Chirurgia最新文献

{"title":"Toward Personalized Surgery in Advanced Prostate Cancer: Stratification by PTEN, AR-V7, TP53, TMPRSS2-ERG, and ERBB2 Genetic Alterations.","authors":"Cristina Anita Ionescu, Georgeta Camelia Cozaru, Mariana Aşchie, Nicoleta Leopa, Bogdan Cîmpineanu, Felix Voinea, Elena Matei, Anca Mitroi, Mariana Deacu, Ionuţ Iorga, Mihaela Pundiche","doi":"10.21614/chirurgia.3151","DOIUrl":"https://doi.org/10.21614/chirurgia.3151","url":null,"abstract":"<p><p><b>Background:</b> Advanced prostate cancer is a biologically heterogeneous disease often marked by multiple genetic and epigenetic alterations that influence tumor progression, treatment resistance, and prognosis. Among the most frequently altered genes are PTEN, AR-V7, TP53, TMPRSS2-ERG, and ERBB2, each with potential relevance for stratifying risk and guiding targeted therapy. <b>Methods:</b> This retrospective study included 43 patients with advanced prostate cancer who underwent radical prostatectomy. Tumor specimens were analyzed using fluorescence in situ hybridization (FISH) to assess the mutational status of the five markers. Clinicopathological parameters, including PSA levels, Gleason score, tumor stage, and invasion status, were correlated with molecular alterations using multinomial logistic regression. <b>Results:</b> The most common isolated alteration was PTEN loss (20.9%), followed by TP53 amplification (16.3%), TMPRSS2-ERG fusion (13.9%), AR-V7 expression (11.6%), and ERBB2 amplification (7%). Combined alterations were also observed, with dual or triple marker expression in select aggressive cases. PTEN- and AR-V7+ were associated with low PSA values despite aggressive pathology, while ERBB2+ correlated with high PSA levels and high Gleason scores. TP53+ and ERBB2+ were also significantly associated with high-grade tumors (Gleason 7). AR-V7+ was the only marker significantly associated with seminal vesicle invasion. Younger age was weakly correlated with AR-V7+ and TP53+ status. <b>Conclusions:</b> The molecular profile defined by PTEN, AR-V7, TP53, and ERBB2 identifies distinct biological subtypes in advanced prostate cancer, each with specific prognostic and therapeutic implications. Integration of these biomarkers into routine clinical assessment may improve treatment personalization and risk stratification. Validation in larger, prospective cohorts is warranted.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 3","pages":"265-274"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Factors in Acute-on-Chronic Pancreatitis: Insights from a Romanian Tertiary Center Cohort.","authors":"Petruta Violeta Filip, Corina Silvia Pop, Laura Sorina Diaconu, Flori Elena Tapu, Nicoleta Tiuca, Dana Galieta Mincă","doi":"10.21614/chirurgia.3137","DOIUrl":"https://doi.org/10.21614/chirurgia.3137","url":null,"abstract":"<p><strong>Background/aims: </strong>This study aimed to assess and compare the severity of acute pancreatitis (AP) in patients with and without underlying chronic pancreatitis (CP). <b>Methods:</b> We included patients diagnosed with AP and categorized them into those with CP and those without CP. Disease severity was defined by the presence of organ failure, intensive care unit (ICU) admission, or mortality. <b>Results:</b> ACP accounted for 25.85% of all AP cases in the study. Patients with ACP were more commonly male smokers with low BMI, lower albumin levels, and higher Balthazar scores. In contrast, patients with AP (without CP) had significantly higher heart rates (HR), Balthazar, and CTSI scores. Length of hospitalization and mortality rate were higher in those patients with AP, who were associated with a high rate of organ dysfunction. Prognostic factors influencing survival at 72 hours were respiratory failure, creatinine/albumin ratio, BISAP, albumin levels, and AKI. Meanwhile, survival at 30 days was influenced by respiratory failure, the creatinine/albumin ratio, and blood urea nitrogen. <b>Conclusions:</b> Compared to AP without CP, ACP is associated with a less severe disease course, lower mortality, reduced organ failure, and shorter ICU stays. However, ACP is more frequently observed in male smokers with lower BMI and albumin and higher CTSI and Balthazar scores.