Hematology & Transfusion International Journal最新文献

{"title":"Rhesus (Rh) blood group antigens in multiparous women attending antenatal clinic in tertiary hospital, port harcourt, Nigeria","authors":"Ransom Baribefii Jacob, Eboh Covenant, Sorgah Dorka ThankGod, Moore-Igwe Beatrice W","doi":"10.15406/htij.2023.11.00294","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00294","url":null,"abstract":"The routine blood screening test carried out for pregnant women attending antenatal clinic in Tertiary Hospital Port Harcourt, Nigeria especially with regards to blood group system is limited to ABO/Rh D antigen screening. This cross-sectional, hospital-based study was aimed at determining the prevalence of the Rh C, c, E and e blood group antigens in multiparous women attending antenatal clinic in Tertiary Hospital Port Harcourt, Nigeria. A total of one hundred and twenty (120) pregnant females within the age range of 18-40years were recruited randomly into the study between February-June, 2022. Blood samples were aseptically collected by venipuncture into EDTA sample bottle; Rh C, c, E and e blood group antigens were assay for using microwell agglutination technique. Data generated was statistically analyzed by simple percentage calculation and defining the percentage frequency of Rh antigens. Results obtained showed the percentage distribution of 17.5% for Rh C, 89.2% for Rh c, 39.2% for Rh E and 90.8% for Rh-e. Percentage distribution of Rh antigens amongst studied population based on parity showed that G3P2 group had the highest percentage positivity of 8(6.7%) for Rh-C antigen while those carrying their first pregnancy (prime) had the highest percentage positivity of 33(27.5%), 15(12.5%) and 36(30.0%) for Rh-c, Rh-E and Rh-e respectively. Distribution of Rh antigens with respect to previous transfusion history in studied participants showed 6 (5.0%), 15 (12.5%), 6 (5.0%) and 17 (14.2%) percentage positivity for Rh-C, Rh-c, Rh-E and Rh-e respectively. This study revealed a percentage positivity of 17.5%, 89.2%, 39.2 % and 90.8% for Rh-C, Rh-c, Rh-E and Rh-e respectively with high percentage expression for Rh-c, E and e antigens found on the red cells of Antennal Women carrying their first pregnancy. Furthermore, there is a high percentage expression of Rh antigens in previously transfused pregnant women in this study. Although routine phenotyping of these blood group antigens will be a financial burden in a resource limited country like Nigeria. It is expedient and needful to take into cognizance the fact that the presence of Rh C, c, E and e antigens may likely be the cause of some delayed transfusion reactions and haemolytic disease of the foetus and new born. Therefore, there is need for the inclusion of Rh C, c, E and e in routine antigen typing for pregnant women in other to help ameliorate red blood cell alloimmunization and delayed haemolytic transfusion reaction during pregnancy. Furthermore, there is need to promulgate policies that promote the optimum stocking of Rh-e, c antigen negative blood in blood banks in the area for emergency use.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127143302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study between a deterministic and stochastic model´s for the hematopoietic reconstitution","authors":"Miguel Ángel Martínez Hernández, Dennis Lumpuy Obregón","doi":"10.15406/htij.2023.11.00293","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00293","url":null,"abstract":"The dynamics of the processes of cell maturation and regeneration is a branch currently in development for medicine, so taking advantage of the facilities of mathematics to model and solve environmental problems, different models of differential equations have been developed to describe these processes. From the existing deterministic models, the particular case of the hematopoietic cell is chosen, for of a comparative study on the influence of the medium on the process of cell maturation. For this, a probabilistic model of differential equations with six compartments is used. The stochastic term or environmental noise in this particular case modeled by a Weiner process. The inclusion of this term makes it possible to perform an analysis conditioned on the influence of the medium of the different processes of cellular maturation, in this case, of the hematopoietic cell. It is established that the stochastic model reflects a more precise approach to the clinical data used.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114624845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary immune thrombocytopenia and cytomegalovirus infection About a case","authors":"Ariel Raúl Aragón Abrantes, Liekna Elena Sosa Saez, Danelis Hernández Aguiar","doi":"10.15406/htij.2022.10.00291","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00291","url":null,"abstract":"Primary Immune Thrombocytopenia (ITP) is an acquired coagulation disease characterized by a decrease in platelets below 100 x 109/L in the absence of other causes of thrombocytopenia and that may be preceded by viral processes or vaccination. A 16-year-old male adolescent who presented a febrile syndrome was diagnosed as part of the studies as an infection by cytomegalovirus, later he began to present purpuric hemorrhagic manifestations on the skin and mucous membranes, for which a medulogram was performed and the diagnosis of Primary ITP was made. Conclusions: an adolescent who developed a TIP after cytomegalovirus infection, requiring treatment with steroids and valganciclovir for its management.