中国现代神经疾病杂志最新文献

{"title":"Application progress of neural prosthesis in rehabilitation of patients with spinal cord injury","authors":"Weijun Gong","doi":"10.3969/CJCNN.V17I6.1610","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I6.1610","url":null,"abstract":"Neural prosthesis is based on brain-computer interface (BCI), which directly acts on the muscle system or an external device by analyzing EEG control commands, so as to compensate the efferent pathway of brain-spinal cord-muscle and recover motor function of patients with spinal cord injury. The technology involves comprehensive research of multiple disciplines such as brain science, cognitive neuroscience, biomedical engineering, information and communication engineering, control science and engineering. This paper reviews recent advances of neural prosthesis in the rehabilitation treatment of patients with spinal cord injury. DOI: 10.3969/j.issn.1672-6731.2017.06.002","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"399-402"},"PeriodicalIF":0.0,"publicationDate":"2017-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44457107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of motor imagery therapy on cognitive function of patients with stroke","authors":"Weijun Gong","doi":"10.3969/CJCNN.V17I6.1613","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I6.1613","url":null,"abstract":"Objective To explore the rehabilitation effect of motor imagery therapy on cognitive function of stroke patients.  Methods A total of 99 stroke patients with mild to moderate cognitive dysfunction were randomly divided into 3 groups: control group (N = 33), cognitive training group (N = 33) and motor imagery training group (N = 33). All patients received conventional rehabilitation training. Before and after 8-week training, all subjects were assessed with Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). At the same time, event-related potential (ERP) was examined to detect P300 latency and amplitude.   Results ompared with before training, MMSE ( P = 0.000) and MoCA ( P = 0.000) scores were significantly increased, P300 latency was shortened ( P = 0.000) and P300 amplitude was increased ( P = 0.000) in 3 groups after 8 - week training. There were significant differences among 3 groups on MMSE ( P = 0.030) and MoCA ( P = 0.013) scores, P300 latency ( P = 0.004) and P300 amplitude ( P = 0.009) before and after training. Among them, cognitive training group and motor imagery training group had significantly higher MMSE ( P = 0.019, 0.021) and MoCA ( P = 0.003, 0.031) scores, shorter P300 latency ( P = 0.020, 0.003) and higher P300 amplitude ( P = 0.003, 0.002) than control group.  Conclusions Motor imagery training can not only improve motor function of stroke patients, but also improve their cognitive function. DOI: 10.3969/j.issn.1672-6731.2017.06.005","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"415-420"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48727108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of respiratory function training on respiratory function of patients with severe cerebrovascular disease","authors":"Ming Guo, Jun Zhao, Bing-jie Li, Tong Zhang, Li-ping Mei, Dan Huang","doi":"10.3969/CJCNN.V17I4.1578","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1578","url":null,"abstract":"Objective To investigate the effect of respiratory function training on respiratory function and conscious state of patients with severe cerebrovascular disease (SCVD). Methods A total of 27 patients with SCVD were divided into control group (N = 17) and observation group (N = 10). Control group received routine drug and rehabilitation treatment, and observation group was added respiratory function training based on routine treatment. The respiratory rate, tidal volume (TV), heart rate, blood pressure and artery oxygen saturation (SaO 2 ) of patients were monitored by breathing machine before and after 4-week treatment. Meanwhile, arterial blood gas analysis was used to detect arterial partial pressure of oxygen (PaO 2 ), oxygenation index, partial pressure of carbon dioxide (PaCO 2 ) and pH value. At the same time, Glasgow Coma Scale (GCS) was used to evaluate the conscious state of patients.  