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 3","pages":"285-293"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PADUA Score as a Predictor for Intraoperative Complications: A Study on Partial Nephrectomy in Open versus Laparoscopic Approach.","authors":"Alexandru Iordache, Claudiu-Octavian Ungureanu, Nicoleta-Alina Mareş, Octav Ginghină, Niculae Iordache","doi":"10.21614/chirurgia.3149","DOIUrl":"https://doi.org/10.21614/chirurgia.3149","url":null,"abstract":"<p><p><b>Introduction:</b> The Preoperative Aspects and Dimensions Used for Anatomical Classification (PADUA) score was developed based on an algorithm incorporating anatomical characteristics and renal tumor size to predict surgical risk and perioperative complications in patients undergoing open nephrectomy. For the current study, we extended the application of the PADUA score to laparoscopic partial nephrectomy and analyzed the outcomes. <b>Materials and Methods:</b> Our study was based on a retrospective analysis of 94 patients who underwent partial nephrectomy at the Urology Department of Prof. Th. Burghele Clinical Hospital between 2020 and 2024. Two groups were analyzed: the first included 44 cases (54.5% male) treated laparoscopically (38 via transperitoneal and 6 via retroperitoneal approach), and the second included 50 cases (54% male) treated with open surgery via a lumbar approach. <b>Results:</b> The mean age of patients in the open (OPN) and laparoscopic (LPN) groups was 64 and 61.2 years, respectively. We analyzed three variables in relation to the PADUA score: ischemia time, operative time, and body mass index (BMI). In the laparoscopic group, no correlation was found between ischemia time and operative time (p=0.655 and p=0.686, respectively). Similarly, no correlation was observed in the open group (p=0.882 and p=0.787, respectively). The PADUA score was significantly correlated with BMI in the laparoscopic group (p=0.023), but not in the open group (p=0.202). Regarding complications, the PADUA score was significantly associated with postoperative complications in the laparoscopic group (p=0.013), but not in the open group (p=0.287). Conclusion: The PADUA score was used to assess the complexity of renal tumor resection using both open and laparoscopic approaches. Our study demonstrated that a higher BMI is associated with a higher PADUA score, suggesting that obesity may increase the complexity of the laparoscopic approach in partial nephrectomy. Furthermore, in the laparoscopic group, a high PADUA score was significantly correlated with the occurrence of postoperative complications.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 3","pages":"255-264"},"PeriodicalIF":0.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First Robotic-assisted DIEP Flap Breast Reconstruction in Eastern Europe: A National Milestone in Reconstructive Surgery.","authors":"Vlad Pieptu, Dragoş Viorel Scripcariu, Dragoş Pieptu, Daniel Murariu","doi":"10.21614/chirurgia.3139","DOIUrl":"https://doi.org/10.21614/chirurgia.3139","url":null,"abstract":"<p><p>This article presents the first robotic-assisted DIEP flap breast reconstruction in Eastern Europe, performed at the Regional Institute of Oncology Iasi, Romania. A 48-year-old female, three years post-Madden mastectomy, underwent autologous breast reconstruction with a bi-pedicled DIEP flap. The procedure utilized the da Vinci Xiî robotic system for precise dissection of the vascular pedicles via a transabdominal preperitoneal approach. Robotic dissection was completed safely, with minimal fascial incisions, and totaling 104 minutes (out of total operative time of 11 hours). The uneventful post-operative course allowed patient discharge on postoperative day 4. This case marks a technological milestone for Romania and demonstrates the feasibility of robotic surgery in autologous breast reconstruction. The successful implementation of this technique opens the door for wider adoption in Eastern Europe, offering the potential for reduced donor site morbidity and improved recovery.