Revista Espa?ola de Enfermedades Metabólicas óseas最新文献

{"title":"Mujer de mediana edad con tumoración palmar y parestesias en el territorio del nervio mediano izquierdo","authors":"M.Á. Contreras Blasco","doi":"10.1016/S1132-8460(08)71137-1","DOIUrl":"10.1016/S1132-8460(08)71137-1","url":null,"abstract":"","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 2","pages":"Pages 33-34"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71137-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126819432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalencia y factores de riesgo clínico de osteoporosis en la consulta de rehabilitación","authors":"I. Serralta-Davia ,&nbsp;J.A. Girbés-Borrás","doi":"10.1016/S1132-8460(08)71134-6","DOIUrl":"10.1016/S1132-8460(08)71134-6","url":null,"abstract":"<div><p>Los factores de riesgo de OP son las variables, estados o condiciones que confieren un riesgo incrementado para su desarrollo. Los objetivos de este trabajo son analizar la influencia de los factores de riesgo clínico y de la edad en la prevalencia de OP en los pacientes que acuden a la consulta de rehabilitación y que presentan dos o más factores de riesgo clínico de baja densidad mineral ósea. Efectuamos un estudio transversal de 108 pacientes, mujeres, en las que se cuantificó la densidad mineral ósea mediante densitometría. Comparamos la prevalencia de osteoporosis en nuestra muestra con la prevalencia en la población femenina española, por grupos de edad. Como resultado obtuvimos una prevalencia de OP en las pacientes de nuestro estudio superior a la de la población femenina española.</p><p>La prevalencia de OP aumenta con la edad, y es en el estrato de 50 a 59 años en el que mayor razón de prevalencias encontramos con respecto a la población general. El uso de los factores de riesgo clínico de OP en la consulta de rehabilitación es útil para el manejo de la OP.</p></div><div><p>The risk factors of osteoporosis are variable and are states or conditions that confer an increased risk for the development of osteoporosis. This study aims to analyze the influence of the clinical risk factors in osteoporosis and age of the osteoporosis prevalence in patients who come to our clinic with two or more clinical risk factors of low bone mineral density. We are conducting a cross-sectional study of 108 female patients in whom bone mineral density was quantified by densitometry. We compare the prevalence of osteoporosis in our sample with the prevalence of the Spanish female population by age group. As a result we obtained a prevalence of osteoporosis in the patients of our study greater than the prevalence in the Spanish female population.</p><p>Osteoporosis prevalence increases with age, the peak being among the 50-59 age group where the greatest prevalence ratio is found in regards to the general population. The use of osteoporosis clinical risk factors in the rehabilitation clinic is useful for its therapeutical management.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 2","pages":"Pages 17-21"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71134-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113980601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteomalacia hipofosfatémica en un paciente infectado por VIH en tratamiento con tenofovir","authors":"F. Jiménez Zorzo,&nbsp;C. Beltrán Audera,&nbsp;C. Bruscas Izu","doi":"10.1016/S1132-8460(08)71135-8","DOIUrl":"10.1016/S1132-8460(08)71135-8","url":null,"abstract":"<div><p>En pacientes infectados por VIH en tratamiento con tenofovir se ha comunicado la ocurrencia de hipofosfatemia y osteomalacia. Presentamos un caso que debutó clínicamente con fracturas vertebrales y dolor óseo. La suspensión de la medicación y la corrección de la acidosis mejoraron la sintomatología. El caso ilustra la importancia de considerar la osteomalacia en pacientes tratados con tenofovir.</p></div><div><p>Cases of hypophosphatamia and osteomalacia have been reported in HIVpositive patients on tenofovir-containing active antiretroviral therapy. We present a case in which vertebral fractures and bone pain were the presenting features. The symptoms resolved after discontinuation of tenofovir and with mineral supplementation. The case highlights the importance of considering the diagnosis of osteomalacia in patients treated with tenofovir.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 2","pages":"Pages 22-24"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71135-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127706967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoporosis en las enfermedades autoinmunes sistémicas","authors":"J.M. Nolla","doi":"10.1016/S1132-8460(08)71136-X","DOIUrl":"10.1016/S1132-8460(08)71136-X","url":null,"abstract":"<div><p>En las enfermedades autoinmunes sistémicas concurren diversas circunstancias que favorecen una pérdida ósea. Hay que considerar el efecto de la terapéutica (glucocorticoides, inmunosupresores), de los factores relacionados con la propia enfermedad (actividad inflamatoria, inmovilidad, alteraciones hormonales en el eje hipotálamo-hipófiso-suprarrenal y desnutrición entre otros) y de los factores intrínsecos al individuo (edad, sexo, estado hormonal, índice de masa corporal y base genética entre otros). En la artritis reumatoide está establecido que los pacientes presentan una menor densidad mineral ósea y un superior riesgo de fractura. Se ha confirmado que los osteoclastos son las células responsables de los tres tipos de lesiones óseas que acontecen en la artritis reumatoide: las erosiones, la pérdida yuxtarticular y la pérdida generalizada (osteoporosis) y que la abolición de la actividad inflamatoria resulta capital para limitar el problema. Se conoce que las mujeres con lupus eritematoso sistémico presentan una menor densidad mineral ósea y un riesgo aumentado de fractura; en varones, estas circunstancias no están aclaradas. En otras enfermedades, como el syndrome de Sjögren, la esclerosis sistémica y las miopatías inflamatorias, la información disponible es aún escasa.