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Multimodal, wearable sensors with tactile communication capabilities for human and robotic applications. 具有触觉通信能力的多模态可穿戴传感器,适用于人类和机器人应用。
IF 8.7
Device Pub Date : 2026-07-24 DOI: 10.1016/j.device.2026.101245
Baha Erim Uzunoglu, Oluwatobi Ojuade, Kayla Hepler, Mahaboobbatcha Aleem, Rajaram Kaveti, Krish Kathpalia, Kyle Su, Bunyamin Sahin, Veena Misra, Charles Dhong, Lilian C Hsiao, Amay J Bandodkar
{"title":"Multimodal, wearable sensors with tactile communication capabilities for human and robotic applications.","authors":"Baha Erim Uzunoglu, Oluwatobi Ojuade, Kayla Hepler, Mahaboobbatcha Aleem, Rajaram Kaveti, Krish Kathpalia, Kyle Su, Bunyamin Sahin, Veena Misra, Charles Dhong, Lilian C Hsiao, Amay J Bandodkar","doi":"10.1016/j.device.2026.101245","DOIUrl":"10.1016/j.device.2026.101245","url":null,"abstract":"<p><p>We demonstrate a multimodal, wearable device with haptics-based communication that enables wearers to perceive environmental hazards through vibrations. The device monitors gaseous, aerosolized, and aqueous contaminants and conveys threshold events via distinct tactile codes. Energy harvesting with low power sensing methods yield a high-fidelity system with day long operation. Communication can be extended from humans to robots by engineering a soft electronic skin (e-skin) incorporating an array of transducers embedded in silicone that resolves the temporal structure of the tactile codes. On a quadrupedal robot, the e-skin decodes haptic sequences to trigger adaptive re-routing upon detecting chemical hazards, bypassing the need for wireless communication. Our approach introduces a framework in which chemical awareness is communicated physically rather than electronically, opening opportunities for embodied intelligence, distributed sensing, and human-robot interactions.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13410864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3D Printable Suture-Free Bioadhesive Electronic Interface for Hypertension Therapy. 用于高血压治疗的3D打印无缝合线生物粘合剂电子接口。
IF 8.7
Device Pub Date : 2026-07-17 DOI: 10.1016/j.device.2026.101150
Marzia Momin, Salahuddin Ahmed, Arafat Hossain, Jia Sun, Xinyi Wang, Basma AlMahmood, Jiashu Ren, Li-Pang Huang, Umar Farooq, John Bisognano, Tao Zhou
{"title":"3D Printable Suture-Free Bioadhesive Electronic Interface for Hypertension Therapy.","authors":"Marzia Momin, Salahuddin Ahmed, Arafat Hossain, Jia Sun, Xinyi Wang, Basma AlMahmood, Jiashu Ren, Li-Pang Huang, Umar Farooq, John Bisognano, Tao Zhou","doi":"10.1016/j.device.2026.101150","DOIUrl":"https://doi.org/10.1016/j.device.2026.101150","url":null,"abstract":"<p><p>Hypertension is a major global contributor to morbidity and mortality due to uncontrolled blood pressure, leading to cardiovascular, renal, and cerebrovascular complications. Electrical stimulation of the carotid sinus baroreflex (CSB) offers a promising alternative therapy; however, current devices require suture-based fixation, leading to invasive implantation, tissue damage, and poor long-term stability. Here, we report CaroFlex, a next-generation carotid sinus baroreflex activation device that integrates soft, stretchable hydrogel-based electrodes with a bioadhesive interface to achieve suture-free fixation on the carotid sinus. In vivo studies in rats demonstrated its stable adhesion on the carotid sinus and effective baroreflex stimulation without sutures. Through soft and bioadhesive material engineering and a suture-free fixation strategy for stimulating the CSB, CaroFlex establishes a framework for minimally invasive, chronic bioelectronic therapies for hypertension or other cardiovascular disorders.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 7","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wireless, battery-free wearable optoelectronic-colorimetric microfluidic sensor for multiplex sweat analysis. 无线,无电池可穿戴光电比色微流控传感器,用于多重汗液分析。
