Science in One Health最新文献

{"title":"One Health and planetary health research landscapes in the Arab world","authors":"Shaher Zyoud ,&nbsp;Sa'ed H. Zyoud","doi":"10.1016/j.soh.2025.100105","DOIUrl":"10.1016/j.soh.2025.100105","url":null,"abstract":"<div><div>This review explored research trends in One Health and planetary health in the Arab world, a region confronting major sustainability challenges. These fields are crucial in combating global pressing concerns like infectious diseases, biodiversity loss, antimicrobial resistance, climate change, and air pollution. The COVID-19 pandemic stressed their significance to global health and sustainable development. This analysis assessed the Arab world's contributions to these concepts applying performance analysis and visualization mapping, revealing that One Health outperformed planetary health in terms of productivity and number of contributed countries. Egypt, Saudi Arabia, and the United Arab Emirates have emerged as leading contributors to One Health and planetary health research in the Arab world. Meanwhile, the United States and the United Kingdom, as non-Arab nations, play a pivotal role in fostering collaborative efforts with the region. The trajectory of One Health research has indeed shown remarkable exponential growth, especially since the beginning of the COVID-19 pandemic in 2019, which is an indication of increasing relevance in the address of global health challenges. Conversely, planetary health presents an irregular growth pattern, with a strong point in the development of this area standing out in 2023. The unique set of social, cultural, governance, and agricultural attributes of the Arab region are joined by major environmental challenges that define the focus of both One Health and planetary health research efforts. Climate change, environmental contexts, and public health feature prominently in both One Health and planetary health, with One Health focusing mainly on infectious diseases and planetary health addressing the implications of climate change on human health. Advancing these concepts demands the establishment of a regional governing body to oversee an integrated One Health and planetary health strategy, foster regional research communities and alliances, secure political will and funding, and ensure the integration of these concepts into policy and academic frameworks.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nipah virus outbreak trends in Bangladesh during the period 2001 to 2024: a brief review","authors":"Awnon Bhowmik ,&nbsp;Mahmudul Hasan ,&nbsp;Md. Mehedi Hasan Redoy ,&nbsp;Goutam Saha","doi":"10.1016/j.soh.2024.100103","DOIUrl":"10.1016/j.soh.2024.100103","url":null,"abstract":"<div><div>Nipah virus (NiV) is a zoonotic threat that has caused recurrent outbreaks in Bangladesh since 2001, raising significant public health concerns. This study provides a descriptive analysis of NiV outbreaks from 2001 to 2024, examining trends in infection and death rates and their correlation with climatic factors such as temperature, humidity, and rainfall. The findings highlight significant spikes in NiV cases during specific years, with environmental factors, particularly temperature and precipitation, showing solid correlations with outbreak patterns. The study also explores the impact of population dynamics on transmission risks, including urbanization and density. By focusing on these factors, this research supports the development of targeted public health interventions in high-risk areas, particularly in Bangladesh's northwestern and central districts, where recurrent outbreaks have been observed. These insights improve surveillance and preventive strategies for mitigating future NiV outbreaks.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fieldwork on animals living in extreme conditions as a source of biomedical innovation","authors":"Yvon Le Maho ,&nbsp;Aurélie Tasiemski ,&nbsp;Fabrice Bertile ,&nbsp;Philippe Bulet","doi":"10.1016/j.soh.2024.100096","DOIUrl":"10.1016/j.soh.2024.100096","url":null,"abstract":"<div><div>Most biomedical research on animals is based on the handful of the so-called standard model organisms, i.e. laboratory mice, rats or <em>Drosophila</em>, but the keys to some important biomedical questions may simply not be found in these. However, compared with the high number of molecules originating from plants in clinical