Clinical and Experimental Optometry最新文献

{"title":"Increased SCUBE-1 levels in the aqueous humour of patients with pseudoexfoliation syndrome.","authors":"Esra Bahadır Camgöz, Berrak Sekeryapan Gediz, Mehmet Senes, Fatih Serin, Kadriye Ufuk Elgin","doi":"10.1080/08164622.2024.2445071","DOIUrl":"https://doi.org/10.1080/08164622.2024.2445071","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Pseudoexfoliation syndrome (PXS) is a common age-related disorder associated with glaucoma and cataract. Despite its clinical importance, the pathogenesis of PXS is not yet fully understood.</p><p><strong>Background: </strong>To evaluate levels of SCUBE-1 (signal peptide, CUB domain, and epidermal growth factor-like domain containing protein 1) in the serum and aqueous humour of patients with PXS in comparison with non-PXS controls.</p><p><strong>Methods: </strong>This prospective study included patients with and without PXS undergoing phacoemulsification surgery for cataract. Patients with pseudoexfoliative glaucoma were excluded. Aqueous humour samples collected at the beginning of phacoemulsification surgery were analysed by using the sandwich enzyme-linked immunosorbent assay method (human SCUBE-1 enzyme-linked immunosorbent assay kit; Elabscience).</p><p><strong>Results: </strong>There was a significant difference in mean aqueous humour SCUBE-1 levels between PXS patients (1.69 ± 0.41 ng/µL) and non-PXS controls (0.89 ± 0.33 ng/µL) (<i>p</i> = 0.012). However, the difference in mean serum SCUBE-1 levels was not significant (0.87 ± 0.36 ng/µL and 0.81 ± 0.35 ng/µL, respectively; <i>p</i> = 0.560). There was no significant correlation between aqueous humour and serum SCUBE-1 levels in either group (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>SCUBE-1 is an important marker of ischaemia and oxidative stress. Increased SCUBE-1 levels in the aqueous humour of patients with PXS may indicate a local effect of SCUBE-1 in the pathogenesis of PXS.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Branch retinal vein occlusion and Valsalva manoeuvre in wind instrument players and singers.","authors":"Christolyn Raj, Ian F Gutteridge","doi":"10.1080/08164622.2024.2448234","DOIUrl":"https://doi.org/10.1080/08164622.2024.2448234","url":null,"abstract":"<p><strong>Clinical relevance: </strong>There are many recognised risk factors for retinal vein occlusions. It is plausible that musicians who play wind instruments or use their voice as their primary instrument may be at increased risk of branch retinal vein occlusions through repeated Valsalva manoeuvre.</p><p><strong>Background: </strong>Repeated valsalva manoeuvres are commonly performed by musicians using high resistance wind instruments. This also true for singers. This case series illustrates a correlation between repeated Valsalva manoeuvres and retinal vein occlusion in three patients and explores the clinical and functional underlying mechanisms.</p><p><strong>Methods: </strong>A retrospective review of three cases presenting to a private Ophthalmology clinic.</p><p><strong>Results: </strong>Case 1 is an 85-year-old male, French Horn player and Case 2 is a 77-year-old male, bass-baritone singer each presented with a left-sided non-ischaemic branch retinal vein occlusion. Case 3 is a 79-year-old male Tenor presented with a left -sided ischaemic branch retinal vein occlusion. All cases were treated with intravitreal anti-vascular endothelial growth factor stabilising vision.</p><p><strong>Conclusion: </strong>Repeated Valsalva manoeuvre as demonstrated in wind musicians and singers may play a role in pathogenies of branch retinal vein occlusions in susceptible individuals.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"1-4"},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photopsias are associated with greater levels of depression and anxiety.","authors":"Nikolaos Gouliopoulos, Ioannis Roumeliotis, Dimitra Oikonomou, Stylianos Kympouropoulos, Nikolaos-Achilleas Arkoudis, Alexandros Rouvas, Ilias Georgalas, Panagiotis Theodossiadis","doi":"10.1080/08164622.2024.2445069","DOIUrl":"https://doi.org/10.1080/08164622.2024.2445069","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Vitreous floaters have been associated with depressive and anxiety symptoms. However, there is a scarcity in the literature regarding the possible impact of vitreous flashes on the psychological status of the patients.</p><p><strong>Background: </strong>Photopsias and vitreous floaters frequently co-exist. Floaters have been accompanied by exacerbated levels of depression and anxiety. The aim of this study was to examine whether the presence of photopsias in patients suffering from vitreous floaters is accompanied by exacerbated levels of anxiety and depression.</p><p><strong>Methods: </strong>One hundred and four patients complaining of floaters were included in the study; 51 experienced also photopsias and 53 did not. A comprehensive ocular examination, including funduscopy and optical coherence tomography scans was performed to every patient, while their clinical and demographic data were also assessed. Every participant completed the PHQ-9, the Zung SDS, and the HADS anxiety and depression questionnaires.