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"228-231"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Staging and Treatment of Rectal Cancer between Patients Younger and Older than 70 years - An International Multicenter Study.","authors":"Jerzy Krzeszowiak, Ciprian Duta, RadosÅ Aw Pach, Piotr Richter, Zbigniew Lorenc, Andrzej Rutkowski, Wojciech Zegarski, Mariusz Frączek, Łukasz Zyskowski, Maciej Gaciong, Bartosz Skonieczny, Wojciech Polkowski, Vlad Braicu, Michał Święch, Katarzyna Sędłak, Dorian Andrade, Florian Kuhn, Konrad Karcz, Michal Tenderenda, Andrzej Cichocki, Jarosław Kobiela, Piotr Spychalski, Kajetan Ochwat, Aneta Obcowska-Hamerska, Antoni Szczepanik","doi":"10.21614/chirurgia.3108","DOIUrl":"10.21614/chirurgia.3108","url":null,"abstract":"<p><p><b>Introduction:</b> Colorectal cancer remains one of the major issues in modern healthcare, being one of the most common neoplasms and the second leading cause of cancer-related deaths. Despite significant recent advances, treatment modalities and the popularization of screening programs, treatment course and outcomes still vary among patients. This study aimed to observe the differences in staging, course of treatment, and survival between patients 70 and 70 years old with rectal cancer. Material and <b>Methods:</b> The study was a retrospective analysis of data collected prospectively in nine centers located in Poland, Romania, and Germany. Consecutive patients operated on for rectal cancer between 2013-2019 were included and divided into groups 70 and â?Â¥70. <b>Results:</b> A total of 2443 patients were included with a median age of 66 years and a predominance of male (63.16%). There were no significant differences in terms of sex, tumor localization or staging between the younger and the older group. A significantly higher number of procedures with stoma creation was observed and a lower number of lymph nodes yielded in older patients. There were no significant differences in the rate of R0 resections. The use of preoperative radiotherapy was also higher in the younger group. The rate of complete response did not differ significantly, and the overall survival was significantly lower in older patients. <b>Conclusions:</b> Despite similar staging, older and younger patients receive different treatment course, including less radical surgery and less frequent use of radiotherapy. Overall survival is poorer in older patients in stages I-IV.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"131-141"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic versus Open Approach in Gallbladder Cancer Treatment - 9-Year Experience in Fundeni Clinical Institute.","authors":"Elena-Mihaela Vrabie, Iulian Mosteanu, Mihai-Adrian Eftimie, Irina Balescu, Alexandra Trotea, Gheorghe Potlog, Catalin-Andrei Savin, Luiza-Maria Tirca, Ali Alloub, Cezar Stroescu, Traian Dumitrascu, Irinel Popescu, Vladislav Brasoveanu, Nicolae Bacalbasa","doi":"10.21614/chirurgia.3111","DOIUrl":"https://doi.org/10.21614/chirurgia.3111","url":null,"abstract":"<p><p><b>Introduction:</b> Gallbladder cancer is the most common biliary malignancy frequently diagnosed incidentally on cholecystectomy specimens for presumed benign disease. Once the diagnosis is confirmed on histopathologically, the treatment must be completed by resecting the gallbladder liver bed and regional lymph nodes. The laparoscopic approach seems to be efficient and oncologically safe. The aim of our study was to present the 9-year experience in treating gallbladder cancer in our surgery clinic by both open and laparoscopic approach completed by a literature review with the latest updates regarding the state of the laparoscopic approach in treating this type of cancer. <b>Materials and Methods:</b> Fifty-seven patients underwent radical surgery and 26 resections had a palliative purpose. Among radical resections, 52 were performed by using the open approach and 5 by using the laparoscopic approach. 14 cases out of 57 were completion procedures performed after a malignant histopathological finding was confirmed on a simple cholecystectomy specimen. In the majority of cases, the primary simple cholecystectomy was performed by laparoscopic approach. The laparoscopic approach was used in 3 cases of re-resection and 2 per-primam resections. <b>Results:</b> The median age of the patients was 64.21 years in the open group and 67.2 years in the laparoscopic group. Most patients were females. All patients had one or more comorbidities with an ASA score of 3 or 4 in 52 patients out of 57. ASA score had lower values in the laparoscopic group. The average surgery time for the laparoscopic group was 308 minutes, similar to the one for the open group that was 294 minutes. The complication rate was higher in the open group. The number of harvested lymph nodes was similar between the