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Artificial intelligence in endoscopic diagnosis of esophageal squamous cell carcinoma and precancerous lesions.
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-26 DOI: 10.1097/CM9.0000000000003490
Nuoya Zhou, Xianglei Yuan, Wei Liu, Qi Luo, Ruide Liu, Bing Hu
{"title":"Artificial intelligence in endoscopic diagnosis of esophageal squamous cell carcinoma and precancerous lesions.","authors":"Nuoya Zhou, Xianglei Yuan, Wei Liu, Qi Luo, Ruide Liu, Bing Hu","doi":"10.1097/CM9.0000000000003490","DOIUrl":"10.1097/CM9.0000000000003490","url":null,"abstract":"<p><strong>Abstract: </strong>Esophageal squamous cell carcinoma (ESCC) poses a significant global health challenge, necessitating early detection, timely diagnosis, and prompt treatment to improve patient outcomes. Endoscopic examination plays a pivotal role in this regard. However, despite the availability of various endoscopic techniques, certain limitations can result in missed or misdiagnosed ESCCs. Currently, artificial intelligence (AI)-assisted endoscopic diagnosis has made significant strides in addressing these limitations and improving the diagnosis of ESCC and precancerous lesions. In this review, we provide an overview of the current state of AI applications for endoscopic diagnosis of ESCC and precancerous lesions in aspects including lesion characterization, margin delineation, invasion depth estimation, and microvascular subtype classification. Furthermore, we offer insights into the future direction of this field, highlighting potential advancements that can lead to more accurate diagnoses and ultimately better prognoses for patients.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial RNA metabolism, a potential therapeutic target for mitochondria-related diseases.
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-26 DOI: 10.1097/CM9.0000000000003516
Tongyue Duan, Liya Sun, Kaiyue Ding, Qing Zhao, Lujun Xu, Chongbin Liu, Lin Sun
{"title":"Mitochondrial RNA metabolism, a potential therapeutic target for mitochondria-related diseases.","authors":"Tongyue Duan, Liya Sun, Kaiyue Ding, Qing Zhao, Lujun Xu, Chongbin Liu, Lin Sun","doi":"10.1097/CM9.0000000000003516","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003516","url":null,"abstract":"<p><strong>Abstract: </strong>In recent years, the roles of mitochondrial RNA and its associated human diseases have been reported to increase significantly. Treatments based on mtRNA metabolic processes and nuclear gene mutations are thus discussed. The mitochondrial oxidative phosphorylation process is affected by mtRNA metabolism, including mtRNA production, maturation, stabilization, and degradation, which leads to a variety of inherited human mitochondrial diseases. Moreover, mitochondrial diseases are caused by mitochondrial messenger RNA, mitochondrial transfer RNA, and mitochondrial ribosomal RNA gene mutations. This review presents the molecular mechanisms of human mtRNA metabolism and pathological mutations in mtRNA metabolism-related nuclear-encoded/nonencoded genes and mitochondrial DNA mutations to highlight the importance of mitochondrial RNA-related diseases and treatments.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroblastoma risk decreased by NSUN3 rs7653521 C>T polymorphism in Chinese children.
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-26 DOI: 10.1097/CM9.0000000000003512
Meng Li, Xinxin Zhang, Chunlei Zhou, Lei Lin, Lei Miao, Haiyan Wu, Jing He
{"title":"Neuroblastoma risk decreased by NSUN3 rs7653521 C>T polymorphism in Chinese children.","authors":"Meng Li, Xinxin Zhang, Chunlei Zhou, Lei Lin, Lei Miao, Haiyan Wu, Jing He","doi":"10.1097/CM9.0000000000003512","DOIUrl":"10.1097/CM9.0000000000003512","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: Insights from the past two years.
