A. Feliciano , M.J. Oliveira , A. Cysneiros , C. Martinho , R.P. Reis , D. Penque , P. Pinto , C. Bárbara
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OSAS patients were similar to snorers except for higher body mass index (BMI) and dyslipidemia. Severe OSAS patients showed higher glycemia, HbA1c, insulin, and insulin resistance, and lower HDL cholesterol in comparison to mild–moderate (<em>p</em> <!--><<!--> <!-->0.05, <em>p</em> <!--><<!--> <!-->0.05, <em>p</em> <!--><<!--> <!-->0.001, <em>p</em> <!--><<!--> <!-->0.001, <em>p</em> <!--><<!--> <!-->0.05, respectively). Glycemic profile and triglycerides were slightly correlated with OSAS severity. 46 OSAS patients were submitted to 6 months of PAP, with a statistical decrease in mean values of homocysteine, glycemia, total and LDL cholesterol (<em>p</em> <!--><<!--> <!-->0.05, <em>p</em> <!--><<!--> <!-->0.05, <em>p</em> <!--><<!--> <!-->0.05, respectively), and in glycemia and LDL cholesterol in severe group only (<em>p</em> <!--><<!--> <!-->0.05, <em>p</em> <!--><<!--> <!-->0.05, respectively).</p></div><div><h3>Results</h3><p>This study demonstrated an association between glucose metabolism parameters and triglycerides with OSAS severity underlying the complexity of the process leading to cardiovascular/metabolic complications in this disorder. Moreover, homocysteine, glycemic and lipidic profiles changed significantly after 6 months of PAP therapy in OSAS, supporting its cardiovascular and metabolic protective effect.</p></div><div><h3>Conclusion</h3><p>Our study has reinforced the importance of analytical cardiovascular/metabolic evaluation as complementary tool of diagnosis/treatment response in OSAS.</p></div>","PeriodicalId":101122,"journal":{"name":"Revista Portuguesa de Pneumologia (English Edition)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.rppnen.2017.02.010","citationCount":"2","resultStr":"{\"title\":\"Effects of positive airway pressure therapy on cardiovascular and metabolic markers in males with obstructive sleep apnea\",\"authors\":\"A. Feliciano , M.J. Oliveira , A. Cysneiros , C. Martinho , R.P. Reis , D. Penque , P. Pinto , C. 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引用次数: 2
摘要
阻塞性睡眠呼吸暂停综合征(OSAS)与心血管/代谢并发症相关。一些分析参数(同型半胱氨酸、血糖和血脂谱)被认为是这些后果的标志。这些标志物与OSAS严重程度/对气道正压治疗(PAP)的反应之间的关联数据有限。材料与方法在本前瞻性研究中，我们分析了睡眠实验室收治的男性患者的多导睡眠图和分析数据。目的是评估打鼾者和OSAS患者的代谢/心血管标志物，与睡眠参数和PAP反应相关。纳入103例患者，其中73例(71%)为OSAS患者。OSAS患者除了身体质量指数(BMI)较高和血脂异常外，与打鼾者相似。与轻度-中度OSAS患者相比，重度OSAS患者表现出更高的血糖、HbA1c、胰岛素和胰岛素抵抗，以及更低的高密度脂蛋白胆固醇(p <0.05, p <0.05, p <0.001, p <0.001, p <分别为0.05)。血糖谱和甘油三酯与OSAS严重程度略有相关。46例OSAS患者接受6个月的PAP治疗，同型半胱氨酸、血糖、总胆固醇和低密度脂蛋白胆固醇的平均值均有统计学意义下降(p <0.05, p <0.05, p <0.05)，严重组血糖和低密度脂蛋白胆固醇(p <0.05, p <分别为0.05)。结果本研究表明葡萄糖代谢参数和甘油三酯与OSAS严重程度之间存在关联，这一过程的复杂性导致了这种疾病的心血管/代谢并发症。此外，在osa患者接受PAP治疗6个月后，同型半胱氨酸、血糖和血脂谱发生了显著变化，支持其心血管和代谢保护作用。结论本研究强化了分析性心血管/代谢评价作为OSAS诊断/治疗反应补充工具的重要性。
Effects of positive airway pressure therapy on cardiovascular and metabolic markers in males with obstructive sleep apnea
Introduction
Obstructive sleep apnea syndrome (OSAS) is associated with cardiovascular/metabolic complications. Some analytical parameters (homocysteine, glycemic and lipidic profiles) are recognized markers of these consequences. Limited data is available on the association of these markers and OSAS's severity/response to positive airway pressure therapy (PAP).
Material and methods
In this prospective study we analyzed polysomnographic and analytical data of male patients admitted to sleep laboratory. The aim was to evaluate metabolic/cardiovascular markers in snorers and OSAS patients, to relate with sleep parameters and PAP response. One-hundred and three patients were included, and 73 (71%) were OSAS patients. OSAS patients were similar to snorers except for higher body mass index (BMI) and dyslipidemia. Severe OSAS patients showed higher glycemia, HbA1c, insulin, and insulin resistance, and lower HDL cholesterol in comparison to mild–moderate (p < 0.05, p < 0.05, p < 0.001, p < 0.001, p < 0.05, respectively). Glycemic profile and triglycerides were slightly correlated with OSAS severity. 46 OSAS patients were submitted to 6 months of PAP, with a statistical decrease in mean values of homocysteine, glycemia, total and LDL cholesterol (p < 0.05, p < 0.05, p < 0.05, respectively), and in glycemia and LDL cholesterol in severe group only (p < 0.05, p < 0.05, respectively).
Results
This study demonstrated an association between glucose metabolism parameters and triglycerides with OSAS severity underlying the complexity of the process leading to cardiovascular/metabolic complications in this disorder. Moreover, homocysteine, glycemic and lipidic profiles changed significantly after 6 months of PAP therapy in OSAS, supporting its cardiovascular and metabolic protective effect.
Conclusion
Our study has reinforced the importance of analytical cardiovascular/metabolic evaluation as complementary tool of diagnosis/treatment response in OSAS.
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