RSC Applied Polymers最新文献

Emerging stimuli-responsive hydrogels for enhancing chronic wound healing. 促进慢性伤口愈合的新兴刺激反应水凝胶。

RSC Applied Polymers Pub Date : 2025-08-27 DOI: 10.1039/d5lp00092k

Maya Yun, Logan Langford, Lewis Russell, Natalie Ndiforamang, Anran Zhang, Wubin Bai

{"title":"Emerging stimuli-responsive hydrogels for enhancing chronic wound healing.","authors":"Maya Yun, Logan Langford, Lewis Russell, Natalie Ndiforamang, Anran Zhang, Wubin Bai","doi":"10.1039/d5lp00092k","DOIUrl":"10.1039/d5lp00092k","url":null,"abstract":"Stimuli-responsive hydrogels have gained significant attention in wound care due to their ability to adapt to dynamic physiological conditions, making them promising candidates for facilitating chronic wound healing. These hydrogels can respond to both internal and external environmental stimuli such as temperature, pH, reactive oxygen species (ROS), glucose levels, MMP, mechanical forces, magnetism, and ultrasound, enabling precise, on-demand therapeutic interventions through controlled drug release. This responsiveness is governed by reversible changes in their polymer network structure caused by interactions with external stimuli. By creating an optimized environment for wound healing, stimuli-sensitive hydrogels can promote moisture retention, cellular migration, and mechanical flexibility while accelerating critical tissue repair processes like angiogenesis or collagen synthesis. Additionally, incorporating bioactive agents such as antimicrobial compounds, growth factors, and other therapeutically active substances like honey, has further expanded their functionality, though such modifications may be secondary to their inherent stimuli-responsive nature. This review provides a comprehensive overview of recent advancements in stimuli-responsive hydrogels for chronic wound management, highlighting their ability to respond to environmental cues and addressing their potential to enhance healing through the controlled release of therapeutic agents, promotion of hemostasis, and tissue regeneration.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12406989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145002487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic solvent-free gelation of syndiotactic-rich poly(vinyl alcohol) 富辛迪克聚乙烯醇的有机无溶剂凝胶化

RSC Applied Polymers Pub Date : 2025-08-22 DOI: 10.1039/D5LP00156K

Yusuke Taoka and Kazuaki Matsumura

{"title":"Organic solvent-free gelation of syndiotactic-rich poly(vinyl alcohol)","authors":"Yusuke Taoka and Kazuaki Matsumura","doi":"10.1039/D5LP00156K","DOIUrl":"https://doi.org/10.1039/D5LP00156K","url":null,"abstract":"Poly(vinyl alcohol) (PVA) is commonly used in a wide variety of applications due to its desirable characteristics. However, limitations exist regarding its solubility and mechanical properties. To address this, the gelation of syndiotactic-rich polyvinyl alcohol (sPVA) with a regular three-dimensional structure was performed using an organic solvent-free approach. The obtained sPVA exhibited a higher crystallinity than the commonly used atactic PVA (aPVA). However, both systems exhibit low solubilities in solvents such as water and dimethyl sulfoxide due to their high crystallinities, thereby rendering it impossible to exploit their properties. However, since the hot pressing method does not require the dissolution of PVA in a solvent, it is possible to perform gelation using sparingly soluble materials such as sPVA. Consequently, a hydrogel was formed by applying the hot pressing method to water-swollen sPVA. The obtained sPVA hydrogel (sPVA-H) was subsequently dried and heat-treated at different temperatures to compare its crystallinity and thermal and mechanical properties with those of the aPVA hydrogel (aPVA-H). It was found that sPVA-H exhibited comparable properties to the original sPVA-H following heat treatment at higher temperatures, and also when heat-treated at a temperatures lower than those required for aPVA-H. The obtained results indicated that sPVA-H exhibits excellent mechanical properties, suggesting its potential for incorporation in materials for long-term loading applications, such as artificial cartilage.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1385-1392"},"PeriodicalIF":0.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00156k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of light-curing ionogels by response surface methodology 响应面法优化光固化离子凝胶

