Chinese Medicine最新文献

{"title":"Mechanisms of acupuncture in treating depression: a review.","authors":"Jianfu Ma, Xuan Yin, Kaiyu Cui, Jiqing Wang, Wei Li, Shifen Xu","doi":"10.1186/s13020-025-01080-7","DOIUrl":"10.1186/s13020-025-01080-7","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture as a representative treatment method of traditional Chinese medicine, has been found to have a significant effect on mild to moderate depression without obvious side effects, but the mechanism through which it exerts its antidepressant effect is still unclear.</p><p><strong>Methods: </strong>We searched PubMed, Web of Science, and Embase databases for basic research on acupuncture in the treatment of depression from the database established to June 14, 2024, and finally included 44 studies from 2020 to June 14, 2024, into the table analysis. The main outcomes of this study are the effects of acupuncture on the relevant biological indicators of depression model.</p><p><strong>Results: </strong>By analyzing the effect of acupuncture on rodent model of depression, the mechanism of acupuncture against depression was explored. In general, several acupuncture methods, mainly based on electroacupuncture (EA), regulate the levels of 5-hydroxytryptamine (5-HT), glutamic acid (Glu) and dopamine (DA), regulate the calcium signaling pathway, increase the expression of synaptic protein, promote mitochondrial repair and reduce oxidative stress, and enhance synaptic plasticity. Inhibition of key inflammatory pathways such as P2X7R/NLRP3 and NF-κB signaling pathways, regulation of hypothalamic-pituitary-adrenal axis (HPA axis) function, and tryptophan metabolism improved depression-like behavior in rodent models.</p><p><strong>Conclusions: </strong>In summary, acupuncture treatment represented by EA has multiple mechanisms to play a role by regulating neurotransmitter balance, improving neuroplasticity, reducing inflammatory responses, and regulating the neuroendocrine system. However, the differences between acupoint catgut embedding (ACE), manual acupuncture (MA), and EA in the treatment of depression and the operating parameters of EA in the treatment of depression with different causes (such as frequency, intensity, duration, etc.) still need further research to be confirmed. This review has not been registered with PROSPERO or other protocol registration platforms because protocol registration was not a mandatory requirement for this study.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"29"},"PeriodicalIF":5.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folium Hibisci Mutabilis extract suppresses M1 macrophage polarization through mitochondrial function enhancement in murine acute gouty arthritis.","authors":"Yichen Zhao, Jiahui Zhang, Wei Yan, Ping Jiang, Juncheng Li, Haojun He, Honghong Ma, Yuxin Zhang, Kai Yang, Min Jiang, Xiaobing Xi","doi":"10.1186/s13020-025-01081-6","DOIUrl":"10.1186/s13020-025-01081-6","url":null,"abstract":"<p><strong>Background: </strong>Acute gout arthritis (AGA) is a common metabolic joint disease and urgently needs a safer alternative therapy due to the significant side effects from long-term use of primary medications. Folium Hibisci Mutabilis, a traditional medicinal herb, has demonstrated promising therapeutic efficacy in the clinical management of AGA, but its pharmacological mechanisms remain to be elucidated.</p><p><strong>Methods: </strong>Folium Hibisci Mutabili was isolated and refined into the Folium Hibisci Mutabilis Extract (FHME). Then, monosodium urate-induced AGA animal models were applied to identify the anti-inflammatory and analgesic effects of FHME in vivo through various techniques, including ultrasonography, Paw withdrawal thresholds, histological staining, etc. We used RNA-seq, qRT-PCR, ELISA, and flow cytometry to evaluate the efficacy of FHME on M1 polarization. Utilizing transmission electron microscope and oxygen consumption rate examinations in conjunction with Mito-Tracker staining, we observed the effects of FHME on mitochondrial morphology and function. Finally, we employed proteomics analysis, siRNA, qRT-PCR, western blot and other techniques to investigate the underlying mechanism of FHME's actions between the two phenotypes and the key targets.</p><p><strong>Results: </strong>We observed a notable reduction in inflammation and pain, as well as the decreased infiltration of inflammatory cells and expression of IL-1β in synovial tissue of AGA mice upon treatment with FHME. FHME suppressed TNF-α, IL-1β, iNOS, and IL-18 expression in BMDM-derived macrophages and inhibited the formation of F4/80⁺CD86⁺ cells. Mechanically, FHME protected mitochondrial morphology and stimulated the expression of key oxidative phosphorylation proteins, such as Ubiquinol Cytochrome c Reductase Core Protein I (UQCRC1), UQCRC2, CYCS, and NDUFA4. Additionally, it enhanced the activity of respiratory complex III, recovered cellular aerobic respiration under LPS and MSU induction. FHME lost its effect to downregulate M1 macrophage polarization with the presence of rotenone or si-UQCRC1. Finally, 10 compounds were identified from FHME having potential binding affinity with the UQCRC1 protein.