Comparative study between a deterministic and stochastic model´s for the hematopoietic reconstitution

Miguel Ángel Martínez Hernández, Dennis Lumpuy Obregón
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Abstract

The dynamics of the processes of cell maturation and regeneration is a branch currently in development for medicine, so taking advantage of the facilities of mathematics to model and solve environmental problems, different models of differential equations have been developed to describe these processes. From the existing deterministic models, the particular case of the hematopoietic cell is chosen, for of a comparative study on the influence of the medium on the process of cell maturation. For this, a probabilistic model of differential equations with six compartments is used. The stochastic term or environmental noise in this particular case modeled by a Weiner process. The inclusion of this term makes it possible to perform an analysis conditioned on the influence of the medium of the different processes of cellular maturation, in this case, of the hematopoietic cell. It is established that the stochastic model reflects a more precise approach to the clinical data used.
造血重建的确定性与随机模型之比较研究
细胞成熟和再生过程的动力学是目前医学发展的一个分支,因此利用数学的设施来建模和解决环境问题,不同的微分方程模型已经发展到描述这些过程。在现有的确定性模型中,选择了造血细胞的具体情况,比较研究了培养基对细胞成熟过程的影响。为此,我们采用了六隔室微分方程的概率模型。随机项或环境噪声在这种特殊情况下由韦纳过程建模。这一术语的包含使我们有可能根据培养基对细胞成熟不同过程的影响进行分析,在本例中是对造血细胞的影响。这是建立了随机模型反映了一个更精确的方法来使用临床数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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