ultrasound. We evaluated the diagnostic performance of instantaneous wave-free ratio (iFR) and resting full-cycle ratio (RFR) under Dobutamine stress, with Dobutamine diastolic fractional flow reserve (dFFR) as a reference standard. Dobutamine iFR and Dobutamine RFR were assessed in the first 18 patients, while only Dobutamine RFR was assessed in the remaining 46. Dobutamine dFFR ≤0.76 was considered indicative of a functionally significant MB.</p><p><strong>Results: </strong>There was a strong correlation between Dobutamine iFR (<i>R</i>²=0.67, <i>P</i><0.001) and Dobutamine RFR (<i>R</i>²=0.80, <i>P</i><0.001) with Dobutamine dFFR. Receiver operating characteristics curve analysis to identify the cutoff for Dobutamine dFFR ≤0.76 was 0.81 for Dobutamine iFR (area under the curve 0.961) and 0.76 for Dobutamine RFR (area under the curve 0.996). The diagnostic accuracy of Dobutamine iFR was 94.4%, with a sensitivity of 100% and specificity of 85.7%. For Dobutamine RFR, the diagnostic accuracy was 96.9%, with a sensitivity of 95.8% and specificity of 100%.</p><p><strong>Conclusions: </strong>In patients with angina and nonobstructive coronary arteries and an MB confirmed by intravascular ultrasound, Dobutamine iFR and Dobutamine RFR may serve as alternatives to Dobutamine dFFR in identifying a functionally significant MB, with Dobutamine RFR having superior diagnostic accuracy.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e014824"},"PeriodicalIF":6.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin-Free Strategy for PCI in Patients With High Bleeding Risk With or Without Acute Coronary Syndrome: A Subgroup Analysis From the STOPDAPT-3 Trial.","authors":"Tetsuya Ishikawa, Masahiro Natsuaki, Hirotoshi Watanabe, Takeshi Morimoto, Ko Yamamoto, Yuki Obayashi, Ryusuke Nishikawa, Kenji Ando, Satoru Suwa, Tsuyoshi Isawa, Hiroyuki Takenaka, Ruka Yoshida, Hiroshi Suzuki, Gaku Nakazawa, Takanori Kusuyama, Itsuro Morishima, Syun Hojo, Joshi Tsutsumi, Hirosada Yamamoto, Hiroshi Ueda, Koh Ono, Takeshi Kimura","doi":"10.1161/CIRCINTERVENTIONS.124.015197","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.015197","url":null,"abstract":"<p><strong>Background: </strong>The effects of the aspirin-free strategy on bleeding and cardiovascular events were unknown in patients with high bleeding risk (HBR), with or without acute coronary syndrome (ACS), undergoing percutaneous coronary intervention.</p><p><strong>Methods: </strong>We conducted a subgroup analysis stratified by ACS among patients with HBR in the STOPDAPT-3 trial (Short and Optimal Duration of Dual Antiplatelet Therapy-3), which randomly compared no-aspirin (prasugrel monotherapy) with dual antiplatelet therapy (DAPT) in patients with ACS and HBR.</p><p><strong>Results: </strong>There were 3258 patients with HBR, including 1803 ACS and 1455 non-ACS patients. The effects of no-aspirin compared with DAPT at 1 month after percutaneous coronary intervention were not significant for major bleeding regardless of ACS or non-ACS (7.3% vs.7.9%; hazard ratio [HR], 0.91 [95% CI, 0.65-1.28], and 3.1% versus 2.9%; HR, 1.06 [95% CI, 0.58-1.93]; <i>P</i> interaction=0.66). There was a numerically higher risk in the no-aspirin group relative to the DAPT group for a composite of cardiovascular death, myocardial infarction, definite stent thrombosis, or ischemic stroke in patients with ACS, but not in patients with non-ACS (7.9% versus 5.8%; HR, 1.39 [95% CI, 0.97-1.99], and 2.4% versus 3.0%; HR, 0.78 [95% CI, 0.41-1.47]; <i>P</i> interaction=0.12). There was a significant treatment-by-subgroup interaction for myocardial infarction (1.6% versus 0.3%; HR, 4.57 [95% CI, 1.31-15.89], and 1.4% versus 1.8%; HR, 0.78 [95% CI, 0.34-1.77]; <i>P</i> interaction=0.02).</p><p><strong>Conclusions: </strong>The aspirin-free strategy compared with the DAPT strategy failed to reduce major bleeding in patients with HBR irrespective of ACS. There was a signal of the excess risk of the aspirin-free strategy relative to the DAPT strategy for cardiovascular events, myocardial infarction in particular, in patients with ACS, but not in patients with non-ACS. The aspirin-free strategy may be considered as a potential treatment option after percutaneous coronary intervention in patients with non-ACS.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT04609111.