RSC Applied Polymers最新文献

Cryopreservation and post-thaw differentiation of monocytes enabled by macromolecular cryoprotectants which restrict intracellular ice formation. 通过限制细胞内冰形成的大分子冷冻保护剂实现单核细胞的低温保存和解冻后分化。

RSC Applied Polymers Pub Date : 2025-06-09 DOI: 10.1039/d5lp00131e

Natalia Gonzalez-Martinez, Ruben M F Tomás, Akalabya Bissoyi, Agnieszka Nagorska, Alexandru Ilie, Matthew I Gibson

{"title":"Cryopreservation and post-thaw differentiation of monocytes enabled by macromolecular cryoprotectants which restrict intracellular ice formation.","authors":"Natalia Gonzalez-Martinez, Ruben M F Tomás, Akalabya Bissoyi, Agnieszka Nagorska, Alexandru Ilie, Matthew I Gibson","doi":"10.1039/d5lp00131e","DOIUrl":"10.1039/d5lp00131e","url":null,"abstract":"THP-1 is a monocytic cell line which can differentiate into macrophage and dendritic cells, widely used in immunology. Immune cells are particularly sensitive to cryopreservation, leading to low recovery and/or reduced differentiation capacity compared to non-frozen cells. Current cryopreservation protocols are unsuitable to cryopreserve THP-1 cells in 'assay-ready' format, due to the time and resource intensive culturing steps required post-thaw to recover functional cells. We report the cryopreservation of THP-1 cells in vial and multi-well plate format, with significantly enhanced recovery compared to commercial cryoprotectants. This was achieved using macromolecular cryoprotectants (polyampholytes and ice nucleators) which doubled post-thaw recovery relative to DMSO-alone and improved macrophage phenotype post-differentiation comparable to non-frozen controls. Cryo-Raman microscopy demonstrated that the polyampholytes reduced intracellular ice formation compared to DMSO-alone. These results will enable routine banking and 'assay-ready' THP-1 cells direct from the freezer, accelerating immunological research.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene inks for printing based on thermoresponsive ABC triblock terpolymer gels. 基于热敏ABC三嵌段三元共聚物凝胶的印刷用石墨烯油墨。

RSC Applied Polymers Pub Date : 2025-06-02 DOI: 10.1039/d5lp00071h

Xu Liu, Bailin Feng, Stefano Tagliaferri, Anna P Constantinou, Alexandra E Porter, Cecilia Mattevi, Theoni K Georgiou

引用次数: 0

Impact of hydrolysis pretreatment on the compostability of biodegradable poly(caprolactone) and poly(lactic acid) films† 水解预处理对可生物降解聚己内酯和聚乳酸薄膜可降解性的影响

RSC Applied Polymers Pub Date : 2025-04-07 DOI: 10.1039/D5LP00041F

Jordan D'Amario, Wanwarang Limsukon, Anibal Bher and Rafael Auras

{"title":"Impact of hydrolysis pretreatment on the compostability of biodegradable poly(caprolactone) and poly(lactic acid) films†","authors":"Jordan D'Amario, Wanwarang Limsukon, Anibal Bher and Rafael Auras","doi":"10.1039/D5LP00041F","DOIUrl":"https://doi.org/10.1039/D5LP00041F","url":null,"abstract":"The biodegradation performance of non-pretreated and pretreated commercial polyesters was evaluated under simulated composting conditions to understand how abiotic pretreatment accelerates biotic degradation. Polylactic acid (PLA) and polycaprolactone (PCL) were subjected to hydrolysis pretreatment and assessed under simulated composting conditions for 120 days. In addition to tracking CO2 evolution, polymer-intrinsic factors such as chain scission, measured by reductions in intrinsic viscosity molecular weight (Mη), and changes in crystallinity (Xc) were also evaluated for both non-pretreated and pretreated samples during the biodegradation process. Hydrolysis pretreatment resulted in a reduction of initial Mη and an increase of initial Xc for all polymer samples. The initial decrease in Mη was particularly marked for PLA, which showed about 30% decrease, while PCL exhibited a reduction of just around 7%. Regarding initial Xc, the most significant increase was also seen in PLA, which jumped from approximately 0% to c. 30%. Hydrolysis of semi-crystalline polymers primarily affects the amorphous region, where elevated temperatures allow water to break polymer chains easily. However, for PLA, the disruption of the crystalline structure leads to a less stable type of crystal, probably due to an increase in the rigid amorphous region that enhances the overall biodegradation process. The effect of pretreatment on the biotic phase showed minimal differences for PCL but a noticeable overall increase in biodegradation for the pretreated PLA.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 3","pages":" 711-721"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00041f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bindone-based polymer for colorimetric detection of volatile amines† 用于挥发性胺比色检测的苯丙酮基聚合物†

