中华小儿外科杂志最新文献

{"title":"Current surgical therapeutics for simple bone cysts","authors":"Ronger Zhou","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.018","url":null,"abstract":"Simple bone cysts (SBCs) are common benign bone tumors among children and adolescents. With variable surgical approaches and curative outcomes, SBCs are often treated in a non-standard way. Different surgical approaches and prognostic factors of SBCs are summarized with their advantages and disadvantages. \u0000 \u0000 \u0000Key words: \u0000Bone cysts; Surgical procedures, operative; Review","PeriodicalId":10157,"journal":{"name":"中华小儿外科杂志","volume":"57 1","pages":"1146-1150"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78741351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsurgery for deep cerebralarteriovenous malformations in thalamus, basal ganglia and insula in children","authors":"H. Zeng, Wujie Shi, Peiliang Zhang, Jianbin Weng, Chao Lin, Ning Wang","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.007","url":null,"abstract":"Objective \u0000To summarize the experiences of microsurgical removal of deep cerebral arteriovenous malformations (AVMs) in thalamus, basal ganglia and insula in children. \u0000 \u0000 \u0000Methods \u0000A retrospective analysis was conducted for 10 cases of deep cerebral AVMs undergoing microsurgery from June 2015 to June 2018. There were 8 boys and 2 girls with an average age of 7.8 years. The lesions were located in insular lobe (n=4), thalamus (n=3) and basal ganglia (n=3). Eight lesions were <3 cm in diameter, 9 lesions ruptured, 8 lesions were localized, Spetzler-Martin grade III and supplementary grade below IV accounted for 6 and 10 respectively. The outcomes were evaluated by postoperative digital subtraction angiography (DSA) and modified Rankin Scale (mRS) scores at different timepoints. \u0000 \u0000 \u0000Results \u0000The operative approaches were trans-cortical (n=8), lateral fissure (n=1) and corpus callosum (n=1). Among 8 cases of total resection, 1 case of Spetzler-Martin IV underwent emergency microsurgery while another case had emergency ventricular drainage plus second-stage microsurgical lesion removal. Among 4 cases of hemiplegia, one child of Spetzler-Martin IV had a remission after postoperative rehabilitation training. During a follow-up period of 6 months to 3 years, there was no onset of recurrence or rebleeding and 6 of them achieved an excellent outcome. Children scoring <3 via mRS during follow-ups (n=6) were more than preoperation (n=5) and after discharge (n=5). \u0000 \u0000 \u0000Conclusions \u0000Children with deep cerebral AVMs has a high risk of bleeding. For selected small and localized lesions, microsurgical resection offers the advantages of high total resection rate and low rebleeding rate. However, due to high operative difficulties, experienced neurosurgeons are recommended. \u0000 \u0000 \u0000Key words: \u0000Intracranial arteriovenous malformations; Microsurgery; Child","PeriodicalId":10157,"journal":{"name":"中华小儿外科杂志","volume":"5 1","pages":"1097-1101"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72724990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complications and management for children after open reduction for developmental dysplasia of the hip joint","authors":"Hongwen Xu","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.001","url":null,"abstract":"","PeriodicalId":10157,"journal":{"name":"中华小儿外科杂志","volume":"52 1","pages":"1057-1061"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75134926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factor analysis of recurrent subluxation after Pemberton and proximal femur osteotomy in infancy and childhood with developmental dysplasia of the hip","authors":"Wei Yishan, Li Wanlin, Wang Hairui, Bai Rui, Dai-he Li, Zhao Zhenqun, Wang Yong, S. Liang, S. Chao, Na Muhan","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.005","url":null,"abstract":"Objective \u0000To investigate the risk factors of recurrent subluxation after Pemberton and proximal femur osteotomy with developmental dysplasia of the hip(DDH)in infancy and childhood. \u0000 \u0000 \u0000Methods \u0000From January 2004 to December 2007, 62 patients (79 hips) of DDH in infancy and childhood were treated with Pemberton and proximal femoral subtrochanteric shortening and varus and derotation individualized osteotomy were evaluated at a minimum follow up of 10 years. The average age was (4.28±2.13)years