{"title":"Management of trigeminal neuralgia by peripheral neurectomy.","authors":"Sapna Tandon, Saurabh Srivastava, Madan Mishra, Ramesh R Fry, Sanober Sohail, Anusha Sidhwa","doi":"10.4103/njms.njms_169_22","DOIUrl":"10.4103/njms.njms_169_22","url":null,"abstract":"<p><strong>Background: </strong>Peripheral neurectomy(PN)is a minimally invasive procedure, for the management of trigeminal neuralgi (TN)consisting of surgical avulsion of terminal branches of the trigeminal nerve.</p><p><strong>Aim: </strong>To assess the efficacy of PN in the treatment of refractory TN and their recurrences in a follow up of 18 months.</p><p><strong>Materials and methodology: </strong>Retro-prospective and prospective study was conducted on randomly selected 30 TN patients irrespective of age, gender and socio-economic status. The branch of trigeminal nerve involved was identified according to the site of pain. Then the PN procedure was performed under local or general aesthesia. The follow up of each patient was done for next 18 months.</p><p><strong>Results: </strong>Mean age of the TN patients 53.17 ± 13.84 years, with 66.7% of patients were within 60 years of age. Male to female ratio was 1:1.5. All patients showed unilateral TN. Mostly 26.7% trigger point was located in lower lip followed by 13.3% in upper lip. After 3,6 and 9 months follow-up, none of the TN patients treated with PN had pain and none had any effect on general activity. However, from 12 months till 18 months' follow up, 2 (6.7%) patients reported of pain.</p><p><strong>Conclusion: </strong>PNs are viable treatment alternative for TN, although peripheral neurectomy has chances of reoccurrence but still offer better quality of life in patients for many years without relaps.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 2","pages":"295-301"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142135109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tapasya V Karemore, Kanchan A Ashtankar, Mukta Motwani
{"title":"Comparative efficacy of pre-operative and post-operative administration of amoxicillin in third molar extraction surgery - A systematic review and meta-analysis.","authors":"Tapasya V Karemore, Kanchan A Ashtankar, Mukta Motwani","doi":"10.4103/njms.njms_163_22","DOIUrl":"https://doi.org/10.4103/njms.njms_163_22","url":null,"abstract":"<p><p>To compare the effectiveness of pre-operative and post-operative administration of amoxicillin in patients undergoing third molar extraction surgery. A systematic search was executed according to PRISMA guidelines for studies published till December 2021. Studies were included based on the pre-eligibility criteria. The risk of bias was assessed using the Cochrane risk of bias tool. The heterogeneity was evaluated, and a random effect model was used for meta-analysis. A total of five studies were included from an initial search of 96 studies. The included studies were randomized controlled trials and comparative studies assessing pre-operative and post-operative administration of antibiotics among patients undergoing third molar extraction surgery. For comparison between pre-operative and post-operative groups, interincisal distance, complications, pain, and swelling were systematically reviewed and meta-analysis was done for interincisal distance and complications. The mean change in interincisal distance ranged from 5.5 to 47.9 and from 4.56 to 46.1 in the pre-operative and post-operative amoxicillin groups, respectively. Complications reported were infections, alveolar osteitis, nausea, diarrhea, gastric pain, rash, and headache with a pooled incidence of 4.3-33% in the pre-operative amoxicillin group and 0-22.7% in the post-operative amoxicillin group. Quantitative synthesis of data carried out from meta-analysis shows a significant difference in the pre-operative and post-operative amoxicillin groups in improving the interincisal distance and incidence of complications post surgery. The qualitative synthesis of data derived from systematic review for pain provides favoring results for post-operative amoxicillin administration. In case of swelling, a non-conclusive result was obtained.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rishabh Shah, Rashmi Venkatesh, Kavita Badi, Kreena Shah
{"title":"Surgical management of intramuscular hemangioma of left masseter muscle: A case report.","authors":"Rishabh Shah, Rashmi Venkatesh, Kavita Badi, Kreena Shah","doi":"10.4103/njms.njms_140_22","DOIUrl":"https://doi.org/10.4103/njms.njms_140_22","url":null,"abstract":"<p><p>Hemangiomas are benign soft tissue tumors which are congenital and occur due to abnormal proliferations of blood vessels. Most common location of hemangiomas is subcutaneous adipose tissue, but skeletal muscle hemangiomas are very rare which make up to 0.8% of all hemangiomas. Usually, the intramuscular lesions are common in thigh region and calf muscles and are relatively rare in the facial muscles. Long-standing lesions results in phleboliths, and this may cause some symptoms. Conventional treatment of these isolated lesions may not yield satisfactory results. Hence, surgical excision of the lesion in toto results in aesthetically pleasing results with low chances of recurrence. In this article, we report a case of a left masseter intramuscular hemangioma in 19-year-old patient which was successfully managed by complete surgical excision.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"160-163"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ajay Kumar, Adit Srivastava, Neha Sah, Sonam Sah, Vinayalekshmy I N Nair, Aruna Das, Akhilesh Kumar Singh
