{"title":"Perilaku Deteksi Dini Kanker Serviks Melalui Metode Pemeriksaan Inspeksi Visual Asam Asetat (IVA) pada Mahasiswa Magister FKM UI Menurut Teori Proceede – Preceede Tahun 2019","authors":"Gabe Gusmi Aprilla, Rachmadhi Purwanana","doi":"10.33476/jky.v27i3.1084","DOIUrl":"https://doi.org/10.33476/jky.v27i3.1084","url":null,"abstract":"","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122204656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Endrini, S. Suherman, A. Rahmat, P. Ismail, Y. Taufiq-Yap, F. Othman
{"title":"Effects of strobilanthes crispus extract on the apoptotic pathway of human liver carcinoma cell lines","authors":"S. Endrini, S. Suherman, A. Rahmat, P. Ismail, Y. Taufiq-Yap, F. Othman","doi":"10.33476/jky.v15i1.998","DOIUrl":"https://doi.org/10.33476/jky.v15i1.998","url":null,"abstract":"Previous study has been shown the potential anticarcinogenic effect of Strobilanthes crispus, a plant native to countries from Madagascar to Indonesia, on human liver cancer (HepG-2) cell lines. The objective of the present study was to investigate the mechanism of anticarcinogenic effectof S.crispus extract through apoptotic pathway. Exposure of HepG-2 cells to S.crispus extract resulted in induction of apoptosis in a dose-dependent manner as measured by Fluoresence Microscopy and Confocal Laser Scanning Microscopy analysis. These findings provide important new insight into the possible molecular mechanisms of the anticancer activity of S.crispus.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"86 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132440191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pengaruh kemampuan metakognitif terhadap kemampuan pemecahan masalah pada mahasiswa program akademik dan profesi Fakultas Kedokteran","authors":"E. P. Pamungkasari, B. Murti, Haris Mudjiman","doi":"10.33476/jky.v15i1.1006","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1006","url":null,"abstract":"Problem solving ability is one of several competences that should be mastered by medical graduates. Metacognitive skill, which refers to skills of thinking about thinking, is presumed in the literature to have some relation with problem solving ability. This study aims to investigate the effect ofmetacognitive skill on problem solving ability among medical students of academic and professional programmes at the Faculty of Medicine. This study is analytic and observational, conducted at the Faculty of Medicine, Sebelas Maret University. The study subjects are medical students currentlyundertaking academic or professional programme at the Faculty of Medicine, Sebelas Maret University. Subject were selected purposively by distinguishing sub populations undertaking academic and professional programmes. From each sub population, 20 subjects were selected atrandom to result in a total of 40 subjects for this study. The data were collected by use of a questionnaire that has been previously designed by researchers abroad. The questionnaire was translated from English to Indonesian, modified accordingly, and subsequently tested for its validityand reliability, before use. The data were analyzed employing multiple linear regression model. The results of the regression analysis show that one score in metacognitive skill increases 0.71 score in problem solving ability (?= 0.71; 95%CI 0.37 to 1.06). In addition, students at the professional programme on average have problem solving ability 11.36 scores higher than those at the academic programme (?= 11.36; 95%CI 2.00 to 20.71). This study concludes that there is a statisticallysignfificant effect of metacognitive skill on problem solving ability among medical students at the Faculty of Medicine. After controlling for confounding factors such as learning stages, age, and sex, an increase in metacognitive skill will signficantly increase problem solving ability.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116755161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perlukah menghitung ukuran sampel?","authors":"B. Murti","doi":"10.33476/jky.v15i1.1009","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1009","url":null,"abstract":"Sample size is an issue worth-considering but not the most essential thing to fulfil for a good research. A much more crucial cause of concern to any research is the validity of inference a research is drawing, i.e. the extent to which the research is able to control systematic error that stems from bias and confounding. Sample size refers to random error; it does not address nor correct systematic error. The larger sample size, the less random error, the more precise estimates a research can yield about difference/ association/ effect of a variable(s). Most of the assignment of values in any sample size formula is arbitrary. As such, the product of estimating sample size, regardless of the formula being used, cannot be viewed as an absolute end; the actual sample size can be larger or smaller than the estimated one. Beyond statistical aspect, several other important factors should be considered when estimating sample size, such as ethics, cost, and the amount oftime available for conducting the research.