Supramolecular Materials最新文献_第6页

Optical absorption of supramolecular aggregates of vanadyl etioporphyrin-III in solutions and thin films 溶液和薄膜中香草醛基乙二卟啉-III 超分子聚合体的光学吸收

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.1016/j.supmat.2024.100075

Andrey I. Koptyaev , Ekaterina D. Rychikhina , Yury A. Zhabanov , Vlad V. Travkin , Georgy L. Pakhomov

{"title":"Optical absorption of supramolecular aggregates of vanadyl etioporphyrin-III in solutions and thin films","authors":"Andrey I. Koptyaev , Ekaterina D. Rychikhina , Yury A. Zhabanov , Vlad V. Travkin , Georgy L. Pakhomov","doi":"10.1016/j.supmat.2024.100075","DOIUrl":"10.1016/j.supmat.2024.100075","url":null,"abstract":"<div><div>Relative abundance of vanadyl etio-porphyrin-III, VO-EtioP-III, a typical geoporphyrin, reaches its maximum in solid fossil fuels (coals). This determines the interest in studying supramolecular structure and solid-state properties of this compound. Unlike planar etio-type porphyrins, the visible absorption spectra of VO-EtioP-III undergo significant transformation in transition from a solution to solid films, which is associated with formation of supramolecular aggregates. In this work, we compare the spectra of VO-EtioP-III films deposited by thermal evaporation of powder in vacuum (VTE) or by spin-coating of dissolved compound (SC) to prove that they are similar to those observed for binary solutions in which adding water to methanol also initiates aggregation. The absorption spectra of VTE-films are very sensitive to the film thickness and deposition conditions. The spectral studies are supplemented with analysis of the microscopic morphology and conducting properties of the films. While the photoconductivity of solution-processed VO-EtioP-III films suffers due to the inhomogeneity of their structure, the VTE-films behave as good photoconductors with a lateral current response to sunlight up to 10<sup>5</sup>.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular fluorescence biosensing based on macrocycles 基于大环的超分子荧光生物传感

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-01-16 DOI: 10.1016/j.supmat.2024.100063

Jia-Hong Tian , Haiqi Xu , Xin-Yue Hu , Dong-Sheng Guo

{"title":"Supramolecular fluorescence biosensing based on macrocycles","authors":"Jia-Hong Tian , Haiqi Xu , Xin-Yue Hu , Dong-Sheng Guo","doi":"10.1016/j.supmat.2024.100063","DOIUrl":"https://doi.org/10.1016/j.supmat.2024.100063","url":null,"abstract":"<div><p>Fluorescence sensing converts chemical events into measurable readings by utilizing fluorescence signals for the qualitative or quantitative detection of specific analytes. Supramolecular chemistry, reliant upon non-covalent interactions, has emerged as a potent paradigm for sensing applications, garnering significant scholarly attention. The adoption of supramolecular chemistry within the realm of sensing offers several significant advantages, including easy construction, rapid response, dynamic reversibility, and compatibility with pattern recognition. Notably, molecular recognition stands as a pivotal facet of supramolecular sensing. Among the integral constituents of supramolecular chemistry, an array of macrocyclic compounds boasts remarkable molecular recognition properties, apt for diverse guest molecules, and finds extensive utility in fluorescence sensing. This review highlights the pivotal contributions of fluorescent sensors rooted in crown ethers, cyclodextrins, calixarenes, cucurbiturils, and other macrocycles in single sensing, differential sensing and bioimaging. The versatility of these sensors extends to diverse media, encompassing aqueous environments, buffer solutions, and biofluid matrices. Additionally, this review provides insights into the future endeavors and forthcoming research directions in the field of supramolecular sensing and imaging.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100063"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240524000011/pdfft?md5=96dd51e2b7aed59928f49fce30504427&pid=1-s2.0-S2667240524000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139549813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile preparation of jellyfish-inspired color transition hydrogels via polymerization induced supramolecular geletion (PISG) 通过聚合诱导超分子发生（PISG）多功能制备水母启发的颜色转换水凝胶

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-05-10 DOI: 10.1016/j.supmat.2024.100072

Xiaowei Wang , Boyu Wu , Chen He , Yifan Bai , Chao Gao , Anchao Feng , San H. Thang

