{"title":"Prognostic Implications of Sarcoidosis Granulomas - Insights From the Multicenter Registry, the Japanese Cardiac Sarcoidosis Prognostic Study.","authors":"Shohei Yoshida, Tomoaki Nakata, Masanao Naya, Mitsuru Momose, Yasuyo Taniguchi, Yoshimitsu Fukushima, Masao Moroi, Atsutaka Okizaki, Akiyoshi Hashimoto, Takatoyo Kiko, Satoshi Hida, Kazuya Takehana, Kenichi Nakajima","doi":"10.1253/circrep.CR-23-0031","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0031","url":null,"abstract":"<p><p><b><i>Background:</i></b> Definitions of cardiac sarcoidosis (CS) differ among guidelines. Any systemic histological finding of CS is essential for the diagnosis of CS in the 2014 Heart Rhythm Society statement, but not necessary in the Japanese Circulation Society 2016 guidelines. This study aimed to reveal the differences in outcomes by comparing 2 groups, namely CS patients with or without systemic histologically proven granuloma. <b><i>Methods and Results:</i></b> This study retrospectively included 231 consecutive patients with CS. CS with granulomas in ≥1 organs was diagnosed in 131 patients (Group G), whereas CS without any granulomas was diagnosed in the remaining 100 patients (Group NG). Left ventricular ejection fraction (LVEF) was significantly reduced in Group NG compared with Group G (44±13% vs. 50±16%, respectively; P=0.001). However, Kaplan-Meier curves showed that major adverse cardiovascular events (MACE)-free survival outcomes were comparable between the 2 groups (log-rank P=0.167). Univariable analyses showed that significant predictors of MACE were Groups G/NG, histological CS, LVEF, and high B-type natriuretic peptide (BNP) or N-terminal pro BNP concentrations, but none of these was significant in multivariable analyses. <b><i>Conclusions:</i></b> Overall risks of MACE were similar between the 2 groups despite different manifestations in cardiac dysfunction. The data not only validate the prognostic value of non-invasive diagnosis of CS, but also show the need for careful observation and therapeutic strategy in patients with CS without any granuloma.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 6","pages":"252-259"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/2a/circrep-5-252.PMC10247353.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Improved Peak Oxygen Uptake Reduces Cardiac Events After 3 Weeks of Inpatient Cardiac Rehabilitation for Chronic Heart Failure Patients.","authors":"Makoto Murata, Saya Yanai, Shogo Nitta, Yuhei Yamashita, Tatsunori Shitara, Hiroko Kazama, Masanori Ueda, Yasuyuki Kobayashi, Yoshihisa Namasu, Hitoshi Adachi","doi":"10.1253/circrep.CR-23-0040","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0040","url":null,"abstract":"<p><p><b><i>Background:</i></b> The incidence of heart failure (HF) is increasing, and the mortality from HF remains high in an aging society. Cardiac rehabilitation (CR) programs (CRP) increase oxygen uptake (V̇O<sub>2</sub>) and reduce HF rehospitalization and mortality. Therefore, CR is recommended for every HF patient. However, the number of outpatients undergoing CR remains low, with insufficient attendance at CRP sessions. In this study we evaluated the outcomes of 3 weeks of inpatient CRP (3w In-CRP) for HF patients. <b><i>Methods and Results:</i></b> This study enrolled 93 HF patients after acute-phase hospitalization between 2019 and 2022. Patients participated in 30 sessions of 3w In-CRP (30 min aerobic exercise twice daily, 5 days/week). Before and after 3w In-CRP, patients underwent a cardiopulmonary exercise test, and cardiovascular (CV) events (mortality, HF rehospitalization, myocardial infarction, and cerebrovascular disease) after discharge were evaluated. After 3w In-CPR, mean (±SD) peak V̇O<sub>2</sub> increased from 11.8±3.2 to 13.7±4.1 mL/min/kg (116.5±22.1%). During the follow-up period (357±292 days after discharge), 20 patients were rehospitalized for HF, 1 had a stroke, and 8 died for any reasons. Proportional hazard and Kaplan-Meier analyses demonstrated that CV events were reduced among patients with a 6.1% improvement in peak V̇O<sub>2</sub> than in patients without any improvement in peak V̇O<sub>2</sub>. <b><i>Conclusions:</i></b> 3w In-CRP for HF patients improved peak V̇O<sub>2</sub> and reduced CV events in HF patients with a 6.1% improvement in peak V̇O<sub>2</sub>.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 6","pages":"238-244"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/07/16/circrep-5-238.PMC10247349.