old before the operation, 17 hips of bilateral dislocation and 45 hips of unilateral dislocation, 23 patients (33 hips) were younger than 3 years and 39 patients (46 hips) were older than 3 years, according to Tonnis classification, 16 hips, 19 hips and 44 hips were graded asⅡ, Ⅲ and Ⅳ respectively. Pearson contingency coefficient was used to analyze the correlation between gender, age, Tonnis classification, unilateral/bilateral hip, avascular necrosis(AVN) and recurrent subluxation, Mckay clinical criteria and Severin radiographic classification. The paired sample t test was used to compare the Bony Acetabular Index, the Center-Edge Angle and the Reimers Index of preoperative, 1 years after operation and the last follow-up. \u0000 \u0000 \u0000Results \u0000All cases were followed up for (12.10±1.02) years. Compared with preoperative parameters, 1 year after operation and the last follow-up, the Bony Acetabular Index recovered from (37.76±10.65)° to (5.04±3.76)°to (8.71±3.42)°, and the Center-Edge Angle recovered from (-55.61±43.29)° to (40.18±8.73)°to (33.58±8.75)°, and the Reimers Index recovered from (73.14±28.11)% to (14.17±11.78)% to (14.17±11.78)%, the average value recovered to the normal range. There was significant difference between the Bony Acetabular Index, the Center-Edge Angle and the Reimers Index of 1 years after operation and the last follow-up, as compared with preoperative parameters(P<0.05). The Reimers Index was significantly different for patients in the 1 years after operation and the last follow-up (P<0.05). The good rate of hip function was 84.81% (67/79)according to the Mckay clinical criteria to assess hip function, and the good rate of imageology was 75.95%(60/79) according to Severin radiographic classification in the last follow-up. Pearson contingency coefficient correlation analysis showed that main risk factors for Mckay clinical criteria seem to be unilateral/bilateral hip, AVN and recurrent subluxation(contingency coefficient =0.359、0.599、0.649, P<0.05); and the main risk factors for Severin radiographic classification were age, AVN and recurrent subluxation(contingency coefficient =0.356、0.478、0.707, P<0.05). In the last follow-up, 6 hips (7.59%) had recurrent subluxation after at a mean of 2.21 years after the initial open reduction. Pearson contingency coefficient correlation analysis showed that main risk factors for recurrent subluxation seem to be age, unilateral/bilateral hip, Tonnis classification and AVN (contingency coefficient ","PeriodicalId":10157,"journal":{"name":"中华小儿外科杂志","volume":"1 1","pages":"1083-1089"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89376475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenesis and current diagnostics of lower urinary tract dysfunction in children with anorectal malformations","authors":"Yangyue Huang","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.017","url":null,"abstract":"Functional outcome of anorectal malformations has been recognized as a significant prognostic factor of affecting patient's quality-of-life. Some children are complicated with lower urinary tract dysfunction (LUTD). The causes of LUTD include spinal dysraphism, sacral agenesis, iatrogenic injuries, congenital dysplasia of pelvic floor and postoperative bowel dysfunction. Identifying the underlying causes of LUTD is the prerequisite of early diagnosis and treatment. However, lacking standardized preoperative screening examinations, postoperative follow-ups and quantitative urodynamic evaluations of lower urinary tract function leads to controversial managements. An earlier standardization of diagnosis and treatment may delay further aggravation of lower urinary tract function. \u0000 \u0000 \u0000Key words: \u0000Urodynamics; Congenital ano-rectal malformation; Lower urinary tract dysfunction","PeriodicalId":10157,"journal":{"name":"中华小儿外科杂志","volume":"37 1","pages":"1141-1145"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79139220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the Eighth Forum on Biliary Atresia & Pediatric Liver Transplantation","authors":"Qingyun Gou, Wei Gao, J. Zhan","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.019","url":null,"abstract":"","PeriodicalId":10157,"journal":{"name":"中华小儿外科杂志","volume":"123 1","pages":"1151-1152"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78640745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoplasmic reticulum stress and neonatal necrotizing