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015197"},"PeriodicalIF":6.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Natriuretic Peptide and Prior Hospitalization in Patients With Severe Mitral Regurgitation: COAPT Trial.","authors":"Sachin S Goel, Ashrith Guha, JoAnn Lindenfeld, William T Abraham, Saibal Kar, Samir R Kapadia, Stephen H Little, D Scott Lim, Michael J Reardon, Neal S Kleiman, Janani Aiyer, Lak Kotinkaduwa, Michael Mack, Gregg W Stone","doi":"10.1161/CIRCINTERVENTIONS.125.015192","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.125.015192","url":null,"abstract":"<p><strong>Background: </strong>The clinical significance of elevated baseline natriuretic peptide level and prior heart failure hospitalization (HFH) within the prior year in mitral transcatheter edge-to-edge repair outcomes is unclear. This analysis examined the impact of BNP (B-type natriuretic peptide) or N-terminal prohormone BNP NT-proBNP (N-terminal pro-B-type natriuretic peptide) and prior HFH on outcomes in patients with severe secondary mitral regurgitation.</p><p><strong>Methods: </strong>The COAPT trial (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional Mitral Regurgitation) was a randomized controlled trial of subjects assigned to mitral valve transcatheter edge-to-edge repair with the MitraClip device versus guideline-directed medical therapy alone. COAPT patients were grouped by BNP/NT-proBNP levels and prior HFH within 1 year: (1) Mild heart failure (HF): no prior HFH with BNP/NT-proBNP<median; (2) Moderate HF: prior HFH with BNP/NT-proBNP<median or no prior HFH with BNP/NT-proBNP≥median; and (3) Severe HF: prior HFH and BNP/NT-proBNP≥median. The primary measures were 2-year rates of death or HFH.</p><p><strong>Results: </strong>Of 572 patients, mild, moderate, and severe HF were present in 125 (21.9%), 288 (50.3%), and 159 (27.8%) patients, respectively. With guideline-directed medical therapy alone, the 2-year rates of death or HFH in mild, moderate, and severe HF were 56.4%, 60.5%, and 84.1%, respectively (<i>P</i>_trend=0.001). These rates were 48.7% and 73.4% among patients with moderate HF and a prior HFH only versus elevated BNP/NT-proBNP≥median only (<i>P</i>=0.003). Mitral transcatheter edge-to-edge repair reduced death/HFH compared with guideline-directed medical therapy alone regardless of HF severity (<i>P</i>_interaction=0.50).</p><p><strong>Conclusions: </strong>In patients with HF with severe secondary mitral regurgitation enrolled in the COAPT trial, 2-year rates of death/HFH were increased with an elevated baseline BNP/NT-proBNP≥median, and more so if HFH within 1 year prior had occurred. Treatment with mitral transcatheter edge-to-edge repair reduced all-cause mortality and HFH consistently in mild, moderate, and severe HF.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifier: NCT01626079.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015192"},"PeriodicalIF":6.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure-Derived Indices in the Left Main Coronary Artery: Insights From Comprehensive In Vivo Hemodynamic Studies of Diseased and Unobstructed Vessels.","authors":"Ozan M Demir, Aish Sinha, Haseeb Rahman, Matthew Ryan, Kevin O'Gallagher, Howard Ellis, Matthew Li Kam Wa, Smriti Saraf, Khaled Alfakih, Ian Webb, Narbeh Melikian, Kalpa De Silva, Amedeo Chiribiri, Sven Plein, Divaka Perera","doi":"10.1161/CIRCINTERVENTIONS.125.015320","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.125.015320","url":null,"abstract":"<p><strong>Background: </strong>Pressure-based physiological evaluation of coronary artery disease is well established, but its application is limited in left main coronary artery (LMCA) disease. Our aim was to investigate whether pressure-based indices are comparable in the left anterior descending (LAD) and left circumflex artery (LCx) branches of the LMCA, and if discordance is due to differences in microvascular function in these territories.</p><p><strong>Methods: </strong>Simultaneous measurements of coronary pressure and flow were made in patients with (1) isolated LMCA disease and (2) unobstructed coronary arteries. Fractional flow reserve, instantaneous wave-free ratio, and microvascular resistance reserve values in the LAD were compared with those of the LCx.