Revista Portuguesa de Pneumologia (English Edition)最新文献

{"title":"Predictors of talc slurry pleurodesis success in patients with malignant pleural effusions","authors":"P.S. Santos ,&nbsp;M.A. Marques ,&nbsp;C. Cruz ,&nbsp;H. Monteiro ,&nbsp;F. Fradinho","doi":"10.1016/j.rppnen.2017.01.008","DOIUrl":"10.1016/j.rppnen.2017.01.008","url":null,"abstract":"<div><h3>Introduction</h3><p>Malignant pleural effusions are an important burden of malignant disease. Slurry talc pleurodesis remains one of the most common and effective therapeutic options.</p></div><div><h3>Aim</h3><p>Investigate the predictive factors related with the efficacy of this technique in malignant pleural effusions.</p></div><div><h3>Methods</h3><p>Retrospective analysis of all pleurodesis performed during a 10-year period in a Pulmonology Unit. All demographic and clinical data were collected, including the histologic tumoral type and the biochemical, microbiological and cytological fluid features. Efficacy was defined as the lack of recurrence of pleural effusion. It was used Kaplan–Meyer analysis to estimate overall survival.</p></div><div><h3>Results</h3><p>From a total of 202 patients submitted to pleurodesis (47% men; mean age 66.9<!--> <!-->±<!--> <!-->12.02 years). Light's criteria identified 86.6% as exudates. We found 85.1% survival at 30-day post-pleurodesis, which means the therapy used has significant success. A logistic regression model applied explained that variance in post-pleurodesis events was mostly due to age and gender rather than pleural biochemical factors (<em>X</em>²₍₅₎ <!-->=<!--> <!-->44.648, <em>p</em> <!-->&lt;<!--> <!-->0.001, <em>R</em>² 28.3%).</p></div><div><h3>Conclusion</h3><p>This study suggests that clinical evaluation of biochemical values, bacteriological results and malignant tumor diagnosis may not be enough to predict post-pleurodesis relapse with high accuracy. Furthermore, we observed, in ten years of pleurodesis performed in our Hospital, that pleurodesis is an effective life prolonging therapy for patients that fit the criteria for this intervention.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.01.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35081711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parents’ educational level and second-hand tobacco smoke exposure at home in a sample of Portuguese children","authors":"Paulo D. Vitória ,&nbsp;Célia Nunes ,&nbsp;José Precioso","doi":"10.1016/j.rppnen.2017.02.005","DOIUrl":"10.1016/j.rppnen.2017.02.005","url":null,"abstract":"<div><p>Second-hand tobacco smoke (SHS) exposure is a major and entirely avoidable health risk for children's health, well-being and development. The main objective of the current study was to investigate the association between parents’ educational level and children's SHS home exposure.</p><p>A self-administered questionnaire was conducted within a sample of 949 students in 4th grade (mean age 9.56<!--> <!-->±<!--> <!-->0.75, 53.4% male). The sample was randomly selected from all schools located at Lisbon District, Portugal.</p><p>The current study confirmed that Portuguese children are exposed to unacceptable high levels of SHS at home, mainly by their parents’ smoke. Prevalence of smokers was higher amongst parents with low educational level. Children of parents with low educational level were more likely to suffer SHS exposure at home. These results confirmed the social inequalities associated with smoking, support the relevance of more research on this subject and stress the need for more interventions to control this problem. Some interventions should be specifically aimed at less educated parents, particularly at less educated mothers.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.02.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34859524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between age and sweat chloride levels in sweat tests","authors":"A.G. Faria ,&nbsp;F.A.L. Marson ,&nbsp;A.F. Ribeiro ,&nbsp;J.D. Ribeiro","doi":"10.1016/j.rppnen.2016.11.001","DOIUrl":"10.1016/j.rppnen.2016.11.001","url":null,"abstract":"","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2016.11.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49337482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of late-onset pompe disease in Portuguese patients with diaphragmatic paralysis – DIPPER study","authors":"M.J. Guimarães ,&nbsp;J.C. Winck ,&nbsp;B. Conde ,&nbsp;A. Mineiro ,&nbsp;M. Raposo ,&nbsp;J. Moita ,&nbsp;A. Marinho ,&nbsp;J.M. Silva ,&nbsp;N. Pires ,&nbsp;S. André ,&nbsp;C. Loureiro","doi":"10.1016/j.rppnen.2017.02.004","DOIUrl":"10.1016/j.rppnen.2017.02.004","url":null,"abstract":"<div><p>Pompe disease is a rare autosomal recessive neuromuscular disorder caused by acid α-glucosidase enzyme (GAA) deficiency and divided into two distinct variants, infantile- and late-onset. The late-onset variant is characterized by a spectrum of phenotypic variation that may range from asymptomatic, to reduced muscle strength and/or diaphragmatic paralysis. Since muscle strength loss is characteristic of several different conditions, which may also cause diaphragmatic paralysis, a protocol was created to search for the diagnosis of Pompe disease and exclude other possible causes.</p></div><div><h3>Methods</h3><p>We collected a sample size of 18 patients (10 females, 8 males) with a median age of 60 years and diagnosis of diaphragmatic paralysis of unknown etiology, followed in the Pulmonology outpatient consultation of 9 centers in Portugal, over a 24-month study period. We evaluated data from patient's clinical and demographic characteristics as well as complementary diagnostic tests including blood tests, imaging, neurophysiologic and respiratory function evaluation. All patients were evaluated for GAA activity with DBS (dried blood test) or serum quantification and positive results confirmed by serum quantification and sequencing.