{"title":"Epidemiological changes and causes of sudden unexpected death in infancy: A 30-year population-based study in Basque Country","authors":"Eneko Belmonte , Ana Monzó , Benito Morentin","doi":"10.1016/j.remle.2023.03.004","DOIUrl":"https://doi.org/10.1016/j.remle.2023.03.004","url":null,"abstract":"<div><h3>Introduction</h3><p><span>Sudden unexpected deaths in infancy (SUDI) represents a serious </span>public health problem. The objective of this work is to analyze its epidemiological and clinical-pathological characteristics.</p></div><div><h3>Method</h3><p>Retrospective population study of SUDI in Bizkaia between 1991-2020. Data from the Mortality Registry and Forensic Pathology Service were examined.</p></div><div><h3>Results</h3><p><span>1,109 deaths in children under one year were recorded. A forensic autopsy was performed in 107: 61 cases of sudden infant death syndrome (SIDS) and 23 SUDI of explained cause. In other 10 cases SIDS was coded as cause of death without forensic autopsy. The incidence of SIDS was 0.26/1,000/year and decreased from 0.74 (1991-1995 five-year period) to 0.07 (2011-15 and 2016-20 periods). The percentage of SIDS in relation to total mortality decreased from 11.2 to 2.5%. In SIDS, category IB from San Diego (67%) and infants between 1 and 4 months (63%) predominated. An “unsafe sleep environment” was detected in 6 SIDS. 56.5% of the explained SUDI were infectious. Of the 84 autopsied SUDI cases, 70% had no pre-existing disease and 15% were premature and/or low birth weight infants. In 32% there were </span>prodromal symptoms, mainly respiratory tract infection. Microscopic findings suggestive of respiratory infection were diagnosed in 10 SIDS.</p></div><div><h3>Conclusions</h3><p>The incidence of SIDS in Bizkaia is low and has decreased notably in the last 30 years. Prodromal symptoms and histopathological signs suggestive of infection are relatively common. Forensic studies provide relevant data, although prospective multidisciplinary and multicenter research would be desirable.</p></div>","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"49 1","pages":"Pages 11-19"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50193598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. García-Morillo, R. Blanco-Alonso, E. Morales-Ruíz
{"title":"Complement blockade in the management of antineutrophil cytoplasmic antibodyassociated vasculitis","authors":"J. García-Morillo, R. Blanco-Alonso, E. Morales-Ruíz","doi":"10.24875/sjmed.22000008","DOIUrl":"https://doi.org/10.24875/sjmed.22000008","url":null,"abstract":"Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) are characterized by the presence of ANCA, particularly those directed against proteinase 3 (PR3) or myeloperoxidase (MPO). At present, the most accepted pathogenic pathway is based on the pathogenic nature of ANCA, which stimulate neutrophils with the consequent activation of the alternative complement pathway, leading to the production of C5a, an anaphylatoxin which plays a key role in amplifying the inflammatory process in AAV. Remission induction in patients with AAV continues to depend on the use of glucocorticoids (GC) in combination with rituximab or cyclophosphamide. Indeed, there are very limited treatment options and a clear need for strategies that reduce the use of GC without compromising efficacy. Avacopan is the first drug specifically developed for patients with AAV as its mechanism of action inhibits C5aR1, thus acting on one of the pathophysiological mechanisms of AAV.","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73200928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Author-level metrics: h-index and beyond","authors":"J. Porcel, L. Liesa","doi":"10.24875/sjmed.22000011","DOIUrl":"https://doi.org/10.24875/sjmed.22000011","url":null,"abstract":"","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84712354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Rodríguez Trigueros, José Ramón Lopez-Morales, J. A. Alarcón García, S. Rodríguez Suárez, P. Sancho, J. García-Morillo
{"title":"Diagnosis delay, phenotypic variety, and therapeutic outcome of Erdheim-Chester disease","authors":"Andrea Rodríguez Trigueros, José Ramón Lopez-Morales, J. A. Alarcón García, S. Rodríguez Suárez, P. Sancho, J. García-Morillo","doi":"10.24875/sjmed.22000007","DOIUrl":"https://doi.org/10.24875/sjmed.22000007","url":null,"abstract":"","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90264836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Escribano-Serrano, E. Jiménez-Varo, M. Méndez-Esteban, Antonio García-Bonilla, Manuela Márquez-Ferrando, A. Hormigo-Pozo, J. Mancera-Romero, A. Michán-Doña
{"title":"A population-based analysis of insulin management patterns in a province of southern Spain (2014-2018)","authors":"J. Escribano-Serrano, E. Jiménez-Varo, M. Méndez-Esteban, Antonio García-Bonilla, Manuela Márquez-Ferrando, A. Hormigo-Pozo, J. Mancera-Romero, A. Michán-Doña","doi":"10.24875/sjmed.22000005","DOIUrl":"https://doi.org/10.24875/sjmed.22000005","url":null,"abstract":"Aim: The aim of this study was to analyze the patterns of insulin consumption between 2014 and 2018 in Cádiz. Methods: This study was a cross-sectional retrospective study. All people that used any insulin were included in the study. The Cadiz Diabetes Database includes data on yearly anti-diabetic prescriptions and hemoglobin A1c (HbA1c) levels. Results: The prevalence of insulin-users was 2.15%. More prevalent in women and increased with age (0.18% in the 0-15-year-old group to 8.53% in the > 75-year-old group); insulin’ users represent 28.8% of the total population with diabetes mellitus treatments. Seventy percent of insulin-treated patients (ITP) were over 60 years old. Long-acting insulin was consumed by 79% of users, representing 55% of