CD44 rs187115 的多态性作为早期结直肠癌诊断的预测性生物标记物

IF 0.8 Q4 SURGERY

Chirurgia Pub Date : 2024-09-01 DOI:10.21614/chirurgia.3007

Raluca Dumache, Alexandra Mihailescu, Dana Liana David, Flavius-Lucian Herlo, Gabriel Verdeş, Dan Brebu, Ionuţ Faur, Vlad Braicu, Amadeus Dobrescu, Ciprian Duţă

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引用次数: 0

摘要

简介近年来，结直肠癌（CRC）在全球的发病率呈上升趋势，这凸显了早期诊断方法的重要性。本研究旨在评估 CD44 基因多态性 rs187115 对 CRC 易感性的影响。材料与方法：研究对象包括 470 名 CRC 患者和 165 名健康对照者。在 ABI 7500 Real Time PCR 系统（美国应用生物系统公司）上使用 TaqMan 分析法对所有生物血液样本进行基因分型。结果显示基因分型结果显示，变异 G 等位基因（包括基因型为 AG 和 GG）携带者与 AA 基因型携带者相比，患 CRC 的风险更高，几率比 (OR) 为 1.89（95% 置信区间 [CI] = 1.57-1.97；P = 0.047）。结论研究结果强调了 CD44 rs187115 多态性作为预测 CRC 预后的新型生物标志物的潜在作用。

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Polymorphisms of CD44 rs187115 as a Predictive Biomarker in Early Colorectal Cancer Diagnostic.

Introduction: Colorectal cancer (CRC) has exhibited an increasing incidence worldwide in recent years, underscoring the importance of early diagnosis methods. This study aimed to assess the influence of CD44 gene polymorphism rs187115 on CRC susceptibility. Material and Methods: The study encompassed 470 CRC patients and 165 healthy controls. Genotyping of all biological blood samples was conducted using the TaqMan assay on the ABI 7500 Real Time PCR System (Applied Biosystems, USA). Results: The genotyping revealed that carriers of the variant G allele, including the genotypes AG and GG, exhibited a heightened risk of CRC occurrence, with an odds ratio (OR) of 1.89 (95% confidence interval [CI] = 1.57-1.97; p = 0.047) compared to those carrying the AA genotype. Conclusions: The findings underscore the potential utility of CD44 rs187115 polymorphisms as a novel predictive biomarker for CRC prognosis.

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来源期刊

Chirurgia Medicine-Surgery

CiteScore

1.00

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Chirurgia is a bimonthly journal. In Chirurgia, original papers in the area of general surgery which neither appeared, nor were sent for publication in other periodicals, can be published. You can send original articles, new surgical techniques, or comprehensive general reports on surgical topics, clinical case presentations and, depending on publication space, - reviews of some articles of general interest to surgeons from other publications. Chirurgia is also a place for sharing information about the activity of various branches of the Romanian Society of Surgery, information on Congresses and Symposiums organized by the Romanian Society of Surgery and participation notes in other scientific meetings. Letters to the editor: Letters commenting on papers published in Chirurgia are welcomed. They should contain substantive ideas and commentaries supported by appropriate data, and should not exceed 2 pages. Please submit these letters to the editor through our online system.