Clinical Autonomic Research最新文献_第5页

rs1801253 Gly/Gly carriage in the ADRB1 gene leads to unbalanced cardiac sympathetic modulation as assessed by spectral analysis of heart rate variability. 通过心率变异性的频谱分析评估，Gly/Gly携带ADRB1基因导致心脏交感调节不平衡。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2023-11-30 DOI: 10.1007/s10286-023-01001-4

E Grossini, D De Zanet, D Apostolo, V R Mallela, G La Rocca, A Greco, G Coratza, R Minisini, M Pirisi

引用次数: 0

Asymptomatic orthostatic hypotension in synucleinopathies: to treat or not to treat? 突触核蛋白病中的无症状正张力低血压：治还是不治？

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2023-12-11 DOI: 10.1007/s10286-023-01006-z

Abhishek Lenka, Guillaume Lamotte, Paul Beach

引用次数: 0

Sympathetic vascular transduction and baroreflex sensitivity in the context of severe COPD. 严重慢性阻塞性肺病患者交感血管转导和压力反射敏感性。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2023-12-03 DOI: 10.1007/s10286-023-01003-2

Gianni Sesa-Ashton, Vaughan G Macefield

引用次数: 0

Recent updates in autonomic research: orthostatic hypotension in prodromal synucleinopathy; longitudinal morbidity and mortality in orthostatic hypotension with and without supine hypertension; a cardiac vagal sensory system underlying reflex syncope. 自律神经研究的最新进展：前驱突触核蛋白病的正性低血压；正性低血压伴有或不伴有仰卧位高血压的纵向发病率和死亡率；反射性晕厥背后的心脏迷走神经感觉系统。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2024-01-28 DOI: 10.1007/s10286-023-01011-2

Paul Beach, Abhishek Lenka

引用次数: 0

Clinical Autonomic Research: welcome to 2024. 临床自主神经研究：欢迎来到 2024 年。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI: 10.1007/s10286-024-01018-3

Vaughan G Macefield, Horacio Kaufmann, Jens Jordan

引用次数: 0

In memoriam: a celebration of the autonomic contributions of David Robertson (1947-2024). 悼念：庆祝大卫-罗伯逊（1947-2024 年）在自律方面的贡献。

IF 5.8 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2024-03-04 DOI: 10.1007/s10286-024-01025-4

Italo Biaggioni, Amy C Arnold, Bonnie Black, Andre Diedrich, Raffaello Furlan, Alfredo Gamboa, Emily Garland, Giris Jacob, Jens Jordan, Luis E Okamoto, Satish R Raj, Kyoko Sato, John Shannon, Jens Tank, Amanda Peltier, Cyndya A Shibao

引用次数: 0

Tilt-evoked, breathing-driven blood pressure oscillations: Independence from baroreflex-sympathoneural function. 倾斜诱发、呼吸驱动的血压振荡：独立于气压反射-交感神经功能。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2024-03-06 DOI: 10.1007/s10286-024-01022-7

Edward Grabov, Patti Sullivan, Siqi Wang, David S Goldstein

{"title":"Tilt-evoked, breathing-driven blood pressure oscillations: Independence from baroreflex-sympathoneural function.","authors":"Edward Grabov, Patti Sullivan, Siqi Wang, David S Goldstein","doi":"10.1007/s10286-024-01022-7","DOIUrl":"10.1007/s10286-024-01022-7","url":null,"abstract":"Purpose: Orthostasis increases the variability of continuously recorded blood pressure (BP). Low-frequency (LF) BP oscillations (Mayer waves) in this setting are related to the vascular-sympathetic baroreflex. Mechanisms of increased high-frequency (HF) BP oscillations at the periodicity of respiration during orthostasis have received less research attention. A previously reported patient with post-neurosurgical orthostatic hypotension (OH) and vascular-sympathetic baroreflex failure had large tilt-evoked, breathing-driven BP oscillations, suggesting that such oscillations can occur independently of vascular-sympathetic baroreflex modulation. In the present study we assessed effects of orthostasis on BP variability in the frequency domain in patient cohorts with or without OH.Methods: Power spectral analysis of systolic BP variability was conducted on recordings from 73 research participants, 42 with neurogenic OH [13 pure autonomic failure, 14 Parkinson's disease (PD) with OH, 12 parkinsonian multiple system atrophy, and 3 status post-brainstem neurosurgery] and 31 without OH (control group of 16 healthy volunteers and 15 patients with PD lacking OH), before, during, and after 5' of head-up tilt at 90 degrees from horizontal. The data were log transformed for statistical testing.Results: Across all subjects, head-up tilting increased HF power of systolic BP variability (p = 0.001), without a difference between the neurogenic OH and control groups. LF power during orthostasis was higher in the control than in the OH groups (p = 0.009).Conclusions: The results of this observational cohort study confirm those based on our case report and lead us to propose that even in the setting of vascular-sympathetic baroreflex failure orthostasis increases HF power of BP variability.","PeriodicalId":10168,"journal":{"name":"Clinical Autonomic Research","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10944440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140038862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND). 静脉注射免疫球蛋白治疗自身免疫性体位性正位性心动过速综合征（iSTAND）的随机对照试验。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2024-02-04 DOI: 10.1007/s10286-024-01020-9

Steven Vernino, Steve Hopkins, Meredith Bryarly, Roberto S Hernandez, Amber Salter