</p><p><strong>Results: </strong>The clinical and demographic data did not differ significantly between the study groups (<i>p</i> > 0.05).The scores of every questionnaire were significantly higher among the patients with vitreous flashes (<i>p</i> < 0.05 for all). After adjustment for several confounders, the values remained significantly impaired.</p><p><strong>Conclusion: </strong>Photopsias negatively affect the psychological and mental well-being of the patients, by the terms of amplified levels of depression and anxiety. These findings underscore the necessity for a more holistic approach to managing patients presenting with vitreous flashes.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142977648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in corneal wavefront aberrations and anterior segment parameters after horizontal rectus muscle surgeries assessed using Pentacam®.","authors":"Aynura Sariyeva Aydamirov, Ayna Sariyeva Ismayilov, Duygu Topaktaş Emekli","doi":"10.1080/08164622.2024.2446485","DOIUrl":"https://doi.org/10.1080/08164622.2024.2446485","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Horizontal rectus muscle surgeries may cause changes in corneal and anterior segment parameters. Corneal topography is an important device for identifying these alterations.</p><p><strong>Background: </strong>The aim of this work is to evaluate the effects of horizontal rectus muscle surgeries on corneal topography, anterior chamber parameters and corneal wavefront aberrations.</p><p><strong>Methods: </strong>Patients who had horizontal rectus muscle surgery from a single hospital in Turkey between September 2021 and March 2022 were invited to participate. Anterior segment parameters and corneal wavefront aberrations were analysed using a Pentacam device. Axial lengths were measured with an intraocular lens biometric instrument. Tests were performed prior to surgery and 3 months after surgery and results were compared. Parameters with significant change were determined in the whole study group, single muscle and two-muscle groups. The amount of change (Δ) in all parameters was compared between the groups that underwent single muscle and two-muscle surgeries.</p><p><strong>Results: </strong>For this prospective study, 44 eyes of 35 patients were included. The mean age was 18.10 ± 6.93 (7-28) (mean ± standard deviation (range)) years. Of the eyes, 22 (50%) underwent single muscle recession surgery. Two-muscle surgeries (recession and resection combination) were performed in 22 eyes. In the whole study group, axial length, anterior corneal surface-steep keratometry, anterior corneal astigmatism and anterior chamber volume increased significantly in the postoperative period (<i>p</i> = 0.002, <i>p</i> < 0.001, <i>p</i> < 0.001, and <i>p</i> = 0.007 respectively). Anterior corneal surface-flat keratometry decreased significantly (<i>p</i> = 0.002). While root mean square (RMS)-Spherical aberration increased significantly for the total corneal surface (<i>p</i> < 0.001), RMS-Trefoil 0° decreased (<i>p</i> = 0.039). Only ΔSteep keratometry and ΔMean keratometry parameters were changed significantly between the two groups.</p><p><strong>Conclusions: </strong>Horizontal muscle surgeries may cause changes in corneal topography, anterior chamber parameters and corneal aberrations. The number of muscles operated during the surgery does not seem to greatly affect the magnitude of changes that occur.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142969785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duplicate iris: a case report on bilateral accessory iris membrane.","authors":"Vineet Ratra, P Preethi, Thandalam Sundararajan Surendran, Subramanian Krishnakumar, Dhanashree Ratra","doi":"10.1080/08164622.2023.2291066","DOIUrl":"10.1080/08164622.2023.2291066","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"97-99"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138497893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired brachial flow-mediated dilation may predict choroidal and retinal nerve fibre layer thickness changes in people with obesity.","authors":"Gurcan Dogukan Arslan, Levent Dogan, Burcu Gonul, Gulcin Zengin, Emrah Tas","doi":"10.1080/08164622.2024.2306960","DOIUrl":"10.1080/08164622.2024.2306960","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Choroidal thickness and peripapillary retinal nerve fibre layer (RNFL) changes are known to occur in obesity. Endothelial dysfunction and systemic atherosclerosis may play a role in the pathophysiology of these differences.</p><p><strong>Background: </strong>Flow-mediated dilation (FMD) is reduced in patients with endothelial dysfunction, and the ankle-brachial index is a surrogate marker for atherosclerosis. This study was conducted to examine the relationship between systemic vascular parameters (FMD, and ankle-brachial index), subfoveal choroidal thickness, and peripapillary RNFL thickness in obese individuals.