{"title":"Scalable Bioelectronic Production of Extracellular Vesicles for Cardiac Tissue Regeneration.","authors":"Lingyuan Meng, Jing Zhang, Pengju Li, Wen Li, Jiuyun Shi, Zhe Cheng, Eleanor Ostroff, Chuanwang Yang, Jiping Yue, Aleksander Prominski, Saehyun Kim, Jiwang Chen, Bozhi Tian","doi":"10.1016/j.device.2025.100968","DOIUrl":"10.1016/j.device.2025.100968","url":null,"abstract":"<p><p>EV-based therapies are hindered by low production efficiency and poor scalability. Conventional methods to enhance EV yield-such as hypoxia or chemical stimulation-often compromise vesicle quality and cell health. This study introduces a bioelectronic platform featuring a planar interdigitated electrode array that enables simultaneous low-voltage (±1 V), low-frequency (2 Hz) biphasic stimulation and real-time super-resolution imaging of EV biogenesis via TIRF microscopy. This bioelectrical stimulation on primary cardiac cells significantly increases EV secretion without affecting cell viability. The resulting electrically-induced EVs (e-EVs) exhibit enhanced microRNA cargo-loading capacity, preserved tissue tropism, and functional therapeutic potential. In a murine model of acute myocardial infarction, miRNA-loaded e-EVs improved cardiac function and reduced fibrosis. These results highlight the potential of bioelectronic modulation as a scalable, non- destructive strategy for improving EV yield and functional performance in translational regenerative medicine.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12574593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145433504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DevicePub Date : 2025-10-17DOI: 10.1016/j.device.2025.100894
Graeme F Woodworth, Pavlos Anastasiadis, Ahmad Ozair, Chixiang Chen, Dheeraj Gandhi, Ying Meng, Agessandro Abrahao, Jeffrey S Carpenter, Christopher P Cifarelli, Howard Eisenberg, Mary Jane Lim-Fat, Kullervo Hynynen, Ali R Rezai, Arjun Sahgal, Jason P Sheehan, Erickson Torio, Zhiyuan Xu, Nir Lipsman, Costas Arvantis, Nathan J McDannold, Alexandra J Golby
{"title":"Acoustic emissions dose and spatial control of blood-brain barrier opening with focused ultrasound.","authors":"Graeme F Woodworth, Pavlos Anastasiadis, Ahmad Ozair, Chixiang Chen, Dheeraj Gandhi, Ying Meng, Agessandro Abrahao, Jeffrey S Carpenter, Christopher P Cifarelli, Howard Eisenberg, Mary Jane Lim-Fat, Kullervo Hynynen, Ali R Rezai, Arjun Sahgal, Jason P Sheehan, Erickson Torio, Zhiyuan Xu, Nir Lipsman, Costas Arvantis, Nathan J McDannold, Alexandra J Golby","doi":"10.1016/j.device.2025.100894","DOIUrl":"10.1016/j.device.2025.100894","url":null,"abstract":"<p><p>Focused ultrasound (FUS), when combined with circulating microbubbles (MB), enables transient blood-brain barrier opening (BBBO). Numerous trials using different devices, treatment parameters, and monitoring technologies have created a need for approaches enabling comparative evaluation and standardization of MB-enhanced FUS treatments (MB-FUS). Analyzing 972 MB-FUS sonications performed with closed-feedback loop (CFL) power control in patients with high-grade gliomas, we investigated patient-specific, operator-adjusted, and device-related variables contributing to BBBO with a transcranial multi-element device with integrated acoustic emissions (AE) detectors and image-guidance. Real-time monitoring of AE signals and CFL-controller-automated adaptive adjustment allowed for spatiotemporal power control, along with enabling a dosing paradigm for gauging MB-FUS BBBO treatments. We find that 'AE dose' is an independent, continuous, and robust predictor of BBBO. We identify a dynamic dose range where BBBO increase per unit was maximized. This work provides comprehensive technical descriptions of AE-based CFL control and dosing of transcranial, targeted MB-FUS.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 10","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12700070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DevicePub Date : 2025-09-17DOI: 10.1016/j.device.2025.100925