</p></div><div><h3>Results</h3><p>Three patients were diagnosed with Pompe's disease and recommended for enzyme replacement therapy. The prevalence of Pompe, a rare disease, in our diaphragmatic paralysis patient sample was 16.8%.</p></div><div><h3>Conclusion</h3><p>We conclude that DBS test for GAA activity should be recommended for all patients with diaphragmatic paralysis which, despite looking at all the most common causes, remains of unknown etiology; this would improve both the timing and accuracy of diagnosis for Pompe disease in this patient population. Accurate diagnosis will lead to improved care for this rare, progressively debilitating but treatable neuromuscular disease.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.02.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34991170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bronchial mucous gland adenoma: A rare tumor","authors":"R.C. Oliveira ,&nbsp;L. Carvalho ,&nbsp;A.J. Ferreira ,&nbsp;C.R. Cordeiro","doi":"10.1016/j.rppnen.2017.04.006","DOIUrl":"10.1016/j.rppnen.2017.04.006","url":null,"abstract":"","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.04.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35040180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis, alcohol and tobacco: Dangerous liaisons","authors":"A.F. Santos-Silva ,&nbsp;G.B. Migliori ,&nbsp;R. Duarte","doi":"10.1016/j.rppnen.2017.05.001","DOIUrl":"10.1016/j.rppnen.2017.05.001","url":null,"abstract":"","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35058194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wood charcoal dust pneumoconiosis","authors":"P.P.T.S Torres ,&nbsp;E. Marchiori ,&nbsp;S.A. Pinto ,&nbsp;M.F. Rabahi","doi":"10.1016/j.rppnen.2017.02.006","DOIUrl":"10.1016/j.rppnen.2017.02.006","url":null,"abstract":"","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.02.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34875171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of positive airway pressure therapy on cardiovascular and metabolic markers in males with obstructive sleep apnea","authors":"A. Feliciano ,&nbsp;M.J. Oliveira ,&nbsp;A. Cysneiros ,&nbsp;C. Martinho ,&nbsp;R.P. Reis ,&nbsp;D. Penque ,&nbsp;P. Pinto ,&nbsp;C. Bárbara","doi":"10.1016/j.rppnen.2017.02.010","DOIUrl":"10.1016/j.rppnen.2017.02.010","url":null,"abstract":"<div><h3>Introduction</h3><p>Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular/metabolic complications. Some analytical parameters (homocysteine, glycemic and lipidic profiles) are recognized markers of these consequences. Limited data is available on the association of these markers and OSAS's severity/response to positive airway pressure therapy (PAP).</p></div><div><h3>Material and methods</h3><p>In this prospective study we analyzed polysomnographic and analytical data of male patients admitted to sleep laboratory. The aim was to evaluate metabolic/cardiovascular markers in snorers and OSAS patients, to relate with sleep parameters and PAP response. One-hundred and three patients were included, and 73 (71%) were OSAS patients. OSAS patients were similar to snorers except for higher body mass index (BMI) and dyslipidemia. Severe OSAS patients showed higher glycemia, HbA1c, insulin, and insulin resistance, and lower HDL cholesterol in comparison to mild–moderate (<em>p</em> <!-->&lt;<!--> <!-->0.05, <em>p</em> <!-->&lt;<!--> <!-->0.05, <em>p</em> <!-->&lt;<!--> <!-->0.001, <em>p</em> <!-->&lt;<!--> <!-->0.001, <em>p</em> <!-->&lt;<!--> <!-->0.05, respectively). Glycemic profile and triglycerides were slightly correlated with OSAS severity. 46 OSAS patients were submitted to 6 months of PAP, with a statistical decrease in mean values of homocysteine, glycemia, total and LDL cholesterol (<em>p</em> <!-->&lt;<!--> <!-->0.05, <em>p</em> <!-->&lt;<!--> <!-->0.05, <em>p</em> <!-->&lt;<!--> <!-->0.05, respectively), and in glycemia and LDL cholesterol in severe group only (<em>p</em> <!-->&lt;<!--> <!-->0.05, <em>p</em> <!-->&lt;<!--> <!-->0.05, respectively).</p></div><div><h3>Results</h3><p>This study demonstrated an association between glucose metabolism parameters and triglycerides with OSAS severity underlying the complexity of the process leading to cardiovascular/metabolic complications in this disorder. Moreover, homocysteine, glycemic and lipidic profiles changed significantly after 6 months of PAP therapy in OSAS, supporting its cardiovascular and metabolic protective effect.</p></div><div><h3>Conclusion</h3><p>Our study has reinforced the importance of analytical cardiovascular/metabolic evaluation as complementary tool of diagnosis/treatment response in OSAS.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.02.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35073498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival analysis of patients with non-small cell lung cancer treated by surgery with curative intent","authors":"C. Cruz ,&nbsp;M. Afonso ,&nbsp;B. Oliveiros ,&nbsp;A. Pêgo","doi":"10.1016/j.rppnen.2017.03.003","DOIUrl":"10.1016/j.rppnen.2017.03.003","url":null,"abstract":"","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35029179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal micronodular pneumocyte hyperplasia associated with tuberous sclerosis complex: A case report without lymphangioleiomyomatosis association","authors":"M. Rodrigues ,&nbsp;E. Padrão ,&nbsp;K. Irion","doi":"10.1016/j.rppnen.2017.04.004","DOIUrl":"10.1016/j.rppnen.2017.04.004","url":null,"abstract":"","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.04.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35033064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}