Chonnam Medical JournalPub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.63
Hyung Ki Jeong, Namsik Yoon
{"title":"Implantable Cardioverter-Defibrillator Lead in an Explanted Human Heart.","authors":"Hyung Ki Jeong, Namsik Yoon","doi":"10.4068/cmj.2022.58.1.63","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.63","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.1.63 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:63 Corresponding Author: Namsik Yoon Division of Cardiology, Department of Internal Medicine, Chonnam National University Medical School, 42 Jaebong-ro, Dong-gu, Gwangju 61469, Korea Tel: +82-62-220-6272, Fax: +82-62-223-3105, E-mail: yoonnamsik@gmail.com Article History: Received October 22, 2021 Revised November 7, 2021 Accepted November 9, 2021 FIG. 1. After dissection of right ventricle free-wall, the ICD lead was visible. The lead body adhered to the tricuspid valve leaflets, and the tip was fixed near the right ventricle apex (A). The fibrotic change in the right ventricular septum was assumed to be related to the mechanical irritation of the endocardium by the ICD lead. The lead tip was embedded by fibrotic encapsulation (B), which often renders the lead extraction challenging.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"63"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4a/83/cmj-58-63.PMC8813652.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39927431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.18
Shinae Hwang, Jong-Keun Kim
{"title":"N-Acetylcysteine Induces Apoptotic, Oxidative and Excitotoxic Neuronal Death in Mouse Cortical Cultures.","authors":"Shinae Hwang, Jong-Keun Kim","doi":"10.4068/cmj.2022.58.1.18","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.18","url":null,"abstract":"<p><p>N-acetylcysteine (NAC) has been used as an antioxidant to prevent oxidative cell death. However, we found NAC itself to induce neuronal death in mouse cortical cultures. Therefore, the current study was performed to investigate the mechanism of neuronal death caused by NAC. Cell death was assessed by measuring lactate dehydrogenase efflux to bathing media after 24-48 h exposure to NAC. NAC (0.1-10 mM) induced neuronal death in a concentration- and exposure time-dependent manner. However, NAC did not injure astrocytes even at a concentration of 10 mM. Also, 10 mM NAC markedly attenuated oxidative astrocyte death induced by 0.5 mM diethyl maleate or 0.25 mM H<sub>2</sub>O<sub>2</sub>. The NMDA receptor antagonist MK-801 (10 µM) markedly attenuated the neuronal death caused by 10 mM NAC, while NBQX did not affect the neuronal death. Cycloheximide (a protein synthesis inhibitor, 0.1 µg/mL) and z-VAD-FMK (a caspase inhibitor, 100 µM) also significantly attenuated neuronal death. Apoptotic features such as chromatin condensation, nuclear fragmentation, and caspase 3 activation were observed 1 h after the NAC treatment. The neuronal death induced by 1 or 10 mM NAC was significantly attenuated by the treatment with 100 µM Trolox or 1 mM ascorbic acid. NAC induced the generation of intracellular reactive oxygen species (ROS), as measured by the fluorescent dye 2',7'-dichlorofluorescein diacetate. The ROS generation was almost completely abolished by treatment with Trolox or ascorbic acid. These findings demonstrate that NAC can cause oxidative, apoptotic, and excitotoxic neuronal death in mouse neuronal cultures.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"18-23"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/27/cmj-58-18.PMC8813647.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.24
Jungmin Lee, Soo Ho Choi, Jin Ho Baek, Dong Won Baek, Jong Gwang Kim, Byung Woog Kang
{"title":"Clinical Impact of Prognostic Nutrition Index for Advanced Gastric Cancer Patients with Peritoneal Metastases Treated Nivolumab Monotherapy.","authors":"Jungmin Lee, Soo Ho Choi, Jin Ho Baek, Dong Won Baek, Jong Gwang Kim, Byung Woog Kang","doi":"10.4068/cmj.2022.58.1.24","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.24","url":null,"abstract":"<p><p>Although nivolumab shows survival benefits for patients with advanced gastric cancer (AGC), predictive biomarkers for nivolumab treatment in AGC remain unclear, especially in the case of peritoneal metastases. This study investigated the clinical significance of the prognostic nutrition index (PNI), reflecting the host nutritional status and immunity, in AGC patients undergoing nivolumab monotherapy. This study retrospectively analyzed 53 AGC patients who received nivolumab between October 2017 and February 2021. Among them, 35 patients with peritoneal metastases were reviewed to investigate the relationship between the PNI and oncological outcomes. The PNI was calculated as 10×serum albumin level (g/dl)+0.005×total lymphocyte count (per mm<sup>3</sup>) at the first administration