DevicePub Date : 2024-10-18Epub Date: 2024-08-14DOI: 10.1016/j.device.2024.100517
Hen-Wei Huang, Peter R Chai, Seungho Lee, Tom Kerssemakers, Ali Imani, Jack Chen, Marco Heim, Jessica Y Bo, Adam Wentworth, Fokion T Sanoudos-Dramaliotis, Ian Ballinger, Saurav Maji, Matt Murphy, Alexander Alexiev, Gloria H Kang, Niora Fabian, Josh Jenkins, Andrew Pettinari, Keiko Ishida, Jason Li, Siheng Sean You, Alison M Hayward, Anantha Chandrakasan, Giovanni Traverso
{"title":"An implantable system for opioid safety.","authors":"Hen-Wei Huang, Peter R Chai, Seungho Lee, Tom Kerssemakers, Ali Imani, Jack Chen, Marco Heim, Jessica Y Bo, Adam Wentworth, Fokion T Sanoudos-Dramaliotis, Ian Ballinger, Saurav Maji, Matt Murphy, Alexander Alexiev, Gloria H Kang, Niora Fabian, Josh Jenkins, Andrew Pettinari, Keiko Ishida, Jason Li, Siheng Sean You, Alison M Hayward, Anantha Chandrakasan, Giovanni Traverso","doi":"10.1016/j.device.2024.100517","DOIUrl":"10.1016/j.device.2024.100517","url":null,"abstract":"<p><p>Naloxone can effectively rescue victims from opioid overdose, but less than 5% survive due to delayed or absent first responder intervention. Current overdose reversal systems face key limitations, including low user adherence, false positive detection, and slow antidote delivery. Here, we describe a subcutaneously implanted robotic first responder to overcome these challenges. This implantable system for opioid safety continuously monitors vital signs, detecting opioid overdose through an algorithm analyzing the interplay of cardiorespiratory responses. To address battery concerns with continuous monitoring and multi-sensing modality, an adaptive algorithm dynamically adjusts sensor resolution, reducing the need for frequent charging. Furthermore, the implant includes an ultra-rapid naloxone delivery pump, delivering the 10-mg antidote within 10 s. In animal trials, the robotic first responder successfully revived 96% of overdosed pigs (<i>n</i> = 25) within 3.2 min, showcasing its potential to dramatically improve survival rates and combat the opioid epidemic.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"2 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DevicePub Date : 2024-10-18DOI: 10.1016/j.device.2024.100560
Lorenzo Kinnicutt, Leah T Gaeta, Jacob Rogatinsky, Jungjae Lee, Amy Cameron, Amartya J Naik, Donald T Hess, Tommaso Ranzani
{"title":"A soft robotic, modular laparoscopic grasper for atraumatic retraction of the small intestine.","authors":"Lorenzo Kinnicutt, Leah T Gaeta, Jacob Rogatinsky, Jungjae Lee, Amy Cameron, Amartya J Naik, Donald T Hess, Tommaso Ranzani","doi":"10.1016/j.device.2024.100560","DOIUrl":"10.1016/j.device.2024.100560","url":null,"abstract":"<p><p>In order to address the risk of iatrogenic trauma and retraction challenges associated with minimally invasive surgery, we propose a novel laparoscopic grasper equipped with a suction unit and elastomeric actuators that are inherently soft and compliant, as well as sensors to monitor tissue interaction forces. The device complies with laparoscopic size constraints by entering the abdominal cavity in a closed configuration, then expanding upon entry to gently grasp and retract even severely dilated intestinal segments. In order to minimize the usage of surgical access ports and personnel, the end effector of the proposed grasper is designed to detach and be anchored to the abdominal wall to serve as a passive retraction mechanism. Testing has demonstrated the ability of the proposed grasper to hold and retract <i>in vitro</i> and <i>ex vivo</i> intestinal segments in various contexts, including intestines that have been dilated with air and water to represent small bowel distention.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"2 10","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12309402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Photochemical iontronics with multitype ionic signal transmission at single pixel for self-driven color and tridimensional vision","authors":"Puguang Peng, Penghui Shen, Qian Han, Jiajin Liu, Hui Lu, Yanyan Jiao, Feiyao Yang, Houfang Liu, Tian-Ling Ren, Zhong Lin Wang, Di Wei","doi":"10.1016/j.device.2024.100574","DOIUrl":"https://doi.org/10.1016/j.device.2024.100574","url":null,"abstract":"","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 3","pages":"100574-100574"},"PeriodicalIF":0.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DevicePub Date : 2024-09-20Epub Date: 2024-08-22DOI: 10.1016/j.device.2024.100512
Leah T Gaeta, M Deniz Albayrak, Lorenzo Kinnicutt, Susanna Aufrichtig, Pranav Sultania, Hanna Schlegel, Terry D Ellis, Tommaso Ranzani
{"title":"A magnetically controlled soft robotic glove for hand rehabilitation.","authors":"Leah T Gaeta, M Deniz Albayrak, Lorenzo Kinnicutt, Susanna Aufrichtig, Pranav Sultania, Hanna Schlegel, Terry D Ellis, Tommaso Ranzani","doi":"10.1016/j.device.2024.100512","DOIUrl":"10.1016/j.device.2024.100512","url":null,"abstract":"<p><p>For individuals with hand motor function losses, rehabilitation is necessary for regaining strength and range of motion to accomplish daily activities. Typically within a clinical setting, repetitive strength-based and task-specific exercises are prescribed. However, these therapies are generally costly and non-portable, limiting patient accessibility and rendering patient compliance impractical. There is thus a clinical need for a system that is low-cost, portable, and accessible to improve patient compliance and outcomes. This work presents a proof-of-concept magnetically-controlled glove to provide targeted resistance-based rehabilitation for patients with hand motor impairments. The glove is inexpensive, customizable, and portable, allowing for use within a clinic and at home. Customizable resistance is achieved by electropermanent magnets (EPMs), which locally control magnetic attraction of the digits and produce rapid stiffness changes from magnetically induced jamming. Various rehabilitative exercises using the glove are demonstrated and the magnetic fields can be customized to provide necessary resistance.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"2 9","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11864777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}