</p><p><strong>Methods: </strong>This observational, cross-sectional study involved 108 total participants who were divided into two groups. One group consisted of 54 obese subjects who each had a body mass index of 30 kg/m² or more. The other control group contained 54 participants who each had a body mass index of 25 kg/m² or less but higher than 20 kg/m² . For each participant, only one eye was examined in this study. Subfoveal choroidal thickness, RNFL thickness, ankle-brachial index, and ultrasound measurement of the brachial artery FMD were performed. FMD was categorised according to receiver operating characteristic analysis, and endothelial dysfunction was defined as an FMD ≤ 7.29%.</p><p><strong>Results: </strong>Subfoveal choroidal and RNFL thicknesses in the temporal quadrant were significantly lower in the obese group (<i>p</i> < 0.05). Lower mean values of subfoveal choroidal and RNFL thicknesses in the temporal and inferior quadrants were observed in subjects with an FMD ≤ 7.29% (<i>p</i> < 0.05). In people with obesity, FMD was positively correlated with subfoveal choroidal thickness (<i>r</i> = 0.322, <i>p</i> = 0.001), inferior RNFL thickness (<i>r</i> = 0.259, <i>p</i> = 0.007), and temporal RNFL thickness (<i>r</i> = 0.297, <i>p</i> = 0.002). However, the ankle-brachial index was not correlated with obesity.</p><p><strong>Conclusions: </strong>Impaired FMD was associated with reduced subfoveal choroidal and RNFL thicknesses in the temporal and inferior quadrants of people with obesity.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"49-55"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139520305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burning eyes - a medical explanation for Elvis's iconic sunglasses.","authors":"Richard Hc Zegers, Katy C Liu, Joost Heutink, Forest Tennant, Robert N Weinreb","doi":"10.1080/08164622.2024.2385134","DOIUrl":"10.1080/08164622.2024.2385134","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"92-93"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large choroidal tuberculoma simulating a choroidal melanoma as the first manifestation of disseminated tuberculosis.","authors":"Miguel Ángel Montenegro-Quintana, Carla Rodríguez Fernández, José Luis Sánchez-Vicente, González-Jáuregui-López Bosco, Magdalena Sotomayor-Toribio, López-Herrero Fernando","doi":"10.1080/08164622.2023.2268057","DOIUrl":"10.1080/08164622.2023.2268057","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"100-102"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriate addition power for aphakic infants determined by a smart wearable device Clouclip.","authors":"Xinting Liu, Shuyun Wen, Muhan Sun, Yu Rong, Sijun Zhao, Tianhao Huang, Weizhong Lan, Chong Chen, Fan Lu, Xinjie Mao","doi":"10.1080/08164622.2024.2316811","DOIUrl":"10.1080/08164622.2024.2316811","url":null,"abstract":"<p><strong>Clinical relevance: </strong>It is particularly important to perform reasonable and effective optical correction to enable visual development after primary lens removal surgery for congenital cataracts. Aphakic infants need a suitable addition power of prescription (ADD) to help them focus on close visual objects.</p><p><strong>Background: </strong>It is challenging to obtain appropriate ADD power for infants due to poor cooperation and lack of subjective feedback. We aimed to determine the appropriate ADD for aphakic infants using a recently developed smart wearable device called Clouclip.</p><p><strong>Methods: </strong>The study was a cross-sectional, observational pilot study. Twenty-three aphakic infants (aged from 6 months to 3.5 years) were invited to wear a smart wearable device for 7 days consecutively to monitor the near viewing distance in real life. Viewing habits and its associations with the possible influencing factors were investigated based on the data obtained from the device.</p><p><strong>Results: </strong>The average proportion of near viewing time was 77.9% (95% confidence interval (CI) 72.1-83.7%). The average of the median near viewing distance was 23.8 cm (95% CI 20.6 cm-27.0 cm), which corresponded to an ADD of +4.25 D (95% CI + 3.75 D - +4.75 D) spectacle prescription. The height of the child was found to be positively correlated with the median of near viewing distance (<i>r</i> = 0.646, <i>p</i> = 0.001). Age, current ADD, age of cataract extraction surgery and bilaterality or monocularity of the aphakic eyes showed no significant correlation with the aforementioned viewing habits (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>By using the novel wearable device, we found the suitable ADD of spectacle prescription for aphakic infants is about +4.25 D. The height of the child was an influencing factor for ADD.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"65-71"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare presentation of peripapillary staphyloma with normal visual acuity.","authors":"Anthony Chapman-Davies, Regine Chapman-Davies","doi":"10.1080/08164622.2024.2341834","DOIUrl":"10.1080/08164622.2024.2341834","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"103-105"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}