use, and with the countless unique adaption mechanisms that animals have developed over the course of evolution to cope with environmental constrains, there is still few investigations on wild animals with biomedical objectives, and field studies are far fewer. A major limitation is insufficient funding, the main causes of which we analyze. We argue, however, that fieldwork is a key driver in generating new scientific knowledge as part of a One Health approach, by observing/documenting and understanding the diverse and largely unexplored biological processes evolved by animals adapted to unusual environmental conditions, which would be extreme conditions for humans. These conditions do not only refer to extreme temperatures, since lack of food or water, high pressures or lack of oxygen, are clearly extreme constraints. To conduct this research, there are serious limitations we propose to address. Specific techniques and methods are requested, not only to work in extreme environments, but also to minimize the ecological footprint of field work. The erosion of biodiversity is a major threat. The reduction of animal disturbance, a key issue, requires specific technologies and expertise. An ethical approach is requested, for the sake of transparency and to comply with the Nagoya Protocol on genetic resources. An interdisciplinary expertise and a meticulous planning are requested to overcome the field constraints and interface the associated laboratory work. We recommend focusing on the major threats to global human health today, which wild animals appear to resist particularly well, such as antibioresistance and diseases associated with lifestyle and senescence.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox (monkeypox): a comprehensive updated of current epidemic evidence","authors":"Amir Hossain ,&nbsp;Md. Abdul Monem ,&nbsp;Mamunur Rahman ,&nbsp;Rashadur Raza","doi":"10.1016/j.soh.2024.100100","DOIUrl":"10.1016/j.soh.2024.100100","url":null,"abstract":"<div><div>Mpox, formerly referred to as monkeypox, is a viral disease endemic to central Africa, resulting from the monkeypox virus (MPXV). This study provides a current overview of the Mpox epidemic as of 2024, emphasizing significant developments and epidemiological trends. The World Health Organization (WHO) initially designated a clade Ⅱb outbreak as a global health emergency in May 2022, which was subsequently managed through vaccination and public health interventions by May 2023. In September 2023, a resurgence of cladeⅠ in the Democratic Republic of the Congo (DRC) resulted in a 160 % increase in cases by 2024. The WHO declared this increase a public health emergency of international concern (PHEIC) in August 2024. The outbreak timeline indicates substantial rises in cases and fatalities, especially among children under 15 in the DRC. Regional analysis reveals that the European Region initially recorded the highest incidence of cases and fatalities. In contrast, regions including African Region (AFRO), Eastern Mediterranean Region (EMRO), South-East Asia Region (SEARO), and Western Pacific Region (WPRO) exhibited a rise in cases, indicating a potential spread or resurgence of the health event. Gender disparities in transmission pathways were apparent, with males exhibiting higher case numbers, particularly via person-to-person contact. The research highlights the necessity of ongoing surveillance, global collaboration, and focused public health measures. The discourse addresses obstacles in vaccine distribution and the necessity for emergency use authorizations, highlighting the imperativeness for adaptive strategies in public health management. This extensive update offers critical insights into the present condition of the Mpox epidemic and the necessary measures to mitigate its proliferation.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategy and mechanism of One Health governance: case study of China","authors":"Xinchen Li ,&nbsp;Yanyan Zhang ,&nbsp;Qiyu Zhang ,&nbsp;Jingshu Liu ,&nbsp;Zelin Zhu ,&nbsp;Xinyu Feng ,&nbsp;Lefei Han ,&nbsp;Xiaoxi Zhang","doi":"10.1016/j.soh.2024.100098","DOIUrl":"10.1016/j.soh.2024.100098","url":null,"abstract":"<div><h3>Background</h3><div>Strategy and mechanism are crucial components of One Health governance in China, designed to address the interconnected health issues between humans, animals, and the environment. This study aims to evaluate China's current One Health governance framework, identify key strengths and gaps, and provide recommendations for establishing a more integrated and effective system.