{"title":"Versatile preparation of jellyfish-inspired color transition hydrogels via polymerization induced supramolecular geletion (PISG)","authors":"Xiaowei Wang , Boyu Wu , Chen He , Yifan Bai , Chao Gao , Anchao Feng , San H. Thang","doi":"10.1016/j.supmat.2024.100072","DOIUrl":"https://doi.org/10.1016/j.supmat.2024.100072","url":null,"abstract":"<div><p>Supramolecular hydrogels based on host–guest interactions constitute a class of intriguing soft matter and have attracted great attention due to their unique properties, etc. In this study, we successfully synthesized 4-methylene-7-diethylaminocoumarin methacrylate (DEACMMA) monomer and carried out reversible addition-fragmentation chain transfer (RAFT) polymerization using methylated <em>β</em>-cyclodextrin via a host-guest encapsulation mechanism. This process led to the formation of ternary copolymer hydrogel supramolecular photoresponsive hydrogels through polymerization induced supramolecular gelation (PISG). The encapsulation of coumarin monomers by methylated cyclodextrins was confirmed using 2D ROESY NMR and fluorescence spectroscopy. We have carefully analyzed the microstructure of these supramolecular hydrogels by rheological profiles and scanning electron microscopy (SEM). Stimulated by UV light, the copolymers transition from non-luminescence to a bright fluorescent blue color, which is reminiscent of the self-transforming colors observed in jellyfish. The development of photostimuli-responsive hydrogels based on methylated <em>β</em>-cyclodextrin-coated coumarin esters opens new avenues in the fields of smart materials and clinical medicine.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240524000102/pdfft?md5=b10d7130ebe87cac6f8822cbe22b865d&pid=1-s2.0-S2667240524000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphatidylserine-targeting bis(zinc-dipicolylamine) farnesol inhibits ATP production in cancer cells to overcome multidrug resistance 磷脂酰丝氨酸靶向双(锌-二羟基胺)法尼醇抑制癌细胞产生 ATP，克服多药耐药性

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-04-24 DOI: 10.1016/j.supmat.2024.100068

Wei Huang , Xuan Nie , Xiao-Hong Zhou , Lei Qiao , Hong-Jie Gao , Jing Zang , Long-Kang Yu , Long-Hai Wang , Ye-Zi You

{"title":"Phosphatidylserine-targeting bis(zinc-dipicolylamine) farnesol inhibits ATP production in cancer cells to overcome multidrug resistance","authors":"Wei Huang , Xuan Nie , Xiao-Hong Zhou , Lei Qiao , Hong-Jie Gao , Jing Zang , Long-Kang Yu , Long-Hai Wang , Ye-Zi You","doi":"10.1016/j.supmat.2024.100068","DOIUrl":"10.1016/j.supmat.2024.100068","url":null,"abstract":"<div><p>Multidrug resistance significantly impedes the efficacy of cancer chemotherapy. Resistance often arises from the reduced cellular uptake of chemotherapeutic drugs, a process crucial for their cytotoxic effects. This reduction is frequently due to transmembrane efflux pumps powered by ATP from mitochondria and the cytoplasmic matrix, leading to lower intracellular concentrations of these drugs. This study introduces an amphiphilic molecule, bis(zinc-dipicolylamine) farnesol (Bis-ZnDPA), which targets phosphatidylserine (PS) – a negatively charged phospholipid prominently displayed on the outer leaflet of cancer cell plasma membranes. Integrating the hydrophobic segment of Bis-ZnDPA into the plasma membrane disrupts its integrity, potentially leading to hole formation and facilitating the uptake of chemotherapeutic drugs. Furthermore, the binding of Bis-ZnDPA to phosphatidylserine inhibits ATP production caused by Ca<sup>2+</sup> influx and deregulation of the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) signaling pathway, reducing the efflux of drugs from cells. The results indicate the potent synergistic effect of Bis-ZnDPA with chemotherapeutic agents, suggesting that targeting PS is a viable strategy for overcoming multidrug resistance in cancer chemotherapy.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240524000060/pdfft?md5=9e33a692665c2f861924388c7f5e6efd&pid=1-s2.0-S2667240524000060-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen-bonding induced assembly of polymer-grafted nanoparticles towards photothermal antibacterial activities 氢键诱导组装聚合物接枝纳米粒子，实现光热抗菌活性

