Clinical and Experimental Optometry最新文献

{"title":"Unusual anterior segment phenotype in juvenile-onset open-angle glaucoma.","authors":"Anand Kumar Pathak, Suresh Kumar Yadav","doi":"10.1080/08164622.2026.2664891","DOIUrl":"https://doi.org/10.1080/08164622.2026.2664891","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"1-3"},"PeriodicalIF":1.5,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of iris pigmented naevus on pupil tracking during femtosecond LASIK surgery.","authors":"Cheng-Hua Wei, Wei-Yi Fu, Juan Cao, Linlin Wang, Peng-Fei Zhang, Yanfeng Gao","doi":"10.1080/08164622.2025.2544855","DOIUrl":"10.1080/08164622.2025.2544855","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"786-789"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rigid gas permeable contact lens correction for young children with special refractive errors.","authors":"Mingrui Jin, Lizhou Liu, Xuejing Mi, Ying Cui, Jing Ma, Hai Lu, Yonghong Jiao","doi":"10.1080/08164622.2025.2579165","DOIUrl":"10.1080/08164622.2025.2579165","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Rigid gas permeable (RGP) contact lenses effectively correct special refractive errors in young children when spectacles fail, supporting visual development.</p><p><strong>Background: </strong>To analyse the visual outcomes of young children (under 6 years) with special refractive errors corrected using RGP contact lenses during the visual development.</p><p><strong>Methods: </strong>This retrospective study included 50 young children fitted with RGP lenses at Beijing Tongren Eye Centre (2019-2024). Special refractive errors included ultra-high hyperopia due to aphakia, ultra-high myopia (spherical equivalent≤-9.00D), high astigmatism (astigmatism ≥2.00D), and high anisometropia (interocular difference ≥3.00D). Some anisometropia cases had coexisting ocular lesions (myelinated retinal nerve fibres, familial exudative vitreoretinopathy, persistent pupillary membrane). All children were > 4.5 years at final visit with ≥6 months RGP wear. We compared the changes in best-corrected visual acuity (BCVA) before and after RGP contact lens wear in these children and analysed their final visual outcomes. Binocular function was considered 'good' if the Worth 4-dot test showed fusion at near and far distances, with stereoacuity ≤100 seconds of arc.</p><p><strong>Results: </strong>Median age at RGP initiation was 3.16 years (interquartile range (IQR) 2,4), with a median wear duration of 2 years (IQR 1,3.17). BCVA improved significantly from 1.10 logMAR (IQR 1.23,1.01) to 0.30 logMAR (IQR 0.50,0.10) (<i>p</i> < 0.001). A total of 28 patients (56%) achieved a BCVA of 6/12 or better, with 17 showing good binocular function. The highest binocular function rates were in groups with ultra-high myopia (50%), high astigmatism (67%), and pure high anisometropia (50%). None of the nine patients with coexisting ocular lesions achieved good binocular function.</p><p><strong>Conclusions: </strong>RGP lenses significantly improve BCVA in young children with special refractive errors. The best results were observed in cases of refractive errors alone, while those with other ocular lesions showed limited but notable improvements from baseline.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"698-707"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of mire spacing on the subjective non-invasive break-up time measurement: a comparison of instruments.","authors":"Eric Lortie-Milner, Etty Bitton","doi":"10.1080/08164622.2025.2593889","DOIUrl":"10.1080/08164622.2025.2593889","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Non-invasive break-up time (NIBUT) has become the measurement of choice to evaluate stability of the tear film. Tear film stability is essential in the diagnosis and follow-up of dry eye disease.</p><p><strong>Background: </strong>Instruments used to measure NIBUT have different spacing of luminous mires, but the influence of this characteristic on the measurement of NIBUT is poorly understood. This study aimed at comparing the characteristics of five different instruments used to measure NIBUT and to determine if the mire spacing had an impact on the measured NIBUT.</p><p><strong>Methods: </strong>Mire spacing of the instruments was assessed using a calibration sphere. Two raters then measured the NIBUT of 20 participants (20 eyes) with normal ocular surfaces three consecutive times with five different instruments (Oculus Placido Disk, Keeler Tearscope Plus with the Coarse and the Fine Grid, Medmont E300 Topographer and Oculus Keratograph 5M). A two-way repeated measure analysis of variance was performed to compare the NIBUT data and correlation values (intra-class and Spearman) were computed for intra-rater agreement and test-retest reliability.