RSC Applied Polymers Pub Date : 2025-08-18 DOI: 10.1039/D4LP00381K

Dejun Peng, Zeyu Zhang, Xueyan Shang, Jiguo Zhang and Shixue Ren

{"title":"Optimization of light-curing ionogels by response surface methodology","authors":"Dejun Peng, Zeyu Zhang, Xueyan Shang, Jiguo Zhang and Shixue Ren","doi":"10.1039/D4LP00381K","DOIUrl":"https://doi.org/10.1039/D4LP00381K","url":null,"abstract":"Because of their unique properties, ionogels are very suitable for wide application in fields such as energy storage devices and wearable devices, but poor mechanical strength limits their practical use. Polyols or compounds containing multiple unsaturated double bonds are typically used as cross-linking agents in the construction of gels, but it is difficult to balance mechanical strength with flexibility because these compounds mainly form linear or simple reticular structures. It is, therefore, important to design ionogels with improved mechanical properties. Here, response surface methodology was used to optimize the preparation of light-curing ionogels, using the biomass-derived polymer rutin as an antioxidant cross-linking agent. The prepared ionogels had a tensile strength as high as 639.15 kPa, which was attributed to the three-dimensional cross-linked network structure formed by esterified rutin and to the sacrificial hydrogen bond energy dissipation mechanism. After light curing of the esterified rutin by free radical polymerisation, the structure retained the intact conjugated system and thus provided good UV protection (light transmission in UVB region = 0%). This study offers a new way to rapidly prepare high-performance UV-resistant polymer coatings, which show promise for applications in sunscreen coatings, such as parasols and automotive/architectural sunscreen glass.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1366-1375"},"PeriodicalIF":0.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d4lp00381k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of green-based carbon-doped nanosilica for enhanced mechanical properties of coconut oil-based rigid polyurethane foam 绿基碳掺杂纳米二氧化硅的合成及其增强椰子油基硬质聚氨酯泡沫材料力学性能的研究

RSC Applied Polymers Pub Date : 2025-08-12 DOI: 10.1039/D5LP00161G

Carlo Kurt F. Osorio, Christine Joy M. Omisol, Dan Michael A. Asequia, Blessy Joy M. Aguinid, Daisy Jane D. Erjeno, Kassandra Jayza Gift D. Tejas, Roger G. Dingcong, Tomas Ralph B. Tomon, Renzo Miguel R. Hisona, Andrei E. Etom, Ann Pearl G. Triana, Gerard G. Dumancas, Arnold C. Alguno, Joshua B. Zoleta, Roberto M. Malaluan and Arnold A. Lubguban

{"title":"Synthesis of green-based carbon-doped nanosilica for enhanced mechanical properties of coconut oil-based rigid polyurethane foam","authors":"Carlo Kurt F. Osorio, Christine Joy M. Omisol, Dan Michael A. Asequia, Blessy Joy M. Aguinid, Daisy Jane D. Erjeno, Kassandra Jayza Gift D. Tejas, Roger G. Dingcong, Tomas Ralph B. Tomon, Renzo Miguel R. Hisona, Andrei E. Etom, Ann Pearl G. Triana, Gerard G. Dumancas, Arnold C. Alguno, Joshua B. Zoleta, Roberto M. Malaluan and Arnold A. Lubguban","doi":"10.1039/D5LP00161G","DOIUrl":"https://doi.org/10.1039/D5LP00161G","url":null,"abstract":"High-strength, bio-based rigid polyurethane foam (RPUF) was synthesized using coconut oil-based polyol reinforced with green silica nanoparticles (SNP) derived from rice husk ash (RHA). The SNPs were carbon-doped using κ-carrageenan to enhance their functional properties. Comprehensive characterization of the synthesized SNP and SNP-enhanced RPUF was conducted using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), dynamic light scattering (DLS), and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX). X-ray photoelectron spectroscopy (XPS) confirmed successful κ-carrageenan-mediated carbon doping, improving SNP reactivity. The incorporation of SNP (up to 0.3% by mass) significantly enhanced the compressive strength of RPUF by 92.42%, attributed to hydrogen bonding and induced crosslinking interactions between the SNP and amine groups in the bio-polyol, as evidenced by FTIR, SEM, and pycnometric analyses. Thermogravimetric analysis (TGA) demonstrated that SNP integration improved the thermal stability of RPUF without compromising its thermal conductivity, meeting industrial standards. This study highlights the potential of sustainably derived nanomaterials to improve the mechanical and thermal properties of bio-based composites. Furthermore, the SNP-reinforced RPUF offers promising applications in environmentally friendly materials for thermal insulation, structural components, and environmental remediation, contributing to the development of high-performance, sustainable materials for various industrial applications.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1356-1365"},"PeriodicalIF":0.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00161g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermoplastic-like mechanical performance of heterogeneous photopolymers for additive manufacturing with tailored hyperbranched rubbers 用定制超支化橡胶增材制造的非均相光聚合物的热塑性类机械性能

