Device最新文献 - Book学术

Automated all-in-one device for handling Magnetic Bead-Based Samples in immunoassays. 用于处理免疫分析中基于磁珠的样品的自动化一体化设备。

IF 8.7

Device Pub Date : 2026-09-18 Epub Date: 2026-07-03 DOI: 10.1016/j.device.2026.101216

Young Kwan Cho, Hyunho Kim, Dae-Han Jung, Haeun Lee, Sang-Hyun Jeon, Hyun-Kyung Woo, Changhyun Kim, Ik-Soo Shin, Hakho Lee

{"title":"Automated all-in-one device for handling Magnetic Bead-Based Samples in immunoassays.","authors":"Young Kwan Cho, Hyunho Kim, Dae-Han Jung, Haeun Lee, Sang-Hyun Jeon, Hyun-Kyung Woo, Changhyun Kim, Ik-Soo Shin, Hakho Lee","doi":"10.1016/j.device.2026.101216","DOIUrl":"10.1016/j.device.2026.101216","url":null,"abstract":"Reliable processing of biospecimens such as plasma in liquid biopsy is crucial to achieving robust analytical results; however, manual procedures involved in sample preparation remain a major source of variability. Here, we present MECHA (Magnetic-Enrichment and Centrifugal-Homogenization Assembly), a fully automated system that standardizes magnetic bead (MB)-based sample handling. MECHA integrates coordinated magnetic actuation, controlled vibration, and orbital mixing to perform target capture, washing, and labeling steps with minimal operator input. The prototype was designed to process eight samples in parallel for electrochemiluminescence (ECL) detection. The signal variation was <10% across replicates. In a pilot analytical study, the MECHA-ECL pipeline enabled quantitative profiling of extracellular vesicles (EVs) from clinical plasma samples of colorectal cancer patients. The automated EV assay achieved a detection limit of 4 × 104 EVs/mL, a dynamic range spanning 4 orders of magnitude, and identified EGFR and CD133 as predictive biomarkers for chemotherapy response.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 9","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149121767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiplex ovarian hormone monitoring in sweat using a dual-aptamer wearable sensor. 使用双适体可穿戴传感器监测汗液中的多重卵巢激素。

IF 8.7

Device Pub Date : 2026-09-11 DOI: 10.1016/j.device.2026.101299

Yerim Lee, Cui Ye, Jeonghee Yeom, Yonglin Chen, Jiahong Li, Jihong Min, Minqiang Wang, Wei Gao

{"title":"Multiplex ovarian hormone monitoring in sweat using a dual-aptamer wearable sensor.","authors":"Yerim Lee, Cui Ye, Jeonghee Yeom, Yonglin Chen, Jiahong Li, Jihong Min, Minqiang Wang, Wei Gao","doi":"10.1016/j.device.2026.101299","DOIUrl":"https://doi.org/10.1016/j.device.2026.101299","url":null,"abstract":"Estradiol (E2) and progesterone (P4) jointly regulate reproductive function, menopausal transition, and hormone-therapy response, yet their assessment relies on intermittent blood sampling that provides only snapshots of dynamic endocrine processes. We report a wearable sweat sensor for multiplex E2 and P4 monitoring. Two redox-orthogonal aptamer-reporter systems, encoded by methylene blue and ferrocene, are integrated on a single inkjet-printed gold electrode, enabling independent quantification of the hormones through sequential square-wave voltammetry scans at physiologically relevant picomolar concentrations. An integrated passive microfluidic module normalizes sweat pH and ionic strength before analysis, eliminating auxiliary correction channels and enabling consistent operation across different sweat-induction methods and body locations. In a single-subject feasibility study spanning reproductive, perimenopausal, and postmenopausal participants, measurements agreed with laboratory reference assays and enabled longitudinal tracking of ovarian hormone dynamics. This approach establishes a strategy for multiplex wearable endocrine profiling and motivates larger cohort studies for personalized women's health monitoring.","PeriodicalId":101324,"journal":{"name":"Device","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordinated control of miniature magnetic pumps for liquid sampling and delivery in a knee implant. 微型磁力泵在膝关节植入物中液体取样和输送的协调控制。

