{"title":"Septal E/e' Ratio Is Associated With Cerebral White Matter Hyperintensity Progression in Young-Old Hypertensive Patients.","authors":"Kenichiro Nomoto, Akihiro Hirashiki, Noriko Ogama, Takahiro Kamihara, Manabu Kokubo, Taiki Sugimoto, Takashi Sakurai, Atsuya Shimizu, Hidenori Arai, Toyoaki Murohara","doi":"10.1253/circrep.CR-22-0104","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0104","url":null,"abstract":"<p><p><b><i>Background:</i></b> The incidence of hypertension increases with age, as does that of brain abnormalities associated with cerebral pathologic and functional degeneration. Little is known about the relationship between hypertension-related cardiac changes and cerebral pathologic degeneration. We examined the relationship between left ventricular (LV) diastolic dysfunction and cerebral white matter hyperintensity (WMH) progression in young-old hypertensive patients. <b><i>Methods and Results:</i></b> This single-center prospective longitudinal observational study included 156 individuals aged 65-75 years with well-controlled hypertension, normal LV contraction, and no history of symptomatic heart failure. WMH was quantified on brain magnetic resonance imaging (MRI). The primary outcome was the rate of WMH volume progression between the baseline and follow-up MRI (∆WMH). Participants were classified into tertiles on the basis of ∆WMH (small, medium, and large ∆WMH). The mean (±SD) age at recruitment was 69.6±2.8 years, and the mean follow-up period was 4.6 years. The ratio of early diastolic mitral inflow velocity to early diastolic septal mitral annulus velocity (septal E/e') was significantly higher in the large ∆WMH group than in the small and medium ∆WMH groups. On multiple regression analysis, septal E/e' was significantly positively associated with square-root-transformed ∆WMH (β=0.457, P<0.001). <b><i>Conclusions:</i></b> Septal E/e' was significantly positively associated with the rate of progression of WMH volume, suggesting that LV diastolic dysfunction is associated with the progression of abnormal brain aging.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 2","pages":"38-45"},"PeriodicalIF":0.0,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/03/circrep-5-38.PMC9908522.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10756703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deterioration of Phosphate Homeostasis Is a Trigger for Cardiac Afterload - Clinical Importance of Fibroblast Growth Factor 23 for Accelerated Aging.","authors":"Yuji Mizuno, Toshifumi Ishida, Fumihito Kugimiya, Seiko Takai, Yoshiharu Nakayama, Koichiro Yonemitsu, Eisaku Harada","doi":"10.1253/circrep.CR-22-0124","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0124","url":null,"abstract":"<p><p><b><i>Background:</i></b> After the discovery of the Klotho gene, phosphate came into focus as a pathogenetic aging agent. Phosphate homeostasis is controlled by phosphate-regulating hormones: fibroblast growth factor 23 (FGF23), vitamin D<sub>3</sub>, and parathyroid hormone. This study investigated the relationship between the deterioration in phosphate homeostasis and arterial stiffness by measuring serum FGF23 concentrations. <b><i>Methods and Results:</i></b> The study subjects comprised 82 hospitalized patients (31 males, 51 females; mean [±SD] age 78.6±10.5 years). All patients underwent chest computed tomography, measurement of central blood pressure (BP), and blood chemistry tests. Arterial calcification and/or stiffness was evaluated using the Agatston calcification score (ACS) and pulse wave velocity (PWV). PWV was significantly correlated with age (t=23.47, P<0.0001), estimated glomerular filtration rate (eGFR; t=-4.40, P<0.0001), and ACS (t=4.36, P<0.0001). Serum FGF23 concentrations were significantly correlated with age (t=2.52, P=0.014), eGFR (t=-3.37, P<0.001), serum inorganic phosphorus concentrations (t=3.49, P<0.001), serum vitamin D<sub>3</sub> concentrations (t=-4.57, P<0.001), ACS (t=2.30, P=0.025), augmentation pressure (t=2.48, P=0.015), central systolic BP (t=2.00, P=0.049), plasma B-type natriuretic peptide (BNP) concentrations (t=3.48, P<0.001), and PWV (t=2.99, P=0.004). PWV was positively related to augmentation pressure (t=4.09, P<0.001), central systolic BP (t=3.13, P=0.002), and plasma BNP concentrations (t=3.54, P<0.001). <b><i>Conclusions:</i></b> This study shows that the increase in serum FGF23 concentrations reflects deterioration of phosphate homeostasis and is an important predictor for arterial stiffness, which intensifies cardiac afterload.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 1","pages":"4-12"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/a1/circrep-5-4.PMC9815959.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9456956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yasuhiro Matsuda, Masaharu Masuda, Takashige Sakio, Hiroyuki Uematsu, Toshiaki Mano