enterocolitis","authors":"Peng Li","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.016","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.016","url":null,"abstract":"Endoplasmic reticulum stress is prevalent in a variety of cell which is caused by external thorns or their own functional abnormalities. Endoplasmic reticulum stress can activate the unfolded protein response to maintain the homeostasis of the endoplasmic reticulum. But sustained endoplasmic reticulum stress leads to cell apoptosis. Endoplasmic reticulum stress is associated with necrotizing enterocolitis, but its mechanism is not clear. In this paper, we first introduce the signal pathways in endoplasmic reticulum stress, and then explain the relationship between endoplasmic reticulum stress and necrotizing enterocolitis in the aspects of intestinal paneth cells, goblet cells and stem cells to provide new ideas in the pathogenesis and the treatment of necrotizing enterocolitis. \u0000 \u0000 \u0000Key words: \u0000Enterocolitis, necrotizing; Neonate; Endoplasmic reticulum stress","PeriodicalId":10157,"journal":{"name":"Chinese Journal of Pediatric Surgery","volume":"71 1","pages":"1137-1141"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77710728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic management of urachal remnants in children","authors":"Linfeng Zhu, Yiding Shen, C. Tao, Guangjie Chen, De-hua Wu, Yong Huang, Xiaohao Wang, W. Ru, Rulai Yang, D. Tang","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.010","url":null,"abstract":"Objective \u0000To evaluate the efficacy and approach of laparoscopic excision of urachal remnants in children. \u0000 \u0000 \u0000Methods \u0000From May 2012 to April 2018, retrospective reviews were conducted for medical records of all children undergoing laparoscopic excision of urachal remnants. \u0000 \u0000 \u0000Results \u0000There were 10 boys and 5 girls with a median age of 4.5(0.3-16.8) years. Umbilicus-sparing laparoscopic urachal excision was performed. The causes were urachal cyst (n=11) and patent urachus (n=4). Complete excision (n=11) and conversion into open surgery & partial cystectomy (n=4) were performed. Postoperative antibiotics were offered. All diagnoses were confirmed by pathological examinations. During a follow-up period of 3-60 months, there was no onset of re-infection or cyst recurrence. \u0000 \u0000 \u0000Conclusions \u0000Umbilicus-sparing laparoscopy is both safe and effective for treating persistent or infected urachus. It offers superior cosmetic outcomes. Partial cystectomy depends upon the presence of an adherent communicating urachal cyst attached to bladder dome. For acute infection, antibiotic dosing or initial incision & drainage with delayed cyst excision may be adopted for avoiding unnecessary complications. \u0000 \u0000 \u0000Key words: \u0000Urachus; Therapeutic laparoscopy; Child","PeriodicalId":10157,"journal":{"name":"Chinese Journal of Pediatric Surgery","volume":"47 1","pages":"1113-1117"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88920484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A survey on the prevalence of different subtypes of primary enuresis in children","authors":"Z. Han, Y. Wen, Xizheng Wang, Chaoyang Hua, Pengchao Xu","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.011","url":null,"abstract":"Objective \u0000To explore the prevalence of different subtypes of primary nocturnal enuresis (PNE) of children aged 5-12 years in Henan Province. \u0000 \u0000 \u0000Methods \u0000From October 2016 to May 2017, a cross-sectional survey of primary enuresis prevalence was performed by randomly selecting 9650 children aged 5-12 years from 18 primary schools and 12 middle schools in Henan Province. An anonymous questionnaire was employed for surveying the epidemiology of primary enuresis and its different subtypes. \u0000 \u0000 \u0000Results \u0000A total of 9650 questionnaires were distributed and 8978 questionnaires recovered. There were 8517 valid questionnaires with an effective questionnaire recovery rate of 88.3%. The overall prevalence of PNE was 6.4%(545/8517), the overall prevalence of monosymptomatic enuresis (MNE) 4.6%(395/8517) and the overall prevalence of non-monosymptomatic enuresis (NMNE) 1.8%(150/8517) while accounted for 27.5% of PNE. With advancing age, the prevalence of PNE decreased (χtrend2=143.06, P 0.05). The overall incidence of frequent nocturnal enuresis in children with PNE was 