</p><p><strong>Results: </strong>A total of 80 patients were enrolled (mean age 65±10 years, 56% male). In those with isolated LMCA disease, fractional flow reserve in the LAD was lower than in the LCx (0.74±0.11 versus 0.81±0.11; <i>P</i><0.0001). Instantaneous wave-free ratio was also lower in the LAD (0.89 [0.76-0.92] versus 0.94 [0.88-0.97]; <i>P</i><0.0001). The misclassification rates of functionally significant coronary disease, when these indices were measured in the LCx, were 21% for fractional flow reserve and 28% for instantaneous wave-free ratio. Microvascular resistance reserve was higher in the LAD than the LCx, in cohorts with diseased (3.57±1.40 versus 2.50±0.81; <i>P</i><0.0001) or unobstructed LMCA (3.40±0.78 versus 2.47±0.68; <i>P</i><0.0001). Microvascular resistance reserve in the LAD territory was similar regardless of whether the LMCA was obstructed or not (<i>P</i>=0.56). Similarly, microvascular resistance reserve in the LCx territory was comparable between cohorts (<i>P</i>=0.88).</p><p><strong>Conclusions: </strong>Microvascular resistance in the LAD is lower than in the LCx territory. Consequently, fractional flow reserve and nonhyperemic pressure-derived indices are lower in the LAD than the LCx. These findings have important implications for how LMCA atheroma should be assessed in clinical practice and also suggest the need for territory-specific thresholds for defining abnormal microvascular function or epicardial conductance.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015320"},"PeriodicalIF":6.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stent-Edge Hinge Movement in a Calcified Lesion Is Associated With Increased Prevalence of a Calcified Nodule at Follow-Up.","authors":"Yoichiro Sugizaki, Mitsuaki Matsumura, Yu-Wei Chen, Takunori Tsukui, Takehiko Kido, Evan Shlofmitz, Doosup Shin, Koshiro Sakai, Ali Dakroub, Matthew J Granville, Genie M Miraglia, Kaylee Bressler, Charles Tarantino, Justin C Magee, Jeffrey W Moses, Omar K Khalique, David J Cohen, Gary S Mintz, Richard A Shlofmitz, Allen Jeremias, Ziad A Ali, Akiko Maehara","doi":"10.1161/CIRCINTERVENTIONS.124.015028","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.015028","url":null,"abstract":"<p><strong>Background: </strong>Coronary stenting alters vessel dynamics, displacing hinge movement closer to stent edges. We aimed to investigate whether calcified nodules (CNs) are more frequent at stent edges associated with calcium.</p><p><strong>Methods: </strong>In vessels with previously implanted stents evaluated by optical coherence tomography, 4 different calcified lesions were studied: stent-edge calcified lesions with or without a CN, and unstented native calcified lesions with or without a CN.</p><p><strong>Results: </strong>In 801 patients, 989 stent-edge calcified lesions and 354 unstented native calcified lesions were identified. Stent-edge calcified lesions exhibited a higher prevalence of CNs versus native calcified lesions (15.7% versus 5.1%; <i>P</i><0.001) and were observed in locations (mid left anterior descending artery, mid left circumflex, or branches) where no unstented native vessel CNs were seen. Stent-edge (versus native vessel) location (odds ratio [OR], 4.58 [95% CI, 2.23-9.43]) predicted the presence of a CN. Correspondingly, greater angiographic (systole-diastole) ∆angle at the stent edge or unstented lesion (per 10°, OR, 2.27 [95% CI, 1.43-3.60]) and greater calcium burden: calcium length (per 10 mm, OR, 4.04 [95% CI, 2.36-6.92]), maximum calcium arc (per 90°, OR, 1.65 [95% CI, 1.25-2.17]), and maximum calcium thickness (per 0.1 mm, OR, 1.25 [95% CI, 1.15-1.36]) were associated with the presence of a CN. Stent-edge CNs were associated with a higher rate of stent-edge calcified lesion-related major adverse cardiac events (a composite of cardiac death, target vessel-related myocardial infarction, clinically driven target lesion revascularization, or definite/probable stent thrombosis) compared with stent edges without a CN (15.9% versus 6.5%; <i>P</i>=0.01), mainly driven by target lesion revascularization.</p><p><strong>Conclusions: </strong>Stent-edge calcium may predispose to the development of a CN. Stent-edge CNs were associated with a higher major adverse cardiac events rate than stent edges without a CN, whether treated or untreated.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015028"},"PeriodicalIF":6.