IF 8.7

Device Pub Date : 2026-08-21 DOI: 10.1016/j.device.2026.101203

Honglu Lin, Shengwei Xu, Peixi Xuan, Yusheng Wang, Ruijian Ge, Hanwen Fan, Byron F Stephens, Yuxiao Zhou, Xiaoguang Dong

{"title":"Coordinated control of miniature magnetic pumps for liquid sampling and delivery in a knee implant.","authors":"Honglu Lin, Shengwei Xu, Peixi Xuan, Yusheng Wang, Ruijian Ge, Hanwen Fan, Byron F Stephens, Yuxiao Zhou, Xiaoguang Dong","doi":"10.1016/j.device.2026.101203","DOIUrl":"10.1016/j.device.2026.101203","url":null,"abstract":"Total knee arthroplasty (TKA) is widely used to surgically treat knee arthritis; however, clinical results remain suboptimal, with issues such as infection, aseptic loosening, and implant failure often requiring invasive revision surgery. Existing implants also lack integrated sensing and drug-delivery capabilities due to the challenge of embedding wireless pumps within constrained spaces. Here, we report a next-generation TKA device that integrates miniature magnetic pumps and wireless sensors for closed-loop, on-demand liquid delivery. The pumps are independently actuated by external magnetic fields below 15 mT, enabling simultaneous biofluid sampling and therapeutic release. Joint biofluid properties are monitored continuously, and ~70 μL of liquid can be refilled and delivered via magnetically driven pumping. The implant withstands compressive stresses of ~26.7 MPa, exceeding physiological loads during daily activities. Closed-loop functionality is validated in an ex vivo porcine bone. This device enables continuous implant health monitoring and targeted anti-inflammatory therapy, advancing intelligent orthopedic implants.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 8","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148979118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A monolithic fabrication platform for intrinsically stretchable polymer transistors and complementary circuits. 本构可拉伸聚合物晶体管和互补电路的单片制造平台。

IF 8.7

Device Pub Date : 2026-08-21 DOI: 10.1016/j.device.2026.101204

Yujia Yuan, Chuanzhen Zhao, Margherita Ronchini, Yuya Nishio, Donglai Zhong, Can Wu, Hyukmin Kweon, Zehao Sun, Rachael K Mow, Yuran Shi, Lukas Michalek, Haotian Wu, Qianhe Liu, Weichen Wang, Yating Yao, Zelong Yin, Junyi Zhao, Zihan He, Ke Chen, Ruiheng Wu, Jiuyun Shi, Jian Pei, Zhenan Bao

{"title":"A monolithic fabrication platform for intrinsically stretchable polymer transistors and complementary circuits.","authors":"Yujia Yuan, Chuanzhen Zhao, Margherita Ronchini, Yuya Nishio, Donglai Zhong, Can Wu, Hyukmin Kweon, Zehao Sun, Rachael K Mow, Yuran Shi, Lukas Michalek, Haotian Wu, Qianhe Liu, Weichen Wang, Yating Yao, Zelong Yin, Junyi Zhao, Zihan He, Ke Chen, Ruiheng Wu, Jiuyun Shi, Jian Pei, Zhenan Bao","doi":"10.1016/j.device.2026.101204","DOIUrl":"10.1016/j.device.2026.101204","url":null,"abstract":"Stretchable organic field-effect transistors (OFETs) provide signal conditioning for bioelectronics while offering tunable mechanical and chemical properties, but their fabrication remains materialspecific and difficult to extend to complementary circuits, where sequentially patterning of multiplex semiconductors often degrades device performance. In this work, we introduce a monolithic photolithography process for intrinsically stretchable complementary OFETs and circuits, with high yield, high resolution, and material versatility. This platform combines a directly photopatternable, solvent-resistant crosslinked dielectric/semiconductor interface, crosslinked high-mobility polymer-semiconductor blends, and self-aligned encapsulation that also serves as an etch mask. It patterns multiple p- and n-type polymer semiconductors, achieving a record density of 55,000 OFETs per cm2, 2 μm resolution, and 5 V operation voltages. We fabricated stretchable complementary inverters and 3.3 kHz ring oscillators, the first stretchable complementary OFET oscillators above 1 kHz and >60× faster than state-of-the-art processes, providing a scalable foundation for skin-like electronics.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 8","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13556919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unifying Consent Standards for Implantable Brain-Computer Interfaces. 植入式脑机接口的统一同意标准。