groups. The laparoscopic group benefited of lower postoperative pain, faster recovery and shorter hospital stay (6.2 days versus 13 days). Gallbladder cancer evolves asymptomatic in early stages and the diagnosis in advanced stages limits the therapeutic options. Still, in cases incidentally diagnosed on cholecystectomy specimens for presumed benign disease (stages T1-T3), the re-resection might be performed by laparoscopic approach. Also, in per-primam diagnosed selected cases, the laparoscopic resection might be performed by experimented teams. <b>Conclusions:</b> The laparoscopic approach is an ideal alternative to the open approach in treating early-stage gallbladder cancer. This surgical approach provides oncological safety, similar R0 resection rates and number of harvested lymph-nodes. The maximum benefit of this surgical approach is achieved in high-volume centers with experimented teams.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"178-192"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Protective Ileostomy on Postoperative Electrolyte Imbalances in Rectal Cancer Surgery: A Retrospective Analysis.","authors":"Sabrina Florentina Florea, Victor Constantin Stefanescu, Draga-Maria Mandi, Cătălin Vlăduţ Ionuţ, Dan Brebu, Sergiu Florin Bara, Mihai Alexandru Vasile, Daniel Cochior","doi":"10.21614/chirurgia.3116","DOIUrl":"https://doi.org/10.21614/chirurgia.3116","url":null,"abstract":"<p><p><b>Introduction:</b> Electrolyte imbalances are common following minimally invasive rectal resections, particularly in patients with protective ileostomies. Such imbalances can severely hinder postoperative recovery, resulting in dehydration, renal dysfunction, and various metabolic abnormalities. Objectives: This study aims to evaluate the incidence and ramifications of electrolyte imbalances in rectal cancer patients undergoing minimally invasive surgical procedures, irrespective of ileostomy status. <b>Methods:</b> A retrospective analysis was performed on 117 rectal adenocarcinoma patients who underwent minimally invasive resections between 2016 and 2023. Patient categorization was based on ileostomy status, with rigorous assessment of preoperative and postoperative electrolyte levels and comprehensive documentation of complications. <b>Results:</b> Of 117 patients, 91 (77.8%) had a protective ileostomy. Hypokalemia and hyponatremia were significantly prevalent in the ileostomy cohort; hypokalemia affected 16.2% of patients by postoperative day two, declining to 7.7% by day four (p=0.03). Dehydration-related complications were recorded in 3.4% of cases, while acute renal insufficiency was observed in 0.9%. Readmission rates were significantly increased in the ileostomy group (32.5%) due to fluid and electrolyte disorders (p 0.01). <b>Conclusions:</b> The presence of a protective ileostomy during rectal cancer surgery is associated with an increased risk of postoperative electrolyte imbalances and subsequent complications, highlighting the need for diligent monitoring and management strategies.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"142-150"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed Graft Function and Tacrolimus Overdosage: A Case Report.","authors":"Teodor Căluşi, Bogdan Sorohan, Dragş Eugen Georgescu, Dan Spânu, Alexandru Iordache, Florea Purcaru","doi":"10.21614/chirurgia.120.eC.3104","DOIUrl":"10.21614/chirurgia.120.eC.3104","url":null,"abstract":"<p><p>Delay graft function (DGF) is a condition that is frequently associated with kidney transplantation and could complicate subsequent evolution of the renal graft. There are multiple factors implicated in the development of DGF, some avoidable through careful management, others without the possibility of correction. Gordon syndrome or type II pseudo-hypoaldosteronism and nephrotoxicity induced by calcineurin inhibitors are complications that can precipitate the development of DGF. These unfavorable manifestations can occur after high levels of Tacrolimus secondary starting calcineurin inhibitors treatment and can be prevented with careful monitorization of its levels. We reported a case of a 58-year-old patient who was admitted as receptor for cadaveric kidney transplantation (KT) and developed all the complications associated with Gordon-like syndrome and nephrotoxicity including DGF in the context of high Tacrolimus levels after starting calcineurin inhibitors treatment.