IF 8.7
Device Pub Date : 2026-05-15 DOI: 10.1016/j.device.2026.101107
Ruihao Song, Seokjoo Cho, Gwangmook Kim, Soyoung Shin, Shukun Yin, Ruixiao Liu, Ruijin Zeng, Jiaobing Tu, Yirui Xiong, Inkyu Park, Wei Gao
{"title":"Wireless, battery-free wearable optoelectronic-colorimetric microfluidic sensor for multiplex sweat analysis.","authors":"Ruihao Song, Seokjoo Cho, Gwangmook Kim, Soyoung Shin, Shukun Yin, Ruixiao Liu, Ruijin Zeng, Jiaobing Tu, Yirui Xiong, Inkyu Park, Wei Gao","doi":"10.1016/j.device.2026.101107","DOIUrl":"10.1016/j.device.2026.101107","url":null,"abstract":"<p><p>Wearable colorimetric biosensors enable noninvasive, real-time monitoring with intuitive readouts, yet most platforms rely on photographing the sensing area, making measurements highly susceptible to ambient light, background reflections, and user-dependent factors from camera angle, distance, and motion. Here, we present a fully integrated wireless, battery-free multi-modal optoelectronic-colorimetric microfluidic system that directly quantifies colorimetric signals in situ, eliminating the need for photography. The device combines a microfluidic patch containing colorimetric sensors for uric acid, alcohol, and pH with a detachable near-field communication (NFC) optoelectronic module comprising custom light-emitting diode (LED)-photodiode pairs for localized illumination and reflectance detection, enabling reading by both the NFC primary antenna and a smartphone. On-body studies in healthy participants and gout patients show robust interference-resistance performance across diverse ambient light levels and human skin tones, and reliable multiplex sweat analysis to track metabolic fluctuations following purine-rich and alcohol-rich diets and to evaluate allopurinol therapy.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 5","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wireless battery-free oxygenation devices enable extended immunosuppression-free islet transplantation in minimally invasive sites. 无线无电池氧合装置可以在微创部位进行无免疫抑制的胰岛移植。
IF 8
Device Pub Date : 2026-05-15 DOI: 10.1016/j.device.2026.101084
Siddharth R Krishnan, Matthew A Bochenek, Jingwen Pan, Shravika Pendyala, Shek Nga Chan, Claudia Liu, Emily Prokop, Nathaniel Hogrebe, Peter D Rios, Daisy Lopez, Shaunak Potdar, Derin Gumustop, Brian S Her, Laura O'Keeffe, Jeffrey R Millman, Jose Oberholzer, Robert Langer, Daniel G Anderson
{"title":"Wireless battery-free oxygenation devices enable extended immunosuppression-free islet transplantation in minimally invasive sites.","authors":"Siddharth R Krishnan, Matthew A Bochenek, Jingwen Pan, Shravika Pendyala, Shek Nga Chan, Claudia Liu, Emily Prokop, Nathaniel Hogrebe, Peter D Rios, Daisy Lopez, Shaunak Potdar, Derin Gumustop, Brian S Her, Laura O'Keeffe, Jeffrey R Millman, Jose Oberholzer, Robert Langer, Daniel G Anderson","doi":"10.1016/j.device.2026.101084","DOIUrl":"https://doi.org/10.1016/j.device.2026.101084","url":null,"abstract":"<p><p>Here, we develop a next-generation wireless, battery-free oxygen generating O<sub>2</sub>-Macrodevice and wearable power transfer platform that can enable long-term immune protection and subcutaneous function of therapeutic cells. We demonstrate this device supports xenogeneic islet transplantation in C57BL/6J mice evidenced by 90-day diabetes reversal and glucose responsiveness <i>in vivo</i>. We also show partial glycemic control via high-density (>8,000 islets/cm<sup>2</sup>) human stem-cell derived islets (SC-islets) without immune-suppression in subcutaneous sites for 90 days. Additionally, we confirmed the device supports allogenic islet cell survival and 90-day diabetic reversal in rats. Finally, we demonstrate 1-month islet survival in a nonhuman primate without the need for immune suppression in the subcutaneous space. Collectively, these results indicate the device supports cell survival and function across multiple transplant models in three species without the need for any immunosuppression or external user intervention. These results represent an important set of advances towards immunosuppression free, minimally invasive islet transplantation.