of nivolumab. With a median follow-up duration of 2.0 (0.3-13.5) months, the median overall survival (OS) was 2.0 months. The overall response and disease-control rates were 0.0% and 20.0%, respectively. Among the 35 patients, 13 patients were identified as a high-PNI group. In the univariate analysis, the high-PNI group showed a significantly longer PFS and OS than the low-PNI group. In the multivariate analysis, the high-PNI was independently associated with a longer PFS (p=0.021) and OS (p=0.022). The PNI can be useful for predicting PFS and OS in AGC patients with peritoneal metastases. However, further studies are required to validate these results in AGC and new strategies are needed to improve the outcome for AGC patients with peritoneal metastases.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"24-28"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/87/cmj-58-24.PMC8813651.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2022-01-01Epub Date: 2022-01-25DOI: 10.4068/cmj.2022.58.1.37
Hyeon-Jeong Yoon, Won-Hee Jang, Susun An, Yong Sok Ji, Kyung Chul Yoon
{"title":"Tear Neuromediators in Subjects with and without Dry Eye According to Ocular Sensitivity.","authors":"Hyeon-Jeong Yoon, Won-Hee Jang, Susun An, Yong Sok Ji, Kyung Chul Yoon","doi":"10.4068/cmj.2022.58.1.37","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.1.37","url":null,"abstract":"<p><p>To investigate differences of tear neuromediators between subjects with and without dry eye (DE) depending on the ocular sensitivity. Thirty-one subjects with DE and 29 subjects without DE were recruited in this study. The eyes were stimulated by exposure to an irritating product applied to the periocular region. Both DE and non-DE subjects were divided into the high sensitivity and low sensitivity groups based on the degree of ocular sensitivity to ocular irritation. Baseline tear film break-up time (TBUT) and corneal staining score were examined, and tear samples were collected. The concentrations of the tear neuromediators, including nerve growth factor (NGF), serotonin, calcitonin gene-related peptide (CGRP), substance P, neuropeptide Y, and vasoactive intestinal peptide were measured using the enzyme-linked immune sorbent assay. The baseline neuromediator concentrations were compared between subjects with and without DE based on ocular sensitivity. In both DE and non-DE subjects, baseline TBUT was significantly lower in the high sensitivity group than in the low sensitivity group. In the high sensitivity group, baseline tear NGF levels were higher in subjects with DE than in those without DE. In the low sensitivity group, baseline levels of tear CGRP were lower in subjects with DE than in those without DE. Tear neuromediators associated with DE had differences in their concentrations depending on ocular sensitivity. In patients with DE, tear NGF levels increased with high ocular sensitivity to ocular irritation, whereas tear CGRP levels decreased with low ocular sensitivity.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 1","pages":"37-42"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/5f/cmj-58-37.PMC8813648.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39634632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2021-09-01Epub Date: 2021-09-24DOI: 10.4068/cmj.2021.57.3.211
Jee Hee Yoon, A Ram Hong, Wonsuk Choi, Ji Yong Park, Hee Kyung Kim, Ho-Cheol Kang
{"title":"Real-World Efficacy and Safety of Dulaglutide in Korean Patients with Type 2 Diabetes Mellitus: A Retrospective Study in a Tertiary Referral Center.","authors":"Jee Hee Yoon, A Ram Hong, Wonsuk Choi, Ji Yong Park, Hee Kyung Kim, Ho-Cheol Kang","doi":"10.4068/cmj.2021.57.3.211","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.211","url":null,"abstract":"<p><p>This study was conducted to evaluate the efficacy and safety of once-weekly dulaglutide therapy as add-on to oral antidiabetic drugs (OADs) and basal insulin in Korean patients with type 2 diabetes mellitus (T2DM) in real-world clinical practice. We retrospectively reviewed the medical records of 112 patients who received dulaglutide in a tertiary referral center. The primary efficacy endpoint was a change in glycated hemoglobin (HbA1c) between baseline and 6 months. The secondary endpoints were the percentage of patients achieving HbA1c <7.0% or ≤6.5% and the change of body weight at 6 months. At baseline, the mean HbA1c was 8.7 % (8.8% in the OAD combination and 8.5% in the basal insulin combination group). The mean adjusted HbA1c at 6 months decreased by -1.13% in all patients (p<0.001), and by -1.36 and -0.74% in the OAD combination and basal insulin combination group, respectively. A significant reduction of -2.9 kg in body weight was observed in all patients at 6 months (p<0.001). Approximately 34.8% and 23.2% of patients achieved HbA1c <7.0% and ≤6.5%, respectively. Higher baseline HbA1c and no previous insulin therapy were associated with positive responses to dulaglutide on multivariate analysis. Mild gastrointestinal issues (23.2%) were the most frequently observed adverse events. Dulaglutide is an effective and durable treatment option as OAD and basal insulin combination therapy in Korean patients with T2DM.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"211-218"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/1b/cmj-57-211.PMC8485082.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2021-09-01Epub Date: 2021-09-24DOI: 10.4068/cmj.2021.57.3.169