RSC Applied Polymers Pub Date : 2025-04-04 DOI: 10.1039/D5LP00017C

Dylan Wilkinson, Dominic Taylor, Neil B. McKeown and Graeme Cooke

{"title":"Bindone-based polymer for colorimetric detection of volatile amines†","authors":"Dylan Wilkinson, Dominic Taylor, Neil B. McKeown and Graeme Cooke","doi":"10.1039/D5LP00017C","DOIUrl":"https://doi.org/10.1039/D5LP00017C","url":null,"abstract":"Effective detection and monitoring of volatile amines are crucial for protecting human health and the environment, particularly in areas such as disease diagnosis and food spoilage detection. Traditional gas sensors, including electrochemical, semiconductor, and photochemical types, often suffer from limited selectivity, sensitivity and require complex and expensive synthesis and detection equipment. Colorimetric sensors, which are easily interpreted through visible colour changes, have recently gained attention for their simplicity and real-time detection capabilities. In this study, we present a chemosensing system based on the bindone motif, both as a small molecule (Bin) and embedded in a polymer backbone (PBin), for the effective colorimetric detection of volatile amines. Our system exhibits high selectivity and sensitivity, with detection limits as low as 0.04 ppm for Bin and 1.57 ppm for PBin. The colour change, driven by amine-induced tautomerisation, was confirmed through UV-Vis spectroscopy, NMR spectroscopy, and TD-DFT calculations. pH dependent studies reveal the importance of basicity on the mechanism and selectivity. By incorporating the bindone moiety into the polymer backbone, its thermal stability was significantly enhanced. The versatility of the sensor was demonstrated in solution, and paper-based film formats, with successful application in detecting amines released during fish spoilage. This work highlights the potential of the bindone-based chemosensor as a cost-effective, portable, and efficient tool for monitoring food freshness and other applications requiring the detection of volatile amines.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 3","pages":" 701-710"},"PeriodicalIF":0.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00017c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interfacial stress transfer in graphene-based polymeric inks on a textile surface for long term cycling stability 石墨烯基聚合物油墨在纺织品表面长期循环稳定性中的界面应力转移

RSC Applied Polymers Pub Date : 2025-03-27 DOI: 10.1039/D4LP00289J

Monika Swami, Shanu Prabhakar, Susanta Ghosh and Debmalya Roy

{"title":"Interfacial stress transfer in graphene-based polymeric inks on a textile surface for long term cycling stability","authors":"Monika Swami, Shanu Prabhakar, Susanta Ghosh and Debmalya Roy","doi":"10.1039/D4LP00289J","DOIUrl":"https://doi.org/10.1039/D4LP00289J","url":null,"abstract":"The viscosity of graphene-based conducting ink has been shown to significantly affect printed geometries, and it has been illustrated that it can be controlled by adjusting the crosslinking density. A porous substrate, such as a textile surface, has been selected for printing to emphasize the structure formation of nanofillers during cyclic bending. The graphene loading in the elastomer matrix was deliberately chosen beyond the percolation threshold to gain insight into the conducting network channels on the fabric substrate. Structure–property analysis revealed the formation of stable conducting geometries of graphene on textile yarns under cyclic stress. The processing parameters have been found to play a crucial role in fabricating a tightly packed, conducting ink-filled textile substrate, which reorganizes the structural integrity of the flexible film by application of stress. The flexibility of graphene flakes is found to be critical as it allows them to conform to the fabric's surface for enhanced wetting and to minimize the stress concentration. The composition of fabric materials plays an important role in enhancing adhesion with conducting layers, thus contributing to the overall resistance stability. Formulation and processing of graphene-based inks have been optimized to achieve consistent deposition of flexible conductive ink on textile surfaces capable of enduring bending stress, making it ideal for the next generation of wearable electronics applications.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 3","pages":" 722-731"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d4lp00289j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing mechanochemical fluorescence toward autonomous damage-reporting coatings† 利用机械化学荧光实现自主损伤报告涂层