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116704964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary testicular diffuse large B-cell lymphoma in young patient: an uncommon presentation","authors":"Alami Drideb, Bouchnafat Saddi","doi":"10.15406/htij.2022.10.00290","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00290","url":null,"abstract":"Primary testicular lymphoma (PTL) is a rare form of extranodal lymphoma, this neoplasm is the most common malignant tumor of the testis in the elderly age, and the majority of cases are histologically diffuse large B-cell lymphoma (DLBCL), accounting for 80% to 98% of non-hodgkin lymphoma. Patients with primary testicular DLBCL show a continuously high risk of recurrence with no plateau in the survival curves and a tendency to involve other extranodal sites, especially the central nervous system and the contralateral testis. We report a rare and uncommon presentation of a primary testicular diffuse B cell lymphoma in young patient.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131423602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecthyma gangrenosum complicating first line treatment of chronic lymphocytic leukemia","authors":"N. A. Drideb, S. Bouchnafati, I. Khoussar, M. Ouazzani, W. Ghandour, Z. Khammar, R. Berrady","doi":"10.15406/htij.2022.10.00289","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00289","url":null,"abstract":"Ecthyma Gangrenosum is a severe skin disease commonly associated with Pseudomonas aeruginosa septicemia, there is an increased risk of infection in patients with malignancy undergoing chemotherapy notably Chronic lymphocytic leukemia (CLL). We present a case report of CLL patient infested by P. aeruginosa.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123775405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between morphology and immunophenotype in the diagnosis of pure erythroid leukemia","authors":"Ariel Raúl Aragón Abrantes, Liekna Elena Sosa Saez, Danelis Hernández Aguiar","doi":"10.15406/htij.2022.10.00288","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00288","url":null,"abstract":"Pure erythroid leukemia is a rare entity that represents less than 5% of pediatric acute myeloid leukemias and is classified according to the World Health Organization (WHO) within the group of unspecified acute leukemias. A clinical case of a 5-year-old patient admitted with septic arthritis in the Pediatric Hospital, he also presenting with fever and anemia, for which a medullogram and immunophenotype were performed and erythroleukemia was diagnosed. It can be concluded that it is necessary for its diagnosis to integrate clinical, morphological and immunophenotypic, genetic and molecular studies.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"228 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126042002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of 206 oncohematological patients admitted to the intensive care unit","authors":"Antelo Guadalupe, Cosacow Cesar, Maymó Daniela, Laviano Julia, Rivero Equiza Tomas, Fornillo Florencia, Bonelli Ignacio, F. Jose","doi":"10.15406/htij.2022.10.00287","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00287","url":null,"abstract":"The Intensive Care Unit (ICU) provides support that includes oncohematology (OH) patients. There is tendency to delay admission of this patients to the unit. Currently, advances in the molecular biology of specific mutations; advances in stem cell transplant and immunotherapy have produced a change in the prognosis of patients. A descriptive, retrospective cohort study was carried out in adult patients with oncohematological diseases who were admitted to the ICU, in the period from January 2009 to February 2021 to evaluate mortality in the unit as the main objective as well as associations between epidemiological, clinical variables and others related to the oncohematological situation and mortality during this period. 206 patients were included. The median age was 59years (IQR: 46-68). The median on days of hospitalization was 15 (IQR: 8-28) whilst the median of days in the ICU was 5 (3-8). Mortality was evaluated at the time of discharge from the ICU, reaching 45% (93 patients), 47% at 30days and 49% at 60days, respectively. The median survival of the global population was 15.5days (IQR: 4.25-60). The median APACHE II scored 22 points (IQR: 15-25). A statistically significant relationship was found in the multivariate analysis for mortality with the APACHE II variables (p = 0.0001) and the requirement for mechanical ventilation (p = 0.021). Using the ROC curve method, the APACHE II score value of 22 was obtained as the point of greatest statistical significance. The log rank test method was used to compare patients with a value greater or less than 22. In conclusion, the value of 22 points scored on APACHE II and the requirement for mechanical ventilation served to discriminate between two groups of patients with different prognosis.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"250 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128808962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-transplantation cyclophosphamide as graft versus host disease prophylaxis in patients with acute leukemia received fully matched allogeneic HSCT or haplo-identical HSCT","authors":"A. Elshamy, E. A. Abd ElMohsen, M. Denewer, M. Mabed","doi":"10.15406/htij.2022.10.00285","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00285","url":null,"abstract":"Post-transplant Cyclophosphamide (PT-Cy) has proved efficacy as GVHD prophylaxis regimen after HSCT. However, experiences are limited with controversial results. We herein, assess the efficacy of PT-Cy compared to Methotrexate regimen. Eighty patients with acute leukemia received a fully matched allogeneic HSCT or a Haplo-identical HSCT were analyzed. Group I (Historical group) included 40 patients received Methotrexate, Cyclosporine