</p><p><strong>Conclusions: </strong>The therapeutic potential of FHME for AGA is associated with the maintenance of mitochondrial function to inhibit M1 macrophage polarization, which is intimately linked to the UQCRC1. Our findings highlight the potential of Folium Hibisci Mutabilis as a safe and effective approach for AGA.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"28"},"PeriodicalIF":5.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salidroside protects against myocardial infarction via activating MIF-mediated mitochondrial quality control.","authors":"Baiyang You, Jie Zhang, Chuyan Yang, Yaoshan Dun, Dake Qi, Yuqiong Long, Jing Cheng, Yuan Lin, Nanjiang Zhou, Tanghao Zeng, Jie Dong, Suixin Liu","doi":"10.1186/s13020-025-01076-3","DOIUrl":"10.1186/s13020-025-01076-3","url":null,"abstract":"<p><strong>Background: </strong>Salidroside is a potential therapeutic agent for myocardial infarction (MI), exerting therapeutic effects on macrophage migration inhibitory factor (MIF)-regulated mitochondrial quality control. Our aim was to explore the mechanism through which the MIF pathway regulates salidroside-mediated resistance to hypoxia-induced cardiomyocyte apoptosis.</p><p><strong>Methods: </strong>Ligation surgery of the left anterior descending branch of the coronary artery was employed to establish a myocardial infarction mouse model. Salidroside at low and high doses was administered to the mice for 4 weeks after the surgery. Cardiac function was evaluated via echocardiography. Morphological changes, apoptosis, and mitochondrial damage in the myocardium were examined. For the cell experiments, cardiomyocytes were treated with salidroside under oxygen‒glucose deprivation (OGD) conditions and were either treated with recombinant MIF (rMIF) or transfected with Mif-siRNA. Subsequently, mitochondrial quality control and apoptosis were assessed.</p><p><strong>Results: </strong>Salidroside enhanced mitochondrial quality control in MI model mice, mitigated apoptosis and improved cardiac dysfunction. Transmission electron microscopy indicated that there were fewer damaged mitochondria in the salidroside-treated mice compared with the control mice. MIF and downstream mitochondrial quality control pathways were activated in the mice treated with salidroside. Consistently, the cell experiments demonstrated that salidroside and rMIF alleviated apoptosis, improved impaired mitochondrial quality control in OGD-induced cells and activated MIF signaling in OGD-induced cells. However, these effects of salidroside were partially blocked by Mif-siRNA transfection.</p><p><strong>Conclusion: </strong>Salidroside alleviated myocardial apoptosis and ameliorated cardiac dysfunction in MI model mice through the MIF pathway and downstream mitochondrial quality control.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"27"},"PeriodicalIF":5.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-depth characterization of minor 2-(2-phenylethyl)chromone oligomers from Chinese agarwood by integrating offline two-dimensional liquid chromatography and hybrid ion trap time-of-flight mass spectrometry.","authors":"Huixia Huo, Hang Zhang, Huiting Liu, Jiale Ma, Qian Zhang, Yunfang Zhao, Jiao Zheng, Pengfei Tu, Yuelin Song, Jun Li","doi":"10.1186/s13020-025-01073-6","DOIUrl":"10.1186/s13020-025-01073-6","url":null,"abstract":"<p><p>Those minor, even trace natural products sometimes exhibit exciting activities and possess unique structures; however, it is challenging to pursue and identify such components using routine LC-MS/MS platforms attributing to their low distribution levels in herbs, the overlapping effects from the abundant ingredients and the high-level structural diversity. Here, an off-line two-dimensional liquid chromatography hook up hybrid ion trap time-of-flight mass spectrometry program was exploited to facilitate the exposure of those minor components in chromatographic domain and to acquire high-resolution multi-stage mass spectra, and the less abundant 2-(2-phenylethyl)chromone (PEC) oligomers from Chinese agarwood that is one of the most precious herbal medicines were concerned to illustrate and assess the applicability towards capturing and structurally annotating those minor components. The mass fragmentation pathways of PEC dimers, in particular the linkage fission between monomers, were proposed by assaying eighteen authentic compounds that covered different conjugation manners, and subsequently applied for the tentative structural identification of observed components. Thereafter, targeted purification was conducted to generate eight new, trace PEC dimers to justify the annotated structures. As a result, heterocyclic ring fission was the diagnostic fragmentation pathways for PEC dimers. In total, 199 PECs were discovered and characterized, consisting of 74 dimers and five trimers. Noteworthily, after structural identification with NMR assays, the confirmative structures of those eight new PEC dimers agreed well with the identities suggested by mass fragmentation rules. Above all, PEC derivatives, notably trace oligomers, in Chinese agarwood were profiled in depth, resulting in a number of interesting structures.