Hematology & Transfusion International Journal最新文献

{"title":"SARS-CoV-2 pandemic and its impact on blood transfusion services: challenges, experience and lessons learnt at king Abdullah medical city, Makkah, Saudi Arabia","authors":"Hanadi M Aljedani, Abdulaziz F Alshaikh, Arwa Mokhtar, Farzal Anwar","doi":"10.15406/htij.2022.10.00279","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00279","url":null,"abstract":"SARS-COVID (COVID-19) epidemic is a great challenge for blood transfusion practice. Hospitals were overwhelmed with increasing number of admitted patients with severe COVID-19 infections as well as limitation of variable medical and pharmaceutical resources partly due to lockdown. This retrospective study analyzes the transfusion medicine practice and approach of health institution toward the pandemics before and during the pandemic era over the four years period, 2018 through 2021. Data was collected from blood bank records and laboratory information system for the whole blood donors, apheresis platelets donors, numbers and types of prepared blood components, details of blood components storage and expiry, and blood components for the study period. The data analyzed showed that the total number of whole blood donors dropped during 2020. However, there is a steady increase in number of voluntary non-numerated whole blood donors. The production of packed Red Blood Cells units, Fresh Frozen Plasma units, and Cryoprecipitate units were actually more or less similar or slightly higher in 2020 compared to 2019 and 2018. However, the production of Platelets components showed a drop during 2020. The transfusion for patients at the institution has slightly increased for 2020 compared to 2019. Therefore, the need to procure blood components from other facilities was increased in 2020 compared to pre COVID-19 pandemics. The percentage of expired and wasted blood components units steadily decreasing over the past few years. The data of expired and or wasted collected blood components were compared through the study period and it illustrates that the percentage of expired and wasted units was steadily dropped over the years. This to mention that automated blood transfusion system was implemented late 2019 and put in full effect in 2020. The presence of validated and secured electronic system supports blood bank to eliminate the number of expired and wasted units due to proper inventory management. Along with all the hard work to maintain adequate and safe blood supply to increasing requests of blood transfusion, blood bank at KAMC participated in the national multidisciplinary study of Convalescent Plasma use for critically ill COVID-19 patients.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129142863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of leukocyte cell population data (CPD) as biomarkers in the diagnosis of sepsis","authors":"Portell Rigo IM, Alarcón Rodríguez R, Benayas Bellido MP, Avivar Oyonarte C","doi":"10.15406/htij.2022.10.00278","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00278","url":null,"abstract":"Background: Leukocyte cell population data (CPD) are parameters currently being studied as biomarkers in sepsis and other pathologies. CPD was procured with the BC 6800 Plus Mindray® hematology analyzer that also provides information on the internal cellular complexity, nucleic acid content, and size of leukocytes. This study aimed to assess the efficacy of CPD parameters as biomarkers in the diagnosis of sepsis by comparing these with the standard sepsis biomarker, procalcitonin (PCT). Methods: In total 107 patients with suspected sepsis were included in the study, and serum procalcitonin levels were measured and WBC cell population data (CPD) were analyzed in a hemogram to confirm the diagnostic accuracy of these biomarkers. ROC curves were plotted for all parameters and patients were categorized based on their serum procalcitonin levels. IBM SPSS Stadistics version 24 was used for statistical analysis of the data. Results: All parameters except the CPD NEU-X (neutrophil complexity), NEU-Z (neutrophil size), LYM-Z (lymphocyte size) and MON-Z (monocyte size) showed statistically significant results (p<0.05). ROC curve analysis showed that the CPD parameters MON-X and NEU-Y had area under the ROC curve (AUC) > 0.7, reflecting the better diagnostic performance in sepsis. A lower AUC of 0.650 was obtained for PCT; 87.8% of septic patients had serum PCT levels between ≥5 ng/mL and 51.2% ≥ 2 ng/mL. Conclusion: This study suggests that some of the new CPD parameters (MON-X and NEU-Y) have the potential to be a useful diagnostic marker for sepsis.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115044785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation of multiple myeloma with absolute lymphocytosis? Coexistence of CLL & multiple myeloma","authors":"N. Fareed, Noor Muhammad Somroo, Ghulam Fatima","doi":"10.15406/htij.2022.10.00277","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00277","url":null,"abstract":"The presence of a chronic lymphocytic leukemia and multiple myeloma in a single patient is very rare. Multiple myeloma is a plasma cell disorder, whereas CLL (Chronic Lymphocytic Leukemia) is the mature B-cell lymphocytes disorder. We described a 50 year-old man who presented with fatigue and lethargy of 1 month duration. He was found to be anemic, with lymphocytosis, decreased renal function, high calcium level, and conspicuous M-Spike on serum electrophoresis. Furthermore, peripheral smear & bone marrow biopsy demonstrated two distinct hematological malignancies on morphological basis.