and MMF. They were transplanted with fully matched allogeneic transplantation. Group II included 40 patients received PT-Cy, Cyclosporine and MMF. They were subdivided to 2 subgroups. Subgroup IIA included 22 patients received fully matched allo- HSCT and subgroup IIB included 18 patients received Haplo- HSCT. Group IIA showed significantly lower incidence of cGVHD when compared to group I with an incidence of 22.7% and 67% respectively (P = 0.002). Group IIA was associated with reduced risk of extensive cGVHD compared to MTX group (P =0.003). No significant differences were found in the incidence of aGVHD, relapse rates, relapse or non-relapse related mortalities, OS and DFS data among the different groups (P>0.05). In conclusion, PT-Cy with addition of IS drugs has statistically significant difference in reducing the incidence of cGvHD in both fully matched and Haplo SCT with less hepatic and renal toxicity.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115887247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of transfusion incidents and near-misses in a hospital on the coast of Santa Catarina","authors":"Amanda Regina Belem Lermen, Daiane Cobianchi da Costa, Edneia Casagranda Bueno, Larissa Pucci Vieira, A. Geraldo","doi":"10.15406/htij.2022.10.00282","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00282","url":null,"abstract":"Transfusion medicine is not free of risks and their source could be both technical and human. The near-miss is a deviation from a procedure detected before its occurrence, which could result in an erroneous transfusion and/or a transfusion reaction. The incidents in turn comprise the deviations in the security policy, leading to inadequate transfusions. This study aimed to evaluate transfusion incidents and near-misses of a transfusion agency on the coast of Santa Catarina, Brazil. The pre-analytical, analytical and post-analytical phases of the pre-transfusion tests and transfusion procedure were evaluated using forms based on the current hemotherapy legislation and filled out locally by the researchers. The obtained data were sectioned in identifications (IDs) and their respective phases. Among the evaluations, 10,562 on-site observations were counted, and nonconformities were detected in the pre-analytical and analytical phases of the pre-transfusion tests. Nonconformities were detected due to the non-execution of the tests (6.7%), non-identification of the patient prior to biological sample collection (69.9%) and blood component installation (75.3%). Non-follow-up of the initial transfusion was 81.9% of non-compliance. However, there were a low number of near-misses, totaling 0.10%. In the period of this study it was possible identifying that the in loco evaluation of hemotherapy activities is important to detect incidents and near-misses. In this way, an audit of hemotherapy procedures and the training of professionals can help to reduce incidents and near-misses caused by lack of human attention.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114759982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of ABO blood group antigen on activated partial thromboplastin and prothrombin time tests in healthy university students kosti city, White Nile state, Sudan","authors":"Elham Elamin, Abdelhakam G. Tamomh, AbdElhadi M Agena, Rahma Abd Elfatah M Eltaib, Nada Y Ali, Mohammed Elmadani, Alaa F Mohammed, Fatima M Almahdi, Mozdlefa B Musa","doi":"10.15406/htij.2022.10.00280","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00280","url":null,"abstract":"Background: Variances in blood group antigen have been related with susceptibility particular to diseases. Prothrombin time [PT], measures the efficiency of the extrinsic and common coagulation pathways, although Activated partial Thromboplastin time [APTT] test evaluates the intrinsic and common coagulation pathways. Objective: To explore the influence of blood groups antigen on APTT and PT among Healthy University Students on different ABO blood groups. Materials and methods: Cross section study including student during the period of three months from September 2020 to December 2020 at Medical campus, University of El Imam El Mahdi, White Nile State, Kosti City, total of 480 students were enrolled. Four milliliters of venous blood was collected from each student, ABO blood grouping was done by the tile method whereas APTT, and PT were analyzed using the manual methods. Data were processed using the Statistical Package for the Social Sciences (SPSS) program version 26 by means of descriptive and inferential statistics. Results: Blood group O was largest among the test individuals [45%], followed by blood group A [30%] and B [16%], while blood group AB has the smallest percentage of (9%). Blood group O is significantly higher APTT value [39.07 ± 4.81] second compared to blood groups A [36.60 ± 5.89] second, AB [35.23 ± 4.86] second, and B [34.39 ± 5.30] second, P value < 0.05. Likewise, blood group A showed a significantly higher PT value [15.94 ± 1.36] second compared to blood groups O [14.12 ± 1.43] second, B [13.54 ± 1.35] second, and AB [14.67 ± 1.80] second, P < 0.05. Male had a higher APTT level (44.44± 7.27] second, PT [15.66 ± 1.88] second, and, compared with the female APTT [35.14 ± 6.49] second, PT [14.08 ± 1.29] second, P value < 0.05. Conclusion: Males have a higher APTT and PT levels compared to females. Blood group [O] individuals having a significantly higher APTT, while blood group [A]individuals having higher PT. This proposal that blood group of individuals may be affect their intrinsic (APTT) and extrinsic Coagulation mechanisms (PT].","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127537870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}