{"title":"Association Between Periprocedural Heart Rate Trend and Postprocedural Worsening Heart Failure in Patients Receiving Catheter Ablation for Atrial Fibrillation - Reply.","authors":"Yasuhiro Matsuda, Masaharu Masuda, Takashige Sakio, Hiroyuki Uematsu, Toshiaki Mano","doi":"10.1253/circrep.CR-22-0115","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0115","url":null,"abstract":"spective study. As Drs. Kataoka and Imamura note, the optimal heart rate in atrial fibrillation (AF) patients is unclear, and a few patients in our study had bradyarrhythmia that required pacemaker implantation. However, as discussed in the paper, sinus node dysfunction is found in AF patients.4 In such patients, the heart rate tended to decrease under the influence of sedation during the procedure,5 and a failure of cardiac function to adapt to the decrease in heart rate may cause DHF. In the case of a decrease in heart rate after catheter ablation, patients should be closely observed, and, when pulmonary congestion is found on chest X-rays or elevated intracardiac pressure is found on echocardiography, early interventions to prevent DHF, such as the administration of diuretics and/or nitrates, should be considered. If a considerable decrease in heart rate occurs, prevention of bradycardia by temporary cardiac pacing may be also considered as optional therapy.","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"5 1","pages":"16-17"},"PeriodicalIF":0.0,"publicationDate":"2023-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/e8/circrep-5-16.PMC9815958.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Masanori Yamamoto, Ai Kagase, Ryotaku Kawabata, Takahiro Tokuda
{"title":"Successful Giant Thrombus Aspiration Using a Guide Cather in the Right Atrium Before Emergency Transcatheter Edge-to-Edge Mitral Valve Repair.","authors":"Masanori Yamamoto, Ai Kagase, Ryotaku Kawabata, Takahiro Tokuda","doi":"10.1253/circrep.CR-22-0077","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0077","url":null,"abstract":"","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"4 12","pages":"611-612"},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/57/d3/circrep-4-611.PMC9726523.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10441912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ai Kagase, Masanori Yamamoto, Mikan Kojima, Takahiro Tokuda
{"title":"Long Extending Thrombus Formation Around a Transseptal Puncture Site After Transcatheter Edge-to-Edge Mitral Valve Repair.","authors":"Ai Kagase, Masanori Yamamoto, Mikan Kojima, Takahiro Tokuda","doi":"10.1253/circrep.CR-22-0051","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0051","url":null,"abstract":"right atrium around the transseptal puncture (TSP) site (Figure C). The patient had no history of coagulation disorders and oral anticoagulation was not prescribed; however, dual antiplatelet therapy was administered because of recent coronary stenting. The active clotting time was maintained over 200 s during TEER. The following day, transthoracic echocardiography (TTE) revealed a wriggling, long structure extending from the TSP site to the right ventricle (Figure D; Supplementary Movie). We suspected A 90-year-old woman was transferred to Nagoya Heart Center because of cardiogenic shock with severe mitral valve regurgitation. The mitral valve regurgitation was caused by chordal elongation, which led to anterior central scallop prolapse (Figure A). Transcatheter edge-to-edge mitral valve repair (TEER) was successfully performed without complications (Figure B). After TEER, transesophageal echocardiography showed a newly developed small mass not found previously in the","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"4 12","pages":"609-610"},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3d/b6/circrep-4-609.PMC9726532.