Veterinary Vaccine最新文献

{"title":"Vaccination of calves at day of birth with attenuated vaccines against bovine respiratory syncytial virus, bovine parainfluenza type 3 virus and respiratory bovine coronavirus","authors":"Mark H. van Rooij ,&nbsp;Mélodie Schmitz ,&nbsp;Joris M.H. Meessen ,&nbsp;Pieter A.W.M. Wouters ,&nbsp;Mieke P. Vrijenhoek ,&nbsp;Birgit Makoschey","doi":"10.1016/j.vetvac.2023.100014","DOIUrl":"https://doi.org/10.1016/j.vetvac.2023.100014","url":null,"abstract":"<div><p>Bovine Respiratory Disease (BRD) is a major cause of calfhood mortality. Bovine Respiratory Syncytial Virus (BRSV), Bovine Parainfluenza 3 Virus (BPIV3), Bovine Herpes Virus-1 (BHV-1), and Bovine Corona Virus (BCV) are major pathogens in BRD outbreaks.</p><p>The importance of early protection of newborn calves is undoubted. The BRD vaccines licensed in Europe can be applied from one or two weeks of age onwards. We have investigated the safety and immunity of a commercial intranasal live BRSV-BPIV3 combination vaccine and a live-attenuated BCV vaccine (in development) in calves at day of birth.</p><p>In the safety study the calves were revaccinated two weeks after the first vaccination. In the efficacy studies, the calves were experimentally infected with field isolates six days (BRSV, study #2), seven days (BPIV3, study #3) and five days (BCV, study #4), post vaccination.</p><p>Animals were monitored for any adverse effects of the vaccination and clinical disease following the challenge infection. Samples were collected and tested for RNA specific for the respective vaccine and challenge viruses. Fourteen days after the BRSV challenge infection, the animals in study #2 were euthanized and a necropsy was performed.</p><p>The frequency and degree of symptoms of abnormal health observed in the safety study, were comparable to those observed in older animals after vaccination with the same vaccines.</p><p>Mild to moderate signs of upper respiratory tract disease (URTD) were the predominant clinical signs after challenge infection. The average scores in the vaccinated groups were lower than in the control groups, but the differences did not reach statistical significance.</p><p>Moreover, the virus load in nasal swabs was significantly lower in the vaccinated group as was the BCV virus load in rectal swab samples taken from the vaccinated animals.</p><p>From the four studies it can be concluded that the vaccines used in these studies can be applied from the day of birth onwards.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"2 1","pages":"Article 100014"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49715889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly(I:C), a double stranded RNA analog, activates the anti-viral DNA sensors in buffalo fibroblasts","authors":"Jatinder Singh Chera ,&nbsp;Sushil Kumar ,&nbsp;Amit Kumar Bairagi ,&nbsp;Amit Kumar ,&nbsp;Prakash Chandra ,&nbsp;Ashutosh Vats ,&nbsp;Murtaza Ali ,&nbsp;Mayank Roshan ,&nbsp;Ranjit Singh Kataria ,&nbsp;Sachinandan De","doi":"10.1016/j.vetvac.2023.100016","DOIUrl":"https://doi.org/10.1016/j.vetvac.2023.100016","url":null,"abstract":"<div><p>Polyinosinic:polycytidylic acid or poly(I:C) is a double stranded RNA analog that is known for stimulating RNA sensing pathways in a variety of cell culture and animal models. Activation of nucleic acid sensing pathways lead to the up-regulation of Interferon-β which ultimately creates an antiviral state in the host. The involvement of intracellular DNA sensors in poly(I:C) mediated immune response has not been extensively explored. Poly(I:C) stimulates the intracellular DNA sensing in addition to RNA sensing pathways in buffalo fibroblasts. Genomic DNA leak into the cytosol due to poly(I:C) is likely to stimulate the intracellular DNA sensing pathways. The mRNA expression of DNA sensors cGAS, IFI16-L (IFI16-like) and DAI are elevated while DDX41 and STING are down-regulated in poly(I:C) treated cells. However, STING activation is evident in poly(I:C) treated cells through the formation of aggregates around the nucleus. IFI16-L also aggregates like STING and translocates from the nucleus to the cytoplasm in response to poly(I:C). The activation of DNA sensors by a dsRNA mimic indicates that mammalian cells can use their own molecules for defending themselves against pathogenic RNA viruses. This provides an opportunity to search for novel therapeutic targets against RNA viruses that evade detection by canonical pattern recognition receptors.