</div></div><div><h3>Methods</h3><div>A qualitative approach was employed, including in-depth interviews, policy analysis, and a review of existing literature, to evaluate the strengths and gaps in China's One Health framework.</div></div><div><h3>Results</h3><div>The analysis identified progress and challenges in six key areas: (1) political commitment: strong national support exists, but lacks a unified strategy; (2) legislation and regulation: notable legislative efforts are in place, yet they remain fragmented; (3) leadership building: effective leadership structures have been established during crises but are not institutionalized; (4) strategic planning: initial regional planning is underway, but a comprehensive national focus is needed; (5) coordination and communication: mechanisms exist but require formalized, consistent information-sharing channels; (6) stakeholder engagement: public and academic awareness is growing, yet local community involvement needs strengthening.</div></div><div><h3>Conclusion</h3><div>To advance its One Health governance, China must focus on creating a unified strategy, enhancing interdepartmental coordination, and deepening stakeholder engagement, ensuring its alignment with international standards and improving public health outcomes.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk assessment of emerging infectious diseases in China under the One Health framework","authors":"Ne Qiang ,&nbsp;Tianyun Li ,&nbsp;Lijun Jia ,&nbsp;Zelin Zhu ,&nbsp;Xinyu Feng ,&nbsp;Jinjun Ran ,&nbsp;Xiaoxi Zhang ,&nbsp;Lefei Han","doi":"10.1016/j.soh.2025.100104","DOIUrl":"10.1016/j.soh.2025.100104","url":null,"abstract":"<div><h3>Background</h3><div>Emerging infectious diseases (EIDs) pose significant public health challenges due to increasing interactions between humans, animals, and the environment. The One Health framework, an interdisciplinary and collaborative approach, plays a critical role in the risk assessment of EIDs. The study aims to systematically review the risk assessment of EIDs in China under the One Health framework, covering policy support, monitoring and assessment systems, and implementation methods.</div></div><div><h3>Methods</h3><div>Relevant literature and official documents between 1997 and 2024 were retrieved from Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, Wan Fang, China Science and Technology Journal Database, and government websites. Data were synthesized to analyze progress, challenges, and gaps.</div></div><div><h3>Results</h3><div>There were 43 academic studies and 31 official documents included in this review. The study found that risk assessment systems existed across human, animal, and environmental health sectors in China, and the government was advancing intelligent monitoring and fostering inter-departmental cooperation. However, several challenges remain in risk assessment of EIDs, including inadequate monitoring systems for unknown EIDs, limited capacity building for risk assessment in ecosystems and environmental systems, insufficiently detailed risk assessment guidance at the county level, and barriers to cross-sectoral information sharing at the international and county levels.</div></div><div><h3>Conclusion</h3><div>The findings highlighted the need to enhance risk assessment of EIDs at the local level, expand the scope of disease surveillance including aquatic and wild animals, and strengthen inter-departmental data sharing to improve early warning capabilities under the One Health framework.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated surveillance and early warning system of emerging infectious diseases in China at community level: current status, gaps and perspectives","authors":"Chenjia Zhou ,&nbsp;Suping Wang ,&nbsp;Chenxi Wang ,&nbsp;Ne Qiang ,&nbsp;Leshan Xiu ,&nbsp;Qinqin Hu ,&nbsp;Wenyu Wu ,&nbsp;Xiaoxi Zhang ,&nbsp;Lefei Han ,&nbsp;Xinyu Feng ,&nbsp;Zelin Zhu ,&nbsp;Leilei Shi ,&nbsp;Peng Zhang ,&nbsp;Kun Yin","doi":"10.1016/j.soh.2024.100102","DOIUrl":"10.1016/j.soh.2024.100102","url":null,"abstract":"<div><div>Emerging infectious diseases (EIDs) pose a significant threat to public health. Effective surveillance and early warning systems that monitor