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-25 DOI: 10.1097/CM9.0000000000003542
Jian Wan, Jiaming Zhou, Zhuo Wang, Dan Liu, Hao Zhang, Shengmao Xie, Kaichun Wu
{"title":"Recent advances in epidemiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease: Insights from the past two years.","authors":"Jian Wan, Jiaming Zhou, Zhuo Wang, Dan Liu, Hao Zhang, Shengmao Xie, Kaichun Wu","doi":"10.1097/CM9.0000000000003542","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003542","url":null,"abstract":"<p><strong>Abstract: </strong>Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a chronic inflammation of the gastrointestinal tract with unknown etiology. The cause of IBD is widely considered multifactorial, with prevailing hypotheses suggesting that the microbiome and various environmental factors contribute to inappropriate activation of the mucosal immune system in genetically susceptible individuals. Although the incidence of IBD has stabilized in Western countries, it is rapidly increasing in newly industrialized countries, particularly China, making IBD a global disease. Significant changes in multiple biomarkers before IBD diagnosis during the preclinical phase provide opportunities for earlier diagnosis and intervention. Advances in technology have driven the development of telemonitoring tools, such as home-testing kits for fecal calprotectin, serum cytokines, and therapeutic drug concentrations, as well as wearable devices for testing sweat cytokines and heart rate variability. These tools enable real-time disease activity assessment and timely treatment strategy adjustments. A wide range of novel drugs for IBD, including interleukin-23 inhibitors (mirikizumab, risankizumab, and guselkumab) and small-molecule drugs (etrasimod and upadacitinib), have been introduced in the past few years. Despite these advancements, approximately one-third of patients remain primary non-responders to the initial treatment, and half eventually lose response over time. Precision medicine integrating multi-omics data, advanced combination therapy, and complementary approaches, including stem cell transplantation, psychological therapies, neuromodulation, and gut microbiome modulation therapy, may offer solutions to break through the therapeutic ceiling.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research.
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-25 DOI: 10.1097/CM9.0000000000003535
Kailun Liu, Xiaowei Chen, Zhen Fan, Fei Ren, Jing Liu, Baoyang Hu
{"title":"From organoids to organoids-on-a-chip: Current applications and challenges in biomedical research.","authors":"Kailun Liu, Xiaowei Chen, Zhen Fan, Fei Ren, Jing Liu, Baoyang Hu","doi":"10.1097/CM9.0000000000003535","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003535","url":null,"abstract":"<p><strong>Abstract: </strong>The high failure rates in clinical drug development based on animal models highlight the urgent need for more representative human models in biomedical research. In response to this demand, organoids and organ chips were integrated for greater physiological relevance and dynamic, controlled experimental conditions. This innovative platform-the organoids-on-a-chip technology-shows great promise in disease modeling, drug discovery, and personalized medicine, attracting interest from researchers, clinicians, regulatory authorities, and industry stakeholders. This review traces the evolution from organoids to organoids-on-a-chip, driven by the necessity for advanced biological models. We summarize the applications of organoids-on-a-chip in simulating physiological and pathological phenotypes and therapeutic evaluation of this technology. This section highlights how integrating technologies from organ chips, such as microfluidic systems, mechanical stimulation, and sensor integration, optimizes organoid cell types, spatial structure, and physiological functions, thereby expanding their biomedical applications. We conclude by addressing the current challenges in the development of organoids-on-a-chip and offering insights into the prospects. The advancement of organoids-on-a-chip is poised to enhance fidelity, standardization, and scalability. Furthermore, the integration of cutting-edge technologies and interdisciplinary collaborations will be crucial for the progression of organoids-on-a-chip technology.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organ medicine: New concept of life sciences.
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-21 DOI: 10.1097/CM9.0000000000003524
Zhitao Chen, Shuangjin Yu, Zhiying Liu, Yefu Li, Haidong Tan, Yifang Gao, Qiang Zhao, Xiaoshun He
{"title":"Organ medicine: New concept of life sciences.","authors":"Zhitao Chen, Shuangjin Yu, Zhiying Liu, Yefu Li, Haidong Tan, Yifang Gao, Qiang Zhao, Xiaoshun He","doi":"10.1097/CM9.0000000000003524","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003524","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
STAR Recommendations: A novel framework for generating recommendations.