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131881365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metode mikrokoloni (slide culture) sebagai metode diagnostic alternative yang lebih cepat untuk diagnosis tuberculosis paru","authors":"Eko Budi Koendhori, Setio Harsono","doi":"10.33476/jky.v15i1.1001","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1001","url":null,"abstract":"Despite wide distribution of pulmonary tuberculosis in Indonesia, its diagnosis is still an important issue to be dealt with. Fourty seven sputums from pulmonary tuberculosis patients in Surabaya were examined to detect Mycobacterium tuberculosis using three methods, i.e. the acidfast stain Ziehl Neelsen, microcolony (slide culture) and Lowenstein Jensen. Sputums were collected spontaneously from the patients. All of them were decontaminated and centrifuged. After the supernatant fluids were carefully decanted, the sediments were resuspended in 1 ml of 10 mMphosphate buffer (pH 7.4) and the suspensions were then inoculated on to two 76 x 13 mm glass microscope slides. One of them was stained by Ziehl Neelsen method and the other was inoculated into microcolony media for seven days and the waste suspension was inoculated into LowensteinJensen media. The results of the microcolony method analysis were compared with the Ziehl Neelsen staining. Employing McNemar test, a significant difference was observed between the microcolony method and the Ziehl Neelsen staining (?² = 5,88). The sensitivity and spesificity ofmicrocolony were 100% and 89% while the Ziehl Neelsen were 60% and 84% respectively. In conclusions microcolony method was better compared with the Ziehl Neelsen staining in the detection of Mycobacterium tuberculosis. Microcolony method was able to reduce time required todetect Mycobacterium tuberculosis in patient suspected with pulmonary tuberculosis.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116506667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Murwani, Mulyohadi Ali, Ketut Muliartha, P. Purwanto, I. Susilawati, Dinda Nur Aini, Yuni Yuni
{"title":"Studi seroepidemiologis Chlamydia pneumoniae dan beberapa mikroorganisme yang diduga menyebabkan infark miokard akut","authors":"S. Murwani, Mulyohadi Ali, Ketut Muliartha, P. Purwanto, I. Susilawati, Dinda Nur Aini, Yuni Yuni","doi":"10.33476/jky.v15i1.1002","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1002","url":null,"abstract":"Acute myocardial infarction (AMI) is still a major health problem. Approximately 20% of death in the world was caused by atherosclerotic diseases like stroke, myocardial infarct. Recent studies explain the role of infection in the pathogenicity of AMI. The purpose of this study was to examine seroepidemiological study of Chlamydia pneumoniae infection related to AMI and its occurrence as pathogen burden-infection with other microorganisms. Subjects for this study were patients diagnosed clinically and laboratorically as AMI, from RSUD Saiful Anwar and RS. Lavalette,Malang. Blood samples were collected from each subject and serum was analyzed for IgG antibodies against C. pneumoniae, CMV, H. pylori and S. mutans. Clinical status was analyzed to find IMA conventional risk factors, such as smoking, hypertension, hypercholesterolemia, and diabetes mellitus. The result showed that the average age of these patients were 55 years and men were more common than women. All of these patients were infected by microorganism. Patients with infection and conventional risk factors were 51,9%, infection without conventional risk factors was 48,2%, and conventional risk factors for IMA without infection was 51, 85%. The most common conventional risk factor was smoking (37, 0%). Infection by S. mutans was detected in all patients (100%), C. pneumoniae 92,6%, CMV 92,6%, H. pylori 77,8%; however multiple infections were observed in most of the patients. It was concluded that microorganisms played rolesin the pathogenicity of IMA. It was suggested that the development of IMA might be contributed by single infection as well as multiple infections. However, multiple infections tend to be observed in most of the patients.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129256096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hadi Suwasono, Hasan Boesri, Heru Priyanto, Tri Suwaryono
{"title":"Uji efikasi insektisida berbahan aktif alphacypermethrin terhadap lalat rumah Musca domestica dengan pengasapan","authors":"Hadi Suwasono, Hasan Boesri, Heru Priyanto, Tri Suwaryono","doi":"10.33476/jky.v15i1.1007","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1007","url":null,"abstract":"Although being of less importance to the incidence of the vector-borne disease than mosquitoes, houseflies (Musca domestica) are mechanical transmitters of the disease. The chemical control carried out until now has brought about the emergence of resistance of houseflies against DDT and many other insecticides including organophosphates and carbamates. In order to look for an alternative insecticide which can control houseflies, a study was performed on the efficacy of insecticide belonging to the synthetic pyrethroid group containing 30 g/l of the active substance such as alphacypermethrin. Four dosages of insecticide with active ingredient of 30 g/l alphacypermethrin at dosages of 17.5 ml/ha, 35 ml/ha, 50 ml/ha and 70 ml/ha respectively wereused by fogging against houseflies kept in cages. The result showed that dosages of 35 ml/ha, 50 ml/ha and 70 ml/ha were all effective to kill M. domestica.