Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie最新文献_第5页

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-06-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80032-7

R.A. Newman

引用次数: 0

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80009-1

F. Scheiffarth

引用次数: 0

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80016-9

K.E. Schneweis

引用次数: 0

Cell-Mediated Immunity in Lymphocytic Choriomeningitis I. The Specificity of the Cytotoxic T Lymphocytes 淋巴细胞性脉络丛脑膜炎的细胞介导免疫ⅰ。细胞毒性T淋巴细胞的特异性

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80037-6

K. Pfizenmaier , H. Trostmann, M. Röllinghoff, H. Wagner

{"title":"Cell-Mediated Immunity in Lymphocytic Choriomeningitis I. The Specificity of the Cytotoxic T Lymphocytes","authors":"K. Pfizenmaier , H. Trostmann, M. Röllinghoff, H. Wagner","doi":"10.1016/S0300-872X(76)80037-6","DOIUrl":"10.1016/S0300-872X(76)80037-6","url":null,"abstract":"<div><p>The specificity of cytotoxic T lymphocytes (CTL) generated during murine lymphocytec choriomeningitis (LCM) has been investigated. CTL were obtained from the spleens of mice injected i.p. with LCM virus. The cytotoxic activity of the CTL was tested in an in vitro <sup>51</sup>Cr cytotoxicity assay using infected macrophages or fibroblasts as target cells. At the peak of the cytotoxic T cell response (7–8 days after infection) the cytotoxic action was restricted to syngeneic virusinfected target cells. Using H-2 recombinant mice the target antigen of the CTL generated could be identified as products coded for by either the H-2 K or H-2 D region of the major histocompatibility complex. I region identity between CTL and infected target cells was insufficient for optimal lysis to occur. During the early phase of LCM virus infection there was a transient phase during which noninfected H-2 histocompatible targets were lysed as efficiently as virus-infected target cells. This finding may suggest, that during the early phase of LCM disease self-reactive cytotoxic T lymphocytes are temporarily present in LCM virusinfected mice.</p></div>","PeriodicalId":101289,"journal":{"name":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","volume":"151 3","pages":"Pages 224-236"},"PeriodicalIF":0.0,"publicationDate":"1976-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-872X(76)80037-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128279534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80019-4

H. Brandis

引用次数: 0

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80010-8

H. Finger

引用次数: 0

Active Immunization against Tetanus in Man II. Combined Active and Passive Prophylaxis with Human Tetanus Immune Globulin 人破伤风主动免疫。人破伤风免疫球蛋白主动与被动联合预防

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80034-0

K. Ullberg-Olsson , E. Eriksson , R. Lundström , S. Wiholm

引用次数: 2

Active Immunization against Tetanus in Guinea-Pigs An Attempt to Evaluate “Rapid Immunization” with Tetanus Vaccine 豚鼠破伤风主动免疫——破伤风疫苗“快速免疫”评价的尝试

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80007-8

K. Ullberg-Olsson

引用次数: 0

Cell-Mediated Hypersensitivity in Guinea-Pigs Infected with Toxoplasma gondii 刚地弓形虫感染豚鼠细胞介导的超敏反应

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80041-8

Donald D. Ourth , M.N. Lunde , R.R. Watsonč

引用次数: 0

BPO-Specific, Complement-Dependant Cell-Lysis of Differently Sensitized Sheep Red Cells: Evaluation of Haptenic Groups and their Influence on IgM- and IgG-induced Lysis bpo特异性、补体依赖性不同致敏绵羊红细胞的细胞裂解:半抗原组的评价及其对IgM和igg诱导的细胞裂解的影响

Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie Pub Date : 1976-04-01 Epub Date: 2012-03-15 DOI: 10.1016/S0300-872X(76)80008-X

G. Wiedermann , H. Stemberger, O. Förster, M. Müller

{"title":"BPO-Specific, Complement-Dependant Cell-Lysis of Differently Sensitized Sheep Red Cells: Evaluation of Haptenic Groups and their Influence on IgM- and IgG-induced Lysis","authors":"G. Wiedermann , H. Stemberger, O. Förster, M. Müller","doi":"10.1016/S0300-872X(76)80008-X","DOIUrl":"10.1016/S0300-872X(76)80008-X","url":null,"abstract":"<div><p>Sheep erythrocytes were coated with bencylpenicilloyl-(BPO)groups. Different incubation periods resulted in erythrocyte preparations with different hapten density. Complement dependent lysis induced by IgM or IgG antibodies was studied with the cell preparations. The calculation of hapten density on the erythrocyte surface was not possible by direct measurement of coupled radioactive BPO, since more than 90% of radioactive material was found in the soluble supernatant after osmotic cell lysis and less than 10% was fixed to the cellular membrane. Measurement of membrane bound immunologically relevant BPO-groups was achieved, therefore, by comparison of the inhibitory capacity of the test cells with that of a standard cell preparation. The latter consisted of tannic acid treated erythrocytes coated with protein complexed radioactive BPO. Surface hapten density of the different target cell preparations varied between 1.9 × 10<sup>5</sup> and 4.8 × 10<sup>5</sup> BPO-groups per cell depending on the time of incubation. Complement dependent antibody mediated cell lysis was significantly reduced by reduction of haptenic sites per target cell, IgG induced lysis being much more affected than hemolysis induced by IgM antibodies. Statistical calculations led to the conclusion that 18,000 protein islets per cell bearing 4 or more BPO-groups are not sufficient for hemolysis induced by IgG antibodies. 48,000 protein islets with this hapten density are necessary for «optimal« sensitization. IgG antibodies must be apparently bound to the cell surface in bivalent form.</p></div>","PeriodicalId":101289,"journal":{"name":"Zeitschrift für Immunitaetsforschung, Experimentelle und Klinische Immunologie","volume":"151 2","pages":"Pages 173-180"},"PeriodicalIF":0.0,"publicationDate":"1976-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0300-872X(76)80008-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125563809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0