The mental health clinician最新文献_第3页

Standardized reporting on studies of psychiatric pharmacist interventions. 精神科药剂师干预研究的标准化报告。

The mental health clinician Pub Date : 2024-08-02 eCollection Date: 2024-08-01 DOI: 10.9740/mhc.2024.08.271

Brittany L Parmentier, Jonathan F Lister, Tera D Moore, Kristina Reinstatler, Ranel Troy Santos, Gregory H Payne

引用次数: 0

A review of the impact of sensory processing sensitivity on mental health in university students. 感官加工敏感性对大学生心理健康影响的综述。

The mental health clinician Pub Date : 2024-08-02 eCollection Date: 2024-08-01 DOI: 10.9740/mhc.2024.08.247

Allison Mac, Myo-Kyoung Kim, Rajkumar J Sevak

{"title":"A review of the impact of sensory processing sensitivity on mental health in university students.","authors":"Allison Mac, Myo-Kyoung Kim, Rajkumar J Sevak","doi":"10.9740/mhc.2024.08.247","DOIUrl":"10.9740/mhc.2024.08.247","url":null,"abstract":"Introduction: The concept of sensory processing sensitivity (SPS) was first introduced by Aron and Aron (1996) as an innate trait characterized by heightened processing of sensory, emotional, and physical stimuli. Since the concept's introduction in 1996, high SPS has been shown to be associated with poor physical and mental health. It is possible that this is especially true in university students, who are frequently faced with numerous stressors, such as intense workloads and test anxiety.Methods: This article is a systematic literature review conducted through EBSCOHost using the following databases: Academic Search Complete, APA PsycArticles, APA PsycInfo, Education Research Complete, ERIC, MEDLINE Complete, and SocINDEX. Search terms included terms regarding high sensory processing sensitivity, university or professional students, and mental health.Results: A total of 6 studies were included. University students with high SPS experienced heightened reactions to sensory, emotional, and physical stimuli. The studies demonstrate correlations of high SPS with outcomes such as depressive tendencies and difficulty adjusting to college.Discussion: These findings highlight that SPS is associated with poor mental health outcomes. The results underscore the importance of developing support methods for students with high SPS. Future studies should further explore SPS in university students to develop targeted support methods and programs.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 4","pages":"247-252"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the harm reduction paradigm: the role of Board-Certified Psychiatric Pharmacists. 探索减低伤害范例：获得委员会认证的精神科药剂师的作用。

The mental health clinician Pub Date : 2024-08-02 eCollection Date: 2024-08-01 DOI: 10.9740/mhc.2024.08.253

Amber R Douglass, Ashley Maister, Karen E Moeller, Aaron Salwan, Anuja Vallabh, Kristin Waters, Gregory H Payne

{"title":"Exploring the harm reduction paradigm: the role of Board-Certified Psychiatric Pharmacists.","authors":"Amber R Douglass, Ashley Maister, Karen E Moeller, Aaron Salwan, Anuja Vallabh, Kristin Waters, Gregory H Payne","doi":"10.9740/mhc.2024.08.253","DOIUrl":"10.9740/mhc.2024.08.253","url":null,"abstract":"Deaths related to opioid overdoses continue to climb, and there remains a need for innovative strategies to address this ongoing crisis. Harm reduction (HR), a nonjudgmental philosophy aimed at reducing consequences associated with drug use and other potentially unsafe behavior, has emerged as a compassionate and effective approach. Harm reduction further emphasizes overdose prevention and fosters a shift in perspective that recognizes substance use disorder as a disease and not a moral failing. The tenets of HR collectively advocate for the well-being of individuals who use substances and support any positive change as defined by the individual. Given the high rate of morbidity and mortality associated with substance misuse and barriers or ambivalence to receiving treatment, awareness of and advocacy for HR practice is essential. This manuscript aims to describe evidence-based HR interventions, provide a foundation for the implementation of services, and further promote the importance of providing humanistic care without judgment. As valued members of the multidisciplinary treatment team, Board-Certified Psychiatric Pharmacists should implement and engage in HR services in the settings where people with substance use disorders receive care.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 4","pages":"253-266"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a practice model for inpatient psychiatric clinical pharmacist practitioners with prescriptive authority at a veterans health care facility. 在一家退伍军人医疗保健机构实施具有处方权的住院精神病临床药剂师实践模式。