IF 8.7

Device Pub Date : 2026-08-11 DOI: 10.1016/j.device.2026.101271

Michael J Young, Julian D Sandbrink, Laura Y Cabrera, Komal Kampasi, Philip Kennedy, Maryam Masood, Daniel B Rubin, Lynn Brielmaier, Paul Ford

{"title":"Unifying Consent Standards for Implantable Brain-Computer Interfaces.","authors":"Michael J Young, Julian D Sandbrink, Laura Y Cabrera, Komal Kampasi, Philip Kennedy, Maryam Masood, Daniel B Rubin, Lynn Brielmaier, Paul Ford","doi":"10.1016/j.device.2026.101271","DOIUrl":"https://doi.org/10.1016/j.device.2026.101271","url":null,"abstract":"Implantable brain-computer interfaces (iBCIs) are approaching clinical deployment and can transform care for people with speech and motor impairment by restoring their ability in communication, movement, and aspects of agency. As a means of neurological intervention, iBCIs are not ethically or clinically analogous to current clinically established procedures or devices. They combine invasive neurosurgery, continuous neural data capture, adaptive machine-learning-based decoding, software dependence, and functionality that can change over time. These features create distinctive ethical, legal, clinical, and practical challenges that conventional informed consent frameworks do not adequately address. In this review and analysis, we present a framework and checklist to help guide more consistent and comprehensive informed consent for iBCIs to strengthen respect for autonomy, align stakeholder expectations, reduce fragmentation across sites, and support ethically robust translation of iBCIs into clinical practice.","PeriodicalId":101324,"journal":{"name":"Device","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13599423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal, wearable sensors with tactile communication capabilities for human and robotic applications. 具有触觉通信能力的多模态可穿戴传感器，适用于人类和机器人应用。

IF 8.7

Device Pub Date : 2026-07-24 DOI: 10.1016/j.device.2026.101245

Baha Erim Uzunoglu, Oluwatobi Ojuade, Kayla Hepler, Mahaboobbatcha Aleem, Rajaram Kaveti, Krish Kathpalia, Kyle Su, Bunyamin Sahin, Veena Misra, Charles Dhong, Lilian C Hsiao, Amay J Bandodkar

{"title":"Multimodal, wearable sensors with tactile communication capabilities for human and robotic applications.","authors":"Baha Erim Uzunoglu, Oluwatobi Ojuade, Kayla Hepler, Mahaboobbatcha Aleem, Rajaram Kaveti, Krish Kathpalia, Kyle Su, Bunyamin Sahin, Veena Misra, Charles Dhong, Lilian C Hsiao, Amay J Bandodkar","doi":"10.1016/j.device.2026.101245","DOIUrl":"10.1016/j.device.2026.101245","url":null,"abstract":"We demonstrate a multimodal, wearable device with haptics-based communication that enables wearers to perceive environmental hazards through vibrations. The device monitors gaseous, aerosolized, and aqueous contaminants and conveys threshold events via distinct tactile codes. Energy harvesting with low power sensing methods yield a high-fidelity system with day long operation. Communication can be extended from humans to robots by engineering a soft electronic skin (e-skin) incorporating an array of transducers embedded in silicone that resolves the temporal structure of the tactile codes. On a quadrupedal robot, the e-skin decodes haptic sequences to trigger adaptive re-routing upon detecting chemical hazards, bypassing the need for wireless communication. Our approach introduces a framework in which chemical awareness is communicated physically rather than electronically, opening opportunities for embodied intelligence, distributed sensing, and human-robot interactions.","PeriodicalId":101324,"journal":{"name":"Device","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13410864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Printable Suture-Free Bioadhesive Electronic Interface for Hypertension Therapy. 用于高血压治疗的3D打印无缝合线生物粘合剂电子接口。