{"title":"Randomized controlled trial of intravenous immunoglobulin for autoimmune postural orthostatic tachycardia syndrome (iSTAND).","authors":"Steven Vernino, Steve Hopkins, Meredith Bryarly, Roberto S Hernandez, Amber Salter","doi":"10.1007/s10286-024-01020-9","DOIUrl":"10.1007/s10286-024-01020-9","url":null,"abstract":"Objective: This study assesses response to intravenous immunoglobulin (IVIG) in presumed autoimmune postural orthostatic tachycardia syndrome (POTS).Background: POTS may be associated with autoimmune disorders, serum autoantibodies, or recent infection. Uncontrolled case studies suggest that IVIG is beneficial for treating autoimmune POTS. No previous randomized controlled trials have been conducted.Methods: This single-site randomized controlled trial compared IVIG with intravenous albumin infusions. Albumin comparator ensured blinding and control for effects of volume expansion. Eligible patients with POTS had COMPASS-31 total weighted score ≥ 40 and met predetermined criteria suggesting autoimmunity. Over 12 weeks, participants received eight infusions (0.4 gm/kg each). Four infusions were given weekly followed by four infusions every other week. Primary outcome measure was improvement in COMPASS-31 2 weeks after final infusion.Results: A total of 50 participants consented; 30 met inclusion criteria and received study drug (16 IVIG and 14 albumin; 29 female). Group baseline characteristics were well matched; 27 participants completed treatment protocol. Change in COMPASS-31 did not differ between groups (median change [IQR]; IVIG: -5.5 [-23.3, 2.5] versus albumin: -10.6 [-14.1, -4.7]; p-value = 0.629). The IVIG group had a higher response rate (46.7% versus 38.5%), but this was not statistically significant. Adverse events were common but usually mild and did not differ between treatment groups.Conclusions: This small randomized controlled trial of IVIG in POTS found no statistical difference in response compared with albumin infusion. Both groups showed improvement possibly related to volume expansion or other effects obscuring group differences. These findings inform development of future immunomodulatory clinical trials in POTS.","PeriodicalId":10168,"journal":{"name":"Clinical Autonomic Research","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential for reducing resting sympathetic nerve activity with new classes of glucose-lowering drugs in heart failure with preserved ejection fraction. 使用新型降糖药物降低射血分数保留型心力衰竭患者静息交感神经活动的潜力。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2024-01-29 DOI: 10.1007/s10286-023-01013-0

Takuro Washio, Sarah L Hissen, Ryosuke Takeda, John D Akins, Denis J Wakeham, Tiffany Brazile, Christopher M Hearon, James P MacNamara, Satyam Sarma, Benjamin D Levine, Paul J Fadel, Qi Fu

引用次数: 0

Asystole on loop recorder in patients with unexplained syncope and negative tilt testing: age distribution and clinical predictors. 原因不明的晕厥和倾斜试验阴性患者环形记录器上的搏动：年龄分布和临床预测因素。

IF 3.9 3区医学

Clinical Autonomic Research Pub Date : 2024-02-01 Epub Date: 2024-02-25 DOI: 10.1007/s10286-024-01021-8

Vincenzo Russo, Angelo Comune, Erika Parente, Anna Rago, Andrea Antonio Papa, Gerardo Nigro, Michele Brignole

{"title":"Asystole on loop recorder in patients with unexplained syncope and negative tilt testing: age distribution and clinical predictors.","authors":"Vincenzo Russo, Angelo Comune, Erika Parente, Anna Rago, Andrea Antonio Papa, Gerardo Nigro, Michele Brignole","doi":"10.1007/s10286-024-01021-8","DOIUrl":"10.1007/s10286-024-01021-8","url":null,"abstract":"Background: Approximately 50% of patients with unexplained syncope and negative head-up tilt test (HUTT) who have an electrocardiogram (ECG) documentation of spontaneous syncope during implantable loop recorder (ILR) show an asystolic pause at the time of the event.Objective: The aim of the study was to evaluate the age distribution and clinical predictors of asystolic syncope detected by ILR in patients with unexplained syncope and negative HUTT.Methods: This research employed a retrospective, single-center study of consecutive patients. The ILR-documented spontaneous syncope was classified according to the International Study on Syncope of Uncertain Etiology (ISSUE) classification.Results: Among 113 patients (54.0 ± 19.6 years; 46% male), 49 had an ECG-documented recurrence of syncope during the observation period and 28 of these later (24.8%, corresponding to 57.1% of the patients with a diagnostic event) had a diagnosis of asystolic syncope at ILR: type 1A was present in 24 (85.7%), type 1B in 1 (3.6%), and type 1C in 3 (10.7%) patients. The age distribution of asystolic syncope was bimodal, with a peak at age < 19 years and a second peak at the age of 60-79 years. At Cox multivariable analysis, syncope without prodromes (OR 3.7; p = 0.0008) and use of beta blockers (OR 3.2; p = 0.002) were independently associated to ILR-detected asystole.Conclusions: In patients with unexplained syncope and negative HUTT, the age distribution of asystolic syncope detected by ILR is bimodal, suggesting a different mechanism responsible for asystole in both younger and older patients. The absence of prodromes and the use of beta blockers are independent predictors of ILR-detected asystole.","PeriodicalId":10168,"journal":{"name":"Clinical Autonomic Research","volume":null,"pages":null},"PeriodicalIF":3.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10944445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139943878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0