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"26"},"PeriodicalIF":5.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration.","authors":"Donghao Yin, Xiang Li, Xuemeng Yang, Xiaofei Shang, Zhen Li, Jiahao Geng, Yanyu Xu, Zijing Xu, Zixuan Wang, Zimeng Shang, Zhiyun Yang, Linlan Hu, Quanwei Li, Jiabo Wang, Xinhua Song, Xiuhui Li, Xiaojun Wang","doi":"10.1186/s13020-025-01061-w","DOIUrl":"10.1186/s13020-025-01061-w","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma (HCC) poses ongoing difficulties for public health systems due to its high incidence and poor prognosis. Huqi formula (HQF), a well-known prescription in traditional Chinese medicine, has demonstrated notable clinical effectiveness in the treatment of HCC. However, the mechanisms underlying its therapeutic effects have yet to be completely elucidated.</p><p><strong>Purpose: </strong>This study aimed to investigate the anti-HCC effects of HQF and its underlying mechanisms.</p><p><strong>Methods: </strong>Chemical profiling and quantification of HQF were conducted by LC-MS and HPLC. Orthotopic and subcutaneous tumor models were established through hydrodynamic injection of Akt/Nras plasmids and subcutaneous injection of c-Met/sgPten cells, respectively, to evaluate the therapeutic effects of HQF on HCC. Network pharmacology, RNA-Seq, molecular docking, Western blot, and flow cytometry were employed to assess the anti-HCC mechanisms.</p><p><strong>Results: </strong>LC-MS analysis identified 41 components, with HPLC quantification showing salvianolic acid B as the most abundant compound (0.303%). In Akt/Nras and c-Met/sgPten-induced HCC models, HQF significantly reduced tissue damage, improved liver function, and inhibited HCC progression. Mechanistic studies revealed that HQF induced apoptosis in HCC cells by downregulating p-PI3K, p-AKT, and p-mTOR expression, with molecular docking indicating the strongest binding affinity between salvianolic acid B and PI3K. HQF further enhanced CD4⁺ and CD8⁺ T cell infiltration within the tumor microenvironment. When combined with PD-1 therapy, HQF improved therapeutic efficacy against HCC. Finally, toxicity assays confirmed the safety profile of HQF.</p><p><strong>Conclusion: </strong>HQF demonstrated significant anti-HCC effects and a synergistic effect with PD-1, could be used as an alternative therapeutic agent for HCC.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"25"},"PeriodicalIF":5.3,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Magnolia kobus DC. suppresses neointimal hyperplasia by regulating ferroptosis and VSMC phenotypic switching in a carotid artery ligation mouse model.","authors":"Jong Min Kim, Yiseul Kim, Hyun-Jin Na, Haeng Jeon Hur, Sang Hee Lee, Mi Jeong Sung","doi":"10.1186/s13020-025-01066-5","DOIUrl":"10.1186/s13020-025-01066-5","url":null,"abstract":"","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"24"},"PeriodicalIF":5.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying traditional Chinese medicine combinations for breast cancer treatment based on transcriptional regulation and chemical structure.","authors":"Shensuo Li, Lijun Zhang, Wen Zhang, Hongyu Chen, Mei Hong, Jianhua Xia, Weidong Zhang, Xin Luan, Guangyong Zheng, Dong Lu","doi":"10.1186/s13020-025-01074-5","DOIUrl":"10.1186/s13020-025-01074-5","url":null,"abstract":"<p><p>Breast cancer (BC) is a prevalent form of cancer among women. Despite the emergence of numerous therapies over the past few decades, few have achieved the ideal therapeutic effect due to the heterogeneity of BC. Drug combination therapy is seen as a promising approach to cancer treatment. Traditional Chinese medicine (TCM), known for its multicomponent nature, has been validated for its anticancer properties, likely due to the synergy effect of the key components. However, identifying effective component combinations from TCM is challenging due to the vast combination possibilities and limited prior knowledge. This study aims to present a strategy for discovering synergistic compounds based on transcriptional regulation and chemical structure. First, BC-related gene sets were used to screen TCM-derived compound combinations guided by synergistic regulation. Then, machine learning models incorporating chemical structural features were established to identify potential compound combinations. Subsequently, the pair of honokiol and neochlorogenic acid was selected by integrating the results of compound combination screening. Finally, cell experiments were conducted to confirm the synergistic effect of the pair against BC. Overall, this study offers an integrated screening strategy to discover compound combinations of TCM against BC. The tumor cell suppression effect of the honokiol and neochlorogenic acid pair validated the effectiveness of the proposed strategy.