IF 8.7

Device Pub Date : 2026-03-20 DOI: 10.1016/j.device.2025.101044

Ferdows Afghah, Sina Kheiri, Ava Ladd, Farrah Ye, Vera McCoy, Jane Bai, Sonika Kohli, Giovanni Zanderigo, Gabriela de Lima, Ritu Raman

{"title":"Advancing Bioink Homogeneity in Extrusion 3D Bioprinting with Active In Situ Magnetic Mixing.","authors":"Ferdows Afghah, Sina Kheiri, Ava Ladd, Farrah Ye, Vera McCoy, Jane Bai, Sonika Kohli, Giovanni Zanderigo, Gabriela de Lima, Ritu Raman","doi":"10.1016/j.device.2025.101044","DOIUrl":"10.1016/j.device.2025.101044","url":null,"abstract":"Maintaining uniform cell and hydrogel distribution in extrusion 3D bioprinting is a critical challenge, especially for long-duration or high-throughput prints. We present a magnetically-actuated mixer (MagMix), a compact modular in situ platform that integrates into standard extrusion bioprinters to actively homogenize bioinks in real-time. MagMix utilizes an internal propeller driven by a servo-controlled external magnet, enabling continuous, active, tunable speed mixing without altering bioink formulation. Computational simulations and experimental validation enable optimizing propeller geometry and mixing parameters. We demonstrate the utility of MagMix across commonly used cellular bioinks with different viscosities to demonstrate that active in situ mixing prevents cell sedimentation, improves cell viability, and eliminates nozzle clogging over extended print sessions while preserving 3D print quality and cell differentiation capacity. MagMix can be readily integrated into any extrusion bioprinting workflow and offers a scalable, bioink-agnostic solution to improve reproducibility and functionality in bioprinted constructs for applications in tissue engineering.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 3","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13060750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer. 用于卵巢癌局部分娩和腹膜液取样的可补充腹膜植入物。

IF 8.7

Device Pub Date : 2026-03-20 DOI: 10.1016/j.device.2026.101050

Aoibhin M Sheedy, Mihir Shetty, Anna Weis, Laura E Bendzick, Terran Stenger, Zhenya Ni, Philippa R Kennedy, Jacob A Myers, Niamh Ward, Lesley Trask, Hannah Prendeville, Joanne O'Dwyer, Michael O'Dwyer, Ellen T Roche, Garry P Duffy, Jeffrey S Miller, Melissa A Geller, Eimear B Dolan, Martin Felices

{"title":"A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer.","authors":"Aoibhin M Sheedy, Mihir Shetty, Anna Weis, Laura E Bendzick, Terran Stenger, Zhenya Ni, Philippa R Kennedy, Jacob A Myers, Niamh Ward, Lesley Trask, Hannah Prendeville, Joanne O'Dwyer, Michael O'Dwyer, Ellen T Roche, Garry P Duffy, Jeffrey S Miller, Melissa A Geller, Eimear B Dolan, Martin Felices","doi":"10.1016/j.device.2026.101050","DOIUrl":"10.1016/j.device.2026.101050","url":null,"abstract":"Intraperitoneal (i.p.) therapy improves outcomes in abdominal cancers but remains underutilized due to complications from repurposed catheters. In this work, we present a replenishable therapeutic implant for repeated, localized delivery of therapies to the peritoneal cavity. In an ovarian cancer mouse model, expanded natural killer (eNK) cells were delivered once weekly and interleukin-15 (IL-15) thrice weekly. This regime reduced tumor burden compared to standard i.p. injection. The implant supports co-administration of chemotherapy, cytokines, monoclonal antibodies, or other protein-based therapies. Negative pressure applied via the port enabled longitudinal sampling of peritoneal fluid without additional surgical intervention. By reducing procedural burden and improving adaptability, the implant can help increase patient retention and therapeutic efficacy in ovarian cancer and other intra-abdominal cancers.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 3","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13048345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-sensor computing with halide perovskite-based optoelectronic reservoir networks. 基于卤化物钙钛矿的光电储层网络传感器内计算。