The mental health clinician Pub Date : 2024-08-02 eCollection Date: 2024-08-01 DOI: 10.9740/mhc.2024.08.267

Chinedu Diokpa, Courtney Givens

{"title":"Implementation of a practice model for inpatient psychiatric clinical pharmacist practitioners with prescriptive authority at a veterans health care facility.","authors":"Chinedu Diokpa, Courtney Givens","doi":"10.9740/mhc.2024.08.267","DOIUrl":"10.9740/mhc.2024.08.267","url":null,"abstract":"Clinical pharmacists play a valuable role on collaborative health care teams, especially in the field of mental health. However, there is a need to explore innovative practice models that optimize their potential in providing comprehensive medication management in inpatient psychiatric settings. This report aims to describe the implementation of a practice model using an inpatient psychiatric clinical pharmacist practitioner performing comprehensive medication management. The implementation of a practice model using a psychiatric clinical pharmacist practitioner was a feasible way to deliver comprehensive medication management and other clinical services in an inpatient psychiatric setting amid staffing challenges. Whereas limitations such as resource constraints must be considered, the success of this model highlights the value of a versatile psychiatric clinical pharmacist practitioner. These findings might offer insight to other health care facilities considering a similar approach to provide mental health care through the use of a psychiatric clinical pharmacist practitioner.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 4","pages":"267-270"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of intramuscular haloperidol and other short-acting injectable antipsychotics for management of acute agitation in an adult inpatient psychiatry unit. 比较肌肉注射氟哌啶醇和其他短效注射型抗精神病药物对成人精神科住院病人急性躁动症的治疗效果。

The mental health clinician Pub Date : 2024-08-02 eCollection Date: 2024-08-01 DOI: 10.9740/mhc.2024.08.242

Sarah Gamcsik, Katie S Adams

{"title":"Comparison of intramuscular haloperidol and other short-acting injectable antipsychotics for management of acute agitation in an adult inpatient psychiatry unit.","authors":"Sarah Gamcsik, Katie S Adams","doi":"10.9740/mhc.2024.08.242","DOIUrl":"10.9740/mhc.2024.08.242","url":null,"abstract":"Introduction: There is no consensus on the optimal antipsychotic for acute agitation. Whereas haloperidol is frequently used and has proven efficacy, second generation antipsychotics show similar efficacy and improved safety and tolerability. This study aimed to determine the effectiveness of short-acting intramuscular (IM) haloperidol versus other IM antipsychotics for acute agitation in adults admitted to an inpatient psychiatry unit.Methods: This was a retrospective medical record review of patients who received 1 or more doses of a short-acting IM antipsychotic, including chlorpromazine, haloperidol, olanzapine, or ziprasidone. The primary endpoint was the need for subsequent IM antipsychotic(s) or physical restraint within 2 hours of the initial IM antipsychotic. Secondary endpoints assessed outcomes at 24 hours and adverse events.Results: One hundred six patients were included. Four patients in the haloperidol group and 0 patients in the other antipsychotic group received an additional IM antipsychotic or required physical restraints within 2 hours (5.3% versus 0%, p = .319). More patients in the other antipsychotic group required an additional dose of IM antipsychotic within 24 hours compared with the haloperidol group (p = .0096). More adverse events were seen in patients who received haloperidol.Discussion: Haloperidol was used more frequently than other short-acting IM antipsychotics. Whereas the effectiveness at 2 hours was not significantly different between groups, patients who received haloperidol were more likely to experience adverse events and were more often subjected to polypharmacy with benzodiazepines and/or diphenhydramine. This study further supports the use of olanzapine and ziprasidone for acute agitation in patients hospitalized in inpatient psychiatry.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 4","pages":"242-246"},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11298034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of alpha-2 agonist versus alpha-1 antagonist for post-traumatic stress disorder-associated nightmares in pediatric patients. 比较α-2受体激动剂和α-1拮抗剂对创伤后应激障碍相关恶梦儿科患者的治疗效果。