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Shah Regarding Article, \"Patent Foramen Ovale Closure in Patients With and Without Nickel Hypersensitivity: A Randomized Trial\".","authors":"Ashish H Shah","doi":"10.1161/CIRCINTERVENTIONS.125.015497","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.125.015497","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015497"},"PeriodicalIF":6.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter by Skalidis et al Regarding Article, \"Comparing the Efficacy of Sirolimus and Paclitaxel-Eluting Balloon Catheters in the Treatment of Coronary In-Stent Restenosis: A Prospective Randomized Study (TIS 2 Study)\".","authors":"Ioannis Skalidis, Thomas Hovasse, Philippe Garot","doi":"10.1161/CIRCINTERVENTIONS.125.015465","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.125.015465","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015465"},"PeriodicalIF":6.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transapical Beating-Heart Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy: Lessons Learned After the Learning Curve Period.","authors":"Jing Fang, Yue Chen, Yani Liu, Rui Li, Ying Zhu, Wei Zhou, Lin Cheng, Qunhui Wang, Juan Shi, Yupeng Wei, Yilei Ma, Eduard Quintana, Juan B Grau, Song Wan, Xiang Wei","doi":"10.1161/CIRCINTERVENTIONS.124.015044","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.124.015044","url":null,"abstract":"<p><strong>Background: </strong>The transapical beating-heart septal myectomy (TA-BSM) procedure was developed to enhance efficiency and reduce surgical trauma compared with conventional septal myectomy in treating obstructive hypertrophic cardiomyopathy. The current study aimed to delineate a refined TA-BSM surgical technique and summarize the midterm outcomes of the cohort immediately after the learning curve period.</p><p><strong>Methods: </strong>Employing a beating-heart myectomy device and guided by real-time transesophageal echocardiography, TA-BSM was conducted through a left mini-thoracotomy. Multiple tailored resections were performed on the beating heart to optimize hemodynamics and morphology. The primary outcome was procedural success, defined by resting/provoked left ventricular outflow tract gradient <30/50 mm Hg and mitral regurgitation ≤grade 2+ (of 4+) at 3- to 6-month follow-up.</p><p><strong>Results: </strong>Between January 2023 and January 2024, 418 patients with heterogeneous anatomic presentations of obstructive hypertrophic cardiomyopathy underwent TA-BSM. The maximal left ventricular outflow tract gradient decreased from a median of 85 (interquartile range, 65-114) mm Hg preoperatively to 19 (interquartile range, 12-28) mm Hg at 3- to 6-month follow-up. Mitral regurgitation improved with 98.8% of patients achieving ≤grade 2+ upon follow-up, versus 47.7% preoperatively. Overall, procedural success was achieved in 91.1% of the patients. Major adverse events included left ventricular apical tear (n=3, 0.7%), iatrogenic mitral valve injury (n=3, 0.7%), permanent pacemaker implantation (n=10, 2.4%), and transient ischemic stroke (n=2, 0.5%). All affected patients recovered uneventfully. The 30-day mortality was 0.2% (n=1). The estimated 1-year survival was 98.7% (95% CI, 97.6%-99.9%) over a median follow-up of 310 (interquartile range, 207-408) days.</p><p><strong>Conclusions: </strong>With real-time echocardiographic guidance, the individualized TA-BSM approach can effectively and safely achieve adequate and precise resections of septal myocardium. The technique's midterm results further confirmed its therapeutic advantages, potentially broadening the applicability of surgical septal reduction in obstructive hypertrophic cardiomyopathy treatment. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT05332691.</p>","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015044"},"PeriodicalIF":6.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Nature of the Hyperemic Continuum.","authors":"Pim A L Tonino, Nils P Johnson","doi":"10.1161/CIRCINTERVENTIONS.125.015406","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.125.015406","url":null,"abstract":"","PeriodicalId":10330,"journal":{"name":"Circulation: Cardiovascular Interventions","volume":" ","pages":"e015406"},"PeriodicalIF":6.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}