Chonnam Medical Journal最新文献_第8页

Successful Treatment of Electrical Storm with Isoproterenol in a Patient of Myocarditis with Early Repolarization in Hypothermia. 异丙肾上腺素成功治疗低温下早期复极心肌炎1例。

Chonnam Medical Journal Pub Date : 2021-09-01 Epub Date: 2021-09-24 DOI: 10.4068/cmj.2021.57.3.223

Hyung Ki Jeong

{"title":"Successful Treatment of Electrical Storm with Isoproterenol in a Patient of Myocarditis with Early Repolarization in Hypothermia.","authors":"Hyung Ki Jeong","doi":"10.4068/cmj.2021.57.3.223","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.223","url":null,"abstract":"https://doi.org/10.4068/cmj.2021.57.3.223 C Chonnam Medical Journal, 2021 Chonnam Med J 2021;57:223-225 Corresponding Author: Hyung Ki Jeong Department of Cardiovascular Medicine, Chonnam National University Hospital, 42 Jaebongro, Dong-gu, Gwangju 61469, Korea Tel: +82-62-220-5778, Fax: +82-62-223-3105, E-mail: jhk30334@hanmail.net Article History: Received December 29, 2020 Revised January 4, 2021 Accepted January 5, 2021 FIG. 1. (A) A twelve lead electrocardiogram (ECG). Sinus tachycardia with ST depression of inferior leads and ST elevation in I, AVL were observed. (B) A twelve lead ECG. J point elevation in the most of leads and notching of terminal portion of QRS complex were observed. It was prominent, especially in the lateral leads (red arrow). (C) Ventricular fibrillation occurred and it was terminated by defibrillation. After defibrillation, Osborn wave still remained. (D) A twelve lead ECG after infusion of isoproterenol. Early repolarization was nearly normalized. The notch in the lateral leads was noticeably decreased. Heart rate was accelerated by the chronotrophic effect of isoproterenol. Successful Treatment of Electrical Storm with Isoproterenol in a Patient of Myocarditis with Early Repolarization in Hypothermia","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"223-225"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/94/cmj-57-223.PMC8485091.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39495711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive Transcatheter Aortic Valve Replacement and Sequential Repair of Abdominal Aortic Aneurysm in an Octogenarian. 微创经导管主动脉瓣置换术及腹主动脉瘤序贯修复一例八旬老人。

Chonnam Medical Journal Pub Date : 2021-09-01 Epub Date: 2021-09-24 DOI: 10.4068/cmj.2021.57.3.228

Seok Oh, Ju Han Kim, Myung Ho Jeong

引用次数: 0

In-Silico Analysis of Chromatin Modifiers and Profiling of Histone Deacetylases (HDAC's) in Human Oral Cancer. 人类口腔癌中染色质修饰剂和组蛋白去乙酰化酶(HDAC’s)的芯片分析。

Chonnam Medical Journal Pub Date : 2021-09-01 Epub Date: 2021-09-24 DOI: 10.4068/cmj.2021.57.3.176

Anand K Sajnani, Sanket G Shah, Mudasir Rashid, Abhiram Natu, Poonam B Gera, Sanjay Gupta

{"title":"In-Silico Analysis of Chromatin Modifiers and Profiling of Histone Deacetylases (HDAC's) in Human Oral Cancer.","authors":"Anand K Sajnani, Sanket G Shah, Mudasir Rashid, Abhiram Natu, Poonam B Gera, Sanjay Gupta","doi":"10.4068/cmj.2021.57.3.176","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.176","url":null,"abstract":"Histone modifications have been demonstrated to play a significant role in oral squamous cell carcinoma (OSCC) epigenetic regulation. An in-silico analysis of The Cancer Genome Atlas (TCGA) of various histone acetyl transferases (HATs) and histone deacetylases (HDACs) suggested that HATs do not differ between normal and tumor samples whereas HDAC2 and HDAC1 change maximally and marginally respectively between normal and tumor patients with no change being noted in HDAC6 expression. Hence, this investigation was carried out to validate the expression states of HDAC 1, 2 and 6 mRNAs in buccal mucosa and tongue SCC samples in an Indian cohort. Buccal mucosa and tongue squamous cell carcinoma tissues with intact histopathology were processed for RNA isolation followed by cDNA synthesis which was then subjected to q-PCR for HDACs. The average RNA yield of the tongue tissue sample was ∼2 µg/mg of tissue and the A260/280 ratios were between 2.03 and 2.06. The average RNA yield of buccal mucosa tissue sample was ∼1 µg/mg of tissue and the A260/280 ratio were between 2.00 and 2.08. We have demonstrated that HDAC2 was overexpressed in tongue and buccal mucosa samples. Over-expression of HDAC2 imply potential use of HDACi along with standard chemotherapeutic drug in oral cancer treatment.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"176-184"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/9a/cmj-57-176.PMC8485086.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Aberrant Migration of Thrombi Originating from Ruptured Plaque Along the "Spinning Roller Coaster Track" after Aspiration Thrombectomy. 吸入性取栓后源自破裂斑块的血栓沿“旋转的过山车轨道”异常迁移。

Chonnam Medical Journal Pub Date : 2021-09-01 Epub Date: 2021-09-24 DOI: 10.4068/cmj.2021.57.3.226

Seok Oh, Dae Young Hyun, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Young Joon Hong

引用次数: 0

Is There a Link between 5α-Reductase Inhibitors and Hypoglycemia? 5α-还原酶抑制剂与低血糖有联系吗?

