Chonnam Medical Journal最新文献_第3页

Left Ventricular Free Wall Rupture Immediately following Successful Coronary Reperfusion Complicating ST Elevation Myocardial Infarction. 冠状动脉再灌注成功后立即发生左心室游离壁破裂并发ST段抬高型心肌梗死。

Chonnam Medical Journal Pub Date : 2023-01-01 DOI: 10.4068/cmj.2023.59.1.105

Hyun Kuk Kim, Sung Soo Kim, In Young Choi, Young Jae Ki, Keun Ho Park, Dong Hyun Choi

引用次数: 0

Recent Advances in ROS-Scavenging Metallic Nanozymes for Anti-Inflammatory Diseases: A Review. 抗炎疾病清除ros的金属纳米酶研究进展

Chonnam Medical Journal Pub Date : 2023-01-01 DOI: 10.4068/cmj.2023.59.1.13

Adityanarayan Mohapatra, In-Kyu Park

{"title":"Recent Advances in ROS-Scavenging Metallic Nanozymes for Anti-Inflammatory Diseases: A Review.","authors":"Adityanarayan Mohapatra, In-Kyu Park","doi":"10.4068/cmj.2023.59.1.13","DOIUrl":"https://doi.org/10.4068/cmj.2023.59.1.13","url":null,"abstract":"Oxidative stress and dysregulated inflammatory responses are the hallmarks of inflammatory disorders, which are key contributors to high mortality rates and impose a substantial economic burden on society. Reactive oxygen species (ROS) are vital signaling molecules that promote the development of inflammatory disorders. The existing mainstream therapeutic approaches, including steroid and non-steroidal anti-inflammatory drugs, and proinflammatory cytokine inhibitors with anti-leucocyte inhibitors, are not efficient at curing the adverse effects of severe inflammation. Moreover, they have serious side effects. Metallic nanozymes (MNZs) mimic the endogenous enzymatic process and are promising candidates for the treatment of ROS-associated inflammatory disorders. Owing to the existing level of development of these metallic nanozymes, they are efficient at scavenging excess ROS and can resolve the drawbacks of traditional therapies. This review summarizes the context of ROS during inflammation and provides an overview of recent advances in metallic nanozymes as therapeutic agents. Furthermore, the challenges associated with MNZs and an outline for future to promote the clinical translation of MNZs are discussed. Our review of this expanding multidisciplinary field will benefit the current research and clinical application of metallic-nanozyme-based ROS scavenging in inflammatory disease treatment.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"59 1","pages":"13-23"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/ab/cmj-59-13.PMC9900225.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unusual Case of Double-Pigtail Biliary Stent Migration. 胆道支架双纤尾移位1例。

Chonnam Medical Journal Pub Date : 2023-01-01 DOI: 10.4068/cmj.2023.59.1.98

Yusaku Kajihara

引用次数: 0

Initial Experience with Left Bundle Branch Area Pacing in Patients with Atrioventricular Block and Impaired LV Function. 左束支区起搏治疗房室传导阻滞和左心室功能受损患者的初步经验

Chonnam Medical Journal Pub Date : 2023-01-01 Epub Date: 2023-01-25 DOI: 10.4068/cmj.2023.59.1.54

Soo Yung Kim, Sung Soo Kim, In Young Choi, Hyun Kuk Kim, Young Jae Ki, Dong Hyun Choi, Keun Ho Park

{"title":"Initial Experience with Left Bundle Branch Area Pacing in Patients with Atrioventricular Block and Impaired LV Function.","authors":"Soo Yung Kim, Sung Soo Kim, In Young Choi, Hyun Kuk Kim, Young Jae Ki, Dong Hyun Choi, Keun Ho Park","doi":"10.4068/cmj.2023.59.1.54","DOIUrl":"10.4068/cmj.2023.59.1.54","url":null,"abstract":"Chronic right ventricular (RV) pacing can exacerbate heart failure in patients with a low left ventricular ejection fraction (LVEF). Left bundle branch area pacing (LBBAP) has emerged as a novel physiological pacing technique; however, information remains limited on its use among patients with a low EF. This study investigated the safety and short-term clinical outcomes of LBBAP among patients with impaired left ventricular (LV) function. This retrospective analysis of pacemakers at Chosun University Hospital, South Korea, included all patients with impaired LV function (EF<50%) who underwent pacemaker implantation for atrioventricular blockage from 2019-2022. Clinical characteristics, 12-lead electrocardiography findings, echocardiography findings, and laboratory parameters were evaluated. Composite outcomes were defined as all-cause mortality, cardiac death, and hospitalization due to heart failure during the 6-month follow-up. Altogether 57 patients (25 men; mean age, 77.4±10.8 y; LVEF, 41.5±3.8%) were divided into LBBAP (n=16), biventricular pacing (BVP; n=16), and conventional RV pacing (RVP; n=25) groups. In the LBBAP group, the mean paced QRS duration (pQRSd) was narrower (119.5±14.7 vs. 140.2±14.3 vs. 163.2±13.9; p<0.001) and cardiac troponin I level was elevated post-pacing (1.14±1.29 vs. 0.20±0.29 vs. 0.24±0.51, p=0.001). Lead parameters were stable. One patient was hospitalized, and four died (one patient each from heart failure admission, myocardial infarction, unexplained death, and pneumonia in RVP vs. one from intracerebral hemorrhage in BVP) during the follow-up period. In conclusion, LBBAP is feasible in patients with impaired LV function without acute or significant complications and provides a remarkably narrower pQRSd with a stable pacing threshold.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"59 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/d5/cmj-59-54.PMC9900220.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10795182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant Peritoneal Mesothelioma. 恶性腹膜间皮瘤。

