K. Ullberg-Olsson , E. Eriksson , R. Lundström , S. Wiholm
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引用次数: 2
摘要
用吸附破伤风类毒素对19人进行主动免疫，同时给予人源破伤风免疫球蛋白TIG(H)，剂量为500-1500 IU。随访1年。7例患者分别给予TIG(H)、500 IU和1500 IU抗毒素滴度，随访3个月至1年。为了比较，我们按照惯例对30名新兵进行了吸附破伤风类毒素的主动免疫。随访1年。当500 IU或1500 IU TIG(H)与类毒素同时给予时，完全主动免疫的应答不受被动免疫的影响。免疫滴度与对新兵进行主动免疫所达到的滴度一致。
Active Immunization against Tetanus in Man II. Combined Active and Passive Prophylaxis with Human Tetanus Immune Globulin
19 persons were actively immunized with adsorbed tetanus toxoid and were simultaneously given tetanus immune globulin of human origin, TIG(H), in doses of 500-1500 IU. Their antitoxin titres were followed for 1 year. Seven persons were given only TIG(H), 500 IU and 1500 IU and their antitoxin titres were followed for 3 months to 1 year.
For comparison, 30 military recruits were actively immunized with adsorbed tetanus toxoid according to common practice. Their antitoxin titres were followed for 1 year.
The response to complete active immunization could not be demonstrated to be impaired by passive immunization, when 500 IU or 1500 IU of TIG(H) were given simultaneously with toxoid. The titres were in accordance with those achieved by active immunization of the recruits.
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