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9619112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Three Weeks of Inpatient Cardiac Rehabilitation Improves Metabolic Exercise Data Combined With Cardiac and Kidney Indexes Scores for Heart Failure With Reduced Ejection Fraction.","authors":"Shinichiro Sakurai, Makoto Murata, Saya Yanai, Shogo Nitta, Yuhei Yamashita, Tatsunori Shitara, Hiroko Kazama, Masanori Ueda, Yasuyuki Kobayashi, Yoshihisa Namasu, Hitoshi Adachi","doi":"10.1253/circrep.CR-23-0016","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0016","url":null,"abstract":"<p><p><b><i>Background:</i></b> Heart failure with reduced ejection fraction (HFrEF) has a high mortality rate, and cardiac rehabilitation programs (CRP) reduce HFrEF rehospitalization and mortality rates. Some countries attempt 3 weeks of inpatient CRP (3w In-CRP) for cardiac diseases. However, whether 3w In-CRP reduces the prognostic parameter of the Metabolic Exercise data combined with Cardiac and Kidney Indexes (MECKI) score is unknown. Therefore, we investigated whether 3w In-CRP improves MECKI scores in patients with HFrEF. <b><i>Methods and Results:</i></b> This study enrolled 53 patients with HFrEF who participated in 30 inpatient CRP sessions, consisting of 30 min of aerobic exercise twice daily, 5 days a week for 3 weeks, between 2019 and 2022. Cardiopulmonary exercise tests and transthoracic echocardiography were performed, and blood samples were collected, before and after 3w In-CRP. MECKI scores and cardiovascular (CV) events (heart failure rehospitalization or death) were evaluated. The MECKI score improved from a median 23.34% (interquartile range [IQR] 10.21-53.14%) before 3w In-CRP to 18.66% (IQR 6.54-39.94%; P<0.01) after 3w In-CRP because of improved left ventricular ejection fraction and percentage peak oxygen uptake. Patients' improved MECKI scores corresponded with reduced CV events. However, patients who experienced CV events did not have improved MECKI scores. <b><i>Conclusions:</i></b> In this study, 3w In-CRP improved MECKI scores and reduced CV events for patients with HFrEF. However, patients whose MECKI scores did not improve despite 3w In-CRP require careful heart failure management.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 6","pages":"231-237"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/90/circrep-5-231.PMC10247351.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9976940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Myocardial Late Iodine Enhancement Using Photon-Counting Computed Tomography in Patients With Hypertrophic Cardiomyopathy.","authors":"Takahiro Nishihara, Toru Miyoshi, Noriaki Akagi, Mitsutaka Nakashima, Kazufumi Nakamura, Hiroshi Ito","doi":"10.1253/circrep.CR-23-0034","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0034","url":null,"abstract":"Received March 30, 2023; revised manuscript received April 17, 2023; accepted April 18, 2023; J-STAGE Advance Publication released online May 18, 2023 Time for primary review: 12 days Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama (T.N., T.M., M.N., K.N., H.I.); Division of Radiological Technology, Okayama University Hospital, Okayama (N.A.), Japan K.N., H.I. are members of Circulation Reports’ Editorial Team. Mailing address: Takahiro Nishihara, MD, Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. email: p2e20upu@ okayama-u.ac.jp All rights are reserved to the Japanese Circulation Society. For permissions, please email: cr@j-circ.or.jp ISSN-2434-0790 Myocardial Late Iodine Enhancement Using Photon-Counting Computed Tomography in Patients With Hypertrophic Cardiomyopathy","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 6","pages":"269-270"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b4/4b/circrep-5-269.PMC10247347.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9612845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Different Therapeutic Strategies With Left Ventricular Assist Devices on Health-Related Quality of Life During Prolonged Device-Based Support.","authors":"Mariko Asase, Takuya Watanabe, Misa Takegami, Kunihiro Nishimura, Kazuko Nin, Norihide Fukushima","doi":"10.1253/circrep.CR-22-0126","DOIUrl":"10.1253/circrep.CR-22-0126","url":null,"abstract":"<p><p><b><i>Background:</i></b> Left ventricular assist device (LVAD) implantation improves survival and health-related quality of life (HRQoL) of patients with heart failure. However, the impact of LVADs or different LVAD-based therapeutic strategies on long-term HRQoL has not been investigated. We evaluated the long-term HRQoL of Japanese patients who were treated with different LVAD-based therapeutic strategies. <b><i>Methods and Results:</i></b> Patients whose data were recorded in the Japanese Registry for Mechanical Assisted Circulatory Support between January 2010 and December 2018 were divided into 3 groups: primary implantable