RSC Applied Polymers Pub Date : 2025-08-06 DOI: 10.1039/D5LP00138B

Vojtěch Musil, Dominik Laa, Mojtaba Ahmadi, Jürgen Stampfl, Robert Liska, Jan Merna and Katharina Ehrmann

{"title":"Thermoplastic-like mechanical performance of heterogeneous photopolymers for additive manufacturing with tailored hyperbranched rubbers","authors":"Vojtěch Musil, Dominik Laa, Mojtaba Ahmadi, Jürgen Stampfl, Robert Liska, Jan Merna and Katharina Ehrmann","doi":"10.1039/D5LP00138B","DOIUrl":"https://doi.org/10.1039/D5LP00138B","url":null,"abstract":"Conventional photopolymers used in light-based additive manufacturing are typically brittle materials with thermoset characteristics. Here we introduce a one-step synthesis of hyperbranched polyethylene rubbers functionalized with pendant methacrylic groups and their application as tougheners of a model brittle photopolymer based on non-volatile styrene and maleimide derivatives. The rubber tougheners can be tailored to tune their compatibility with the matrix, influencing the morphology and the thermomechanical properties of the final printed resins. The resulting polymer structures were analysed by atomic force microscopy, revealing various degrees of phase separation related to the rubber molar mass and methacrylate functionalization. Further, the analysis of the prepared toughened materials revealed the ability of functionalized hyperbranched polyethylene rubbers to improve the mechanical properties significantly (doubled stress at break and improvement of strain at break by a factor of 103 compared to the matrix), while glass transition temperatures around 100 °C could be maintained. Notably, even tensile behaviour mimicking typical thermoplastic yield strain comparable to ABS was observed in one of the prepared materials. This monomer/rubber system appeared to be the most promising and was therefore selected for in-depth analysis of the curing process using photo-rheology and photo-DSC. Finally, this material was used for hot lithography and several highly detailed objects were prepared, demonstrating the good printability of this toughened material.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1165-1176"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00138b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible B–O bond-based epoxy vitrimers with high thermomechanical and dynamic properties enhanced by intermolecular B–N coordination 分子间B-N配位增强了具有高热力学和动力学性能的可逆B-O键基环氧树脂

RSC Applied Polymers Pub Date : 2025-08-06 DOI: 10.1039/D5LP00144G

Qi Li, Dong Wang, Tianjiao Wang, Yang Zhang, Shiyang Liu, Shiwei Zhang, Zhufeng Hu, Liying Li, Guoyong Wang and Yingmin Zhao