</p><p><strong>Results: </strong>The Tearscope Plus with the Fine Grid was the instrument that presented the finest mire spacing. Two instruments, the Medmont E300 and the Keratograph gave shorter NIBUTs compared to the Tearscope Plus with the Fine Grid. All instruments had good inter-rater agreement. The Medmont E300 had a less good test-retest reliability for one of the raters. Bland-Altman plots were used to compare all the instruments with the one having the finest mire spacing. A positive proportional bias between the Tearscope Plus using the Fine Grid and the Coarse Grid was found.</p><p><strong>Conclusion: </strong>The topography-based instruments had shorter subjective NIBUT values in non-dry eye participants compared to the other instruments. Mire spacing is not the most definitive factor that impacts the NIBUT value.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"732-742"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145676554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical androgen therapy: a potential advancement in treating post-menopausal dry eye.","authors":"Harshita Pandey, Raj Kumar, Naga Rani Kagithala","doi":"10.1080/08164622.2025.2509586","DOIUrl":"10.1080/08164622.2025.2509586","url":null,"abstract":"<p><p>Post-menopausal dry eye disease is one of the frequently encountered conditions in ophthalmic and optometric practice. Despite the conventional treatment, it is often observed that these patients repeatedly show up to seek for help since their symptoms did not improve. In addition to pointing to the hormonal imbalance linked to post-menopause as a potential cause of dry eye, this also highlights the urgent need to review the necessary therapeutic approach. Evidence suggests that ocular testosterone therapy, particularly 0.03% testosterone eye drops, can significantly improve tear film stability and relieve dry eye symptoms. Furthermore, it has an added benefit of bypassing the systemic circulation, providing a targeted ocular effect with minimal side effects. However, challenges such as ocular barrier penetration, formulation stability, and regulatory issues in India hinder its widespread adoption. This review critically evaluates the efficacy and challenges of topical androgen treatment in this context. The necessity for more studies to confirm the safety and effectiveness of ocular testosterone therapy in improving the quality of life for postmenopausal women with dry eyes is also emphasised.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"564-571"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keratopathy associated with type 1 autoimmune polyglandular syndrome.","authors":"Bedia Kesimal, Sücattin İlker Kocamış","doi":"10.1080/08164622.2025.2550732","DOIUrl":"10.1080/08164622.2025.2550732","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"778-782"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of the Persian translation of the McMonnies dry eye questionnaire.","authors":"Samira Hassanzadeh, Mohammad Mahdi Ghorbani, Masoud Rostami, Maliheh Karimpour, Mahdi Sharifi, Parviz Marouzi","doi":"10.1080/08164622.2025.2565459","DOIUrl":"10.1080/08164622.2025.2565459","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Forty-nine dry eye questionnaires are available which are different in terms of purpose, length, target population, mode of administration, and content. Psychometric characteristics of a questionnaire in a specific population can determine how effective it will work. and reveal the importance of the studies in this regard.</p><p><strong>Background: </strong>The McMonnies questionnaire (MQ) is one of the effective tools widely used for dry eye screening. The purpose of this study was to translate the McMonnies dry eye questionnaire into Persian language and assess its validity and reliability.</p><p><strong>Methods: </strong>Translation and cultural adjustment of the English language McMonnies dry eye questionnaire into Persian was performed. Forty-two patients with dry eye and 42 healthy subjects were involved and validity and reliability aspects of the questionnaire were evaluated. All the participants were asked to complete the Persian translation of the McMonnies dry eye questionnaire, at baseline and 2 weeks later. Statistical analyses of the survey items were conducted using SPSS version 23.</p><p><strong>Results: </strong>Based on standardised items, the Cronbach ⍺ was acceptable (0.714). The items correlated well with an average inter-item correlation of 0.173 (range, 0.118 to 0.246). The test-retest reliability was high and significant (<i>r</i> = 0.988, <i>p</i> < 0.001). All the items showed factor loadings greater than 0.50. For the recommended cut-off point of 14.5, the sensitivity and specificity were 42.5% and 100% respectively. These values changed to 85.7% and 81% with a new cut-off point of 9.5.</p><p><strong>Conclusion: </strong>The Persian McMonnies questionnaire demonstrated acceptable internal consistency, good validity, and acceptable accuracy as a screening tool for dry eye in the Persian population. To increase the sensitivity of the instrument, a new cut-off point should be considered.