IF 8.7

Device Pub Date : 2026-07-17 DOI: 10.1016/j.device.2026.101150

Marzia Momin, Salahuddin Ahmed, Arafat Hossain, Jia Sun, Xinyi Wang, Basma AlMahmood, Jiashu Ren, Li-Pang Huang, Umar Farooq, John Bisognano, Tao Zhou

{"title":"3D Printable Suture-Free Bioadhesive Electronic Interface for Hypertension Therapy.","authors":"Marzia Momin, Salahuddin Ahmed, Arafat Hossain, Jia Sun, Xinyi Wang, Basma AlMahmood, Jiashu Ren, Li-Pang Huang, Umar Farooq, John Bisognano, Tao Zhou","doi":"10.1016/j.device.2026.101150","DOIUrl":"https://doi.org/10.1016/j.device.2026.101150","url":null,"abstract":"Hypertension is a major global contributor to morbidity and mortality due to uncontrolled blood pressure, leading to cardiovascular, renal, and cerebrovascular complications. Electrical stimulation of the carotid sinus baroreflex (CSB) offers a promising alternative therapy; however, current devices require suture-based fixation, leading to invasive implantation, tissue damage, and poor long-term stability. Here, we report CaroFlex, a next-generation carotid sinus baroreflex activation device that integrates soft, stretchable hydrogel-based electrodes with a bioadhesive interface to achieve suture-free fixation on the carotid sinus. In vivo studies in rats demonstrated its stable adhesion on the carotid sinus and effective baroreflex stimulation without sutures. Through soft and bioadhesive material engineering and a suture-free fixation strategy for stimulating the CSB, CaroFlex establishes a framework for minimally invasive, chronic bioelectronic therapies for hypertension or other cardiovascular disorders.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 7","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13479738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148804413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interface Design and Material Strategies for High-Fidelity Electrotactile Haptic Displays. 高保真电触觉显示界面设计与材料策略。

IF 8.7

Device Pub Date : 2026-07-03 DOI: 10.1016/j.device.2026.101221

Abdulhameed Abdal, Tarek Rafeedi, Ritwik Vatsyayan, Shadi A Dayeh, Yon Visell, Darren J Lipomi

{"title":"Interface Design and Material Strategies for High-Fidelity Electrotactile Haptic Displays.","authors":"Abdulhameed Abdal, Tarek Rafeedi, Ritwik Vatsyayan, Shadi A Dayeh, Yon Visell, Darren J Lipomi","doi":"10.1016/j.device.2026.101221","DOIUrl":"10.1016/j.device.2026.101221","url":null,"abstract":"Electrotactile devices can convey touch information in wearable and extended reality hardware. They offer cutaneous stimuli while being free from moving parts. Electrotactile systems often yield sensations that are inconsistent, skin-irritating, and unnatural. The dynamism and heterogeneity of skin, the disparate properties between skin and electrode, and the challenge of targeting receptors selectively, can cause the inconsistency in stimulation. Previous research has examined stimulus modulation to address these problems. Recent works, however, expand into electrode design, materials, and mechanics for improved stimulation. Conductive polymer and nano-textured electrodes have reduced and stabilized impedances while minimizing obstruction to wearability. Here, we discuss these challenges and their proposed solutions in literature. We emphasize the role of psychophysical evaluation in obtaining desired tactile percepts. We highlight advancements in electrotactile applications in wearables and interactive surfaces. The convergence of insight in materials, electronics, and perceptual study aims to broaden acceptance and deployment of this technology.","PeriodicalId":101324,"journal":{"name":"Device","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149009758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wireless, battery-free wearable optoelectronic-colorimetric microfluidic sensor for multiplex sweat analysis. 无线，无电池可穿戴光电比色微流控传感器，用于多重汗液分析。

IF 8.7

Device Pub Date : 2026-05-15 DOI: 10.1016/j.device.2026.101107

Ruihao Song, Seokjoo Cho, Gwangmook Kim, Soyoung Shin, Shukun Yin, Ruixiao Liu, Ruijin Zeng, Jiaobing Tu, Yirui Xiong, Inkyu Park, Wei Gao