{"title":"Reversible B–O bond-based epoxy vitrimers with high thermomechanical and dynamic properties enhanced by intermolecular B–N coordination","authors":"Qi Li, Dong Wang, Tianjiao Wang, Yang Zhang, Shiyang Liu, Shiwei Zhang, Zhufeng Hu, Liying Li, Guoyong Wang and Yingmin Zhao","doi":"10.1039/D5LP00144G","DOIUrl":"https://doi.org/10.1039/D5LP00144G","url":null,"abstract":"The development of recyclable and self-repairable vitrimer materials featuring reversible B–O bonds has garnered increasing attention. However, their stability and thermomechanical properties remain insufficient for engineering applications in reusable carbon fiber-reinforced composites (CFRCs). Herein, we report a high-performance epoxy vitrimer containing boronic ester bond-based dynamic exchange networks, to which a small amount of N-donating imidazole has been added for introducing intermolecular N–B coordination interactions. The obtained vitrimer (E51-NBO-IMZ) possessed a high glass transition temperature (Tg) of 198 °C and tensile modulus of 3.71 GPa. Compared to the system without imidazole, it exhibited significantly improved solvent resistance due to the stabilization effect of N–B coordination on the B-center atoms. Moreover, stress relaxation tests also indicated a lower activation energy (Ea = 151.31 kJ mol−1) of the E51-NBO-IMZ vitrimer, suggesting better dynamic exchange activity. Despite the high stability and improved thermomechanical properties, the self-repairing, recycling and degradation of the vitrimer and its CFRCs were successfully achieved under heating, stress or chemical environmental conditions, showing outstanding potential for practical applications.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1183-1192"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00144g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-side-chain composite membranes with polyaminobenzene sulfonic acid-enriched single-walled carbon nanotubes for polymer electrolyte fuel cells 富聚氨基苯磺酸单壁碳纳米管短侧链复合膜用于聚合物电解质燃料电池

RSC Applied Polymers Pub Date : 2025-08-06 DOI: 10.1039/D5LP00172B

Baskaran Mohan Dass, Ramya Padmanaban, Aparna Mahalingam, Neeshma Maniprakundil, Harshal Agarwal, Sreekuttan M. Unni, Vishal M. Dhavale and Santoshkumar D. Bhat

{"title":"Short-side-chain composite membranes with polyaminobenzene sulfonic acid-enriched single-walled carbon nanotubes for polymer electrolyte fuel cells","authors":"Baskaran Mohan Dass, Ramya Padmanaban, Aparna Mahalingam, Neeshma Maniprakundil, Harshal Agarwal, Sreekuttan M. Unni, Vishal M. Dhavale and Santoshkumar D. Bhat","doi":"10.1039/D5LP00172B","DOIUrl":"https://doi.org/10.1039/D5LP00172B","url":null,"abstract":"This study reports the fabrication of composite membranes based on short-side-chain perfluorosulfonic acid (SSC-PFSA) polymers reinforced with polyaminobenzene sulfonic acid-functionalized single-walled carbon nanotubes (PABS-f-SWCNTs) for enhanced polymer electrolyte membrane fuel cell (PEMFC) performance. The dual-functionalized SWCNTs, enriched with –SO3H and –NH2 groups, were uniformly dispersed within the SSC-PFSA matrix, promoting dipolar interactions and efficient proton conduction pathways. Comprehensive characterization confirmed improved ion exchange capacity, water uptake, thermal stability, and proton conductivity, with the 0.5 wt% PABS-f-SWCNT composite membrane exhibiting optimal performance. Under fuel cell operating conditions, this membrane demonstrated a peak power density of 1707 mW cm−2 at 100% RH and sustained high current density at reduced humidity, outperforming the pristine SSC-PFSA membrane. The findings highlight the synergistic role of zwitterionic functional groups and nanotube reinforcement in advancing next-generation PEMFC membrane technology.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1376-1384"},"PeriodicalIF":0.0,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00172b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mussel-inspired biomimetic adhesive coatings for food preservation: a review 贻贝仿生粘接涂层用于食品保鲜的研究进展

RSC Applied Polymers Pub Date : 2025-08-04 DOI: 10.1039/D5LP00173K

Deepika Gupta, Dimpy Bhardwaj, Ruchir Priyadarshi, Saurav Kumar and Garima Agrawal