Naina Mohamed Pakkir Maideen
{"title":"Antidiabetic Activity of <i>Nigella Sativa</i> (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies.","authors":"Naina Mohamed Pakkir Maideen","doi":"10.4068/cmj.2021.57.3.169","DOIUrl":"10.4068/cmj.2021.57.3.169","url":null,"abstract":"<p><p>The use of herbal medicine to manage chronic conditions including diabetes has become a recent global trend. Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. The present review is aimed to analyze the antidiabetic activity of <i>N. sativa</i> as many type 2 diabetic patients use it as a complementary therapy along with their modern allopathic medications or as an alternative therapy. The literature was reviewed in databases like Medline/PubMed Central/PubMed, Google Scholar, Science Direct, EBSCO, Scopus, Web of science, EMBASE, Directory of open access journals (DOAJ), and reference lists to identify relevant articles supporting the use of <i>N. sativa</i> in diabetes management. Numerous clinical and animal studies have demonstrated the antidiabetic efficacy of black seeds (<i>N. sativa</i>) and its major bioactive constituent thymoquinone. Based on these findings patients with diabetes may use <i>N. sativa</i> as an adjuvant therapy, which may help to reduce the dose and incidence of adverse effects of modern antidiabetic medicines.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"169-175"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/2d/cmj-57-169.PMC8485088.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2021-09-01Epub Date: 2021-09-24DOI: 10.4068/cmj.2021.57.3.219
Min Chul Kim, In-Seok Jeong, Joon Ho Ahn, Dae Young Hyun, Dowan Kim, Kyoseon Lee, Youngkeun Ahn, Myung Ho Jeong
{"title":"Bi-Caval Dual Lumen Catheter for Pediatric Patients Undergoing Venovenous Extracorporeal Membrane Oxygenation.","authors":"Min Chul Kim, In-Seok Jeong, Joon Ho Ahn, Dae Young Hyun, Dowan Kim, Kyoseon Lee, Youngkeun Ahn, Myung Ho Jeong","doi":"10.4068/cmj.2021.57.3.219","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.219","url":null,"abstract":"https://doi.org/10.4068/cmj.2021.57.3.219 C Chonnam Medical Journal, 2021 Chonnam Med J 2021;57:219-220 Corresponding Author: In-Seok Jeong Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebong-ro, Dong-gu, Gwangju 61469, Korea Tel: +82-62-220-6546, Fax: +82-62-227-1636, E-mail: isjeong1201@gmail.com Article History: Received February 25, 2021 Revised March 28, 2021 Accepted March 29, 2021 FIG. 1. Avalon catheter has dual lumen for both drainage (blue arrow) and perfusion (red arrow) in one tube (A). Transesophageal echocardiography during cannulation showed that the perfusion hole was located at mid right atrium right above tricuspid valve (TV, arrow head). Perfusion flow went from the perfusion hole to the TV direction (B). After establishment of good catheter position, the catheter was clamped (C) and connected to extracorporeal membrane oxygenation (D). Bi-Caval Dual Lumen Catheter for Pediatric Patients Undergoing Venovenous Extracorporeal Membrane Oxygenation Min Chul Kim, In-Seok Jeong*, Joon Ho Ahn, Dae Young Hyun, Dowan Kim, Kyoseon Lee, Youngkeun Ahn, and Myung Ho Jeong Division of Cardiology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Department of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"219-220"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5a/6d/cmj-57-219.PMC8485090.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39495709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2021-09-01Epub Date: 2021-09-24DOI: 10.4068/cmj.2021.57.3.221
Yusaku Kajihara
{"title":"An Unusual Cause of Anemia in a Middle-Aged Woman.","authors":"Yusaku Kajihara","doi":"10.4068/cmj.2021.57.3.221","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.221","url":null,"abstract":"https://doi.org/10.4068/cmj.2021.57.3.221 C Chonnam Medical Journal, 2021 Chonnam Med J 2021;57:221-222 Corresponding Author: Yusaku Kajihara Department of Gastroenterology, Fuyoukai Murakami Hospital, 3-3-14 Hamada, Aomori 030-0843, Japan Tel: +81-17-729-8888, Fax: +81-17-729-8887, E-mail: yukajihara-gi@umin.ac.jp Article History: Received January 11, 2021 Revised January 15, 2021 Accepted January 16, 2021 FIG. 1. (A) Endoscopic view of gastric antral vascular ectasia (GAVE). (B) Endoscopic view of the characteristic longitudinal red columns radiating the pylorus. FIG. 2. Argon plasma coagulation for GAVE. An Unusual Cause of Anemia in a Middle-Aged Woman","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"221-222"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/50/cmj-57-221.PMC8485092.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39495710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2021-09-01Epub Date: 2021-09-24DOI: 10.4068/cmj.2021.57.3.185