70.1% (382/545) and the incidence of frequent nocturnal enuresis with MNE and NMNE was compared [69.1%(273/395) vs. 72.7%(109/150)]. The difference was not statistically significant (χ2=0.66, P>0.05). \u0000 \u0000 \u0000Conclusions \u0000Around 10% of children aged 5-6 years suffer from PNE. It is one of the major diseases affecting children's quality-of-life. And 1/3 of PNE children are associated with daytime symptoms and the frequency of nocturnal enuresis has remains high. Clinicians and parents should pay great attention. \u0000 \u0000 \u0000Key words: \u0000Diurnal enuresis; Epidemiology; Children","PeriodicalId":10157,"journal":{"name":"Chinese Journal of Pediatric Surgery","volume":"41 1","pages":"1118-1122"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85824389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study of DNA methylation modified Shh/Bmp4 signaling pathway in the regulation of enteric nervous system dysplasia in rectal end of rat fetus with anorectal malformations","authors":"Ying Zhou, Yifan Yang, R. Dong","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.11.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.11.017","url":null,"abstract":"Objective \u0000To explore the impact of gene methylation in Shh/Bmp4 signaling pathway on the enteric nervous system (ENS) in rectal end of fetal mice with anorectal malformations (ARM). \u0000 \u0000 \u0000Methods \u0000A total of 15 Sprague Dawley pregnant rats were randomly divided into 3 groups of ETU, ETU+ 5-azaC and normal.At gestational Day 10, ETU and ETU+ 5-azaC groups received 1% ETU via gavage while ETU+ 5-azaC group had an intraperitoneal injection of 5-azaC (3 mg/kg). At gestational Day 12, cesarean section was performed.The incidence of ARMs, the content of DNA methyltransferase (DNMT1, DNMT3a & DNMT3b), the methylation status of Shh gene promoter region and the expression of key components in Shh/Bmp4 signaling pathway in rectal end of fetal mice were detected by polymerase chain reaction (PCR), immunohistochemistry and Western blot. \u0000 \u0000 \u0000Results \u0000a) The incidence of ARMs was 98.3% and 64.9% in ETU and ETU+ 5-azaC groups respectively and there were statistical differences (P<0.0001); b) The expression of DNMTs (DNMT1, DNMT3a & DNMT3b) was significantly higher in rectal tissue of ETU/ETU+ 5-azaC group than that of control group (DNMT1: ETU vs normal, 3.63±0.26 vs 1.00±0.09, P<0.0001; ETU+ 5-azaC vs normal, 2.33±0.27 vs 1.00±0.09, P=0.0003; DNMT3a: ETU vs normal, 3.05±0.28 vs 1.00±0.29, P=0.0003; ETU+ 5-azaC vs normal, 2.20±0.07 vs 1.00±0.29, P<0.0001; DNMT3b: ETU vs normal, 2.62±0.49 vs 1.00±0.26, P=0.0005; ETU+ 5-azaC vs normal, 2.33±0.30 vs 1.00±0.26, P=0.0028). The expression of DNMT1/DNMT3a was significantly higher in rectal tissue of ETU group than that in ETU+ 5-azaC group (DNMT1: 3.63±0.26 vs 2.33±0.27, P=0.0025; DNMT3a: 3.05±0.28 vs 2.20±0.07, P=0.0033) while no significant inter-group difference existed in the expression level of DNMT3b; c) The methylation level of Shh gene promoter was significantly higher in rectal end of ETU group than that in ETU+ 5-azaC/control group (ETU vs ETU+ 5-azaC: 7.13±0.66 vs 5.20±1.21, P=0.0263; ETU vs normal: 7.13±0.66 vs 2.81±0.27, P<0.0001) and ETU+ 5-azaC group was obviously higher than control group (5.20±1.21 vs 2.81±0.27, P=0.0300); d) Shh/Bmp4 expression level was significantly lower in rectal end of ETU/ETU+ 5-azaC group than that of control group (Shh: ETU vs normal, 1.00±0.23 vs 3.81±0.25, P<0.0001; ETU+ 5-azaC vs normal, 2.19±0.60 vs 3.81±0.25, P=0.0121; Bmp4: ETU vs normal, 1.00±0.18 vs 4.91±0.36, P<0.0001; ETU+ 5-azaC vs normal, 2.16±0.23 vs 4.91±0.36, P<0.0001) and Shh/Bmp4 expression level in ETU group was also lower than that in ETU+ 5-azaC group (Shh: 1.00±0.23 vs 2.19±0.60, P=0.011; Bmp4: 1.00±0.18 vs 2.16±0.23, P=0.0019); e) S-100 labeled submucosa and intermuscular nerve plexus in rectal tissue of ETU group significantly decreased compared with that of normal group (P<0.0001) and ETU+ 5-azaC group was significantly different from that in ETU group (P<0.0001). The c-kit labeled Cajal stromal cells and NSE labeled ganglion cells were not obviously expressed in rectum of ETU/ETU+ 5-azaC group. \u0000 \u0000 \u0000","PeriodicalId":10157,"journal":{"name":"Chinese Journal of Pediatric Surgery","volume":"137 1","pages":"1044-1049"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89127758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}