RSC Applied Polymers Pub Date : 2025-03-26 DOI: 10.1039/D5LP00011D

Zeyu Wang, Junfeng Zhou, Zichen Ling, Qixin Zhou and Junpeng Wang

{"title":"Harnessing mechanochemical fluorescence toward autonomous damage-reporting coatings†","authors":"Zeyu Wang, Junfeng Zhou, Zichen Ling, Qixin Zhou and Junpeng Wang","doi":"10.1039/D5LP00011D","DOIUrl":"https://doi.org/10.1039/D5LP00011D","url":null,"abstract":"Protective coatings are essential for shielding engineering materials from environmental and mechanical damage. A significant endeavor in this regard is detecting the damage in coatings and implementing necessary repairs. However, conventional detection methods often require specialized equipment and expertise, rendering them impractical for real-time monitoring. This work introduces an autonomous damage-reporting coating system based on a stress-responsive polymer network containing a Diels–Alder adduct mechanophore. When subjected to mechanical damage, the mechanophore undergoes a retro-Diels–Alder reaction, liberating a fluorescent π-extended anthracene moiety. The mechanically triggered “off-to-on” optical signal allows for highly sensitive detection of material damage preceding failure. A quantitative relationship between the extent of impact damage and the mechanochemically generated fluorescence is established, facilitating the prediction of material failure. Remarkably, the damage-reporting functionality is maintained even after incorporating pigments into the coating formulation, thereby broadening the applicability of this smart coating system in real-world scenarios.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 3","pages":" 592-597"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00011d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of sulfation on a tough hybrid hydrogel network 硫酸盐对坚韧杂化水凝胶网络的影响

RSC Applied Polymers Pub Date : 2025-03-17 DOI: 10.1039/D5LP00013K

Sander Driesen, Valentino Atella, Kristi Kiick, Louis M. Pitet and Geert-Jan Graulus

{"title":"Effect of sulfation on a tough hybrid hydrogel network","authors":"Sander Driesen, Valentino Atella, Kristi Kiick, Louis M. Pitet and Geert-Jan Graulus","doi":"10.1039/D5LP00013K","DOIUrl":"https://doi.org/10.1039/D5LP00013K","url":null,"abstract":"Hybrid hydrogels can mimic the exceptional stiffness of tough native tissues (e.g., articular cartilage). However, many of these tough hybrid hydrogels currently lack bioactive moieties. Therefore, our work focuses on introducing sulfated alginate into a tough poly(acrylamide-co-acrylic acid)/alginate hybrid hydrogel network. This modification introduces the potential for effective tissue interactions and allows further diversification through chemical transformations. These hydrogels are synthesized via the radical-mediated polymerization and covalent crosslinking of acrylamide and acrylic acid. The covalent network is fortified with a second ionically crosslinked sulfated alginate network. FTIR, 13C-NMR, and elemental analysis confirmed a degree of sulfation of 42.5%. Mechanical testing showed that hydrogels with a sulfated alginate content of 2 wt% exhibit comparable compressive stiffness (up to 230 kPa) to native articular cartilage. Cyclical mechanical testing revealed the network's resilience and remarkable toughness. These results suggest the hydrogels’ potential as cartilage mimics and support their additional investigation in vitro.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 3","pages":" 624-636"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00013k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional self-healing aldehyde-derived nanoparticle-crosslinked gelatin/PNIPAm-based adhesive gels† 功能性自修复醛衍生纳米颗粒交联明胶/ pnipam基粘合剂凝胶†