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-04-09 DOI: 10.1016/j.supmat.2024.100069

Simeng Liu, Zhuo-Ran Yang, Yinhan Xu, Mengmeng Zhang, Hao Jiang, Jiangping Xu, Jintao Zhu

{"title":"Hydrogen-bonding induced assembly of polymer-grafted nanoparticles towards photothermal antibacterial activities","authors":"Simeng Liu, Zhuo-Ran Yang, Yinhan Xu, Mengmeng Zhang, Hao Jiang, Jiangping Xu, Jintao Zhu","doi":"10.1016/j.supmat.2024.100069","DOIUrl":"https://doi.org/10.1016/j.supmat.2024.100069","url":null,"abstract":"<div><p>The multiple hydrogen-bond has been introduced as a reversible driving force for directing the assembly of polymer-grafted nanoparticles (PGNPs). The complementary hydrogen-bonds among the polymer ligands lead to the spontaneous aggregation of PGNPs. However, it may also induce the uncontrollable aggregation of PGNPs into assemblies with non-uniform size, even irregular precipitates, due to the immoderate agglomeration associated with the strong interactions of multiple hydrogen-bonds. This severely limits the stable dispersion of PGNP aggregates in a solvent and their applications. In this work, the gold nanoparticles (AuNPs) grafted with thymine-terminated polystyrene (AuNP@PS-Thy) and diaminopyridine-terminated polystyrene (AuNP@PS-Dap) were synthesized, respectively. Their thermal-responsive assembly behavior in an organic solvent was systematically studied. By optimizing the assembly conditions, i.e., the concentration of PGNPs and the incubation time, the assemblies of AuNP@PS-Thy/AuNP@PS-Dap with controllable size were obtained. Interestingly, the assemblies deposited on a solid substrate showed excellent photothermal antimicrobial activities under irradiation of 808 nm and 655 nm lasers. The killing percentage of <em>Staphylococcus aureus (S. aureus)</em> and <em>Escherichia coli</em> (<em>E. coli</em>) could reach 99 % after irradiating for 10 min. This work establishes an approach for controlling the hydrogen-bonding-induced assembly behavior of PGNPs, which may be extended to construct functional metamaterials with controllable structures.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240524000072/pdfft?md5=8d348ae76cfde10c4a8f5996efa47893&pid=1-s2.0-S2667240524000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140550977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular co-assembled hybrid hydrogels for antibacterial therapy 用于抗菌治疗的超分子共组装混合水凝胶

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-01-15 DOI: 10.1016/j.supmat.2024.100064

Zakia Riaz, Sravan Baddi, Chuan-Liang Feng

{"title":"Supramolecular co-assembled hybrid hydrogels for antibacterial therapy","authors":"Zakia Riaz, Sravan Baddi, Chuan-Liang Feng","doi":"10.1016/j.supmat.2024.100064","DOIUrl":"https://doi.org/10.1016/j.supmat.2024.100064","url":null,"abstract":"<div><p>Bacterial infections arising from antibiotic-resistant strains represent a formidable global health threat. In the realm of antibacterial therapies, supramolecular hydrogels stand out with unique advantages owing to their adaptable and flexible non-covalent interactions with diverse biomolecules. Their ability to encapsulate a variety of biologically active agents through co-assembly further amplifies their efficacy, endowing these hybrid hydrogels with a spectrum of functionalities within a unified system. Various functionalities encompass self-healing, injectability, tissue adhesion, facile drug loading, controlled release mechanisms, biocompatibility, antibacterial properties, and antioxidative attributes. This review article delves into two categories of supramolecular antibacterial hydrogels: i) those with intrinsic antibacterial attributes and ii) supramolecular co-assembled hybrid hydrogels formed through the integration of hydrogels with an assortment of active antibacterial agents, including various nanomaterials, antibiotics, biologically active compounds derived from natural sources, and antibacterial polymers. The anticipated role of supramolecular co-assembled hybrid hydrogels, coupled with contemporary medical technologies and devices, is paramount in the development of highly effective and secure platforms for antibacterial therapy. Furthermore, review addresses the current challenges in the realm of antibacterial hydrogels while elucidating prospective future advancements in this field.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240524000023/pdfft?md5=95b9b2dcb3b390f7bc0192229cbcbd14&pid=1-s2.0-S2667240524000023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139487577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic covalent epoxy network of hyperbranched-synergistic-supramolecular: Catalyst-free reprocessing, and application in carbon fiber composites recycling 超支化-协同-超分子的动态共价环氧网络：无催化剂再加工及在碳纤维复合材料回收中的应用