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 5","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13196877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Bioink Homogeneity in Extrusion 3D Bioprinting with Active In Situ Magnetic Mixing. 推进生物墨水均匀性的挤出生物3D打印与主动原位磁混合。
IF 8.7
Device Pub Date : 2026-03-20 DOI: 10.1016/j.device.2025.101044
Ferdows Afghah, Sina Kheiri, Ava Ladd, Farrah Ye, Vera McCoy, Jane Bai, Sonika Kohli, Giovanni Zanderigo, Gabriela de Lima, Ritu Raman
{"title":"Advancing Bioink Homogeneity in Extrusion 3D Bioprinting with Active In Situ Magnetic Mixing.","authors":"Ferdows Afghah, Sina Kheiri, Ava Ladd, Farrah Ye, Vera McCoy, Jane Bai, Sonika Kohli, Giovanni Zanderigo, Gabriela de Lima, Ritu Raman","doi":"10.1016/j.device.2025.101044","DOIUrl":"10.1016/j.device.2025.101044","url":null,"abstract":"<p><p>Maintaining uniform cell and hydrogel distribution in extrusion 3D bioprinting is a critical challenge, especially for long-duration or high-throughput prints. We present a magnetically-actuated mixer (MagMix), a compact modular <i>in situ</i> platform that integrates into standard extrusion bioprinters to actively homogenize bioinks in real-time. MagMix utilizes an internal propeller driven by a servo-controlled external magnet, enabling continuous, active, tunable speed mixing without altering bioink formulation. Computational simulations and experimental validation enable optimizing propeller geometry and mixing parameters. We demonstrate the utility of MagMix across commonly used cellular bioinks with different viscosities to demonstrate that active <i>in situ</i> mixing prevents cell sedimentation, improves cell viability, and eliminates nozzle clogging over extended print sessions while preserving 3D print quality and cell differentiation capacity. MagMix can be readily integrated into any extrusion bioprinting workflow and offers a scalable, bioink-agnostic solution to improve reproducibility and functionality in bioprinted constructs for applications in tissue engineering.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 3","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer. 用于卵巢癌局部分娩和腹膜液取样的可补充腹膜植入物。
IF 8.7
Device Pub Date : 2026-03-20 DOI: 10.1016/j.device.2026.101050
Aoibhin M Sheedy, Mihir Shetty, Anna Weis, Laura E Bendzick, Terran Stenger, Zhenya Ni, Philippa R Kennedy, Jacob A Myers, Niamh Ward, Lesley Trask, Hannah Prendeville, Joanne O'Dwyer, Michael O'Dwyer, Ellen T Roche, Garry P Duffy, Jeffrey S Miller, Melissa A Geller, Eimear B Dolan, Martin Felices
{"title":"A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer.","authors":"Aoibhin M Sheedy, Mihir Shetty, Anna Weis, Laura E Bendzick, Terran Stenger, Zhenya Ni, Philippa R Kennedy, Jacob A Myers, Niamh Ward, Lesley Trask, Hannah Prendeville, Joanne O'Dwyer, Michael O'Dwyer, Ellen T Roche, Garry P Duffy, Jeffrey S Miller, Melissa A Geller, Eimear B Dolan, Martin Felices","doi":"10.1016/j.device.2026.101050","DOIUrl":"10.1016/j.device.2026.101050","url":null,"abstract":"<p><p>Intraperitoneal (i.p.) therapy improves outcomes in abdominal cancers but remains underutilized due to complications from repurposed catheters. In this work, we present a replenishable therapeutic implant for repeated, localized delivery of therapies to the peritoneal cavity. In an ovarian cancer mouse model, expanded natural killer (eNK) cells were delivered once weekly and interleukin-15 (IL-15) thrice weekly. This regime reduced tumor burden compared to standard i.p. injection. The implant supports co-administration of chemotherapy, cytokines, monoclonal antibodies, or other protein-based therapies. Negative pressure applied via the port enabled longitudinal sampling of peritoneal fluid without additional surgical intervention. By reducing procedural burden and improving adaptability, the implant can help increase patient retention and therapeutic efficacy in ovarian cancer and other intra-abdominal cancers.