{"title":"Wireless, battery-free wearable optoelectronic-colorimetric microfluidic sensor for multiplex sweat analysis.","authors":"Ruihao Song, Seokjoo Cho, Gwangmook Kim, Soyoung Shin, Shukun Yin, Ruixiao Liu, Ruijin Zeng, Jiaobing Tu, Yirui Xiong, Inkyu Park, Wei Gao","doi":"10.1016/j.device.2026.101107","DOIUrl":"10.1016/j.device.2026.101107","url":null,"abstract":"Wearable colorimetric biosensors enable noninvasive, real-time monitoring with intuitive readouts, yet most platforms rely on photographing the sensing area, making measurements highly susceptible to ambient light, background reflections, and user-dependent factors from camera angle, distance, and motion. Here, we present a fully integrated wireless, battery-free multi-modal optoelectronic-colorimetric microfluidic system that directly quantifies colorimetric signals in situ, eliminating the need for photography. The device combines a microfluidic patch containing colorimetric sensors for uric acid, alcohol, and pH with a detachable near-field communication (NFC) optoelectronic module comprising custom light-emitting diode (LED)-photodiode pairs for localized illumination and reflectance detection, enabling reading by both the NFC primary antenna and a smartphone. On-body studies in healthy participants and gout patients show robust interference-resistance performance across diverse ambient light levels and human skin tones, and reliable multiplex sweat analysis to track metabolic fluctuations following purine-rich and alcohol-rich diets and to evaluate allopurinol therapy.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 5","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13225623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wireless battery-free oxygenation devices enable extended immunosuppression-free islet transplantation in minimally invasive sites. 无线无电池氧合装置可以在微创部位进行无免疫抑制的胰岛移植。

IF 8

Device Pub Date : 2026-05-15 DOI: 10.1016/j.device.2026.101084

Siddharth R Krishnan, Matthew A Bochenek, Jingwen Pan, Shravika Pendyala, Shek Nga Chan, Claudia Liu, Emily Prokop, Nathaniel Hogrebe, Peter D Rios, Daisy Lopez, Shaunak Potdar, Derin Gumustop, Brian S Her, Laura O'Keeffe, Jeffrey R Millman, Jose Oberholzer, Robert Langer, Daniel G Anderson

{"title":"Wireless battery-free oxygenation devices enable extended immunosuppression-free islet transplantation in minimally invasive sites.","authors":"Siddharth R Krishnan, Matthew A Bochenek, Jingwen Pan, Shravika Pendyala, Shek Nga Chan, Claudia Liu, Emily Prokop, Nathaniel Hogrebe, Peter D Rios, Daisy Lopez, Shaunak Potdar, Derin Gumustop, Brian S Her, Laura O'Keeffe, Jeffrey R Millman, Jose Oberholzer, Robert Langer, Daniel G Anderson","doi":"10.1016/j.device.2026.101084","DOIUrl":"https://doi.org/10.1016/j.device.2026.101084","url":null,"abstract":"Here, we develop a next-generation wireless, battery-free oxygen generating O2-Macrodevice and wearable power transfer platform that can enable long-term immune protection and subcutaneous function of therapeutic cells. We demonstrate this device supports xenogeneic islet transplantation in C57BL/6J mice evidenced by 90-day diabetes reversal and glucose responsiveness in vivo. We also show partial glycemic control via high-density (>8,000 islets/cm2) human stem-cell derived islets (SC-islets) without immune-suppression in subcutaneous sites for 90 days. Additionally, we confirmed the device supports allogenic islet cell survival and 90-day diabetic reversal in rats. Finally, we demonstrate 1-month islet survival in a nonhuman primate without the need for immune suppression in the subcutaneous space. Collectively, these results indicate the device supports cell survival and function across multiple transplant models in three species without the need for any immunosuppression or external user intervention. These results represent an important set of advances towards immunosuppression free, minimally invasive islet transplantation.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 5","pages":""},"PeriodicalIF":8.0,"publicationDate":"2026-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13196877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148019956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0