EIDs in a timely manner are crucial for their control. Given that more than half of EIDs are zoonotic, traditional integrated surveillance systems remain inadequate. Despite recent advances in integrated systems in China, there are few systemic reviews on the integrated surveillance and early warning system of EIDs at community level, particularly under the One Health framework. Here, this systematic review summarizes the current status of surveillance advances in China, including the multi-trigger integrated monitor system. It also highlights the mechanisms for embedding the One Health approach into local policy and practice, while identifying challenges and opportunities for improvement. Additionally, guidelines and recommendations are proposed to optimize the integration of multi-sectoral, multi-level and interdisciplinary cooperation at the human–animal–environment interface.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and antibiotic resistance patterns of Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from chicken droppings on poultry farms in Gondar city, Northwest Ethiopia","authors":"Mitkie Tigabie ,&nbsp;Muluneh Assefa ,&nbsp;Yalewayker Gashaw ,&nbsp;Azanaw Amare ,&nbsp;Aklilu Ambachew ,&nbsp;Sirak Biset ,&nbsp;Feleke Moges","doi":"10.1016/j.soh.2024.100099","DOIUrl":"10.1016/j.soh.2024.100099","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;&lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; and &lt;em&gt;Acinetobacter baumannii&lt;/em&gt; are common nosocomial pathogens in hospital settings. Recently, they have also been found in non-hospital environments, such as poultry farms. While most studies in Ethiopia have focused on these bacteria's antibiotic resistance patterns in hospitals, information regarding their prevalence and resistance in veterinary settings, particularly poultry farms, is limited. This study aimed to assess the prevalence and antibiotic resistance patterns of &lt;em&gt;P. aeruginosa&lt;/em&gt; and &lt;em&gt;A. baumannii&lt;/em&gt; isolated from chicken droppings on poultry farms.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;A cross-sectional study was conducted from March 2022 to June 2022. A total of 87 poultry farms were included in this study, and pooled chicken dropping samples were collected. The samples were subsequently transferred to buffered peptone water and cultured on MacConkey agar. Species of the isolates were identified via routine biochemical tests, including oxidase, catalase, urease, Simon's citrate, sulfide indole motility medium, triple sugar iron agar and growth at temperatures of 37 °C and 42 °C. The Kirby–Bauer disk diffusion technique was used for antibiotic susceptibility testing. The data were entered into &lt;em&gt;EpiData&lt;/em&gt; version 4.6 and then exported to &lt;em&gt;SPSS&lt;/em&gt; version 26 for analysis. Fisher's exact test was used to observe an appropriate association between independent variables and the occurrence of isolates. The results are presented in the text, figures and tables.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Among the 87 poultry farms, 41 (47.1 %) were positive for &lt;em&gt;Pseudomonas&lt;/em&gt; and &lt;em&gt;Acinetobacter&lt;/em&gt;. Among these strains, 24 (27.6 %) &lt;em&gt;P. aeruginosa&lt;/em&gt; strains and 13 (14.9 %) &lt;em&gt;A. baumannii&lt;/em&gt; strains were recovered. &lt;em&gt;P. aeruginosa&lt;/em&gt; showed complete resistance to tetracycline (24, 100.0 %) and trimethoprim-sulfamethoxazole (24, 100.0 %). Additionally, there was a high rate of resistance to ciprofloxacin (13, 54.2 %) and amikacin (12, 50.0 %). Similarly, 13 (100.0 %) &lt;em&gt;A. baumannii&lt;/em&gt; isolates were resistant to tetracycline, and 12 (92.3 %) were resistant to trimethoprim-sulfamethoxazole. However, both isolates presented lower resistance rates to piperacillin-tazobactam (4, 9.8 %) and cefepime (7, 17.1 %). Both &lt;em&gt;A. baumannii&lt;/em&gt; and &lt;em&gt;P. aeruginosa&lt;/em&gt; exhibited multidrug resistance in 10/13 (76.9 %) and 16/24 (66.7 %) of the strains, respectively. The overall prevalence of multidrug resistance in this study was 28/41 (68.3 %).