The mental health clinician Pub Date : 2024-06-03 eCollection Date: 2024-06-01 DOI: 10.9740/mhc.2024.06.199

Seher Khalid, Sandra Mitchell, Cheryl Al-Mateen

{"title":"Comparison of alpha-2 agonist versus alpha-1 antagonist for post-traumatic stress disorder-associated nightmares in pediatric patients.","authors":"Seher Khalid, Sandra Mitchell, Cheryl Al-Mateen","doi":"10.9740/mhc.2024.06.199","DOIUrl":"10.9740/mhc.2024.06.199","url":null,"abstract":"Introduction: Posttraumatic stress disorder (PTSD) in children and adolescents has a high prevalence of accompanying sleep disturbances. Currently, pediatric treatment of PTSD-related nightmares is extrapolated from adult studies. This study aims to determine the effectiveness and safety of clonidine and guanfacine compared with prazosin for the treatment of PTSD-related nightmares.Methods: This was a retrospective, single-center, medical record review of patients 5 to 17 years old admitted to an inpatient psychiatric unit from January 2015 to September 2021. Patients with a new initiation of an alpha-2 agonist (clonidine or guanfacine) or an alpha-1 antagonist (prazosin) with a diagnosis of PTSD, other trauma- or stressor-related disorder or unspecified anxiety disorder were included. The primary endpoint was the percentage of patients with a decrease in the frequency of nightmares.Results: A total of 59 patients were included in the study: 37 in the alpha-2 agonist group and 22 in the alpha-1 antagonist group. There was no statistically significant difference in reduction of nightmares with both groups having a high percentage of patients showing response (alpha-2 agonist: 91.9%, alpha-1 antagonist: 86.4%). Time to decrease in nightmares was comparable between groups with a relatively quick onset. Within the alpha-2 agonist group, clonidine (1.59 ± 1.06 days) compared with guanfacine (3.18 ± 1.74 days) had a statistically significant faster time to reduction in nightmares (p = .005).Discussion: Both pharmacologic classes of medications were effective treatment options for pediatric PTSD-associated nightmares with a low incidence of adverse effects. There was a quick time to onset seen with all agents.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 3","pages":"199-203"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rural ambulatory care pharmacists providing in-clinic and home visit services improve adherence to long-acting injectable antipsychotics. 提供门诊和家访服务的农村非住院治疗药剂师提高了长效注射抗精神病药物的依从性。

The mental health clinician Pub Date : 2024-06-03 eCollection Date: 2024-06-01 DOI: 10.9740/mhc.2024.06.229