Han Wu, Jun Li, Hengwei Gong, Hui Liu, Wei Ou‐Yang
{"title":"Swelling-enabled charge compensation in conductive hydrogel for triboelectric tactile sensing via active rehydration","authors":"Han Wu, Jun Li, Hengwei Gong, Hui Liu, Wei Ou‐Yang","doi":"10.1016/j.device.2025.100925","DOIUrl":"https://doi.org/10.1016/j.device.2025.100925","url":null,"abstract":"","PeriodicalId":101324,"journal":{"name":"Device","volume":"4 1","pages":"100925-100925"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147883302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DevicePub Date : 2025-09-17DOI: 10.1016/j.device.2025.100929
Weikang Wang, Yan Bai, Ning Ding, Zhen You, Weiwei Zhao, Pin Yang, Mingli Liang, Shujuan Liu, Qiang Zhao
{"title":"Electron-photon harvesting via built-in electric field modulation in COF/MXene heterointerfaces","authors":"Weikang Wang, Yan Bai, Ning Ding, Zhen You, Weiwei Zhao, Pin Yang, Mingli Liang, Shujuan Liu, Qiang Zhao","doi":"10.1016/j.device.2025.100929","DOIUrl":"https://doi.org/10.1016/j.device.2025.100929","url":null,"abstract":"","PeriodicalId":101324,"journal":{"name":"Device","volume":"3 12","pages":"100929-100929"},"PeriodicalIF":0.0,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147906547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
DevicePub Date : 2025-08-21DOI: 10.1016/j.device.2025.100898
Mingzheng Wu, Kaiqing Zhang, Priscilla J Y Fok, Haohui Zhang, Andrew I Efimov, Yue Wang, Jingyuan Feng, Shupeng Li, Jianyu Gu, Xinyue Lu, Dane Hintermueller, Liangsong Zeng, Jinglan Zhang, Emily A Waters, Tianyu Yang, Jiaqi Liu, Glingna Wang, Zengyao Lv, Yuanting Wei, Yiyuan Yang, Chad R Haney, Yevgenia Kozorovitskiy, Raudel Avila, Abraham Vázquez-Guardado, Yonggang Huang, John A Rogers
{"title":"Analysis and management of thermal loads generated in vivo by miniaturized optoelectronic implantable devices.","authors":"Mingzheng Wu, Kaiqing Zhang, Priscilla J Y Fok, Haohui Zhang, Andrew I Efimov, Yue Wang, Jingyuan Feng, Shupeng Li, Jianyu Gu, Xinyue Lu, Dane Hintermueller, Liangsong Zeng, Jinglan Zhang, Emily A Waters, Tianyu Yang, Jiaqi Liu, Glingna Wang, Zengyao Lv, Yuanting Wei, Yiyuan Yang, Chad R Haney, Yevgenia Kozorovitskiy, Raudel Avila, Abraham Vázquez-Guardado, Yonggang Huang, John A Rogers","doi":"10.1016/j.device.2025.100898","DOIUrl":"10.1016/j.device.2025.100898","url":null,"abstract":"<p><p>Miniaturized implantable optoelectronic technologies for in vivo biomedical applications are gaining interest, but require strict thermal management for safe operation. Here, we introduce a comprehensive framework combining analytical solutions and numerical modeling to estimate and manage thermal effects of optoelectronic devices. We propose Green's functions to analytically solve temperature distributions in tissue from a point source with coupled thermal-optical power, capturing the influence of critical tissue properties and spatiotemporal parameters. Integrating the Green's function derives temperature distributions for sources with definable geometry. Numerical modeling defines scaling factors to account for variations in radiation patterns and material designs, enabling direct performance comparisons across systems. Guided by this framework, iterative optimization of a filamentary optogenetic probe for deep brain stimulation significantly reduces thermal loads while preserving typical behaviors in freely moving mice. Experimental validation through in vitro and in vivo characterization demonstrates scalable strategies to overcome thermal challenges in advanced bio-optoelectronic systems.</p>","PeriodicalId":101324,"journal":{"name":"Device","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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