RSC Applied Polymers Pub Date : 2025-03-14 DOI: 10.1039/D5LP00038F

P. A. Parvathy, Sriparna De, Manjinder Singh, Gaurav Manik and Sushanta K. Sahoo

{"title":"Functional self-healing aldehyde-derived nanoparticle-crosslinked gelatin/PNIPAm-based adhesive gels†","authors":"P. A. Parvathy, Sriparna De, Manjinder Singh, Gaurav Manik and Sushanta K. Sahoo","doi":"10.1039/D5LP00038F","DOIUrl":"https://doi.org/10.1039/D5LP00038F","url":null,"abstract":"The combination of lower critical solution temperature (LCST) and upper critical solution temperature (UCST) polymers provides varying dissolution to the system, with tunable physiochemical properties. In the current work, injectable, fluorescent, and thermo-responsive poly-N-isopropylacrylamide (PNIPAm)-gelatin nanocomposite gels were prepared by combining non-covalent interactions and Schiff base chemistry. The incorporation of aldehyde-based nanoparticles (2.5–10%) facilitated the crosslinking of the matrix via the formation of imine linkages with gelatin, which significantly reduced the pore size of the gels from 30–40 micron to 4–5 μm. The temperature-dependent viscoelastic properties showed that the storage modulus increased significantly above 40 °C, which confirmed the thermosensitive behaviour of the gels owing to the combined effect of PNIPAm and gelatin. Higher storage modulus over loss modulus for all crosslinked gels indicates the elastic behaviour of the gels. The introduction of imine linkages offered instant self-healing features and the nanoparticles provide photoluminescence to the polymeric gel system. Furthermore, the tackiness offered by gelatin enhances the adherence to human skin and the gels are found to be biocompatible towards fibroblast cell lines (L929) and are promising for drug delivery systems, injectable materials, and optically trackable adhesives. The findings provide new insights into the multifunctional properties of thermoresponsive PNIPAm-gelatin nanocomposite gels with dynamic imine linkages for biological applications.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 3","pages":" 662-674"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00038f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent material development and applications of conjugated polyelectrolytes by leveraging electronic and ionic transport properties 利用电子和离子输运性质的共轭聚电解质的最新材料发展和应用

RSC Applied Polymers Pub Date : 2025-03-14 DOI: 10.1039/D5LP00012B

Chibin Zhang, Liang Yao, Mingrui Pu and Cheng Zhou

引用次数: 0

Cationic nano-objects produced by polymerization-induced self-assembly using sulfonium-macro chain transfer agents with different counter anions† 采用不同反阴离子的硫宏链转移剂聚合诱导自组装制备阳离子纳米物体

RSC Applied Polymers Pub Date : 2025-03-11 DOI: 10.1039/D5LP00009B

Hirotsugu Miyakawa and Hideharu Mori

{"title":"Cationic nano-objects produced by polymerization-induced self-assembly using sulfonium-macro chain transfer agents with different counter anions†","authors":"Hirotsugu Miyakawa and Hideharu Mori","doi":"10.1039/D5LP00009B","DOIUrl":"https://doi.org/10.1039/D5LP00009B","url":null,"abstract":"Sulfonium cations and sulfonium-based polymers have received increased interest as biomedical and ion-conductive materials because of their unique cationic features. However, the feasible construction of cationic nanostructures via polymerization-induced self-assembly (PISA) remains limited owing to charge repulsion. In this study, we report the efficient synthesis of sulfonium cation-based nano-objects from P(MTEA(S+)[R−])s with different counter anions (R = bis(trifluoromethylsulfonyl)imide, TFSI; trifluoromethanesulfonate, OTf; and chloride, Cl), which were prepared by reversible addition–fragmentation chain-transfer (RAFT) of 2-(methylthio)ethyl acylate (MTEA) and a subsequent anion exchange reaction. RAFT dispersion copolymerization of styrene (St) and N-phenylmaleimide (PMI) using cationic P(MTEA(S+)[R−]) macro-chain transfer agents (CTAs) afforded various assembled structures (worms, vesicles, and nanotubes) by tuning the chain lengths of the P(MTEA(S+)[R−]) and P(St-alt-PMI) blocks and their composition and polymerization conditions (e.g., monomer concentration and solvent polarity). Depending on the three cationic macro-CTAs, the PISA of St and PMI enabled the efficient copolymerization and construction of cationic assemblies, including unique nanotubes. This is the first study demonstrating the successful integration of the sulfonium macro-CTA and PISA, enabling the design and manipulation of cationic nano-objects with various morphologies and unique functionalities originating from sulfonium cations.","PeriodicalId":101139,"journal":{"name":"RSC Applied Polymers","volume":" 3","pages":" 651-661"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lp/d5lp00009b?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0