{"title":"Evidence-based effectiveness of Ozone therapy in the treatment for oral lichen planus - A systematic review.","authors":"Ajay Kumar, Adit Srivastava, Neha Sah, Sonam Sah, Vinayalekshmy I N Nair, Aruna Das, Akhilesh Kumar Singh","doi":"10.4103/njms.njms_20_23","DOIUrl":"https://doi.org/10.4103/njms.njms_20_23","url":null,"abstract":"<p><p>Oral lichen planus is a common, chronic mucocutaneous condition of uncertain origin. Early treatment of OLP can dramatically reduce the risk of further development, which in turn reduces the risk of developing cancer. Numerous methods can be used to treat OLP. Since the significance of ozone in treating this disease is still uncertain. This systematic review was conducted based on english databases, including PUBMED, SCOPUS, Embase, Ovid, and Journal of Web up to July 2022. We used the search phrases \"ozone,\" \"ozone in the treatment of oral lichen planus,\" \"oral lichen planus,\" and \"ozone therapy.\" Finally, five papers were selected for qualitative analysis. This review included a total of five papers, four of which were clinical trials and one was a longitudinal study. All studies included the erosive form of OLP, also ozone therapy was applied to patients who did not respond to conventional treatment. Ozone showed significant therapeutic effects in terms of reduction in pain and size of the lesion. The signs and symptoms associated with OLP such as burning sensation, lesion size, and scarring all considerably improved with ozone therapy.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the non-endoscopic and endoscopic-assisted platysma flap - A randomized control trial.","authors":"Sandeep Kumar, Uma Shanker Pal, Shadab Mohammad, Vibha Singh, Vijay Kumar, Amiya Agrawal, Aastha Singh","doi":"10.4103/njms.njms_90_23","DOIUrl":"https://doi.org/10.4103/njms.njms_90_23","url":null,"abstract":"<p><strong>Background and aim: </strong>As oral submucous fibrosis (OSMF) is a chronic progressive disorder, the treatment is based on the severity of the disease. Surgical treatment is the only choice for grade III and grade IV OSMF cases because the patient can neither clean his/her mouth nor properly chew. The resulting soft tissue defect requires resurfacing with various well-vascularized tissues such as extraoral flaps, intraoral flaps, microvascular flaps, and allografts that have been used. Reconstruction of the resultant defects proved to be challenging. Till date, none of the flaps has been proven to be effective and is universally accepted for the treatment of OSMF because of various drawbacks of the available techniques. This study was conducted to know whether an endoscopic-assisted platysma flap is associated with better outcomes in terms of ease of operation and postoperative function than the conventional approach.</p><p><strong>Materials and methods: </strong>This study included 40 patients of grade III and grade IV OSMF reporting to the outpatient department of oral and maxillofacial surgery in a tertiary center of North India. These patients were divided randomly into two groups. Group I and Group II had 20 patients each, undergoing endoscopic-assisted platysma flap and non-endoscopic-assisted platysma flap for reconstruction after resection of OSMF bands, respectively. Data were analyzed for the mouth opening, operating time, flap viability, congestion of neck and oral cavity, signs of inflammation, neurologic assessment, and measurement of the drain.</p><p><strong>Results: </strong>The results showed significant increase in mouth opening from the preoperative value to the values immediately after surgery and at 24 h, 1 week, 15 days, 1 month, 3 months, and 6 months after surgery in both the study groups. Reduced bleeding incidence was found in group I compared to group II, with better postoperative outcomes noted during follow-up. But the mean intraoperative time of the subjects in group I was 130.80 ± 5.5.908 min and in group II was 105.74 ± 2. 491 min. Increased time taken in group I may be due to the long learning curve.</p><p><strong>Conclusion: </strong>The present study concluded that the Endoscope-assisted technique has a key role during supra and subplatysmal dissection to allow for better accessibility, handling, and visibility of the flap and its orientation in relation to the underlying structures to avoid postoperative complications and to overcome the drawback of platysma myocutaneous flap in reconstruction of OSMF defects.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"59-66"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140875125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effectiveness of basic life support training course intervention among dental practitioners and students - An experimental study.","authors":"Shivananda Shivakumar, Vidya Gowdappa Doddawad, Sahith Kumar Shetty, Manjula Shivanagappa, Chandan Sriraghuramapura Narayanaswamy, Akhil Shetty, Hari Kishore Bhat","doi":"10.4103/njms.njms_59_22","DOIUrl":"https://doi.org/10.4103/njms.njms_59_22","url":null,"abstract":"<p><strong>Aim: </strong>To determine the level of knowledge and skill of basic life support (BLS) among undergraduate, postgraduate students, and general practitioners with and without regular attendance of the BLS Healthcare Provider course.