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"2 1","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49716078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanisms of suppression of host innate immunity by foot-and-mouth disease virus","authors":"Kangli Li,&nbsp;Xiaodan Wen,&nbsp;Dandan Dong,&nbsp;Zixiang Zhu,&nbsp;Haixue Zheng","doi":"10.1016/j.vetvac.2023.100015","DOIUrl":"https://doi.org/10.1016/j.vetvac.2023.100015","url":null,"abstract":"<div><p>Foot-and-mouth disease (FMD) is an acute and highly contagious animal disease caused by foot-and-mouth disease virus (FMDV). The outbreaks of FMD have brought huge economic losses and the disease has been considered as one of the most harmful infectious diseases to animal husbandry. The invasion of FMDV can be recognized by host immune system and the activated immune responses are responsible for suppression of viral infection and clearance of the virus. In order to maintain fitness and host adaptation, various viruses have evolved multiple elegant strategies to antagonize host immune response. In this review, we elaborated the molecular mechanisms of regulating host immunity by FMDV. We hope this will provide insights for FMD vaccine design, and help prevent and control FMD.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"2 1","pages":"Article 100015"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49715894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine Epidemiology, Evaluation, and Constraints of Vaccine Effectiveness -A Review","authors":"Habtamu Endale, Saliman Aliye, M. Mathewos","doi":"10.1016/j.vetvac.2022.100004","DOIUrl":"https://doi.org/10.1016/j.vetvac.2022.100004","url":null,"abstract":"","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87516840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of the avian coccidiosis vaccine","authors":"Haiming Cai, N. Qi, Juan Li, M. Lv, Xuhui Lin, Junjing Hu, Jianfei Zhang, S. Liao, Mingfei Sun","doi":"10.1016/j.vetvac.2022.100002","DOIUrl":"https://doi.org/10.1016/j.vetvac.2022.100002","url":null,"abstract":"","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"165 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73525529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Newcastle disease virus in poultry with an interface as a human vector","authors":"Deeba Naz, S. Rahman, M. A. Aslam, Faqir Muhammad","doi":"10.1016/j.vetvac.2022.100003","DOIUrl":"https://doi.org/10.1016/j.vetvac.2022.100003","url":null,"abstract":"","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82532102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine epidemiology, evaluation, and constraints of vaccine effectiveness -A review","authors":"Habtamu Endale,&nbsp;Saliman Aliye,&nbsp;Mesfin Mathewos","doi":"10.1016/j.vetvac.2022.100004","DOIUrl":"https://doi.org/10.1016/j.vetvac.2022.100004","url":null,"abstract":"<div><p>Vaccines are all biological substances produced from living things, administered to trigger the host's body defense system to develop immunity against a specific pathogen from which they are produced. They are produced either from the whole organism or parts of it. There are several types of vaccines like live virulent, live attenuated, inactivated (killed), subunit, toxoid, sero-vaccine, and autogenous vaccine. Vaccines work by stimulating either humoral or cell-mediated immunity or both to differentiate. Even though vaccination is the powerful and cost-effective weapon of disease prevention and control of infectious and non infectious diseases, there are factors those, hinder its effectiveness (constraints of vaccine effectiveness). These factors are technical constraints, pathogen-related constraints, vaccine-related factors, host-related and environmental and management-related constraints. While planning a vaccination regimen, it is important to test the potency of the vaccine, whether it much with circulating serotype, availability of cold chain, skilled manpower, the status of the target group and weather condition. Vaccine epidemiology, the study of vaccine interactions and impacts on the epidemiology of vaccine-preventable diseases also has an impact on vaccine effectiveness. it includes basic reproductive number, the force of infection, herd immunity, and epidemiologic shift. Some review papers mostly deal with constraints of specific vaccines and species of animals and with a specific constraint of the vaccine. However, the papers which review all common constraints of vaccine are limited. Therefore, this review paper is to address the most common constraints on the effectiveness of vaccines in all animal species and to highlight on evaluation of vaccine effectiveness and epidemiology.