Heng Helen Chang, Laura Michelle Vaughn, Danica Liu

{"title":"Rural ambulatory care pharmacists providing in-clinic and home visit services improve adherence to long-acting injectable antipsychotics.","authors":"Heng Helen Chang, Laura Michelle Vaughn, Danica Liu","doi":"10.9740/mhc.2024.06.229","DOIUrl":"10.9740/mhc.2024.06.229","url":null,"abstract":"Patients with schizophrenia often experience symptoms such as poor insight and disorganized thought, which limit their ability to seek and receive care consistently. In rural settings, systemic factors, including limited resources and transportation, further contribute to difficulties in health care access. Long-acting injectable antipsychotics (LAIs) can improve medication adherence and reduce hospitalizations from relapse. Opportunities exist for pharmacists to provide individualized care and improved health care access. The pilot service took place in ambulatory care clinics and home care settings. Pharmacists performed weekly reviews of patients with active orders for LAIs, coordinated care with nonadherent patients, and offered follow-up appointments in the Patient Centered Medical Home (PCMH). For patients unable to be reached, outreach pharmacists provided psychiatric assessment and LAI medication administration at home visits. There were 10 patients with LAI prescriptions in the past year selected for review. The period reviewed was 90 days before and after start of service. Pharmacist interventions resulted in 4 patients reestablished with care who were previously lost to follow-up. The percentage of days covered by LAI fills increased from an average 26% to 67% of days covered (P = .06). Total emergency room visits related to mental health episodes decreased from 11 to 2 visits (P = .03). Four patients who did not have metabolic lab monitoring in more than 1 year received lab monitoring as indicated. PCMH pharmacy services, including home visits by outreach pharmacists, may improve access and bridge care gaps for patients on LAIs by providing community-based services in addition to traditional clinic-based care.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 3","pages":"229-232"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential influence of estrogen-containing oral contraception on clozapine metabolism in a patient with known pharmacogenomic status. 已知药物基因组状态的患者服用含雌激素口服避孕药对氯氮平代谢的潜在影响。

The mental health clinician Pub Date : 2024-06-03 eCollection Date: 2024-06-01 DOI: 10.9740/mhc.2024.06.220

Alyssa K Kuhn, Meina L Determan, Jessica A Wright, Eric Matey, Jonathan G Leung

{"title":"The potential influence of estrogen-containing oral contraception on clozapine metabolism in a patient with known pharmacogenomic status.","authors":"Alyssa K Kuhn, Meina L Determan, Jessica A Wright, Eric Matey, Jonathan G Leung","doi":"10.9740/mhc.2024.06.220","DOIUrl":"10.9740/mhc.2024.06.220","url":null,"abstract":"Clozapine is primarily metabolized via cytochrome P450(CYP)1A2 and to a lesser extent CYP3A4, CYP2C19, and CYP2D6. Metabolic inhibitors of clozapine, such as fluvoxamine and ciprofloxacin, are important to recognize to avoid adverse drug events. Estrogen-containing oral contraceptives (eOCPs) are weaker CYP1A2 and CYP2C19 inhibitors but are associated with a 2-fold increase of clozapine concentrations. The potential for phenoconversion due to a CYP genetic polymorphism can add additional complexities when considering drug interactions. A case report is presented of a suspected interaction between newly initiated clozapine and a prescribed eOCP for which the patient's pharmacogenomic status was known. A 17-year-old, nonsmoking, White female with a history of schizophrenia was initiated on clozapine 12.5 mg at bedtime with a plan to increase by 25 mg every 4 days in the outpatient setting. The patient was a known rapid CYP1A2 metabolizer without identified sources of CYP1A2 induction and a CYP2C19 rapid metabolizer. Based on pharmacogenomic testing, there was no suspicion for significant gene-drug interactions. Yet, as the patient was prescribed an eOCP, a clozapine concentration was obtained after reaching 150 mg at bedtime. This steady-state clozapine concentration was found to be 560 ng/mL, correlating with worsening sedation and constipation. Given ongoing side effects, clozapine was lowered to 100 mg at bedtime; however, ongoing intolerance ultimately led to clozapine discontinuation. This case highlights the potential interaction between clozapine and eOCP in a CYP1A2 and CYP2C19 rapid metabolizer, leading to clozapine intolerance and discontinuation. The concomitant use of clozapine and eOCPs should be undertaken judiciously.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 3","pages":"220-223"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation and evaluation of interprofessional overdose review team recommendations following intentional or accidental overdose events. 在发生故意或意外用药过量事件后，实施和评估专业间用药过量审查小组的建议。

The mental health clinician Pub Date : 2024-06-03 eCollection Date: 2024-06-01 DOI: 10.9740/mhc.2024.06.224