</p><p><strong>Methodology: </strong>The study was carried out at two intervals with two groups. A random sample involving undergraduate students, postgraduate students, and dental professionals was selected for both study groups. Group 1 with 440 participants had not attended BLS for Healthcare Providers Course in the last two years. Group 2 with 410 participants had attended the BLS for Healthcare Providers course regularly once a year. First, participants in Group 1 were evaluated using an MCQ test with 30 questions about their knowledge and skills in BLS. Then, a well-trained BLS instructor team from Dental College & Hospital offered BLS healthcare provider courses to students and dentists. Subsequently, Group 2 participants who had completed a BLS course for healthcare providers last year were also assessed for their knowledge and skills in BLS using another MCQ test.</p><p><strong>Results: </strong>The marks obtained in the tests were tabulated and analyzed. To determine the association between variables with respect to mean knowledge score, t-test was employed. Multiple group comparison was made using analysis of variance and P < 0.05 was considered statistically significant. The group 1 participants score a mean of 5.7 marks against the Group 2 with a mean score of 27.4 marks out of 30 marks. Knowledge and skill in BLS skills among those in Group 1 without prior BLS training was mainly low. Dental practitioners performed marginally better than students in both groups.</p><p><strong>Conclusions: </strong>Based on the results, we make the following observations. With the introduction of BLS training into the academic curriculum and routine BLS hands-on workshops, all healthcare providers will be familiar with the BLS skills to effectively manage the life-threatening emergencies.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"87-92"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Odontogenic keratocysts: A retrospective histopathological study.","authors":"Aadithya Basavaraj Urs, Priya Kumar, Shivani Singh, Sujata Mohanty, Zainab Chaudhary","doi":"10.4103/njms.njms_211_22","DOIUrl":"https://doi.org/10.4103/njms.njms_211_22","url":null,"abstract":"<p><strong>Introduction: </strong>Odontogenic keratocyst (OKC) is an aggressive recurrent cyst with intriguing features. Various factors such as the surgical procedure are involved, and certain histological features contribute to its recurrence. We assessed the clinical, radiographic, and histopathological data of OKCs to better comprehend the true nature of this cyst.</p><p><strong>Material and methods: </strong>A total of 58 lesions including four cases in association with nevoid basal cell carcinoma syndrome (NBCCS) were assessed. Radiographic features and histopathological features within the epithelium and capsule were assessed.</p><p><strong>Results: </strong>72% of cases were seen in males and 28% in females. 43% of cases were seen in the mandibular ramus, and 65% exhibited unilocular radiolucency. 95% showed true parakeratinization. Cuboidal basal cell morphology was seen in 41.3% of cases and reversal of polarity in 60%. Basal budding, rete pegs, and mitosis were also observed within the epithelium. The epithelium showed separation at the subbasal level and suprabasal levels in 55 (94.9%) cases.</p><p><strong>Conclusion: </strong>Features such as basal cell budding, suprabasal mitotic activity, suprabasal split, localized inflammation, subepithelial hyalinization, and satellite cysts were commonly associated with recurrent cysts. Many newer genetic and molecular hypotheses have generated path-breaking contributions to the understanding of the biology of OKC. With the guidance and help of such factors, improved post-surgery results can be anticipated.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"136-141"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sneh Lata Verma, Tripti Tikku, Rohit Khanna, Kamna Srivastava, Rana Pratap Maurya, Priyanka Rai
{"title":"Correlation of mandibular third molar orientation and available retromolar space with arch length discrepancy in subjects with different growth pattern.","authors":"Sneh Lata Verma, Tripti Tikku, Rohit Khanna, Kamna Srivastava, Rana Pratap Maurya, Priyanka Rai","doi":"10.4103/njms.njms_63_22","DOIUrl":"https://doi.org/10.4103/njms.njms_63_22","url":null,"abstract":"<p><strong>Aim and objective: </strong>To evaluate, compare, and correlate the mandibular third molar orientation and available retromolar space with arch length discrepancy in subjects with skeletal class II malocclusion and different growth pattern.