the total insulin types consumed. Glargine was the most consumed (4,654,000 defined daily dose and valuing > 7.000.000€ in 2018). In > 75-year-old group, 50% were treated with long-acting and fast-acting insulin combinations. Annual HbA1c was determined for two out of three ITP and 37% of these had Hb1Ac < 7% (53 mmol/mol). Conclusions: The Cadiz population presents a high consumption of insulin. Insulin prescription patterns have changed during the study. Long-acting insulins, especially Glargine (alone or in combination), are the most widely used types of insulin. In the group of elderly patients, the patterns found are not in line with the current recommendations. ITP in Cadiz has a poor glycemic (median HbA1c 7.84%) control and a low amount of Hb1Ac determinations.","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78989801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The basics of journal-level metrics: What clinical researchers need to know","authors":"J. Porcel, L. Liesa","doi":"10.24875/sjmed.22000010","DOIUrl":"https://doi.org/10.24875/sjmed.22000010","url":null,"abstract":"","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89072632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical errors and communication","authors":"Carlos M. San Román-Terán, R. Gómez-Huelgas","doi":"10.24875/sjmed.22000009","DOIUrl":"https://doi.org/10.24875/sjmed.22000009","url":null,"abstract":"","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72981683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Silvia Cristina Triverio , Manuel Crespillo Márquez
{"title":"The need for cross-border exchange of genetic data for criminal investigation purposes in Latin America: implementation challenges","authors":"Silvia Cristina Triverio , Manuel Crespillo Márquez","doi":"10.1016/j.remle.2022.03.002","DOIUrl":"10.1016/j.remle.2022.03.002","url":null,"abstract":"<div><p>DNA databases for criminal investigation purposes, constitute a tool of indisputable utility in the investigation of criminal acts.</p><p>In the countries of Latin America, there is a progressive advance in the implementation of databases for forensic use. The existing legislation is limited, and it is also heterogeneous both with respect to the crimes included and the procedural situation of the individuals whose DNA is subject to registration. Most of them do not require the accreditation of the forensic laboratories under the ISO 17025 standard. Existing DNA databases currently lack a standard communication regime.</p><p>The establishment of a system of consultation and exchange of genetic data in support of national criminal systems and the prosecution of crimes at the international level, demands cooperation agreements, for which, those implemented in the European Union since 1992, perfected with the decision of Prüm, constitute a valuable reference.</p></div>","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"48 4","pages":"Pages 158-165"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72798744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacobo Salvat Dávila , Juan Salvat Puig , Jesús María Gonçalves Estella , Secundino Vicente González
{"title":"Status of medical information and patient consent in orthopedic surgery and traumatology at the University Hospital of Burgos (period 2017-2018)","authors":"Jacobo Salvat Dávila , Juan Salvat Puig , Jesús María Gonçalves Estella , Secundino Vicente González","doi":"10.1016/j.remle.2022.01.005","DOIUrl":"10.1016/j.remle.2022.01.005","url":null,"abstract":"<div><h3>Introduction</h3><p>The principle of autonomy is the basis of the informed consent<span> concept. Informed consent is a patient´s right consisting in prior to the medical intervention being carried out on his body, he must express his agreement that it must be preceded by the proper information that allows him to decide according to his interests. In this work, our objective was to know the status of medical information and informed consent of the patient in the Traumatology and Orthopedic Surgery Service of the University Hospital of Burgos.</span></p></div><div><h3>Material and methods</h3><p>An anonymous questionnaire was prepared and distributed among 647 orthopedic surgery and trauma patients at the University Hospital of Burgos. Subsequently, a descriptive, cross-sectional, observational quantitative study was carried out. The association of sociodemographic variables with the responses to the questionnaire items was studied.</p></div><div><h3>Results</h3><p>Only 28.9% of the patients know that information is a right, but the majority (97.3%) expressed the need to receive information on risks and complications of the treatment and consider that the information does not increase fear or anxiety (63.4%). The majority stated that they were informed about the care performance (98.1%), understanding the explanations received (98.0%). The time used was sufficient (73.7%). In general, the information received was rated as sufficient (89.8).</p></div><div><h3>Conclusions</h3><p>Most of the patients felt informed and considered that the time that the doctor had had for this was sufficient.</p></div>","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"48 4","pages":"Pages 144-150"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76037254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forensic medicine and human rights","authors":"Josep Arimany-Manso , Amadeo Pujol-Robinat , Eneko Barbería","doi":"10.1016/j.remle.2022.11.001","DOIUrl":"https://doi.org/10.1016/j.remle.2022.11.001","url":null,"abstract":"","PeriodicalId":101178,"journal":{"name":"Spanish Journal of Legal Medicine","volume":"48 4","pages":"Pages 133-135"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137285219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}