Monica Barrett, Sarah Kemerer, Michelle Colvard

{"title":"Implementation and evaluation of interprofessional overdose review team recommendations following intentional or accidental overdose events.","authors":"Monica Barrett, Sarah Kemerer, Michelle Colvard","doi":"10.9740/mhc.2024.06.224","DOIUrl":"10.9740/mhc.2024.06.224","url":null,"abstract":"Drug overdose death rates in the United States remain high despite efforts to mitigate this risk. Many communities and hospitals across the country have implemented overdose review teams, including local overdose fatality review teams or postoverdose intervention programs, to address the opioid crisis. The goal of most of these teams is to identify missed opportunities or patient-specific interventions to prevent future opioid overdose fatalities. Few overdose review teams review a combination of both fatal and nonfatal overdose events. The Veterans Affairs Tennessee Valley Healthcare System implemented a novel overdose review team (ORT) that collaboratively reviews all overdose incidents regardless of fatality, intent, or substance involved. This practice description characterizes reported facility overdose events and patient-specific risk-mitigation strategies recommended by the ORT, highlights the implementation rate and time to implementation of ORT recommendations, and discusses potential areas for process improvement. This practice highlights the potential impact of a pharmacist-led, interdisciplinary ORT following accidental or intentional overdose events involving any substance or medication. Key patient-specific interventions implemented following ORT recommendations included overdose prevention education and naloxone distribution, prescribing of medications for opioid use disorder and/or alcohol use disorder, reducing medication supply to limit lethal means access, and facilitation of mental health and/or substance use disorder specialty appointments. Further research to evaluate clinical outcomes related to specific ORT interventions should be considered.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 3","pages":"224-228"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of major adverse events of clozapine based on accordance to an international titration guideline. 根据国际滴定指南评估氯氮平的主要不良反应。

The mental health clinician Pub Date : 2024-06-03 eCollection Date: 2024-06-01 DOI: 10.9740/mhc.2024.06.204

Matthew Nuebel, Jonathan G Leung, Christopher Hughes, Ian McGrane

{"title":"Evaluation of major adverse events of clozapine based on accordance to an international titration guideline.","authors":"Matthew Nuebel, Jonathan G Leung, Christopher Hughes, Ian McGrane","doi":"10.9740/mhc.2024.06.204","DOIUrl":"10.9740/mhc.2024.06.204","url":null,"abstract":"Introduction: Clozapine is the only antipsychotic approved for treatment-resistant schizophrenia, but without appropriate monitoring, it can be associated with potentially fatal outcomes. An International Adult Clozapine Titration Guideline categorizes patients into normal or slow metabolizers. Categorization provides clozapine titration schedules and recommends regular c-reactive protein (CRP) and clozapine concentration monitoring to reduce the risk of adverse drug reactions (ADRs). The impact of the guideline on clozapine ADRs has not been evaluated.Methods: A retrospective chart review assessed clozapine titrations, laboratory monitoring, ADRs, and discontinuations for clozapine-naive adult inpatients at a single center from January 1, 2013, to June 1, 2022. Each patient's cumulative weekly clozapine dosage was compared with their guideline recommended dosage to create a percent accordance. Linear logistic regression evaluated the relationship between titration speed and the presence of an ADR, while descriptive statistics analyzed laboratory monitoring.Results: Forty-three patients were included, with the majority being White males with schizophrenia. An inverse relationship existed between the last inpatient week clozapine dose percent accordance and the probability of an ADR. Nonobese patients were less likely than obese patients to experience an ADR (odds ratio = 0.17; 95% CI, 0.03-0.99). CRP and clozapine concentration monitoring was suboptimal.Discussion: Based on our small retrospective review of primarily White males, more aggressive clozapine titrations did not increase ADRs. Future studies with more diverse samples are needed and should focus on specific ADRs, which may have increased occurrence with rapid titrations. Obese patients were at higher risk of ADRs, correlating with the guideline-recommended slower titrations for these patients.","PeriodicalId":101313,"journal":{"name":"The mental health clinician","volume":"14 3","pages":"204-211"},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0