Hematology & Transfusion International Journal最新文献

{"title":"Screening of antenatal patients for anaemia and haemoglobinopathies","authors":"Tejal Ahuja, Nidhi Bhatnagar, Mamta Shah, Sangita Shah","doi":"10.15406/htij.2023.11.00306","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00306","url":null,"abstract":"Introduction: Anaemia is an extremely common condition in pregnancy worldwide, conferring a number of health risks to mother and child. Iron deficiency is most widespread micronutritional deficiency in the world and disproportionately affects female because of increased iron requirements during menstruation, pregnancy and lactation. Haemoglobinopathies are a group of inherited disorders because of abnormalities in haemoglobin synthesis or structure. Thalassemia and Sickle cell anaemias are the most prevalent haemoglobinopathies and a national health burden in India so identifying these disorders during antenatal period is necessary to take appropriate measures. Methods: A prospective study of screening for haemoglobin variants in Antenatal Patients due to low haemoglobin and evaluation of other causes was performed for 1 year with 570 samples. In Low Hb patients’ CBC, Reticulocyte staining and sickling test was performed. Haemoglobin analysis was done by HPLC BIO RAD VARIANT II. In Iron Deficiency Anaemia (IDA) Serum ferritin & Serum Iron level were done and in Megaloblastic Anaemia(MA) Vitamin B12 level were done. Result: Prevalence of anaemia in antenatal patients was 90.25%; in this IDA presented with 84.21%, MA with 4.73% and Dimorphic anaemia 1.27%. Prevalence of haemoglobinopathies in this study was 9.75%; in this Beta Thalassemia Minor present with 5.08%, Sickle Cell Trait 4.03%, Hb D Punjab 0.52% and Hb Q india 0.17%. Conclusion: Antenatal screening for genetic disorders, such as Beta thalassemia, Sickle Cell Anaemia, aims to reduce the burden of these diseases by offering information to individual with a high likelihood of giving birth to affected babies and giving parents more choices regarding their reproductive decisions. For this, premarital and antenatal screening should be mandatory to prevent the birth of affected offspring.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124381074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early treatment of subacute combined degeneration of the spinal cord in pernicious anemia will improve the outcome","authors":"Murad Baba","doi":"10.15406/htij.2023.11.00305","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00305","url":null,"abstract":"Vitamin B12 deficiency is probably more common than what is reported in the literature. B12 is an essential vitamin, and its deficiency can lead to neuropsychiatric manifestations such as peripheral neuropathy, myelopathy, cerebellar ataxia, dementia, delirium, even psychosis and mood disorders. We report a case of 45 year old polish male presented with symptoms and signs suggestive of SCD of the spinal cord, due to severe vitamin B12 deficiency as a result of pernicious anemia. Cervical spine MRI showed enhancement in the bilateral posterior columns of the cervical spinal cord with a classic inverted V appearance. Metabolic workup revealed severe vitamin B12 deficiency, complete blood analysis indicated megaloblastic anemia. Intramuscular injection of cobalamin was started on a timely manner with complete resolution of symptoms.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114113060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Luspatercept: a lifesaving therapy for transfusion-dependent thalassemia patients with alloimmunization complications”","authors":"S. Delicou, Effrosini Nomikou, Ioannis-Georgios Koskinas","doi":"10.15406/htij.2023.11.00304","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00304","url":null,"abstract":"This case demonstrates the benefits of luspatercept for thalassemic patients who are unable to receive adequate blood transfusions. It acts as a selective ligand trap and inhibits TGF- signaling via Smad2/3 to promote differentiation and maturation of late-stage erythroid precursors. Phase III clinical data showed that a 33% reduction in transfusion burden from baseline was achieved. The administration of luspatercept was a challenge due to the coexistence of antiphospholipid syndrome, portal vein thrombosis and splenectomy. Since initiating luspatercept, the patient has not experienced any adverse events and her general condition has improved.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115415925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult t-cell leukemia/lymphoma: case report in southern Brazil","authors":"Isadora Paula Pavei","doi":"10.15406/htij.2023.11.00301","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00301","url":null,"abstract":"Adult T-cell leukemia/lymphoma (ATLL) is an aggressive type of non-Hodgkin's lymphoma that can be primary of the skin or secondary, caused by Human T-cell lymphotropic virus (HTLV-1) infection. The prevalence of HTLV-1 infection is high in Brazil, however reports of ATLL are rare, possibly underdiagnosed and underreported. This paper presents a case report of a patient coming from the south of Brazil, a region of the country with few cited cases of this comorbidity. It shows the importance of disclosing data on infection by the virus, so that public policies for prevention can be carried out, as well as the presentation of cases that develop ATLL.