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 eCollection","pages":"1-6"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Emergencies in Pregnancy - A Retrospective Analysis of Six Surgical Departments and Review of Literature.","authors":"Octavian Andronic, Laura Stănescu, Tamaş Talpai, Răzvan Albu, Amalia Voinea, Tibiana Negru, Cătălin Alexandru Pîrvu, Stelian Pantea, Alin Mihai Vasilescu, Costel Bradea, Cristian Lupascu, Cosma Cătălin, Alexandru Szanto, Călin Molnar, Daniel Preda, Emil Moraru, Ştefan Paitici, Ştefania Tudorache, Valeriu Şurlin, Nikolaos Zygouropoulos, Bogdan Socea, Mihai Dimitriu, Alexandru Carâp, Dan Nicolae Păduraru, Ion Daniel, Alexandra Bolocan","doi":"10.21614/chirurgia.3024","DOIUrl":"10.21614/chirurgia.3024","url":null,"abstract":"<p><p><b>Background:</b> Surgical emergencies during pregnancy, although rare, present critical challenges for medical professionals, requiring a careful balance between the immediate needs of the mother and the potential risks to the fetus. Material and <b>Methods:</b> This retrospective multicentric study evaluates the diagnostic characteristics and management strategies for non-obstetric acute abdomen in pregnant women admitted to general surgery departments across six clinics in Romania from 2017 to 2022. <b>Results:</b> The study analyzed 70 cases, focusing on diagnostic processes, management approaches, and outcomes. Findings revealed that while surgical intervention was predominant, conservative management was also significant. Acute appendicitis and acute cholecystitis were the most common emergencies. <b>Conclusions:</b> The study highlights the necessity of a nuanced approach in diagnosis and tailored anesthetic management to ensure favorable outcomes, emphasizing the importance of timely intervention and the need for further research to develop standardized guidelines.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"193-204"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life Analysis in Patients with Simple Cutaneous Ureterostomy versus Ileal Conduit Bricker Following Radical Cystectomy.","authors":"Cosmin-George Radu, George Daniel Rădăvoi, Justin Aurelian, Ion-Florin Achim, Iulia Andras, Maximilian Buzoianu, Elisabeta Ioana Hiriscau, Nicolae Crisan, Silviu Constantinoiu, Viorel Jinga","doi":"10.21614/chirurgia.3128","DOIUrl":"10.21614/chirurgia.3128","url":null,"abstract":"<p><p><b>Introduction:</b> Radical cystectomy (RC) with pelvic lymphadenectomy remains the standard therapeutic approach in the treatment of muscle-invasive bladder cancer (MIBC). The impact of urinary diversion type on postoperative health-related quality of life (HRQoL) remains a debated topic, especially in the context of Eastern European clinical practice. Objective: This retrospective, observational, multicentric study aimed to compare the quality of life in patients undergoing RC followed by either simple cutaneous ureterostomy (SCU) or non-continent ileal conduit (Bricker), across two academic centers in Romania, utilizing different surgical approaches. Material and <b>Methods:</b> A total of 46 patients diagnosed with non-metastatic MIBC were included and equally distributed into two groups. Quality of life was assessed at 3 months postoperatively using the EQ-5D-5L questionnaire and the EQ-VAS visual analogue scale. Indexed scores were calculated using a European value set. A multivariate linear regression was applied to identify independent predictors of quality of life scores. <b>Results:</b> Patients in the Bricker group reported slightly higher EQ-VAS scores. Paradoxically, social support was associated with lower indexed scores (p 0.001), suggesting more severe functional impairment among patients requiring assistance. The type of surgical approach did not significantly impact quality of life. Male patients reported greater limitations in self-care and daily activities (p 0.05). <b>Conclusions:</b> Both urinary diversion techniques yield comparable quality of life outcomes at 3 months postoperatively. Social support may serve as an indirect marker of functional vulnerability, emphasizing the need for an individualized and multidisciplinary approach.</p>","PeriodicalId":10171,"journal":{"name":"Chirurgia","volume":"120 2","pages":"205-217"},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}