Chonnam Medical Journal Pub Date : 2021-09-01 Epub Date: 2021-09-24 DOI: 10.4068/cmj.2021.57.3.230

Jin Woo Jeong, Cheol Won Jang, Tae Yang Yu

引用次数: 0

Poor Prognosis of Contrast-Induced Nephropathy during Long Term Follow Up. 长期随访期间对比度诱发肾病的不良预后。

Chonnam Medical Journal Pub Date : 2021-09-01 Epub Date: 2021-09-24 DOI: 10.4068/cmj.2021.57.3.197

Taili Liu, Sang-Rok Lee

{"title":"Poor Prognosis of Contrast-Induced Nephropathy during Long Term Follow Up.","authors":"Taili Liu, Sang-Rok Lee","doi":"10.4068/cmj.2021.57.3.197","DOIUrl":"10.4068/cmj.2021.57.3.197","url":null,"abstract":"Contrast-induced nephropathy (CIN) is known to associate with poor prognosis. However, there have been few studies for long-term follow up. The purpose of this study was to know the prognosis of CIN during a 10-year follow up. We retrospectively analyzed 528 patients who underwent coronary angiography in Jeonbuk National University Hospital (South Korea, Jeonju) between Jan 2005 to Dec 2006. We excluded the patients who required regular dialysis before study enrollment. We compared adverse events in the no CIN (group I, n=485, 61.9±11.4 years, male 64.1%) and CIN (group II, n=43, 65.7±11.1 years, male 62.8%). Baseline clinical characteristics and cardiovascular risk factors were not different between the two groups except the post-procedure creatinine level (1.04 mg/dL vs 1.84 mg/dL, p=0.0001). The higher rates of all-cause death were observed in group II at 1-year (3.7% vs 13.9%, log-rank, p=0.001), 5-years (17.9% vs 34.9%, log-rank, p=0.003), and 10-years (25.3% vs 48.8%, log-rank, p=0.000). MACE was higher in group II at 1-year (3.9% vs 11.6%, log-rank, p=0.013), 5-years (6.8% vs 20.9%, log-rank, p=0.000) and 10-years (13.4% vs 27.9%, log-rank, p=0.000). In addition, CIN was an independent predictor for 10-year MACE (adjusted HR 3.432, 95% CI 1.314-8.965, p=0.012) after propensity score matching. The worse prognosis of CIN was continuously observed after the 10-year follow-up. Our data suggests that it is worthwhile to prevent the appearance of CIN in order to improve longterm results.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"197-203"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/86/cmj-57-197.PMC8485089.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Screening for Atrial Fibrillation Using a Single Lead ECG Monitoring Device. 使用单导联心电图监测装置筛查心房颤动。

Chonnam Medical Journal Pub Date : 2021-09-01 Epub Date: 2021-09-24 DOI: 10.4068/cmj.2021.57.3.191

Jum Suk Ko, Hyung Ki Jeong

{"title":"Screening for Atrial Fibrillation Using a Single Lead ECG Monitoring Device.","authors":"Jum Suk Ko, Hyung Ki Jeong","doi":"10.4068/cmj.2021.57.3.191","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.191","url":null,"abstract":"Atrial fibrillation (AF) is the most common arrhythmia which needs management for stroke prevention. Therefore, it has emphasized the importance of screening for general population to detect AF earlier. We conducted screening for AF in the Chonbuk region in South Korea. Participants who were older than 50 years were enrolled. The screening test used a single lead electrocardiography (ECG) (KardiaBand, AliveCor, CA, USA). Diagnosis of AF was confirmed by electrophysiologists, if the single lead ECG demonstrated AF of more than 30 seconds. We analyzed the prevalence of AF and the characteristics of newly detected AF patients. A total of 2728 participants, 145 (5.3%) participants had already been diagnosed with AF before. The number of screening positive was 55. Among them, 40 participants were confirmed for AF. Male gender and age older than 70 years were the independent risk factors for AF among the screening positive participants. Most of newly detected AF patients were at high risk for stroke which had more than 2 points on the CHA2DS2-VASc score. We followed up with those patients and encouraged them to visit the hospital. As a result, 31 (77.5%) patients started to manage AF. The additional 1.2% of AF was detected by a screening test with a single lead ECG monitor device. Considering most participants of newly detected AF by screening were at high risk for stroke, it was thought that AF was still undertreated. Therefore, screening tests with simple mobile device might be useful for early detection of AF.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"191-196"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/49/cmj-57-191.PMC8485083.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Endocrinology of Post-Pandemic Era. 后大流行时代的儿科内分泌学