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128981507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood transfusion at home in HAD (hospitalization a domicile) home hospitals","authors":"J. Ginot","doi":"10.15406/htij.2023.11.00300","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00300","url":null,"abstract":"Blood transfusions can be performed at home if done by skillful teams of HAD (Hospitalization A Domicile) Home-hospitals. They are safely ruled by law and scientific societies.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130913507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parvovirus B19 and blood transfusion","authors":"Rania M Saleh","doi":"10.15406/htij.2023.11.00299","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00299","url":null,"abstract":"Parvovirus B19 is a common human pathogen that is responsible for a wide range of clinical manifestations, including erythema infectiosum (fifth disease), arthropathy, and fetal hydrops. Infection with Parvovirus B19 can cause significant morbidity in certain patient populations, including pregnant women and individuals with underlying hematologic or immune disorders. This review highlights the importance of screening of Parvovirus B19 infection, particularly in high-risk populations.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128455051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory rationale for dose reduction anticoagulant for thrombosis complicing treatment patients with hemoblastosis on the background of chemioinduced thrombocytopenia","authors":"V. Dmitriev","doi":"10.15406/htij.2023.11.00298","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00298","url":null,"abstract":"Purpose of the study: To substantiate the minimum hemostatic threshold for platelet count, which regulates the anticoagulant therapy of thrombosis against the background of induced thrombocytopenia in children with malignant neoplasms. Material and research methods: 23 patients (group 1) with hemorrhagic syndrome caused by thrombocytopenia (less than 50∙109/l) were examined. The control group consisted of 21 patients (group 2) with a similar diagnosis, platelet count less than 150∙109/l, who did not have bleeding. All examined patients with hemoblastoses had signs of febrile neutropenia. Additionally, under the conditions of a bench experiment, dilutions of platelet donor plasma were prepared with a platelet content of 5.0×109/l, 10.0×109/l, 20.0×109/l, 30.0×109/l, 40.0×109/L, 50.0×109/L, 60.0×109/L, 70.0×109/L, 80.0×109/L, 90.0×109/L, 100.0×109 /l, 200.0×109/l. Platelets were counted in peripheral blood for each sample using an XN-3000 hematology analyzer (manufactured by Sysmex GmbH, Japan) by the impedance method using original reagents (SysmexGmbH). The endogenous thrombin potential (ETP) in patients' platelet plasma was determined by the Hemker method on a Fluoroskanascent fluoroscan manufactured by Thermo Electron Corporation (Maastricht, Netherlands) using reagent kits from Thrombinoscop eBV. Research results: Between the content of platelets in whole blood and EPT of platelet plasma of patients with hemoblastoses, a relationship was revealed, which is reflected by the regression equation: y = 15.1356 + (0.0745∙ x), where y is the content of platelets in the blood (109/l), and x - EPT nM/l∙min in venous blood plasma. The minimum threshold value of EPT of platelet plasma, which provides hemostasis, 250 nM/l∙min, corresponded to the minimum platelet content of 30.0∙109/l in the blood of FN patients. Decrease in the content of platelets in donor plasma less than 20×109/l led to a decrease in EPT less than 250 nM/l•min. Between the EPT generated in the platelet donor plasma and the content of platelets in the donor plasma in the range (100.0 -20.0) ×109/l, a linear relationship was revealed. When the content of platelets was more than 100.0×109/l, generated by platelet plasma, EPT increased, regardless of the increase in the content of platelets in the plasma under study. Conclusion: in case of thrombosis against the background of chemo-induced thrombocytopenia in the range (100.0 -20.0)×109/l, the patient should receive LMWH at a dose reduced in proportion to the content of platelets in the blood.