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"23"},"PeriodicalIF":5.3,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury.","authors":"Xiang Meng, Yu-Peng Liu, Jia-Wei Dai, Yuan Bai, Xin Hu, Muhammad Azhar, Xian-Ju Huang","doi":"10.1186/s13020-025-01072-7","DOIUrl":"10.1186/s13020-025-01072-7","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Aconitum tanguticum (Maxim.) Stapf (ATS) is a rare Tibetan medicinal plant that belongs to the Ranunculaceae family. This herb is mainly distributed in the high-altitude areas of Qinghai, Gansu provinces, and Tibetan Autonomous Region in China. In Tibetan medicine, ATS is mainly used to treat lung inflammation, hepatitis, gastrointestinal diseases, influenza, fever caused by infectious diseases, food poisoning, snake and scorpion bites, and yellow water disease. ATS has anti-inflammatory, antiviral, and other pharmacological effects, according to recent research. It is welltolerated by individuals from diverse ethnic groups and has a long history of use in Tibetan medicine.</p><p><strong>Aim of the study: </strong>This study investigated the preventive effects of ATS alcoholic extract on acute lung injury (ALI) in mice and aimed to elucidate its possible mechanism of action.</p><p><strong>Materials and methods: </strong>Alveolar epithelial cells A549 and specific pathogen-free C57BL/6 mice were induced with lipopolysaccharide (LPS) to establish ALI models both in vivo and in vitro and to explore the pharmacological effects and therapeutic mechanisms of ATS.</p><p><strong>Results: </strong>ATS down-regulated the mRNA levels of inflammatory factors NF-κB p65, TNF-α, IL-1β, and IL-8, inhibited the release of reactive oxygen species, inhibited epithelial-mesenchymal transition caused by sustained cell injury, promoted the Keap1/Nrf2/HO-1 signalling pathway, reduced the degree of oxidative stress in vivo, and inhibited the production of proteins associated with LPS-induced ferroptosis.</p><p><strong>Conclusion: </strong>The Tibetan medicine ATS reduced pulmonary haemorrhage and oedema in ALI mice, alleviated the degree of lung tissue lesions, inhibited the expression of inflammatory factors and apoptosis, and plays a preventive role against acute lung injury in mice.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"21"},"PeriodicalIF":5.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoid, organ-on-a-chip and traditional Chinese medicine.","authors":"Jiayue Yang, Yu Jiang, Mingxing Li, Ke Wu, Shulin Wei, Yueshui Zhao, Jing Shen, Fukuan Du, Yu Chen, Shuai Deng, Zhangang Xiao, Wen Yuan, Xu Wu","doi":"10.1186/s13020-025-01071-8","DOIUrl":"10.1186/s13020-025-01071-8","url":null,"abstract":"<p><p>In the past few years, the emergence of organoids and organ-on-a-chip (OOAC) technologies, which are complementary to animal models and two-dimensional cell culture methods and can better simulate the internal environment of the human body, provides a new platform for traditional Chinese medicine (TCM) studies. Organoids and OOAC techniques have been increasingly applied in the fields of drug screening, drug assessment and development, personalized therapies, and developmental biology, and there have been some application cases in the TCM studies. In this review, we summarized the current status of using organoid and OOAC technologies in TCM research and provide key insights for future study. It is believed that organoid and OOAC technologies will play more and more important roles in research and make greater contributions to the innovative development of TCM.</p>","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"22"},"PeriodicalIF":5.3,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11823035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Aidi injection inhibits the migration and invasion of gefitinib-resistant lung adenocarcinoma cells by regulating the PLAT/FAK/AKT pathway.","authors":"Jingyuan Zhang, Siyun Yang, Xiaodong Chen, Fanqin Zhang, Siyu Guo, Chao Wu, Tieshan Wang, Haojia Wang, Shan Lu, Chuanqi Qiao, Xiaoguang Sheng, Shuqi Liu, Xiaomeng Zhang, Hua Luo, Qinglin Li, Jiarui Wu","doi":"10.1186/s13020-025-01070-9","DOIUrl":"10.1186/s13020-025-01070-9","url":null,"abstract":"","PeriodicalId":10266,"journal":{"name":"Chinese Medicine","volume":"20 1","pages":"20"},"PeriodicalIF":5.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}