内质网应激与新生儿坏死性小肠结肠炎

Q4 Medicine

中华小儿外科杂志 Pub Date : 2019-12-15 DOI:10.3760/CMA.J.ISSN.0253-3006.2019.12.016

Peng Li

{"title":"内质网应激与新生儿坏死性小肠结肠炎","authors":"Peng Li","doi":"10.3760/CMA.J.ISSN.0253-3006.2019.12.016","DOIUrl":null,"url":null,"abstract":"Endoplasmic reticulum stress is prevalent in a variety of cell which is caused by external thorns or their own functional abnormalities. Endoplasmic reticulum stress can activate the unfolded protein response to maintain the homeostasis of the endoplasmic reticulum. But sustained endoplasmic reticulum stress leads to cell apoptosis. Endoplasmic reticulum stress is associated with necrotizing enterocolitis, but its mechanism is not clear. In this paper, we first introduce the signal pathways in endoplasmic reticulum stress, and then explain the relationship between endoplasmic reticulum stress and necrotizing enterocolitis in the aspects of intestinal paneth cells, goblet cells and stem cells to provide new ideas in the pathogenesis and the treatment of necrotizing enterocolitis. \n \n \nKey words: \nEnterocolitis, necrotizing; Neonate; Endoplasmic reticulum stress","PeriodicalId":10157,"journal":{"name":"中华小儿外科杂志","volume":"71 1","pages":"1137-1141"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Endoplasmic reticulum stress and neonatal necrotizing enterocolitis\",\"authors\":\"Peng Li\",\"doi\":\"10.3760/CMA.J.ISSN.0253-3006.2019.12.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Endoplasmic reticulum stress is prevalent in a variety of cell which is caused by external thorns or their own functional abnormalities. Endoplasmic reticulum stress can activate the unfolded protein response to maintain the homeostasis of the endoplasmic reticulum. But sustained endoplasmic reticulum stress leads to cell apoptosis. Endoplasmic reticulum stress is associated with necrotizing enterocolitis, but its mechanism is not clear. In this paper, we first introduce the signal pathways in endoplasmic reticulum stress, and then explain the relationship between endoplasmic reticulum stress and necrotizing enterocolitis in the aspects of intestinal paneth cells, goblet cells and stem cells to provide new ideas in the pathogenesis and the treatment of necrotizing enterocolitis. \\n \\n \\nKey words: \\nEnterocolitis, necrotizing; Neonate; Endoplasmic reticulum stress\",\"PeriodicalId\":10157,\"journal\":{\"name\":\"中华小儿外科杂志\",\"volume\":\"71 1\",\"pages\":\"1137-1141\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华小儿外科杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华小儿外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.0253-3006.2019.12.016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

摘要

内质网应激普遍存在于多种细胞中，这是由外部刺或自身功能异常引起的。内质网应激可激活未折叠蛋白反应，维持内质网的稳态。但持续的内质网应激导致细胞凋亡。内质网应激与坏死性小肠结肠炎有关，但其机制尚不清楚。本文首先介绍内质网应激的信号通路，然后从肠上皮细胞、杯状细胞和干细胞等方面阐述内质网应激与坏死性小肠结肠炎的关系，以期为坏死性小肠结肠炎的发病机制和治疗提供新的思路。关键词:小肠结肠炎;坏死性;新生儿;内质网应激

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Endoplasmic reticulum stress and neonatal necrotizing enterocolitis

Endoplasmic reticulum stress is prevalent in a variety of cell which is caused by external thorns or their own functional abnormalities. Endoplasmic reticulum stress can activate the unfolded protein response to maintain the homeostasis of the endoplasmic reticulum. But sustained endoplasmic reticulum stress leads to cell apoptosis. Endoplasmic reticulum stress is associated with necrotizing enterocolitis, but its mechanism is not clear. In this paper, we first introduce the signal pathways in endoplasmic reticulum stress, and then explain the relationship between endoplasmic reticulum stress and necrotizing enterocolitis in the aspects of intestinal paneth cells, goblet cells and stem cells to provide new ideas in the pathogenesis and the treatment of necrotizing enterocolitis. Key words: Enterocolitis, necrotizing; Neonate; Endoplasmic reticulum stress

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华小儿外科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.40

自引率

0.00%

发文量

8707

期刊介绍： Chinese Journal of Pediatric Surgery is an academic journal sponsored by the Chinese Medical Association. It mainly publishes original research papers, reviews and comments in this field. The journal was founded in 1980 and is included in well-known databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences) and CSCD Chinese Science Citation Database Source Journal (including extended version). It is one of the national key academic journals under the supervision of the China Association for Science and Technology. Chinese Journal of Pediatric Surgery enjoys a high reputation and influence in the academic community. The articles published in this journal have a high academic level and practical value, providing readers with a large number of practical cases and industry information, and have received widespread attention and citations from readers.