{"title":"Mussel-inspired biomimetic adhesive coatings for food preservation: a review","authors":"Deepika Gupta, Dimpy Bhardwaj, Ruchir Priyadarshi, Saurav Kumar and Garima Agrawal","doi":"10.1039/D5LP00173K","DOIUrl":"https://doi.org/10.1039/D5LP00173K","url":null,"abstract":"In recent years, taking inspiration from mussel, an underwater organism, various packaging alternatives including adhesive coatings have been developed for food preservation to ensure food availability for everyone. The extraordinary adhesion exhibited by mussel is mainly offered by mussel foot proteins containing catechol groups. This catechol-based chemistry not only improves adhesion but also helps in imparting antimicrobial, antioxidant, and UV-blocking properties to packaging materials for increasing the shelf-life of food items. Herein, we first present an overview of catechol-based chemistry followed by a discussion involving a combination of catechol and its derivatives with various biodegradable polymers and nanomaterials. Further, we summarize the recent efforts made for developing mussel-inspired catechol-based coatings for food preservation, keeping minimum environmental impact in mind. Finally, we discuss various challenges and opportunities existing in this area for the successful commercial utilization of such biomimetic coatings in the future.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1145-1164"},"PeriodicalIF":0.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00173k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypercrosslinked polymers for oil adsorption: the influence of porosity and fluorine incorporation 高交联聚合物对油的吸附：孔隙度和含氟量的影响

RSC Applied Polymers Pub Date : 2025-08-04 DOI: 10.1039/D5LP00081E

Le Tang, Paul Schweng, Joseph J. Dale and Robert T. Woodward

引用次数: 0

Hydrogel-filled tubular scaffolds for directional tissue regeneration combining shape-memory polyester blends with hyaluronic acid click-hydrogels† 水凝胶填充管状支架的定向组织再生结合形状记忆聚酯混合物与透明质酸点击水凝胶†

RSC Applied Polymers Pub Date : 2025-07-28 DOI: 10.1039/D5LP00098J

Álvaro Hidalgo-Yerga, Leonor Resina, Jordi Casanovas, Hamidreza Enshaei, Francesc Estrany, José I. Iribarren, Maria M. Pérez-Madrigal and Carlos Alemán

{"title":"Hydrogel-filled tubular scaffolds for directional tissue regeneration combining shape-memory polyester blends with hyaluronic acid click-hydrogels†","authors":"Álvaro Hidalgo-Yerga, Leonor Resina, Jordi Casanovas, Hamidreza Enshaei, Francesc Estrany, José I. Iribarren, Maria M. Pérez-Madrigal and Carlos Alemán","doi":"10.1039/D5LP00098J","DOIUrl":"https://doi.org/10.1039/D5LP00098J","url":null,"abstract":"A clinical need still exists for advanced therapeutics to improve the recovery of patients suffering from large-gap peripheral nerve injuries (PNI). In this study, tubular constructs of submicrometric thickness (<1 μm) are prepared using shape-memory 50 : 50, 70 : 30 and 90 : 10 poly(lactic acid) (PLA)/polycaprolactone (PCL) blends, which are filled with a hyaluronic acid (HA)-based hydrogel. The hydrogel is crosslinked in situ by click chemistry using a 3-arm alkyne-functionalized polyethylene glycol and thiol-modified HA. The Young's moduli of the hydrogels confined inside the different cylindrical constructs are similar to that of the free hydrogel, the tubular shell mainly affecting the tensile strength and deformability. On the other hand, cell adhesion and proliferation assays demonstrate that the cytocompatibility of the blends, the hydrogel and the filled tubular constructs is similar to or even higher than that of the tissue culture polystyrene used as the control. Furthermore, the scaffold derived from the 70 : 30 PLA/PCL blend provides a 3D cell-friendly mechanical environment that promotes the directional migration of cells towards the confined hydrogel. The engineered scaffolds may have important implications in the repairing of directional tissues.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 5","pages":" 1340-1355"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00098j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145073569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0