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"595-602"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ocular surface and meibography in unilateral facial paralysis.","authors":"Semra Koca, Özgür Eroğul","doi":"10.1080/08164622.2025.2579168","DOIUrl":"10.1080/08164622.2025.2579168","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Facial paralysis (FP) often leads to ocular surfacedisorders due to delayed or incomplete blinking.</p><p><strong>Background: </strong>This study aimed to evaluate the ocular surface andmeibomian glands (MG) in patients with unilateral FP.</p><p><strong>Methods: </strong>A total of 26 patients with unilateral FP were included.Invasive tear film break-up time (TF-BUT), ocular surface staining score,Schirmer II test, total eyelid score, and MG secretion score were assessed.Non-contact meibography was used to evaluate the percentage of MG loss area,meiboscore, and morphological features (thickening, thinning, tortuosity,fluffy areas, shortening, ghost areas) of the MGs.</p><p><strong>Results: </strong>TF-BUT and Schirmer II test values were significantlylower in the FP group (<i>p</i> < 0.001 and <i>p</i> = 0.001, respectively). The Oxfordstaining score, MG expressibility score, and total eyelid score weresignificantly higher in the FP group (<i>p</i> < 0.001, <i>p</i> = 0.003, and <i>p</i> = 0.005,respectively). Meiboscore values were higher in both the upper and lowereyelids in the FP group compared to the control group, with a statisticallysignificant difference only in the lower eyelid (<i>p</i> = 0.270 for upper and <i>p</i> = 0.039 for lower). The presence of MG thickening wasremarkable in the FP group. The House-Brackmann grade was identified as theonly independent factor affecting both upper and lower eyelid meiboscores.</p><p><strong>Conclusion: </strong>Facial paralysis impairs ocular surface parameters andincreases lid margin abnormalities. It is associated with higher meiboscoresand deterioration in meibomian gland morphology.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"623-629"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten tips for writing an instructive abstract.","authors":"Nathan Efron","doi":"10.1080/08164622.2025.2579176","DOIUrl":"10.1080/08164622.2025.2579176","url":null,"abstract":"","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"561-563"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145372306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vitamin B12 deficiency on macular and choroidal vascular structures.","authors":"Eyupcan Sensoy, Mehmet Çitirik, Melike Sensoy, Emin Gemcioglu","doi":"10.1080/08164622.2025.2583179","DOIUrl":"10.1080/08164622.2025.2583179","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Vitamin B12 deficiency can affect macular and choroidal vasculature. Optical coherence tomography angiography (OCTA) and enhanced depth imaging OCT (EDI-OCT) are essential for early detection and monitoring of these microvascular changes, helping to prevent potential visual impairment.</p><p><strong>Background: </strong>This study aimed to assess the impact of vitamin B12 deficiency on the vascular structures of the macula and choroid by using OCTA and EDI-OCT.</p><p><strong>Methods: </strong>This prospective cross-sectional study included 34 individuals with vitamin B12 deficiency and 36 healthy participants as the control group. Macular vascular parameters, including superficial capillary plexus (SCP) and deep capillary plexus (DCP) vascular densities, and foveal avascular zone (FAZ) metrics, were measured using OCTA. The choroidal structure was assessed using EDI-OCT to calculate the total choroidal area (TCA), luminal area (LA), stromal area (SA), and choroidal vascularity index (CVI).</p><p><strong>Results: </strong>Compared with the control group, patients with vitamin B12 deficiency showed significantly higher vascular densities in the SCP of the parafoveal superior quadrant, as well as in the DCP of the parafoveal superior hemi and superior quadrants (<i>p</i> = 0.03, <i>p</i> = 0.04, and <i>p</i> = 0.01, respectively). The remaining OCTA parameters did not exhibit any statistically significant variation between the groups. Choroidal assessment showed notable decreases in TCA, LA, SA, and central subfoveal choroidal thickness. Moreover, patients with vitamin B12 deficiency showed a significant increase in the CVI (all <i>p</i> ≤ 0.01).</p><p><strong>Conclusion: </strong>Vitamin B12 deficiency is associated with complex alterations in macular and choroidal vascularity, including localised increased macular capillary densities and a paradoxical increase in the CVI despite decreased choroidal thickness.</p>","PeriodicalId":10214,"journal":{"name":"Clinical and Experimental Optometry","volume":" ","pages":"689-697"},"PeriodicalIF":1.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145630602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}