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131808313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of next generation and whole genome sequencing in the diagnosis of hematological disorders and challenges to apply in routine diagnosis","authors":"Solomon Getawa, M. Melku","doi":"10.15406/htij.2022.10.00276","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00276","url":null,"abstract":"By assessing a patient's genetic makeup at a low cost, next-generation sequencing (NGS) technologies have begun to change the area of hematological malignancies. High-throughput, massively parallel DNA sequencing technologies are rapidly revealing new information in hematology, cancer, clinical genetics, and a variety of other diseases. It provides researchers with a new viewpoint on the onset of sickness, risk assessment, and therapeutic action. In hematology these technologies are used to diagnose hematological malignancies, inherited coagulation bleeding disorders, minimal residual diseases, hereditary hemolytic anemia, and blood typing. The use of next-generation sequencing in regular diagnostic procedures raises a number of challenges, including result interpretation, laboratory workflow, data storage, and ethical concerns.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126410420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron status of sickle cell children in Libreville, Gabon: prevalences and associated factors","authors":"S. Minto’o, E. K. Kamgaing, Mylène Mimbila-Mayi, Fifi Claire Loembet, Leatitia Abang Ekouaghe, S. Ategbo","doi":"10.15406/htij.2021.10.00275","DOIUrl":"https://doi.org/10.15406/htij.2021.10.00275","url":null,"abstract":"Background: Iron is essential for a child's growth. In the Gabonese general pediatric population, iron deficiency is the most widespread nutrient deficiency. Quid of the sickle cell children in Libreville, Gabon? Methods: We conducted a cross-sectional study including sickle cell children aged from 6 months to 15 years, with haemoglobin SS confirmed. Subjects included were examined in steady-state. Data collected were about the socioeconomic background of the families, medical history of the children. To determine iron status, we used: CRP, Ferritin, serum iron, Transferrin, total blood count cell and erythrocytic parameters. Results: We included 247 children; 128 boys (51.8%) and 119 girls (48.2%). The median age of the children was 8 years [1 year - 15 years]. Following definition criteria we found: 9% (95% CI [18.6% - 29.2%]) of iron deficiency, 67.6% (95% CI [62.2% - 73.8%]) of normal iron status, and 8.1% (95% CI [4.7% - 11.5%]) of iron overload. Iron deficiency was associated with a child’s rank >2, OR=2.1 (95%IC [1.2-6], p<0.001). Iron overload was associated with age >11 years OR=2.5 (95%IC [1.7-9], p<0.001); mothers’ low educational level OR=3.6 (945% IC [1.4-9], p=0.03); transfusion OR=10,5 (95%IC [1,9 – 53], p =.0.025); a last transfusion between 4 and 6 months OR=9.1 (95%IC [3.1-21], p<0.001). Conclusion: The majority of sickle cell children in our context has a normal iron status. Iron deficiency and iron overload should be monitor and treated according to associated factors, and greater studies are required to determine algorithms to assess and treat and iron imbalance.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121598029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drone transportation of FFP maintained frozen using a vaccine refrigerated transport box","authors":"Fumiatsu Yakushiji, Koki Yakushiji, M. Murata, Miyuki Teratani, H. Fujita","doi":"10.15406/htij.2022.10.00273","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00273","url":null,"abstract":"Background: In cases of emergency injury, fresh frozen plasma (FFP) is necessary to compensate for the consumption of clotting factors. The emergent delivery of FFP can be critical to survival and reduction of complications. We hypothesize that drone transport of FFP under appropriate conditions below -30°C would be possible if we used a BioBox Cell® normally employed for COVID-19 vaccine transport. Method: We transported FFP packs inside a BioBox Cell® that was continuously chilled by dry ice by an automobile-transport, to Tomi where a test location at a distance of approximately 200 km away from our laboratory. We transported FFP packs inside a BioBox Cell®　by a drone (M1000) and, back to the laboratory by an automobile. For about a day, the FFP was transported car transport, and drone transport under low-temperature without power. Results: The influence of drone flight on FFP clotting factor activity, such as fibrinogen, factors II, V, VIII, IX, X, XI, XIII, and von Willebrand factor (vWF), was minimal. Conclusion: We transported FFPs at an adequate temperature using a drone and confirmed that there was little reduction in clotting factor activity. FFP can be transported easily and quickly using a drone using a low-temperature refrigerator.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124188697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"http://medcraveonline.com/HTIJ/poems-syndrome-presenting-with-colonic-pseudoobstruction-and-calciphylaxis.html","authors":"Vatsala Katiyar, Tiago Araújo, Mina M Kerlos, Poushali Bhattacharjee, Adamsu Kumssa","doi":"10.15406/htij.2022.10.00272","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00272","url":null,"abstract":"Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein, Skin changes (POEMS) syndrome is a rare and poorly understood paraneoplastic syndrome driven by monoclonal plasma cell dyscrasia. Common presenting symptoms include neuropathy, endocrine dysfunction, skin changes, and volume overload. Here we describe a young female with history of neuropathy who presented to our hospital with abdominal pain and was found to have persistent colonic pseudo-obstruction .She was diagnosed with POEMS syndrome based on the International Myeloma Working Group diagnostic criteria and her intestinal dysmotility was thought to be a consequence of the underlying syndromic condition. To our knowledge, this is the first case of POEMS syndrome presenting with intestinal pseudo-obstruction.