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-21 DOI: 10.1097/CM9.0000000000003475
Xu Wang, Janne Estill, Hui Liu, Qianling Shi, Jie Zhang, Shilin Tang, Huayu Zhang, Xueping Li, Zhewei Li, Yaxuan Ren, Bingyi Wang, Fan Wang, Juan Juan, Huixia Yang, Xiuyuan Hao, Junmin Wei, Yaolong Chen
{"title":"STAR Recommendations: A novel framework for generating recommendations.","authors":"Xu Wang, Janne Estill, Hui Liu, Qianling Shi, Jie Zhang, Shilin Tang, Huayu Zhang, Xueping Li, Zhewei Li, Yaxuan Ren, Bingyi Wang, Fan Wang, Juan Juan, Huixia Yang, Xiuyuan Hao, Junmin Wei, Yaolong Chen","doi":"10.1097/CM9.0000000000003475","DOIUrl":"https://doi.org/10.1097/CM9.0000000000003475","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Allogeneic hematopoietic stem cell transplantation for thalassemia major using matched unrelated donors and haploidentical related donors. 异基因造血干细胞移植治疗地中海贫血，使用匹配的非亲属供体和单倍体相同的亲属供体。
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-20 Epub Date: 2025-01-17 DOI: 10.1097/CM9.0000000000003465
Feiyan Wang, Yuhua Qu, Hua Jiang
{"title":"Allogeneic hematopoietic stem cell transplantation for thalassemia major using matched unrelated donors and haploidentical related donors.","authors":"Feiyan Wang, Yuhua Qu, Hua Jiang","doi":"10.1097/CM9.0000000000003465","DOIUrl":"10.1097/CM9.0000000000003465","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"490-492"},"PeriodicalIF":7.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of mitochondrial oxidative phosphorylation disorder in male infertility. 男性不育症中线粒体氧化磷酸化紊乱的机理。
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-20 Epub Date: 2024-06-07 DOI: 10.1097/CM9.0000000000003126
Kai Meng, Qian Liu, Yiding Qin, Wenjie Qin, Ziming Zhu, Longlong Sun, Mingchao Jiang, Joseph Adu-Amankwaah, Fei Gao, Rubin Tan, Jinxiang Yuan
{"title":"Mechanism of mitochondrial oxidative phosphorylation disorder in male infertility.","authors":"Kai Meng, Qian Liu, Yiding Qin, Wenjie Qin, Ziming Zhu, Longlong Sun, Mingchao Jiang, Joseph Adu-Amankwaah, Fei Gao, Rubin Tan, Jinxiang Yuan","doi":"10.1097/CM9.0000000000003126","DOIUrl":"10.1097/CM9.0000000000003126","url":null,"abstract":"<p><strong>Abstract: </strong>Male infertility has become a global concern, accounting for 20-70% of infertility. Dysfunctional spermatogenesis is the most common cause of male infertility; thus, treating abnormal spermatogenesis may improve male infertility and has attracted the attention of the medical community. Mitochondria are essential organelles that maintain cell homeostasis and normal physiological functions in various ways, such as mitochondrial oxidative phosphorylation (OXPHOS). Mitochondrial OXPHOS transmits electrons through the respiratory chain, synthesizes adenosine triphosphate (ATP), and produces reactive oxygen species (ROS). These mechanisms are vital for spermatogenesis, especially to maintain the normal function of testicular Sertoli cells and germ cells. The disruption of mitochondrial OXPHOS caused by external factors can result in inadequate cellular energy supply, oxidative stress, apoptosis, or ferroptosis, all inhibiting spermatogenesis and damaging the male reproductive system, leading to male infertility. This article summarizes the latest pathological mechanism of mitochondrial OXPHOS disorder in testicular Sertoli cells and germ cells, which disrupts spermatogenesis and results in male infertility. In addition, we also briefly outline the current treatment of spermatogenic malfunction caused by mitochondrial OXPHOS disorders. However, relevant treatments have not been fully elucidated. Therefore, targeting mitochondrial OXPHOS disorders in Sertoli cells and germ cells is a research direction worthy of attention. We believe this review will provide new and more accurate ideas for treating male infertility.</p>","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"379-388"},"PeriodicalIF":7.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141295688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Telpegfilgrastim for chemotherapy-induced neutropenia in breast cancer: A multicenter, randomized, phase 3 study. Telpegfilgrastim治疗化疗引起的乳腺癌中性粒细胞减少症：一项多中心、随机、3期研究
IF 7.5 3区 医学
Chinese Medical Journal Pub Date : 2025-02-20 Epub Date: 2025-01-17 DOI: 10.1097/CM9.0000000000003445
Yuankai Shi, Qingyuan Zhang, Junsheng Wang, Zhong Ouyang, Tienan Yi, Jiazhuan Mei, Xinshuai Wang, Zhidong Pei, Tao Sun, Junheng Bai, Shundong Cang, Yarong Li, Guohong Fu, Tianjiang Ma, Huaqiu Shi, Jinping Liu, Xiaojia Wang, Hongrui Niu, Yanzhen Guo, Shengyu Zhou, Li Sun
{"title":"Telpegfilgrastim for chemotherapy-induced neutropenia in breast cancer: A multicenter, randomized, phase 3 study.","authors":"Yuankai Shi, Qingyuan Zhang, Junsheng Wang, Zhong Ouyang, Tienan Yi, Jiazhuan Mei, Xinshuai Wang, Zhidong Pei, Tao Sun, Junheng Bai, Shundong Cang, Yarong Li, Guohong Fu, Tianjiang Ma, Huaqiu Shi, Jinping Liu, Xiaojia Wang, Hongrui Niu, Yanzhen Guo, Shengyu Zhou, Li Sun","doi":"10.1097/CM9.0000000000003445","DOIUrl":"10.1097/CM9.0000000000003445","url":null,"abstract":"","PeriodicalId":10183,"journal":{"name":"Chinese Medical Journal","volume":" ","pages":"496-498"},"PeriodicalIF":7.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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