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 3","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-sensor computing with halide perovskite-based optoelectronic reservoir networks. 基于卤化物钙钛矿的光电储层网络传感器内计算。
IF 8.7
Device Pub Date : 2026-02-20 DOI: 10.1016/j.device.2025.101000
Jeroen J de Boer, Agustin O Alvarez, Moritz C Schmidt, Bruno Ehrler
{"title":"In-sensor computing with halide perovskite-based optoelectronic reservoir networks.","authors":"Jeroen J de Boer, Agustin O Alvarez, Moritz C Schmidt, Bruno Ehrler","doi":"10.1016/j.device.2025.101000","DOIUrl":"10.1016/j.device.2025.101000","url":null,"abstract":"<p><p>Physical reservoir computing can provide efficient neuromorphic in- and near-sensor computing applications. Typically, reservoir networks are designed to process light or voltage inputs. Here, we demonstrate a multimodal optoelectronic reservoir network based on halide perovskite semiconductor devices capable of processing voltage and light inputs, which is also scalable for constructing high-density sensor arrays. The devices consist of micrometer-sized, asymmetric crossbars covered with a methylammonium lead iodide (MAPbI<sub>3</sub>) perovskite film. Using 4-bit inputs and linear readout layers for classification, we demonstrate multimodal networks capable of processing both voltage and light inputs. The networks reach mean accuracies up to 95.3% ± 0.1% and 87.8% ± 0.1% for image and video classification, respectively. The networks significantly outperformed linear classifier references by 3.1% for images and 14.6% for video. We show that longer retention times benefit classification accuracy for single-mode networks and give guidelines for choosing optimal experimental parameters.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 2","pages":"101000"},"PeriodicalIF":8.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels. 用于天然血管和工程血管机械特性的压力肌图和心血流模拟器。
IF 8.7
Device Pub Date : 2026-02-20 DOI: 10.1016/j.device.2025.100996
Antonio J PereiraTavares, Liam Aranda-Michel, Scott Hahn, Owen Kaufman, Brian D Coffin, Syed Faaz Ashraf, Jason M Szafron, Adam C Straub, Daniel J Shiwarski
{"title":"Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels.","authors":"Antonio J PereiraTavares, Liam Aranda-Michel, Scott Hahn, Owen Kaufman, Brian D Coffin, Syed Faaz Ashraf, Jason M Szafron, Adam C Straub, Daniel J Shiwarski","doi":"10.1016/j.device.2025.100996","DOIUrl":"10.1016/j.device.2025.100996","url":null,"abstract":"<p><p>Pressure myography, which is the standard for assessing vascular mechanics and vasoreactivity, is expensive, has low throughput, and is limited to static fluid flow. Here, we developed HemoLens, an open-source 3D-printed pressure myography system for < $750. HemoLens features compact micromanipulators, incremental in-line pressure control, physiological temperature regulation, and modular pulse pressure control between normotensive and hypertensive levels. HemoLen's efficacy was demonstrated by delineation of physiological reactivity and pathological mechanical phenotypes using native mouse arteries and bioprinted acellular scaffolds. Engineered hypertensive vessels demonstrate increased burst pressure (464 mmHg) and reduced dynamic compliance reminiscent of diseased arteries. Together, HemoLens lowers the barrier to entry in pressure myography research by serving as a comprehensive low-cost system for native and engineered vessel characterization.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 2","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Continuum Robotic Bioprinter for in situ Vocal Fold Repair. 用于声带原位修复的连续体机器人生物打印机。