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116169710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roseate and merest-acinar cell carcinoma-pancreas","authors":"Anu Bajaj","doi":"10.15406/htij.2023.11.00297","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00297","url":null,"abstract":"Acinar cell carcinoma pancreas is an epithelial, malignant neoplasm of exocrine pancreas comprised of cells resembling pancreatic acinar cells which are immune reactive to BCL10 and trypsin. Tumefaction arises due to accumulated genetic alterations, chromosomal instability or allelic copy number variation. Cogent clinical symptoms as abdominal pain, dorso-lumbar pain, loss of weight, nausea or vomiting or subcutaneous fat necrosis may ensue. Grossly, a solid, enlarged, well circumscribed, partially encapsulated tumefaction of fleshy consistency is encountered. Neoplastic cells demonstrate granular, eosinophilic cytoplasm pervaded with zymogen granules stainable with periodic acid Schiff’s (PAS) stain with diastase resistance, uniform nuclei and a singular, prominent nucleolus. Scanty and fibrous encompassing stroma exhibits foci of perineural and vascular invasion. Acinar cell carcinoma pancreas is immune reactive to keratins as CK7, CK8, CK18, CK19, BCL10, trypsin nuclear beta catenin or CD200. Computerized tomography (CT) and magnetic resonance imaging (MRI) delineates an enlarged tumefaction with well-defined perimeter, an exophytic pattern of tumour evolution and heterogeneous image enhancement. Surgical resection, chemotherapy with gemcitabine or radiofrequency ablation are appropriate modes of therapy.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115859998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postcovid-19 war era, hematologic disorders significantly increased by Covid-19 variants, mysteriously","authors":"Bahram Alamdary Badlou","doi":"10.15406/htij.2023.11.00296","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00296","url":null,"abstract":"COVID-19 mutant(s)’ attacks are not over yet. Most people who developed COVID-19 infection fully recovered, but current confirmation suggests approximately 10%-20% of people experience a variety of mid- and long-term effects after they recovered from their initial illness. Besides, isolated blood products transfusion is a lifesaving procedure but hematologic disorders after transfusion accelerate morbidity and mortality rates, however. Platelet (hypo-)hyperactivity and dysfunction in different COVID-19 patients were already known facts but whether COVID-19 different variants could activate and/or accelerate death triangle machinery in diabetic and cancer patients, which can initiate synergistic interaction is not entirely elucidated yet. Deficiencies over standard protocols and golden standards in blood transfusion and biological products are of considerable concern now (March 2023). Subsequently, the management of almost all-natural products produced recently and biosimilar and their associated quality controls endure significant ignoring problems. What we learned from the last 3 years pandemic was that different blood banks isolated products still are potential hazardous factors to cause accelerated death and/or recovery; if they (in-)appropriately applied, curiously. In this mini-review is tried to unravel different potential changes, relationships, and associations between lifesaving (blood transfusion, isolated blood products) versus not-lifesaving approaches/procedures after 2023. Besides it tried to highlight specific context and rationale, especially concerning main factors that are playing a crucial role in the Pandemic separately, and/or together in an additive and/or synergistic way, to increase chronic postcovid-19 side effects/ collateral damages to longcovid patients.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125967384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fresh frozen plasma kept at cryogenic temperatures in Bio Boxes during marine transportation","authors":"Koki Yakushiji, Fumiatsu Yakushiji, M. Murata, H. Fujita","doi":"10.15406/htij.2023.11.00295","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00295","url":null,"abstract":"Introduction: It is difficult to maintain fresh frozen plasma (FFP) at cryogenic temperatures during marine transportation, even with a power supply. Methods: In this study, without a power supply and at temperatures below -30 °C, we used BioBoxes used for transportation of coronavirus disease vaccines, for two demonstration experiments involving round-trip FFP transportation to Hachijojima Island (200 km from Tokyo) and Ogasawara (1,000 km from Tokyo). Results: We successfully transported FFP at a temperature of -70 °C or lower. There was no change in the properties of FFP and minimal change in the activities of clotting factors. Conclusion: We could transport FFP to an isolated island in BioBoxes in a passenger ship, without a power supply using only dry ice. Furthermore, we demonstrated that FFP does not get destroyed or thaw due to vibration of the passenger ship, even in an approaching typhoon, proving possibilities for stable supply of FFP.","PeriodicalId":103294,"journal":{"name":"Hematology & Transfusion International Journal","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125005699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}