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129143826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental thrombosis in oncologic patient","authors":"Picallo Lombardía P, Pereiro Sanchez M, Aceituno Caneiro M, Hernández Sánchez MC","doi":"10.15406/htij.2022.10.00271","DOIUrl":"https://doi.org/10.15406/htij.2022.10.00271","url":null,"abstract":"We present a 64 year-old woman case report with lung cancer and active chemotherapy treatment, who developed a Superior Vena Cava Syndrome (SVCS). During the follow up, being with anticoagulant therapy, she presented an incidental thrombosis. This event was discovered at control doppler image of previous SVCS. All hemostasia studies were normal. Anticoagulant therapies in Oncological and Hematological patients are essential and needed. Some issues such as prophylactic and treatment of thrombotic diseases will be discussed, also when and which should be used.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128619240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting P-selectin ligands: ushering in a new treatment paradigm for Sickle Cell Disease","authors":"Dr. Ashraf Abdullah Saad","doi":"10.15406/htij.2021.09.00270","DOIUrl":"https://doi.org/10.15406/htij.2021.09.00270","url":null,"abstract":"Sickle cell disease (SCD) is a debilitating systemic disease with limited treatment options for disease-related complications. Microvascular vaso-occlusion is the hallmark of the disease with profound morbidity and increased mortality. Vaso-occlusion underlies intricate pattern of complications related to hyper-adhesiveness of circulating blood cells and endothelium. Over-expression of P-selectin is central to initiation of the vaso-occlusive cascade by downstream engagement of multiple adhesion receptor/ligand pairs. Blocking P-selectin has been shown to effectively prevent vaso-occlusion by blocking these adhesive interactions. However, the model of the E-selectin inhibitor uproleselan in acute myeloid leukemia (AML) should instigate the development of similar agents that target selectin-ligand adhesive interactions in order to attenuate the clinical effects of vaso-occlusion. Interestingly, the sialylated and fucosylated tetrasaccharide sialyl Lewis(X) (sLeX) was found to be the glycan (carbohydrate) determinant for selectin binding. Therefore, novel synthetic lectins that target glycan determinants on P-selectin-ligands could prove more precise and efficient drugs, not only for prevention, but also for treating patients with vaso-occlusion crises (VOCs).","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131280343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the haematological alterations in cervical cancer patients attending sabratha national cancer institute, Western Libya","authors":"Fikry Ali Abushofa, Azab Elsayed Azab, Hajar Musa Al Ghawi, Azab Elsayed Azab","doi":"10.15406/htij.2021.09.00269","DOIUrl":"https://doi.org/10.15406/htij.2021.09.00269","url":null,"abstract":"Background: Cervix cancer is one of the most common cancers in women worldwide, and is the third most common malignant disease in women. It is one of the main health problems in Libyan women. Blood act as a pathological reflector of the status of exposed patient to infections and other conditions. Laboratory tests on the blood are vital tools that help detect any deviation from normal in the human body As the disease progresses, changes appear in haematological parameters which have been of relevant consideration in context of cancer patients. Objectives: The present study aimed to evaluate the alterations in haematological parameters among cervical cancer patients in Sabratha National Cancer Institute. Subjects and methods: The present study was conducted on 150 cervical cancer patients, attending the National Cancer Institute of Sabratha from the 11th February, 2006 to the 3rd February, 2020. This study was approved by the Research and Ethical Committee of Sabratha University and Sabratha National Cancer Institute. Age was extracted from patient files. Also, 60 healthy individuals without any chronic disease were recruited for the control group. Blood samples were collected by vein puncture, 3 ml of venous blood withdrawn from each participant in the study by using disposable syringes under aseptic technique; they then transferred to a sterile EDTA tube, for complete blood count. The statistical significance of differences between groups was evaluated with the Mann Whitney U test. Results: The results showed that the mean age of the cervix cancer patients was 53.37±11.6 years. RBCs count, hemoglobin concentration, Hct value, MCH, MCHC, and lymphocytes % were significantly (P<0.01) decreased compared with the healthy individuals. On the other hand, leukocytes and platelets count, mixed %, neutrophils %, PLTs/Lymph, and Neutrophils/Lymphocytes ratios were significantly increased as compared with the healthy individuals. Conclusion: It can be concluded that a significant increase in leukocytes and platelets count, mixed %, neutrophils %, and the studied inflammation related haematological parameters and a significant decreased in lymphocytes %, RBCs count and most its indices. Further haematological studies are needed to confirm these results. Also, there is need to routinely monitor the haematological parameters and among cervical cancer patients.","PeriodicalId":103294,"journal":{"name":"Hematology &amp; Transfusion International Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114224173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}