IF 8
Device Pub Date : 2026-01-16 DOI: 10.1016/j.device.2025.100973
Swen A T Groen, Sara Nejati, Salwa AlHumaid, Lan Anh Huynh, Karen Kost, Audrey Sedal, Luc Mongeau
{"title":"A Continuum Robotic Bioprinter for <i>in situ</i> Vocal Fold Repair.","authors":"Swen A T Groen, Sara Nejati, Salwa AlHumaid, Lan Anh Huynh, Karen Kost, Audrey Sedal, Luc Mongeau","doi":"10.1016/j.device.2025.100973","DOIUrl":"10.1016/j.device.2025.100973","url":null,"abstract":"<p><p>Phonosurgery to remove large lesions may require the local delivery of wound filling biomaterials, such as hydrogels. Accurate deposition of hydrogels <i>in situ</i> remains challenging, reducing therapeutic efficiency. <i>In-situ</i> bioprinting has demonstrated efficient and accurate hydrogel delivery for skin, bone and, muscle tissue. Here we present a minimally invasive <i>in situ</i> flexible endoscopic bioprinter and demonstrate its ability to deposit adhesive hydrogels onto vocal fold defect models for tissue repair. A data-driven model for real-time control was developed, resulting in highly accurate control of the nozzle-position with a 1.33 mm position error. The printing resolution was 1.2 mm. Functionality of the design was demonstrated by printing 20 mm constructs on a flat surface. Printing functionality was further demonstrated by recreating the natural geometry of the vocal fold body on simulated defects. The results indicate the feasibility for accurate control on the deposition location and distribution of hydrogels on vocal folds.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 1","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13004627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A radically simple, ingestible colorimetric biosensor pill for cost-effective, non-invasive monitoring of intestinal inflammation. 一种简单、可消化的比色生物传感器药丸,用于成本效益高、无创的肠道炎症监测。
IF 8
Device Pub Date : 2025-11-21 DOI: 10.1016/j.device.2025.100865
Zile Zhuang, Lucia L Huang, Bo Chan Seo, Subhashini Pandey, Jeffrey M Karp, Yuhan Lee, Caitlin L Maikawa
{"title":"A radically simple, ingestible colorimetric biosensor pill for cost-effective, non-invasive monitoring of intestinal inflammation.","authors":"Zile Zhuang, Lucia L Huang, Bo Chan Seo, Subhashini Pandey, Jeffrey M Karp, Yuhan Lee, Caitlin L Maikawa","doi":"10.1016/j.device.2025.100865","DOIUrl":"10.1016/j.device.2025.100865","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBDs) affect millions worldwide, necessitating frequent monitoring of intestinal inflammation to optimize treatment strategies. However, current fecal calprotectin tests have low patient adherence, limiting their utility for inflammation monitoring. Here, we developed an ingestible biosensor for simplified at-home detection of a key inflammation biomarker-reactive oxygen species (ROS). Our pill for ROS-responsive inflammation monitoring (PRIM) employs an ROS-responsive polymer that selectively degrades in the presence of ROS. Degradation triggers the release of blue dye into feces for a visually detectable readout without fecal sampling or laboratory analysis. <i>In vitro</i>, PRIM remained stable under healthy conditions and activated only at elevated ROS levels (10-50 mM H<sub>2</sub>O<sub>2</sub>). In rats with colitis, the miniaturized PRIM demonstrated a sensitivity of 78% and a specificity of 72% in detecting intestinal inflammation. With further optimization, PRIM has the potential to improve accessibility and patient adherence to inflammation monitoring and enhance personalized disease management for IBD.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 11","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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