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117052695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antioksidatif estrogen dalam menghambat advanced oxidation protein product akibat reaksi glikosilasi","authors":"Adenan Adenan, Eko Suhartono, Bambang Setiawan","doi":"10.33476/jky.v15i1.1004","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1004","url":null,"abstract":"Ethinyl estradiol is an estrogen derivative used as contraceptive or hormone replacement therapy to maintain woman’s sexual function. The aim of this study was to examine ethinyl estradiol antioxidative activity and its potency to inhibit protein oxidation by glycocylation reaction. This study was an in vitro assay and its antioxidative activity by H2O2 scavenging, •OH scavenging, metal chelating were measured. Activity as inhibitor of Advanced Oxidation Protein Products (AOPP) was carried out by using glycocylation reaction. Three groups (n=6), i.e P0 control (3 ml of serum), P1 (3 ml of serum + glucose 500 mM), and P2 (3 ml of serum + glucose 500 mM + ethinyl estradiol 0,15gr/100mL) were used in this study. The result of this study showed that H2O2 scavenging, •OH scavenging, metal chelating were 48,889%, 15,139%, 11,538% respectively. For AOPP inhibition, P0 and P1 was different significantly (p0,05), P0 and P2 was not different significantly (p0,05), and P1 and P2 was different significantly (p0,05). It was suggested that antioxidative mechanism from ethinyl estradiol could inhibit AOPP formation generated by glycocylation reaction.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"211 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116398131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pengaruh pemberian minyak ikan terhadap konsentrasi asam lemak dan gejala klinis malaria","authors":"H. Rasyid, dan Suwandi","doi":"10.33476/jky.v15i1.1003","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1003","url":null,"abstract":"The aim of the study is to find out the effects of fish oil supplementation on fatty acids concentration (Eicosapentanoat Acid and Docosahexaenoat Acid), fever attacks and Dikke Drupple (DDR) interpretation of samples. This study was designed as “A Randomized Double Blind Pretest and Post-test Controled Group“. Samples were divided into two groups, experiment group with fish oil suplementation (8% EPA, 35 DHA) and control group (placebo) for 8 weeks. This study was conducted in a malaria endemic, Kadaila village, subdistrict of Karossa, District of Mamuju in 2003. The result of the study showed significant increased concentration of EPA and DHA of the experiment group than the control group (p 0,05). The fever attack was significantly decreased (p 0,05) in experiment group than the control group, while DDR was not significantly different (p 0,05) between two groups.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"785 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133283452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidence and clinical picture of upper respiratory infection in children receiving zinc supplement","authors":"W. Widagdo","doi":"10.33476/jky.v15i1.1000","DOIUrl":"https://doi.org/10.33476/jky.v15i1.1000","url":null,"abstract":"The National Household Health Survey (1995) reported that the prevalence of upper respiratory infection (URI) in Indonesia was found 25.3% for all ages and 47.1% for the under five children. Reports of studies on the effect of zinc in the reduction of respiratory infection stated inconsistentresults. The objective of this community base study is to evaluate the effect of zinc as the attempt to reduce the incidence of URI. We have studied the effect of daily supplementation of 10 mg elemental zinc in a double blind, randomized, controlled trial consisting of 37 children (zinc group) and 36 children (control group) of 6 months - 5 years old. The distribution of preparation and monitoring of morbidity were performed regularly once a week along 2-month study period. During the 2-month study (February-April 2001) we found 24 URI cases in the zinc group and 24 cases in the control group. Time series analysis concerning the incidence and severity of the zinc group showed a negative slope (Yt: a – bx), while the placebo group showed a positive slope (Yt: a + bx). The evidence and severity of URI in zinc groups within the 1st and 2nd months showedsignificant different, while it was not in the control group. The study obviously showed the benefit of zinc supplementation in the reduction of URI as showed by negative slope in the time series analysis, and significant decreased of the incidence and the severity of URI in zinc group. There was no side effect of zinc supplemented noted. We suggest, therefore regular zinc supplementation to the diet of the children in the low economic level community are needed.","PeriodicalId":101844,"journal":{"name":"YARSI medical Journal","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131300010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}