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;This study demonstrated that poultry farms may be potential reservoirs for &lt;em&gt;P. aeruginosa&lt;/em&gt; and &lt;em&gt;A. baumannii,&lt;/em&gt; including antibiotic-resistant strains. This is a significant concern to public health because poultry farmers may be contaminated, increasing their dissemination to the community. Therefore, poultry farmers should improve sanitation and reduc","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mismatched online public concern and tick-borne disease risk in China","authors":"Yuxin Li ,&nbsp;Tengfei Hu ,&nbsp;Tingting Wang ,&nbsp;Sen Li","doi":"10.1016/j.soh.2024.100101","DOIUrl":"10.1016/j.soh.2024.100101","url":null,"abstract":"<div><h3>Introduction</h3><div>Ticks and tick-borne diseases are increasing public health concerns in China. This study examines public awareness and concern using data from the People Cloud, a national public opinion data platform.</div></div><div><h3>Methods</h3><div>We analyzed 358,862 posts related to ticks, tick bites, Lyme disease, and tick-borne encephalitis from October 2022 to November 2023. Temporal trends and geographic distribution were assessed to identify patterns of public interest.</div></div><div><h3>Results</h3><div>Public concern peaked in April, coinciding with tick season, with “ticks” being the most mentioned term, particularly on social media platforms, such as WeChat. High search activity was concentrated in southeastern and northern provinces, especially Zhejiang, Guangdong, and Jiangsu. Lyme disease posts were more dispersed, while tick-borne encephalitis posts clustered in southern areas.</div></div><div><h3>Conclusion</h3><div>Public interest in ticks follows seasonal and regional trends, reflecting tick activity but not always matching disease risk or tick distribution. Monitoring public opinion data can guide targeted health interventions and improve disease prevention efforts.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of HIV-negative multidrug- and extensively drug-resistant tuberculosis based on Global Burden of Disease Study 2021","authors":"Yiming Chen ,&nbsp;Weiye Chen ,&nbsp;Zile Cheng ,&nbsp;Yiwen Chen ,&nbsp;Min Li ,&nbsp;Lingchao Ma ,&nbsp;Nan Zhou ,&nbsp;Jing Qian ,&nbsp;Yongzhang Zhu ,&nbsp;Chang Liu","doi":"10.1016/j.soh.2024.100072","DOIUrl":"10.1016/j.soh.2024.100072","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB), caused by <em>Mycobacterium tuberculosis</em>, remains the second leading cause of death from a single infectious disease globally and poses a significant economic and clinical burden in the world in 2022. Of particular concern is the emergence of drug-resistant TB, accounting for 15%–20% of TB deaths. It is imperative to delve into the global trends of incidence and death rate for multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), drawing upon the comprehensive Global Burden of Disease (GBD) 2021 drug-resistant tuberculosis dataset.</p></div><div><h3>Methods</h3><p>From the GBD 2021, data on incidence, prevalence, disability-adjusted life years (DALYs), and death of MDR-TB and XDR-TB from 1990 to 2021 were collected. We calculated the estimated annual percentage changes in age standardized incidence rate (ASIR) and age-standardized death rate (ASDR), segmented by age, sex, and Socio-demographic Index (SDI). The impacts of various risk factors on MDR-TB and XDR-TB were also analyzed.</p></div><div><h3>Results</h3><p>In 2021, there were an estimated 443,680 (95% uncertainty interval [<em>UI</em>]: 259,196–766,545) incident cases of MDR-TB, and an estimated 106,818 (95% <em>UI</em>: 41,612–211,854) death cases of MDR-TB, while there were an estimated 24,036 (95% <em>UI</em>: 17,144–34,587) incident cases of XDR-TB and 7,946 (95% <em>UI</em>: 3,326–14,859) death cases of XDR-TB. The incidence and death cases of MDR-TB were lowest in high SDI regions, whereas the incidence rates of XDR-TB in high-middle SDI regions were higher than those in middle SDI and high SDI regions.</p></div><div><h3>Conclusion</h3><p>This study reported the disease burden of drug-resistant TB from 1990 to 2021. Until 2021, drug-resistant TB is still a serious problem in low SDI countries, especially for high-risk age populations with high-risk factors. Controlling drug-resistant TB requires effective control strategies and healthcare systems.</p></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"3 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949704324000118/pdfft?md5=521aef4f703bbd32d1a1bd9b547f2d92&pid=1-s2.0-S2949704324000118-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}