Chonnam Medical Journal Pub Date : 2022-09-01 Epub Date: 2022-09-23 DOI: 10.4068/cmj.2022.58.3.133

Tomohiko Fukunaga, Yumi Somatomo, Jun Kamiyama, Toshihiko Kasanami

引用次数: 0

Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression. 银纳米颗粒通过改变膀胱癌细胞Bax/Bcl-2基因表达而发挥凋亡活性。

Chonnam Medical Journal Pub Date : 2022-09-01 Epub Date: 2022-09-23 DOI: 10.4068/cmj.2022.58.3.102

Sajedeh Daei, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Zeynab Aminzadeh, Mohammad Vahabirad

{"title":"Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression.","authors":"Sajedeh Daei, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Zeynab Aminzadeh, Mohammad Vahabirad","doi":"10.4068/cmj.2022.58.3.102","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.3.102","url":null,"abstract":"Bladder cancer is defined as a urinary tract malignancy that threatens men's and women's health. Due to the side effects of common chemotherapies, novel therapeutic strategies are necessary to overcome the issues concerning bladder cancer treatments. Nanotechnology has been suggested as a means to develop the next-generation objectives of cancer diagnosis and treatment among various novel therapies. Owing to the special characteristics that they can offer, silver nanoparticles (AgNPs) were investigated in this study to evaluate their apoptotic impact on bladder cancer 5637 cells. In this study, an MTT assay was conducted and appropriate concentrations of AgNPs were selected. Moreover, reactive oxygen species (ROS) production and apoptosis levels were determined using fluorimetric and Annexin/PI flow cytometry assays, respectively. Moreover, the activity of caspase 3,7, mRNA expression of Bax (Bcl-2-associated X) and Bcl-2 (B-cell lymphoma 2) were assessed based on colorimetric and qRT-PCR methods, respectively. The results indicated that AgNPs can significantly reduce the viability of 5637 cells in a dose-dependent mode as well as having the ability to elevate ROS production. Flow cytometry data showed that AgNPs lead to a remarkable increase in the apoptosis rate as compared with the control. Consistent with this, the induction of apoptosis was revealed by the overexpression of Bax, accompanied by a reduction in Bcl-2 expression compared to the control. Furthermore, AgNPs remarkably stimulated caspase 3,7 activation. In summary, AgNPs can mediate apoptosis in 5637 cells via excessive ROS formation, up-regulating Bax/Bcl-2 expression, and caspase 3,7 activation.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 3","pages":"102-109"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/49/0e/cmj-58-102.PMC9535103.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Gastric Metastasis from Primary Lung Squamous Cell Carcinoma Presenting a "Bull's-Eye" Appearance. 原发性肺鳞状细胞癌胃转移呈“靶心”样。

Chonnam Medical Journal Pub Date : 2022-09-01 Epub Date: 2022-09-23 DOI: 10.4068/cmj.2022.58.3.127

Akira Hokama, Hiroe Hashioka, Kazuya Miyagi, Erika Koga, Yuiko Oishi, Tetsuya Ohira, Atsushi Iraha, Tetsu Kinjo, Jiro Fujita