</p><p><strong>Material and method: </strong>A total of 250 patients (age >18 yrs) having skeletal class II malocclusion (based on YEN angle and WITS appraisal) were divided into two groups. Both the groups (Group I with erupted mandibular third molars {N = 150} and Group II with impacted mandibular third molars {N = 100}) were subdivided into subgroups IA (n = 71), IB (n = 19), IC (n = 71) and Group IIA (n = 54), IIB (n = 30) and IIC (n = 16) for normo-, hypo- and hyperdivergent growth patterns, respectively (based on Jarabak ratio and Sn-Go-Gn angle). Four parameters, that is, retromolar space, width of third molar, third molar angulation, and mandibular incisor angulation were measured on orthopantomogram whereas arch length discrepancy was calculated with the help of lateral cephalogram and study model. Intragroup, intergroup comparisons (using unpaired Student's 't' test), and Pearson's correlation coefficient for assessed parameters were obtained.</p><p><strong>Result: </strong>Third molar angulation and retromolar space were significantly higher in Group I than in Group II (hyperdivergent pattern of Group II had highest value). The width of third molar was less than retromolar space in Group II and vice versa for Group I. Mandibular incisor angulation and arch length discrepancy were more in Group II than in Group I, but difference was statistically nonsignificant. Strong positive correlation was observed for mandibular third molar angulation and available retromolar space in normo- and hyperdivergent growth patterns.</p><p><strong>Conclusion: </strong>Lack of retromolar space along with increased amount of arch length discrepancy and mandibular incisor angulation is responsible for increased chances of third molar impaction in some subjects with class II malocclusion.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"106-115"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bappaditya Bhattacharjee, Roopal Srivastava, Rajesh Bansal, Naresh K Sharma
{"title":"Fabrication of orbital prosthesis by two different methods in patients with post-COVID-19 rhino-orbital maxillary mucormycosis: A case series.","authors":"Bappaditya Bhattacharjee, Roopal Srivastava, Rajesh Bansal, Naresh K Sharma","doi":"10.4103/njms.njms_183_22","DOIUrl":"https://doi.org/10.4103/njms.njms_183_22","url":null,"abstract":"<p><p>Neoplasms, congenital disorders, fungal infections, and traumatic injuries are the predominant causes of orbital defects. Various retentive mechanisms such as application of adhesive, utilization of mechanical undercuts, and implant-supported attachments are generally used in the maxillofacial prosthesis. In the orbital region, the result of magnet-retained attachments is favorable compared with other mechanisms. Different advantages of the magnet-retained prosthesis are less manual dexterity needed during insertion or removal and better maintenance of hygiene. The skin-implant interface and thick tissues in the maxillofacial region are the critically important points that should be given importance during the planning and placement of implants. Ideally, implant sites for orbital prosthesis are the lateral, infra-, and supraorbital rims of the orbital region. The following case series describes two different methods to rehabilitate patients with an exenterated eye due to mucormycosis by individually designed implant with magnetic attachment and mechanical undercut-retained orbital prosthesis.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"164-167"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saiema Ahmedi, Imran Khan, Samah Ghanem, Nikhat Manzoor
{"title":"Limonene synergistically augments fluconazole susceptibility in clinical <i>Candida</i> isolates from cleft lip and palate patients.","authors":"Saiema Ahmedi, Imran Khan, Samah Ghanem, Nikhat Manzoor","doi":"10.4103/njms.njms_34_23","DOIUrl":"https://doi.org/10.4103/njms.njms_34_23","url":null,"abstract":"<p><strong>Background: </strong>Cleft lip and palate (CLP) patients are prone to Candida infections (oral thrush) mainly due to poor oral hygiene, repetitive surgeries, and orthodontic procedures.</p><p><strong>Aim: </strong>This study was undertaken to evaluate the antifungal efficacy of limonene against clinical Candida isolates from CLP patients.</p><p><strong>Materials and methods: </strong>The antifungal efficacy of limonene was studied alone and in combination with fluconazole (FLC) against six standards, twenty nine FLC sensitive, and three FLC resistant clinical strains using broth dilution, checkerboard microdilution, agar disk diffusion, growth curves, and spot assays.</p><p><strong>Results: </strong>This nontoxic monoterpene gave low minimum inhibitory concentration (MIC) values of 300-375 µg/mL and 500-520 µg/mL for FLC susceptible and FLC resistant strains, respectively. It showed synergistic interaction with FLC in all clinical and standard Candida strains (fractional inhibitory concentration (FIC) index ≤0.5).</p><p><strong>Conclusion: </strong>Significant chemosensitization of FLC was observed even against resistant clinical isolates. Complete suppression of fungal growth was observed when using combinations. Negligible toxicity, easy availability, and potent antifungal properties suggest that limonene and FLC combinations in appropriate doses can make excellent antifungal mouthwashes during CLP treatment pre and post surgery. Impending in vivo studies are needed to validate the present data.</p>","PeriodicalId":101444,"journal":{"name":"National journal of maxillofacial surgery","volume":"15 1","pages":"47-54"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11057589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}