IF 8.7

Device Pub Date : 2026-02-20 DOI: 10.1016/j.device.2025.101000

Jeroen J de Boer, Agustin O Alvarez, Moritz C Schmidt, Bruno Ehrler

{"title":"In-sensor computing with halide perovskite-based optoelectronic reservoir networks.","authors":"Jeroen J de Boer, Agustin O Alvarez, Moritz C Schmidt, Bruno Ehrler","doi":"10.1016/j.device.2025.101000","DOIUrl":"10.1016/j.device.2025.101000","url":null,"abstract":"Physical reservoir computing can provide efficient neuromorphic in- and near-sensor computing applications. Typically, reservoir networks are designed to process light or voltage inputs. Here, we demonstrate a multimodal optoelectronic reservoir network based on halide perovskite semiconductor devices capable of processing voltage and light inputs, which is also scalable for constructing high-density sensor arrays. The devices consist of micrometer-sized, asymmetric crossbars covered with a methylammonium lead iodide (MAPbI3) perovskite film. Using 4-bit inputs and linear readout layers for classification, we demonstrate multimodal networks capable of processing both voltage and light inputs. The networks reach mean accuracies up to 95.3% ± 0.1% and 87.8% ± 0.1% for image and video classification, respectively. The networks significantly outperformed linear classifier references by 3.1% for images and 14.6% for video. We show that longer retention times benefit classification accuracy for single-mode networks and give guidelines for choosing optimal experimental parameters.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 2","pages":"101000"},"PeriodicalIF":8.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels. 用于天然血管和工程血管机械特性的压力肌图和心血流模拟器。

IF 8.7

Device Pub Date : 2026-02-20 DOI: 10.1016/j.device.2025.100996

Antonio J PereiraTavares, Liam Aranda-Michel, Scott Hahn, Owen Kaufman, Brian D Coffin, Syed Faaz Ashraf, Jason M Szafron, Adam C Straub, Daniel J Shiwarski

{"title":"Pressure Myography and Cardiac Flow Simulator for Mechanical Characterization of Native and Engineered Blood Vessels.","authors":"Antonio J PereiraTavares, Liam Aranda-Michel, Scott Hahn, Owen Kaufman, Brian D Coffin, Syed Faaz Ashraf, Jason M Szafron, Adam C Straub, Daniel J Shiwarski","doi":"10.1016/j.device.2025.100996","DOIUrl":"10.1016/j.device.2025.100996","url":null,"abstract":"Pressure myography, which is the standard for assessing vascular mechanics and vasoreactivity, is expensive, has low throughput, and is limited to static fluid flow. Here, we developed HemoLens, an open-source 3D-printed pressure myography system for < $750. HemoLens features compact micromanipulators, incremental in-line pressure control, physiological temperature regulation, and modular pulse pressure control between normotensive and hypertensive levels. HemoLen's efficacy was demonstrated by delineation of physiological reactivity and pathological mechanical phenotypes using native mouse arteries and bioprinted acellular scaffolds. Engineered hypertensive vessels demonstrate increased burst pressure (464 mmHg) and reduced dynamic compliance reminiscent of diseased arteries. Together, HemoLens lowers the barrier to entry in pressure myography research by serving as a comprehensive low-cost system for native and engineered vessel characterization.","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 2","pages":""},"PeriodicalIF":8.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148159842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Continuum Robotic Bioprinter for in situ Vocal Fold Repair. 用于声带原位修复的连续体机器人生物打印机。

IF 8

Device Pub Date : 2026-01-16 DOI: 10.1016/j.device.2025.100973

Swen A T Groen, Sara Nejati, Salwa AlHumaid, Lan Anh Huynh, Karen Kost, Audrey Sedal, Luc Mongeau

引用次数: 0

A radically simple, ingestible colorimetric biosensor pill for cost-effective, non-invasive monitoring of intestinal inflammation. 一种简单、可消化的比色生物传感器药丸，用于成本效益高、无创的肠道炎症监测。