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-10-30 DOI: 10.1016/j.supmat.2024.100078

Yueran He, Yanlin Liu, Zhen Yu, Xiangyu Zhou, Jin Zhu, Zhaobin Tang

{"title":"Dynamic covalent epoxy network of hyperbranched-synergistic-supramolecular: Catalyst-free reprocessing, and application in carbon fiber composites recycling","authors":"Yueran He, Yanlin Liu, Zhen Yu, Xiangyu Zhou, Jin Zhu, Zhaobin Tang","doi":"10.1016/j.supmat.2024.100078","DOIUrl":"10.1016/j.supmat.2024.100078","url":null,"abstract":"<div><div>Plastic recycling, especially the recycling of thermosets, is a crucial step towards improving waste management and achieving economic recycling. Here, a method utilizing non-covalent supramolecular interactions and synergistic hyperbranched structures is reported to endow transesterification-based thermosetting materials with recyclability in the absence of a catalyst. A hyperbranched epoxy resin curing agent (HPCA) containing amide bonds, terminated by amine and ester, was designed and synthesized, and further cured with bisphenol A epoxy resin. The hyperbranched topological structure and its abundant amide bonds contribute to the formation of a dense hydrogen bonding network, enhancing the reprocessability, thermal, and mechanical properties of the material. As a result, the resin can be reprocessed by hot pressing at 190 °C and 10 MPa for 40 min without catalyst. Moreover, amide and ester bonds endow resin materials with excellent degradation performance in alkaline solutions, laying the foundation for the recycling and utilization of carbon fibers in composite materials.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100078"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain 丝状无膜细胞器在 3UTR 介导的蛋白质-蛋白质界面和定位中的作用TIGER 域

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2023-12-15 DOI: 10.1016/j.supmat.2023.100060

Kashif Rahim , Muhammad Umair , Ihtisham Ul Haq

{"title":"The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain","authors":"Kashif Rahim , Muhammad Umair , Ihtisham Ul Haq","doi":"10.1016/j.supmat.2023.100060","DOIUrl":"https://doi.org/10.1016/j.supmat.2023.100060","url":null,"abstract":"<div><p>Cells contain numerous membrane-less (MLOs) and multiple membrane-bound organelles. Most of the MLOs have a spherical shape except for a few organelles (that have a filamentous appearance, e.g. FXR1 condensates, <span>L</span>-bodies, and TIS granules). Some MLOs form associations with the membrane-bound organelles, such as the endoplasmic reticulum (ER). This fact was recently revealed by the discovery of a new, unique filamentous membrane-less organelle called \"TIS granule\" that was directly interlinked and twisted with the endoplasmic reticulum (ER). The most interesting insight of the TIS granules is that the transcribed genetic information carried by 3′ UTR of mRNA is translated by them, which makes them one of the most crucial sub-cellular organelles. Multiple TIS granules form a reticular meshwork with the endoplasmic reticulum (ER), ultimately creating an inter-organelle space or subcellular compartment known as the \"TIGER Domain\" that is enriched with membrane proteins-encoding mRNAs, some intermediate proteins (e.g. HuR) and a few chaperones. TIGER domain enables 3′ UTR-mediated protein–protein interactions (PPIs) between specific & functionally relevant proteins, such as membrane and 3′ UTR dependent proteins. For more than six decades, only ribosomes were credited as solo membrane-less organelles involved in the cell's translation process. However, this review acknowledges and highlights another less familiar translation companion of the ribosome (i.e. TIS granule) and elaborates on its composition, assembly, morphology and complete functionality in an easily understandable way.</p></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2667240523000302/pdfft?md5=2ab9ef7b4c0830cfb07c7202f84780ad&pid=1-s2.0-S2667240523000302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138839381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorous-tagged bortezomib supramolecular nanomedicine for cancer therapy 用于癌症治疗的氟标记硼替佐米超分子纳米药物