Jin Hee Kim, Gwang Ha Hwang, Hyun Jung Kim, Songhee Jeon, Boo Ahn Shin
{"title":"<i>Acer mono</i> Extract Inhibits Invasive Activities and G1/S Transition of HT1080 Fibrosarcoma Cells.","authors":"Jin Hee Kim, Gwang Ha Hwang, Hyun Jung Kim, Songhee Jeon, Boo Ahn Shin","doi":"10.4068/cmj.2021.57.3.185","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.185","url":null,"abstract":"<p><p><i>Acer mono</i> is known to contain bioactive substances that exhibit beneficial effects in osteoporosis, gastric ulcers, hepatic damage, and pathologic angiogenesis. The current study aimed to investigate the effects of <i>Acer mono</i> extract on the invasive activities and cell-cycle progression of human fibrosarcoma cells. Cytotoxicity of <i>Acer mono</i> extract was assessed by MTT assay, in-vitro invasiveness of HT1080 fibrosarcoma cells was measured using matrigel assay, expression of invasion- and cell-cycle-related proteins was analyzed by western blot analysis, and that of E2F target genes was quantified using qRT-PCR. <i>Acer mono</i> extract did not show distinct cytotoxicity in the experimental concentrations used. Invasiveness of HT1080 fibrosarcoma cells and expression of cyclin D1 and CDK4 in them were significantly reduced in a dose-dependent manner after treatment with <i>Acer mono</i> extract. <i>Acer mono</i> extract showed inhibitory effects on the G1/S transition during cell-cycle progression; the active phosphorylated Rb protein level was decreased, and expression of E2F target genes was downregulated by the <i>Acer mono</i> extract. Our data collectively demonstrated that <i>Acer mono</i> extract exerts inhibitory effects on the invasiveness and cell-cycle progression of HT1080 human fibrosarcoma cells.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"185-190"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/63/42/cmj-57-185.PMC8485087.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chonnam Medical JournalPub Date : 2021-09-01Epub Date: 2021-09-24DOI: 10.4068/cmj.2021.57.3.204
Seohwa Park, Kyeong Ho Yun, Jae Young Cho, Seung-Yul Lee
{"title":"Platelet Reactivity Was Not Associated with Infarct Size after Primary Percutaneous Coronary Intervention.","authors":"Seohwa Park, Kyeong Ho Yun, Jae Young Cho, Seung-Yul Lee","doi":"10.4068/cmj.2021.57.3.204","DOIUrl":"https://doi.org/10.4068/cmj.2021.57.3.204","url":null,"abstract":"<p><p>Potent antiplatelet therapy after primary percutaneous coronary intervention (PCI) has the potential to reduce infarct size. This study analyzed the association between on-treatment platelet reactivity and myocardial infarct size in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI. In this single-center, retrospective study, 253 patients who underwent primary PCI for STEMI were divided into two groups according to platelet reactivity measurements (53 patients in the high platelet reactivity [HPR] group and 200 in the non-HPR group). Technetium Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) was performed before hospital discharge. We measured the infarct size using SPECT imaging and serial cardiac biomarker levels, and compared the infarct sizes of each group. The patients with HPR were older (65.5±13.2 vs. 60.6±12.1 years, p=0.011) than the patients with non-HPR. On the other hand, the non-HPR group had a higher incidence of smoking (26.4% vs. 51.0%, p=0.001) than the HPR group. Infarct size was similar between the two groups (22.6±17.3% vs. 24.8±17.7%, p=0.416). Multivariate analysis revealed that onset to balloon time >240 min (odds ratio [OR]=1.92; 95% confidence interval [CI]=1.08-3.40; p=0.025) and anterior infarction (OR=5.28; 95% CI=3.05-9.14; p<0.001) were independent predictors of large (>22%) infarct size. HPR was not a predictor of infarct size assessed by SPECT. The two groups also showed analogous cumulative creatinine kinase-myocardial band and troponin T levels. In conclusion, compared to non-HPR, HPR showed no significant association with myocardial infarct size measured by SPECT imaging in early phase of MI.</p>","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"57 3","pages":"204-210"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/9f/cmj-57-204.PMC8485085.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39496772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}