Chonnam Medical Journal Pub Date : 2021-05-01 Epub Date: 2021-05-24 DOI: 10.4068/cmj.2021.57.2.103

Ji-Young Seo

引用次数: 1

Association between Childhood Trauma and Suicidal Behavior in the General Population. 儿童创伤与一般人群自杀行为的关系。

Chonnam Medical Journal Pub Date : 2021-05-01 Epub Date: 2021-05-24 DOI: 10.4068/cmj.2021.57.2.126

Cheol Park, In-Hoo Park, Taeyoung Yoo, Honey Kim, Seunghyong Ryu, Ju-Yeon Lee, Jae-Min Kim, Sung-Wan Kim

{"title":"Association between Childhood Trauma and Suicidal Behavior in the General Population.","authors":"Cheol Park, In-Hoo Park, Taeyoung Yoo, Honey Kim, Seunghyong Ryu, Ju-Yeon Lee, Jae-Min Kim, Sung-Wan Kim","doi":"10.4068/cmj.2021.57.2.126","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.2.126","url":null,"abstract":"This study aimed to investigate the associations between various types of childhood trauma and suicidal behavior in the general population in South Korea. This mental health survey included a total of 1,490 general citizens living in a metropolitan South Korean city who completed a questionnaire that assessed respondents' histories of childhood trauma before the age of 12 years, including bullying victimization, emotional abuse, sexual abuse, and physical abuse, as well as suicidal behavior, including current suicidal ideation and histories of suicide planning and attempts. The following psychiatric scales were administered: Hospital Anxiety and Depression Scale (HADS), Rosenberg Self-Esteem Scale (R-SES), Connor-Davidson Resilience Scale (CD-RISC), Perceived Stress Scale (PSS), and visual analogue scale of EuroQol 5D (EQ-5D). Participants who experienced any childhood trauma had significantly higher HADS and PSS scores, and significantly lower EQ-5D scores. Additionally, participants with any type of childhood trauma were significantly more likely to have current suicidal ideation and histories of planned and attempted suicide. Multivariate analyses adjusted for confounding variables indicated that bullying victimization and sexual abuse were associated significantly with all types of suicidal behavior. Physical abuse was associated significantly with histories of suicide planning and attempts. The present findings showed that any type of childhood trauma was associated with higher levels of suicidality, anxiety, depression, and perceived stress, as well as lower health-related quality of life, in the general population. In particular, associations between childhood trauma and suicidality were identified after adjustment for confounding variables.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 2","pages":"126-131"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b8/37/cmj-57-126.PMC8167439.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39011214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Impact of Bisoprolol on Ventricular Arrhythmias in Experimental Myocardial Infarction. 比索洛尔对实验性心肌梗死室性心律失常的影响。

Chonnam Medical Journal Pub Date : 2021-05-01 Epub Date: 2021-05-24 DOI: 10.4068/cmj.2021.57.2.132

Hyun Kuk Kim, Kyung Seob Lim, Sung Soo Kim, Joo-Young Na

{"title":"Impact of Bisoprolol on Ventricular Arrhythmias in Experimental Myocardial Infarction.","authors":"Hyun Kuk Kim, Kyung Seob Lim, Sung Soo Kim, Joo-Young Na","doi":"10.4068/cmj.2021.57.2.132","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.2.132","url":null,"abstract":"Following acute myocardial infarction (AMI), early use of beta-blockers (BBs) reduced the incidences of ventricular arrhythmia (VA) and death in the pre reperfusion era. However, some studies have reported a worsening of clinical outcomes and therefore, this study used a porcine model of AMI to evaluate the efficacy of bisoprolol on VAs and mortality. Twenty pigs were divided into two groups with one group using oral bisoprolol which was given for 3 hours before the experiment and then maintained for 7 days. A loop recorder was implanted, AMI was induced by balloon occlusion for 60 min, and then, reperfusion. One week later, the echocardiography and loop recorder data were analyzed in the surviving animals. Bisoprolol did not increase the heart rate (62.9±14.5 vs 79.0±20.3; p=0.048), lower the rate of premature ventricular contractions (PVC) (0.8±0.8 vs 11.0±12.8; p=0.021) or tend to lower recurrent VA (0.6±0.5 vs 1.1±1.1; p=0.131) during coronary artery occlusion. After reperfusion, bisoprolol did reduce VA in the early AMI period (0.1±0.3 vs 4.2±4.6; p=0.001) and it was not associated with the extent of myocardial recovery. In this porcine model, early oral bisoprolol might help reduce the incidences of PVC and recurrent VA and determine whether effects are more pronounced during the early AMI period. Our results suggest that bisoprolol might help reduce lethal VA and cardiac death following AMI in this reperfusion era.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 2","pages":"132-138"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/66/cmj-57-132.PMC8167445.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39011215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1