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YARSI medical Journal Pub Date : 2019-10-18 DOI:10.33476/jky.v15i1.1004

Adenan Adenan, Eko Suhartono, Bambang Setiawan

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引用次数: 0

摘要

炔雌醇是一种雌激素衍生物，用于避孕或激素替代疗法，以维持女性性功能。本研究旨在探讨乙炔雌二醇的抗氧化活性及其抑制糖基化反应中蛋白质氧化的作用。对其进行了体外抗氧化实验，测定了其清除H2O2、清除•OH、金属螯合的抗氧化活性。采用糖基化反应研究了其作为高级氧化蛋白产物(AOPP)抑制剂的活性。本研究采用3组(n=6)，即P0对照组(血清3ml)、P1组(血清3ml +葡萄糖500 mM)和P2组(血清3ml +葡萄糖500 mM +乙炔雌二醇0,15gr/100mL)。研究结果表明，H2O2清除率为48,889%，•OH清除率为15,139%，金属螯合性为11,538%。对于AOPP抑制，P0与P1差异有统计学意义(P0,05)， P0与P2差异无统计学意义(P0,05)， P1与P2差异有统计学意义(P0,05)。提示乙炔雌二醇的抗氧化机制可抑制糖基化反应生成AOPP。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Antioksidatif estrogen dalam menghambat advanced oxidation protein product akibat reaksi glikosilasi

Ethinyl estradiol is an estrogen derivative used as contraceptive or hormone replacement therapy to maintain woman’s sexual function. The aim of this study was to examine ethinyl estradiol antioxidative activity and its potency to inhibit protein oxidation by glycocylation reaction. This study was an in vitro assay and its antioxidative activity by H2O2 scavenging, •OH scavenging, metal chelating were measured. Activity as inhibitor of Advanced Oxidation Protein Products (AOPP) was carried out by using glycocylation reaction. Three groups (n=6), i.e P0 control (3 ml of serum), P1 (3 ml of serum + glucose 500 mM), and P2 (3 ml of serum + glucose 500 mM + ethinyl estradiol 0,15gr/100mL) were used in this study. The result of this study showed that H2O2 scavenging, •OH scavenging, metal chelating were 48,889%, 15,139%, 11,538% respectively. For AOPP inhibition, P0 and P1 was different significantly (p0,05), P0 and P2 was not different significantly (p0,05), and P1 and P2 was different significantly (p0,05). It was suggested that antioxidative mechanism from ethinyl estradiol could inhibit AOPP formation generated by glycocylation reaction.

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YARSI medical Journal

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