Results All patients successfully completed 4-week rehabilitation training, without asphyxia, arrhythmia or other adverse events. Compared with before training, the respiratory rate ( P = 0.006) and pH value ( P = 0.010) were significantly decreased, while SaO 2 ( P = 0.001), oxygenation index ( P = 0.000) and GCS scores ( P = 0.004, 0.017) were significantly increased in both groups of patients after training. There was no statistically significant difference between 2 groups on respiratory function indexes and GCS scores after training ( P > 0.05, for all). Conclusions Respiratory function training did not significantly improve the respiratory function and conscious state of patients with SCVD, yet to be further studied. Randomized controlled clinical trials with larger, layered samples and long-term prognosis observation are needed. Examination method of respiratory function of SCVD patients is also a topic to be explored. DOI: 10.3969/j.issn.1672-6731.2017.04.007","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"270-275"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43204226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hirayama's disease: one case report","authors":"Li-li Zhou, Yawen Meng, Zhengxing Jiang, Wenzhong Wang","doi":"10.3969/cjcnn.v17i4.1583","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i4.1583","url":null,"abstract":"患者 男性,28 岁,因渐进性右上肢远端无力 伴肌萎缩 5 年,于 2016 年 2 月 19 日至我院门诊就 诊。患者 5 年前无明显诱因出现右手手指无力,寒 冷时加重,逐渐出现右手手指活动笨拙、不能并拢, 穿针引线等精细活动明显受限,症状持续无明显缓 解,伴右手肌萎缩,无明显肉跳感,其他肢体活动正 常,无疼痛、麻木等感觉异常,无言语障碍、吞咽困 难等。患者自发病以来,精神、睡眠、饮食尚可,大 小便无明显异常,体重无明显改变。既往史、个人 史及家族史均无特殊,自诉 15 ~ 18 岁身高生长显著 (具体不详)。入院后体格检查:患者体温 36.7 °C, 脉搏 71 次/min,呼吸 16 次/min,血压 115/65 mm Hg (1 mm Hg = 0.133 kPa);神志清楚,语言流利,双侧 瞳孔等大、等圆,直径约 3 mm,神经系统查体未见明 显异常;右手大小鱼际肌和骨间肌萎缩,左手未见 明显肌萎缩,伸展双手可见手部肌肉震颤,右上肢 远端肌力 3+ ~ 4 级、肌张力降低,右上肢近端和左侧 肢体肌力 5 级、肌张力均正常,右上肢桡骨骨膜反 射、肱二头肌反射和肱三头肌反射强阳性,左上肢 阳性,双侧 Hoffmann 征和 Babinski 征阴性,共济运动 和深浅感觉未见明显异常,脑膜刺激征阴性。实验 室检查各项指标均于正常值范围。影像学检查:颈 椎 MRI(2016 年 2 月 24 日)显示,C6 ~ 7 水平脊髓轻度 变细伴不规则异常信号,硬脊膜囊后壁向前移位, 背侧硬脊膜外间隙增宽(图 1)。头部 MRI 未见明显 异常。电生理学检查:肌电图(2016 年 2 月 25 日)显 示,双上肢呈神经源性损害,以慢性损害为主,累及 双侧 C7 ~ T1支配肌,尤以右侧显著,首先考虑脊髓前 角细胞损害(图 2)。临床诊断为平山病。予以维生 素 B12 25 μg/d 和维生素 B1 5 mg/d 口服营养神经,以 及颈托制动,减少低头屈颈动作。门诊随访,治疗 后 6 个月复诊,症状未见明显改善,肌萎缩无进展。","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"306-310"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44126493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation effect of trunk control training under suspension on motor function of stroke patients in sequela period","authors":"Xiaoyong Yan, Jianzhong Xiong, Sheng-wei Li, Yongxiang Zhou, Wenjing Wei","doi":"10.3969/cjcnn.v17i4.1577","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i4.1577","url":null,"abstract":"Objective To study the effect of two trunk control trainings on motor function recovery of stroke patients in sequela period.  Methods A total of 42 patients were randomly divided into control group (N = 21) and observation group (N = 21). The control group was treated by traditional trunk control training, and the observation group was treated by trunk control training using suspension technology. Both groups all received other conventional rehabilitation treatment. All patients received Trunk Control Test (TCT), Functional Ambulation Category Scale (FAC), Berg Balance Scale (BBS) and 10 m Maximum Walking Speed (10 m MWS) before and 20 d after treatment. Results After two courses of treatment, the scores of TCT ( P = 0.000), FAC ( P = 0.000), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) were significantly improved in both groups. The scores of TCT ( P = 0.000), FAC ( P = 0.002), BBS ( P = 0.000) and 10 m MWS ( P = 0.000) after treatment in observation group were all significantly higher than those in control group. Conclusions The method of trunk control training under suspension can effectively improve the motor function of stroke patients in sequela period. DOI: 10.3969/j.issn.1672-6731.2017.04.006","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"266-269"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44264519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation analysis between tortuosity of extracranial internal carotid artery and extracranial vertebral artery and acute ischemic stroke","authors":"Yi-rui Cao, Bo Wu, Jiayu Sun","doi":"10.3969/cjcnn.v17i4.1581","DOIUrl":"https://doi.org/10.3969/cjcnn.v17i4.1581","url":null,"abstract":"Objective