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10441914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unilateral Pulmonary Edema in Patients With Acute Mitral Regurgitation Caused by Chordal Rupture.","authors":"Yu-Ki Nishimura, Junya Komatsu, Hiroki Sugane, Hayato Hosoda, Ryu-Ichiro Imai, Yoko Nakaoka, Koji Nishida, Shu-Ichi Seki, Toru Kubo, Naohito Yamasaki, Hiroaki Kitaoka, Sho-Ichi Kubokawa, Kazuya Kawai, Naohisa Hamashige, Yoshinori Doi","doi":"10.1253/circrep.CR-22-0090","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0090","url":null,"abstract":"Background: Cardiogenic unilateral pulmonary edema (UPE) has been reported as an unusual condition and to occur in association with severe mitral regurgitation (MR). However, the prevalence of UPE in patients with severe MR remains unknown. Methods and Results: Among 143 consecutive patients with chordal rupture and significant MR, 38 patients with acute severe MR were studied. The prevalence of UPE was 50% (19 patients); all these patients had right-sided UPE. Eight (21%) patients had bilateral pulmonary edema (BPE). All 8 patients with BPE and 18 of 19 patients with UPE had chordal rupture of the posterior leaflet. All patients with UPE and BPE had severe MR with similar left atrial size. Chest radiographs taken ≤48 h from symptom onset diagnosed UPE in 15 of 19 (79%) patients and BPE in 3 of 8 (38%) patients (P=0.037). Chest radiographs taken >48 h from symptom onset diagnosed UPE in 4 (21%) patients and BPE in 5 (62%) patients (P=0.037). Conclusions: The prevalence of UPE was estimated as 50%; it was most frequently right sided and almost always associated with chordal rupture of the posterior leaflet. UPE is not rare, but common, particularly shortly after the development of acute severe MR caused by chordal rupture.","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"4 12","pages":"571-578"},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3a/5b/circrep-4-571.PMC9726524.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"External Validation of the Kumamoto Criteria in Transthyretin Amyloid Cardiomyopathy Screening - A Retrospective Cohort Study.","authors":"Yukihiro Watanabe, Hiroshige Murata, Hitoshi Takano, Tomonari Kiriyama, Shinobu Kunugi, Masato Hachisuka, Saori Uchiyama, Junya Matsuda, Hiroyuki Nakano, Yoichi Imori, Kenji Yodogawa, Yu-Ki Iwasaki, Eitaro Kodani, Akira Shimizu, Wataru Shimizu","doi":"10.1253/circrep.CR-22-0110","DOIUrl":"https://doi.org/10.1253/circrep.CR-22-0110","url":null,"abstract":"<p><p><b><i>Background:</i></b> The Kumamoto criteria have been proposed as a non-invasive screen for transthyretin amyloid cardiomyopathy. This study assessed the validity of the Kumamoto criteria externally. <b><i>Methods and Results:</i></b> The study included 138 patients (median age 73 years; 65% male) who underwent <sup>99 m</sup>Tc-pyrophosphate (PYP) scintigraphy. Patients were divided into 4 groups according to total scores on the Kumamoto criteria (i.e., 0-3) for the following 3 factors: high-sensitivity cardiac troponin T ≥0.0308 ng/mL, wide (≥120 ms) QRS, and left ventricular posterior wall thickness ≥13.6 mm. The diagnostic performance and positive predictive value (PPV) of the Kumamoto criteria for positive <sup>99 m</sup>Tc-PYP scintigraphy were validated. Eighteen (13%) patients were positive on <sup>99 m</sup>Tc-PYP scintigraphy. The Kumamoto criteria had a favorable diagnostic performance (area under the curve 0.808). The PPV for groups with scores of 0, 1, 2, and 3 was 0% (n=0/42), 11% (n=6/57), 21% (n=7/33), and 83% (n=5/6), respectively, which is lower, particularly for those with a score of 2, than in the original Kumamoto cohort. However, the PPV increased after combining the Kumamoto criteria with a history of orthopedic diseases (spinal canal stenosis and/or carpal tunnel syndrome). <b><i>Conclusions:</i></b> This study suggests that the Kumamoto criteria have a favorable diagnostic performance; however, the PPV may decrease depending on the study population. Combining the Kumamoto criteria with the presence of orthopedic disease may improve the PPV.</p>","PeriodicalId":10276,"journal":{"name":"Circulation Reports","volume":"4 12","pages":"579-587"},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/9d/circrep-4-579.PMC9727327.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10404429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}