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-11-23 DOI: 10.1016/j.supmat.2024.100080

Changping Wang , Xin Gao , Zhan Li , Xinyu Wang , Yiwen Li , Yiyun Cheng

{"title":"Fluorous-tagged bortezomib supramolecular nanomedicine for cancer therapy","authors":"Changping Wang , Xin Gao , Zhan Li , Xinyu Wang , Yiwen Li , Yiyun Cheng","doi":"10.1016/j.supmat.2024.100080","DOIUrl":"10.1016/j.supmat.2024.100080","url":null,"abstract":"<div><div>Lipidation is a well-established post-translational modification strategy to modulate the structure and function of proteins and peptides. Lipids can improve the overall or local hydrophobicity of the biomolecule, boosting its affinity with the cell membranes. Lipidation, despite its great potential, remains an underutilized technique for translating bioactive molecules into the clinic. Herein, we have optimized the lipidation strategy by involving the fluorous lipidation combined with supramolecular engineering, which can be facilely achieved by grafting an anticancer peptide drug (bortezomib, BTZ) with a series of fluorous lipids bearing a catechol moiety <em>via</em> the dynamic catechol-boronate ester bond. Compared with BTZ, the fluorous-tagged BTZ nanomedicine exhibited an on-demand and traceless release behavior, and enhanced therapeutic effect and biocompatibility. More importantly, the fluorous tag could improve the serum stability of the supramolecular nanomedicine, which allowed efficient <em>in vivo</em> utilization of BTZ to kill cancer cells. This work introduces a novel lipidation strategy for bioactive peptides <em>via</em> the integration of fluorination chemistry and supramolecular engineering strategies.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of a supersoft, ultra-stretchable, and 3D printable hydrogel electrical bioadhesive interface for electromyography monitoring 设计用于肌电图监测的超软、超拉伸和可 3D 打印的水凝胶电生物粘合界面

Supramolecular Materials Pub Date : 2024-12-01 Epub Date: 2024-11-10 DOI: 10.1016/j.supmat.2024.100079

Junxiao Qiu , Hude Ma , Mutian Yao , Manting Song , Liping Zhang , Jingkun Xu , Ximei Liu , Baoyang Lu

{"title":"Design of a supersoft, ultra-stretchable, and 3D printable hydrogel electrical bioadhesive interface for electromyography monitoring","authors":"Junxiao Qiu , Hude Ma , Mutian Yao , Manting Song , Liping Zhang , Jingkun Xu , Ximei Liu , Baoyang Lu","doi":"10.1016/j.supmat.2024.100079","DOIUrl":"10.1016/j.supmat.2024.100079","url":null,"abstract":"<div><div>Electromyography (EMG) monitoring has been extensively employed for critical applications in medicine, sports science, and rehabilitation. However, the mechanical mismatch between conventional EMG electrodes and the skin can lead to electrode detachment upon significant skin deformation. To address this limitation, we develop a PEDOT:PSS-based hydrogel electrical bioadhesive interface (EBI) that incorporates molecular doping and robust adhesion strategies to achieve excellent mechanical compatibility with biological tissues. This hydrogel EBI is fabricated using direct writing of printable inks followed by in-situ thermal initiation, enabling the creation of customizable patterns with high shape fidelity. The resultant 3D-printed PEDOT:PSS-based hydrogel EBI exhibits supersoft properties (Young's modulus 5–8.5 kPa), ultra-stretchability (1175 % strain), robust adhesion (>133 kPa), and outstanding electrochemical performance (CIC reduction by 0.45 % over 1,000,000 cycles). Additionally, we further develop a PEDOT:PSS-based hydrogel electrode specifically for stable EMG signal recording. This electrode outperforms superior signal-to-noise ratio (SNR) performance compared to commercial electrodes in EMG monitoring.</div></div>","PeriodicalId":101187,"journal":{"name":"Supramolecular Materials","volume":"3 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0