To analyze the correlation between tortuosity of extracranial internal carotid artery (EICA) and extracranial vertebral artery (EVA) and acute ischemic stroke, so as to discuss the causes of vascular tortuosity and the mechanism on inducing stroke. Methods This study included 103 patients with acute ischemic stroke and 103 patients without acute ischemic stroke whose manifestations were headache and dizziness. CTA was used to measure the tortuosity index (TI), deviation degree (DD), tortuosity degree (TD) and angular number (AN) of EICA and EVA. Pearson correlation analysis and Spearman rank correlation analysis were used to analyze the correlations of arterial tortuosity with risk factors for ischemic stroke and vascular morphology. Univariate and stepwise multivariate Logistic regression analysis were used to screen related risk factors for tortuosity of EICA and EVA.  Results The stroke group had higher TI ( P = 0.000, 0.000), DD ( P = 0.000, 0.000), TD ( P = 0.002, 0.000) and AN ( P =0.019, 0.000) of EICA and EVA than those in control group. According to the site of infarction, the stroke group was divided into anterior circulation infarction (ACI) subgroup (N = 73) and posterior circulation infarction (PCI) subgroup (N = 30), and there was no significant difference in above-mentioned vascular morphological indexes between 2 subgroups ( P > 0.05, for all); in each subgroup, there was no significant difference between infarct side and non-infarct side of EICA, and between left and right EVA ( P > 0.05, for all). Nevertheless, the TI ( P = 0.000), DD ( P = 0.000) and TD ( P = 0.045) of EICA in ACI subgroup were higher than those in control group; TI ( P = 0.000), DD ( P = 0.000), TD ( P = 0.000) and AN ( P = 0.046) of EVA in PCI subgroup were higher than those in control group. In stroke group, correlation analysis revealed that TI of EICA was positively correlated with age, cervical artery atherosclerosis (CAS), EICA and EVA morphological indexes (except DD of EVA; P < 0.05, for all), but was negatively correlated with male ( r s = -0.253, P = 0.010); TI of EVA was positively correlated with age, hypertension, morphological indexes of EICA and EVA ( P < 0.05, for all), but negatively correlated with male ( r s =-0.276, P = 0.005). Univariate and stepwise multivariate Logistic regression analysis showed that female (EICA: OR = 1.458, 95% CI: 1.111-5.166, P = 0.016; EVA: OR = 9.092，95%CI: 1.294-63.872, P = 0.026) and age (EICA: O R = 1.050, 95%CI: 1.013-1.088， P = 0.007; EVA: OR = 1.084, 95%CI: 1.003-1.138, P = 0.001) were independent risk factors for tortuosity of EICA and EVA.  Conclusions There are no significant differences between left and right side, anterior and posterior circulation on tortuosity distribution of patients with ischemic stroke. The EICA and EVA morphological indexes of stroke patients was significantly higher than that of non-stroke patients. Female and age are independent risk factors for tortuosity of EICA and ","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"290-299"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44723345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subependymal giant cell astrocytoma","authors":"T. Han","doi":"10.3969/CJCNN.V17I4.1586","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1586","url":null,"abstract":"","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"310-310"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48357430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of diagnostic transcranial magnetic stimulation","authors":"Bei Huang, Huijuan Wu, Zhen-ying Qian, Jijun Wang, Zhong-xin Zhao","doi":"10.3969/CJCNN.V17I4.1582","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1582","url":null,"abstract":"Transcranial magnetic stimulation (TMS) is a non-invasive and painless neuroelectrophysiological examination technology. TMS-motor evoked potential (TMS-MEP) is widely used to assess motor cortex excitability and conduction of descending corticobulbar tract and corticospinal tract. Recently, deeper understanding on principles of magnetic stimulation and diversification of stimulation coil and pattern has greatly expanded the application of TMS in clinical diagnosis. Moreover, MEP operation procedures are becoming more scientific