LVAD (G-iLVAD; n=483), primary paracorporeal LVAD (n=33), and bridge-to-bridge from paracorporeal to implantable LVAD (n=65). HRQoL was evaluated using the EuroQoL 5-dimension 3-level (EQ-5D-3L) before and 3 and 12 months after LVAD implantation; the mean EQ-5D-3L visual analog scale (VAS) score in the G-iLVAD group at these time points was 47.4, 71.1, and 72.9, respectively (where scores of 0 and 100 indicate worst and best imaginable health state, respectively). Changes in the least squares means of the VAS scores at 3 and 12 months after implantation differed significantly among the 3 groups. Social function, disability, and physical and mental problems were significantly lower in the G-iLVAD than other groups. <b><i>Conclusions:</i></b> HRQoL improved significantly at 3 and 12 months after LVAD implantation in all groups. Physical function showed a stronger improvement than did social function, disability, and mental function.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 7","pages":"289-297"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c5/fd/circrep-5-289.PMC10329900.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9803472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors Influencing Acceptance of the Chairperson Position at Annual Scientific Meetings of the Japanese Circulation Society - A Questionnaire Survey in Chugoku District.","authors":"Noriko Fukue, Mari Ishida, Makiko Taniyama, Natsuko Mukai-Yatagai, Takahiro Sakamoto, Tomoko Tamada, Takeshi Suetomi, Kazuaki Tanabe, Yukiko Nakano","doi":"10.1253/circrep.CR-23-0011","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0011","url":null,"abstract":"<p><p><b><i>Background:</i></b> The Japanese Circulation Society survey revealed that Japanese female cardiologists exhibited a trend to refuse the chairperson position; however, the causal factors remain uncertain. <b><i>Methods and Results:</i></b> We distributed a questionnaire survey among chairpersons of the Chugoku regional meeting in November 2022. The rate of chair acceptance at the annual meeting tended to increase as the chairperson's experience grew (first time chairing a meeting, 25.0%; 2-3 times, 33.3%; 4-5 times, 53.8%; ≥6 times, 70.0%; P=0.021). <b><i>Conclusions:</i></b> Providing inexperienced members with the chance to perform the role of chairperson will lead to them accepting to chair annual meetings.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 6","pages":"260-264"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c2/ce/circrep-5-260.PMC10247348.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Magnetic Resonance Imaging of Cancer-Associated Deep Vein Thrombus in a Patient With Gastric Cancer.","authors":"Toshihiro Gi, Yasuyoshi Kuroiwa, Yasushi Kihara, Sae Miyaushiro, Atsushi Yamashita","doi":"10.1253/circrep.CR-23-0028","DOIUrl":"https://doi.org/10.1253/circrep.CR-23-0028","url":null,"abstract":"","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 6","pages":"265-266"},"PeriodicalIF":0.0,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/6d/circrep-5-265.PMC10247346.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9994028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Tweet Content on the Number of Retweets - \"Tweet the Meeting 2022\".","authors":"Takahiro Suzuki, Atsushi Mizuno, Takuya Kishi, Jeffrey Rewley, Chisa Matsumoto, Yuki Sahashi, Mari Ishida, Shoji Sanada, Memori Fukuda, Tadafumi Sugimoto, Miki Hirano, Koichi Node","doi":"10.1253/circrep.CR-23-0043","DOIUrl":"10.1253/circrep.CR-23-0043","url":null,"abstract":"<p><p><b><i>Background:</i></b> Previous research has investigated the effectiveness of the \"Tweet the Meeting\" campaign, but the relationship between tweet content and the number of retweets has not been fully evaluated. <b><i>Methods and Results:</i></b> We analyzed the number of tweets and retweets during the Japanese Circulation Society's 2022 annual meeting. The ambassador group had significantly more session- and symposium-related tweets than the non-ambassador group (P<0.001), associated with the nubmer of retweets. Symposium-related tweets with figures generated more retweets than those without figures (mean [±SD] 3.47±3.31 vs. 2.48±1.94 retweets per tweet, respectively; P=0.001). <b><i>Conclusions:</i></b> The study revealed that official meeting-designated Twitter ambassadors disseminate more educational content than non-ambassadors, and generated more retweets.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 7","pages":"306-310"},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/76/circrep-5-306.PMC10329898.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9803478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}