{"title":"Gastric Metastasis from Primary Lung Squamous Cell Carcinoma Presenting a \"Bull's-Eye\" Appearance.","authors":"Akira Hokama, Hiroe Hashioka, Kazuya Miyagi, Erika Koga, Yuiko Oishi, Tetsuya Ohira, Atsushi Iraha, Tetsu Kinjo, Jiro Fujita","doi":"10.4068/cmj.2022.58.3.127","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.3.127","url":null,"abstract":"https://doi.org/10.4068/cmj.2022.58.3.127 C Chonnam Medical Journal, 2022 Chonnam Med J 2022;58:127-128 Corresponding Author: Akira Hokama Department of Endoscopy, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan Tel: +81-988951144, Fax: +81-988951414, E-mail: hokama-a@med.u-ryukyu.ac.jp Article History: Received January 25, 2022 Revised March 2, 2022 Accepted March 3, 2022 FIG. 1. A computed tomography scan showed a lung squamous cell carcinoma (arrow). FIG. 2. Esophagogastroduodenoscopy revealed a submucosal tumor with central ulceration in the gastric body, presenting a “bull’s-eye” appearance. Gastric Metastasis from Primary Lung Squamous Cell Carcinoma Presenting a “Bull’s-Eye” Appearance Akira Hokama*, Hiroe Hashioka, Kazuya Miyagi, Erika Koga, Yuiko Oishi, Tetsuya Ohira, Atsushi Iraha, Tetsu Kinjo, and Jiro Fujita Departments of Endoscopy and Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 3","pages":"127-128"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/12/8c/cmj-58-127.PMC9535110.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of the Second Wave of the COVID-19 Pandemic on the Management of Patients with ST-T Segment Elevation Myocardial Infarction. 第二波疫情对ST-T段抬高型心肌梗死患者处理的影响

Chonnam Medical Journal Pub Date : 2022-09-01 Epub Date: 2022-09-23 DOI: 10.4068/cmj.2022.58.3.119

Andreas Mitsis, Christos Eftychiou, John Lakoumentas, Michaela Kyriakou, Nicos Eteokleous, Ioannis Zittis, Panayiotis Avraamides

{"title":"Influence of the Second Wave of the COVID-19 Pandemic on the Management of Patients with ST-T Segment Elevation Myocardial Infarction.","authors":"Andreas Mitsis, Christos Eftychiou, John Lakoumentas, Michaela Kyriakou, Nicos Eteokleous, Ioannis Zittis, Panayiotis Avraamides","doi":"10.4068/cmj.2022.58.3.119","DOIUrl":"https://doi.org/10.4068/cmj.2022.58.3.119","url":null,"abstract":"The ongoing coronavirus disease 2019 (COVID-19) has caused a global health crisis. This prospective, observational, single-centre, cohort study investigated the influence of the second wave of the pandemic on the treatment of ST-segment elevation myocardial infarction (STEMI) patients admitted to the largest tertiary centre in Nicosia, Cyprus. We measured onset-to-door (O2D) time, door-to-balloon (D2B) time, onset-to-balloon (O2B) time, and 30-day mortality for 250 consecutive patients who presented directly or were transferred to Nicosia General Hospital from 1 January 2021, to 31 December 2021, during the second wave of the pandemic in Cyprus. We compared a control group of patients with similar clinical characteristics admitted before the COVID-19 outbreak. Median O2D time was increased from 89 min to 120 min (p-value=0.094). D2B time was not increased significantly (85.5 vs. 87 min, p-value=0.137). The total ischemic time (O2B time) was increased from 173.5 min to 232.5 min, respectively (173.5 vs. 232.5, p=0.001). During the pandemic, more patients presented with cardiogenic shock (3.94 vs. 13.6, p=0.001) and with cardiac arrest (9.85 vs. 17.2, p=0.035,) while there was an increase in 30-day mortality (4.43% vs. 8.8%, p-value=0.100). Patients with STEMI during the second wave of the COVID-19 pandemic seem to have presentation delays with increased total ischaemic times, presented more commonly in cardiogenic shock or cardiac arrest, increasing 30-day mortality.","PeriodicalId":10307,"journal":{"name":"Chonnam Medical Journal","volume":"58 3","pages":"119-126"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/df/17/cmj-58-119.PMC9535113.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Catheter Malposition into the Internal Thoracic Vein. 导管错位进入胸内静脉。

Chonnam Medical Journal Pub Date : 2022-09-01 Epub Date: 2022-09-23 DOI: 10.4068/cmj.2022.58.3.140

Tomohiko Fukunaga

引用次数: 1

Intraoperative Programming Head Application to the Patient with the Unknown Pacemaker. 术中编程头在未知起搏器患者中的应用。

Chonnam Medical Journal Pub Date : 2022-09-01 Epub Date: 2022-09-23 DOI: 10.4068/cmj.2022.58.3.136

Hyun Kuk Kim, Sung Soo Kim, Young Jae Ki, Keun Ho Park, Dong Hyun Choi

引用次数: 0