and standardized. This paper reviews the progress of conventional diagnostic TMS pattern, several special stimulation patterns and the combined application of TMS, electroencephalograpy (EEG) and fMRI. DOI: 10.3969/j.issn.1672-6731.2017.04.011","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"300-305"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45847324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ependymoma, RELA fusion-positive","authors":"Xiao-ling Yan","doi":"10.3969/CJCNN.V17I4.1585","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1585","url":null,"abstract":"","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"305-305"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41635233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of berberine chloride on secondary damage of bilateral thalami in traumatic brain injury model mice","authors":"Shu-xuan Huang, Feiqi Zhu, Z. Pei, Xu-hui Deng, Zhi Yang, Jin-hua Zhu, Chun-chun Chen, Wei-feng Lin","doi":"10.3969/CJCNN.V17I4.1580","DOIUrl":"https://doi.org/10.3969/CJCNN.V17I4.1580","url":null,"abstract":"Objective To investigate the protective effect of berberine chloride on secondary damage (inflammation, oxidative damage and neuron loss) in bilateral thalami of traumatic brain injury (TBI) model mice. Methods Mice were randomly divided into 3 groups: control group (N = 6), TBI group (N = 6) and berberine group (N = 6). TBI model was established by a free-falling hitting device. In control group, mice were not given free-falling hitting. Mice in berberine group were given a gavage of berberine chloride [50 mg/（kg·d)] for 21 d, while mice in TBI group were given the same dosage of normal saline for 21 d. Immunohistochemistry was used to count the number of neurons or gliocytes positive for inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), 8-hydroxy deoxyguanosine (8-OHdG) and neuronal nuclei (NeuN), the number of astrocytes positive for glial fibrillary acidic protein (GFAP) and the number of microglias positive for ionized calcium-binding adaptor molecule 1 (Iba1).  Results The number of neurons or gliocytes positive for iNOS ( P = 0.015), COX-2 ( P = 0.022), 8-OHdG ( P = 0.000) and NeuN ( P = 0.000), the number of astrocytes positive for GFAP ( P = 0.024) and microglias positive for Iba1 ( P = 0.000) in TBI ipsilateral thalamus were significantly different among 3 groups. In TBI group, the number of neurons or gliocytes positive for iNOS ( P = 0.005), COX-2 ( P = 0.011) and 8-OHdG ( P = 0.000), the number of astrocytes positive for GFAP ( P = 0.011) and microglias positive for Iba1 ( P = 0.000) were significantly higher than those in control group, while the number of neurons positive for NeuN ( P = 0.000) was significantly lower than that in control group. In berberine group, the number of neurons or gliocytes positive for iNOS ( P = 0.031), COX-2 ( P = 0.024) and 8-OHdG ( P = 0.008), the number of astrocytes positive for GFAP ( P = 0.031) and microglias positive for Iba1 ( P = 0.012) were significantly lower than those in TBI group, while the number of neurons positive for 8-OHdG ( P = 0.014) and microglias positive for Iba1 ( P = 0.024) were significantly higher than those in control group. The number of neurons positive for NeuN in berberine group was significantly higher than that in TBI group ( P = 0.016), while lower than that in control group ( P = 0.027). Additionally, number of neurons or gliocytes positive for COX-2 ( P = 0.029) and 8-OHdG ( P = 0.000) in TBI contralateral thalamus were significantly different among 3 groups. The number of neurons or gliocytes positive for COX-2 ( P = 0.011) and 8-OHdG ( P = 0.000) in TBI group was significantly higher than that in control group, while the number of neurons or gliocytes positive for COX-2 ( P = 0.047) and 8-OHdG ( P = 0.010) in berberine group was significantly lower than that in TBI group. The number of neurons positive for 8-OHdG in berberine group was significantly higher than that in control group ( P = 0.004).  Conclusions TBI could cause secondary damage of bila","PeriodicalId":10113,"journal":{"name":"中国现代神经疾病杂志","volume":"17 1","pages":"282-289"},"PeriodicalIF":0.0,"publicationDate":"2017-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42531161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}