IF 8.7

Device Pub Date : 2025-11-21 DOI: 10.1016/j.device.2025.100865

Zile Zhuang, Lucia L Huang, Bo Chan Seo, Subhashini Pandey, Jeffrey M Karp, Yuhan Lee, Caitlin L Maikawa

{"title":"A radically simple, ingestible colorimetric biosensor pill for cost-effective, non-invasive monitoring of intestinal inflammation.","authors":"Zile Zhuang, Lucia L Huang, Bo Chan Seo, Subhashini Pandey, Jeffrey M Karp, Yuhan Lee, Caitlin L Maikawa","doi":"10.1016/j.device.2025.100865","DOIUrl":"10.1016/j.device.2025.100865","url":null,"abstract":"Inflammatory bowel diseases (IBDs) affect millions worldwide, necessitating frequent monitoring of intestinal inflammation to optimize treatment strategies. However, current fecal calprotectin tests have low patient adherence, limiting their utility for inflammation monitoring. Here, we developed an ingestible biosensor for simplified at-home detection of a key inflammation biomarker-reactive oxygen species (ROS). Our pill for ROS-responsive inflammation monitoring (PRIM) employs an ROS-responsive polymer that selectively degrades in the presence of ROS. Degradation triggers the release of blue dye into feces for a visually detectable readout without fecal sampling or laboratory analysis. In vitro, PRIM remained stable under healthy conditions and activated only at elevated ROS levels (10-50 mM H2O2). In rats with colitis, the miniaturized PRIM demonstrated a sensitivity of 78% and a specificity of 72% in detecting intestinal inflammation. With further optimization, PRIM has the potential to improve accessibility and patient adherence to inflammation monitoring and enhance personalized disease management for IBD.","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 11","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12889894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnetic Soft Robotic Valve for Minimally Invasive Therapy of Gastroesophageal Reflux Disease. 磁性软机器人瓣膜用于胃食管反流病的微创治疗。

IF 8.7

Device Pub Date : 2025-11-21 DOI: 10.1016/j.device.2025.100932

Yi Zhu, Boyang Xiao, Ane Kirk-Jadric, Hanwen Fan, Rishi Naik, Yuxiao Zhou, Xiaoguang Dong

{"title":"Magnetic Soft Robotic Valve for Minimally Invasive Therapy of Gastroesophageal Reflux Disease.","authors":"Yi Zhu, Boyang Xiao, Ane Kirk-Jadric, Hanwen Fan, Rishi Naik, Yuxiao Zhou, Xiaoguang Dong","doi":"10.1016/j.device.2025.100932","DOIUrl":"10.1016/j.device.2025.100932","url":null,"abstract":"Sphincter dysfunction contributes to various diseases, notably in gastroesophageal reflux disease (GERD). Current GERD treatments are limited by side effects, invasive surgical implants, risk of nerve injury, and complications such as dysphagia. To overcome this challenge, we report a magnetic soft robotic valve for minimally invasive treatment of sphincter dysfunction. The valve employs soft magnetic ring-shaped lattice structures that attract each other to form a robust seal, preventing leakage under external pressures exceeding 7.5 kPa, well above typical gastric reflux pressures (3.2 kPa). On-demand valve opening is enabled via a wearable magnetic actuation system, ensuring controlled passage of food. The device withstands radial forces exceeding 3.5 N during simulated peristalsis and is validated through delivery, sealing, and solid-passage tests in esophageal phantom and ex vivo sheep models, visualized using X-ray imaging. The proposed method thus is promising for enabling early, minimally invasive intervention for gastrointestinal and other organ disorders.","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 11","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12646634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical, legal, and social issues related to ingestible, implantable electronic devices and mRNA delivery devices. 与可摄取、可植入的电子设备和mRNA传递设备相关的伦理、法律和社会问题。