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"1 1","pages":"Article 100004"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277253592200004X/pdfft?md5=7632d8daedf2d115925f0a5cf68802c1&pid=1-s2.0-S277253592200004X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91764852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a plant-produced clade 2.3.4.4 H5 influenza virus-like particle vaccine in layer hens","authors":"C. Abolnik, M. O’Kennedy, M. Murphy, D. B. Wandrag","doi":"10.1016/j.vetvac.2022.100001","DOIUrl":"https://doi.org/10.1016/j.vetvac.2022.100001","url":null,"abstract":"","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86011196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a plant-produced clade 2.3.4.4 H5 influenza virus-like particle vaccine in layer hens","authors":"Celia Abolnik ,&nbsp;Martha M. O'Kennedy ,&nbsp;Mark-Anthony Murphy ,&nbsp;Daniel B.R. Wandrag","doi":"10.1016/j.vetvac.2022.100001","DOIUrl":"https://doi.org/10.1016/j.vetvac.2022.100001","url":null,"abstract":"<div><p>Outbreaks caused by Goose/Guangdong H5 highly pathogenic avian influenza (HPAI)-lineage viruses continue to occur in unprecedented numbers throughout Eurasia, the Middle East and Africa, causing billions of dollars in economic losses and the deaths or destruction of hundreds of millions of poultry, and pose a zoonotic threat. Here, a recombinant virus-like particle (VLP) displaying the hemagglutinin protein of a clade 2.3.4.4b H5N8 HPAI strain was produced in tobacco plants (<em>Nicotiana benthamiana</em>) and its immunogenicity with four commercial adjuvants was compared in layer hens. After two immunizations with 250 hemagglutinating unit doses, hens that received intramuscular injections of H5 VLPs formulated with Emulsigen D, Emulsigen P or Montanide ISA 71VG seroconverted with hemagglutination inhibition geometric mean titres (GMTs) of 7.3 log₂ (± 1.17), 8 log₂ (± 1.08) and 7.9 log₂ (±1.07), respectively, but the GMT of hens inoculated by eye drop with VLPs plus Carbigen only reached 2.05 log₂ (± 1.64). The H5 VLP plus Emulsigen-P vaccinated hens and a sham-vaccinated group were then challenged with a high dose of the homologous H5N8 HPAI virus. Vaccinated hens were completely protected and showed no clinical signs, whereas the sham-vaccinated birds all died within 3–4 days. The average oropharyngeal shedding in vaccinated hens was reduced by 3,487-fold and 472-fold on days 2 and 3 post challenge, respectively, whereas average cloacal shedding was reduced by 2,360,098-fold and 15,608-fold on days 2 and 3, respectively, compared to the sham-vaccinated controls. No virus was detected in the vaccinated hens after day 8 post challenge, and the plant-produced H5 VLP vaccine completely prevented H5N8 HPAI virus transmission to eggs. This highly efficacious, safe and non-toxic plant-produced H5 VLP vaccine with DIVA (differentiation of infected from vaccinated animals) capability could be rapidly produced with a yield of at least 85,000 doses per Kg of plant leaf material.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"1 1","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772535922000014/pdfft?md5=71f1b163e0b4d3cacce22d6129147d25&pid=1-s2.0-S2772535922000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91725347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of the avian coccidiosis vaccine","authors":"Haiming Cai ,&nbsp;Nanshan Qi ,&nbsp;Juan Li,&nbsp;Minna Lv,&nbsp;Xuhui Lin,&nbsp;Junjing Hu,&nbsp;Jianfei Zhang,&nbsp;Shenquan Liao,&nbsp;Mingfei Sun","doi":"10.1016/j.vetvac.2022.100002","DOIUrl":"https://doi.org/10.1016/j.vetvac.2022.100002","url":null,"abstract":"<div><p>Coccidiosis is an intestinal disease of poultry that endangers animal health and causes economic loss to poultry production. For decades, the control of the coccidiosis relies mainly on anticoccidial drugs and live vaccines. However, problems such as widespread of drug resistance, public health pressure after mass administration of anticoccidial drugs, and the risk of expansion of coccidia after administration of live avian coccidiosis vaccine make new anticoccidial alternatives urgent for health development of avian industry. A number of new vaccines have emerged recently, including recombinant vaccines, DNA vaccines and genetically engineered live vaccines. Additionally, various adjuvants, such as DNA adjuvants, recombinant adjuvants, plant-derived adjuvants, probiotics and prebiotics have been evaluated in animal trials. In this article, an overview of the host immune response to avian coccidia is presented, and current vaccine and adjuvant control strategies are outlined as well. It is hoped that this review will contribute to a deeper understanding of avian coccidiosis prevention and control strategies and lay a theoretical foundation in the field.</p></div>","PeriodicalId":101273,"journal":{"name":"Veterinary Vaccine","volume":"1 1","pages":"Article 100002"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772535922000026/pdfft?md5=d4aa34fbd42c8d6dc3ba60bd72f0f3ea&pid=1-s2.0-S2772535922000026-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91764869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}