IF 8.7

Device Pub Date : 2025-11-21 DOI: 10.1016/j.device.2025.100841

Lisa Bero, Natalie Banacos, Christine M Baugh, Peter R Chai, Tiffany R Glynn, Matthew DeCamp, Ben Harnke, Hannah Scotch, Jelena Durdic, Matthew Wynia, Eric G Campbell

{"title":"Ethical, legal, and social issues related to ingestible, implantable electronic devices and mRNA delivery devices.","authors":"Lisa Bero, Natalie Banacos, Christine M Baugh, Peter R Chai, Tiffany R Glynn, Matthew DeCamp, Ben Harnke, Hannah Scotch, Jelena Durdic, Matthew Wynia, Eric G Campbell","doi":"10.1016/j.device.2025.100841","DOIUrl":"10.1016/j.device.2025.100841","url":null,"abstract":"Oral delivery systems are being developed to treat disease, including ingestible devices that implant in the gut and deliver electrical stimulation or mRNA therapeutics. The implementation of these devices raises questions about the associated ethical, legal, and social implications (ELSIs). Our scoping review examined 83 scholarly publications published between 1946 and 2024 that investigate ELSI topics around the development and use of these technologies. We highlight the characteristics of the publications, the ethics topics mentioned, and a content analysis to describe ELSI themes. Themes particularly relevant to ingestible, implantable electronics and mRNA delivery devices were data use, invasiveness, and possible impacts on patient-clinician trust. This review suggests solutions to better protect patients from ethical and clinical risks resulting from data misuse and future empirical research engaging clinicians, patients, and researchers in this field.","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 11","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12662714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145650785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable organic-electrochemical-transistor-based lithium sensor for precision mental health. 用于精密心理健康的可穿戴有机电化学晶体管锂传感器。

IF 8.7

Device Pub Date : 2025-11-21 DOI: 10.1016/j.device.2025.100862

Mohammad Shafiqul Islam, Brince Paul Kunnel, Munia Ferdoushi, Md Farhad Hassan, Sangwon Cha, Wenxin Cai, Adam Frank, Yasser Khan

{"title":"Wearable organic-electrochemical-transistor-based lithium sensor for precision mental health.","authors":"Mohammad Shafiqul Islam, Brince Paul Kunnel, Munia Ferdoushi, Md Farhad Hassan, Sangwon Cha, Wenxin Cai, Adam Frank, Yasser Khan","doi":"10.1016/j.device.2025.100862","DOIUrl":"10.1016/j.device.2025.100862","url":null,"abstract":"Mental health disorders, including bipolar disorder, pose significant challenges worldwide, necessitating precise monitoring of lithium, a gold-standard medication for this condition. We introduce a fully-printed, wearable Organic-Electrochemical-Transistor (OECT)-based sensor for non-invasive and continuous monitoring of lithium levels in sweat. This sensor integrates inkjet and 3D printing to fabricate multilayer OECTs with an ion-selective membrane, alongside iontophoretic sweat induction and microfluidic guidance for real-time sensing. Our sensor demonstrates sensitivity of ΔI ds /I 0 = 0.5/decade, a 0.1 mM detection limit in artificial sweat and selectivity for lithium over common interfering ions. A complete wearable system with wireless readout enables real-time data transmission to a smartphone interface. Validation in both healthy individuals and bipolar patients confirms the device's ability to detect therapeutically significant lithium levels. This report provides a promising path for precision mental health management, presenting a first-of-its-kind wearable real-time monitoring solution for lithium-a vital medication in treating bipolar disorder.","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 11","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12700067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bistable suction device by shell eversion and snapping for microneedle-mediated transdermal delivery and sampling 用于微针介导的透皮给药和取样的外壳外翻和夹持双稳态吸吸装置

Device Pub Date : 2025-10-31 DOI: 10.1016/j.device.2025.100970

Shaohua Li, Lü Shaojie, Jia Fu, Zhiming Li, Minghui Li, Yanan Shi, Hao Chang

引用次数: 0

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