</p></div><div><p>Several different circumstances coincide in systemic autoimmune diseases that favor bone loss. It is necessary to consider the effect of the therapy (glucocorticoids, immunosuppressants), of the factors related with the disease itself (inflammatory activity, immobility, hormone disorders on the hypothalamus-pituitary- adrenal axis and malnutrition, among others) and of the factors intrinsic to the individual (age, gender, hormonal status, body mass index and genetic base, among others). It is established in rheumatoid arthritis that the patients have lower bone mineral density and greater risk of fracture. It has been confirmed that the osteoclasts are the cells responsible for the three types of bone lesions that occur in rheumatoid arthritis: erosions, juxtaarticular loss and generalized lost (osteoporosis) and the abolition of inflammatory activity is essential to limit the problem. It is known that women with systemic lupus erythematosus have lower bone mineral density and increased risk of fracture. In men, these circumstances have not been clarified. In other diseases, such as Sjögren syndrome, systemic sclerosis and inflammatory myopathies, the information available is still very limited.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 2","pages":"Pages 25-32"},"PeriodicalIF":0.0,"publicationDate":"2008-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71136-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"96828624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niveles de vitamina D en población mayor de 65 años","authors":"V. Niño Martín ,&nbsp;J.L. Pérez Castrillón","doi":"10.1016/S1132-8460(08)71130-9","DOIUrl":"10.1016/S1132-8460(08)71130-9","url":null,"abstract":"<div><p>El objetivo de este estudio fue valorar la prevalencia de deficiencia e insuficiencia de vitamina D en pacientes ancianos. Se realizó un estudio descriptivo, transversal en individuos mayores de 65 años que vivían en su domicilio, en una residencia de ancianos o que estaban hospitalizados. Se evaluaron 454 personas. Las concentraciones medias de 25 (OH) D3 eran 37± 20<!--> <!-->nmol/l en individuos en domicilio, 33±17<!--> <!-->nmol/l en pacientes en residencia y 27±14<!--> <!-->nmol/l en pacientes hospitalizados. Se observó una relación inversa entre vitamina D y paratohormona (PTH) (r: -0,257, p<!--> <!-->=<!--> <!-->0,0001). Las prevalencias de deficiencia e insuficiencia en vitamina D eran 79% y 31% en individuos en domicilio, 91% y 32% en pacientes en residencia y 92% y 52% en pacientes ingresados. En conclusión, podemos afirmar que la prevalencia de hipovitaminosis D en ancianos de nuestra área de salud es alta.</p></div><div><p>This study aims to evaluate the prevalence of vitamin D deficiency and insufficiency in older subjects. A cross-sectional population study in subjects over 65 years of age residing in their home, in a nursing home and in-patients was performed. A total of 454 persons were evaluated. Mean serum concentrations of 25 (OH) D3 were 37± 20<!--> <!-->nmol/l in home subjects, 33±17<!--> <!-->nmol/l in nursing home and 27±14<!--> <!-->nmol/l in in-patients. An inverse correlation between paratohormon (PTH) and vitamin D was found (r: -0.257, p<!--> <!-->=<!--> <!-->0.0001). Vitamin D deficiency and insufficiency were present in 79% and 31% in home subjects, 91% and 32% in nursing home and 92% and 52% in in-patients. In conclusion, hypovitaminosis D is a very frequent finding in elderly people of the population of our health care area.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 1","pages":"Pages 1-4"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71130-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"93320358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulación del proceso de remodelado óseo","authors":"R. Reyes García,&nbsp;P. Rozas Moreno,&nbsp;M. Muñoz-Torres","doi":"10.1016/S1132-8460(08)71132-2","DOIUrl":"10.1016/S1132-8460(08)71132-2","url":null,"abstract":"<div><p>El hueso es un tejido metabólicamente activo que experimenta un continuo proceso de remodelado, lo que confiere al esqueleto su capacidad regenerativa y de adaptación funcional. Aunque en los últimos años se ha producido un gran avance en el conocimiento de los factores que intervienen en la regulación del proceso de remodelado, aún quedan por aclarar muchos aspectos dado que esta regulación es compleja ya que integra diversos estímulos como son factores mecánicos, hormonales, citoquinas y factores de crecimiento. Por otra parte, el mayor conocimiento existente sobre las vías y moléculas que intervienen en su regulación abre la posibilidad de futuros tratamientos en el campo de las enfermedades metabólicas óseas.</p></div><div><p>The bone is a metabolically active tissue that undergoes continuous regeneration, which bestows the skeleton its regenerative and functional adaptation capacity. Although there have been significant advances in our understanding of the mechanism of the bone remodeling process in recent years, there is still much to learn on many aspects since the regulation of bone remodeling is a complex process. It integrates different stimuli such as mechanical and hormonal factors, cytokines and growth factors. On the other hand, better understanding of the cellular and molecular events involved in the bone remodeling process could help in futures treatments in the field of bone metabolic diseases.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 1","pages":"Pages 10-14"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71132-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134380143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La vía Wnt y el hueso","authors":"J. Velasco,&nbsp;J.A. Riancho","doi":"10.1016/S1132-8460(08)71131-0","DOIUrl":"10.1016/S1132-8460(08)71131-0","url":null,"abstract":"<div><p>La participación de la vía Wnt en el metabolismo óseo ha sido objeto de numerosos estudios en los últimos años. Esta vía de señalización es compleja y está integrada por numerosos componentes, incluyendo ligandos, receptores de membrana, efectores intracelulares y antagonistas. Los mecanismos mejor conocidos de transmisión de la señal de los ligandos Wnt se incluyen en la llamada vía canónica, en la cual la β-catenina desempeña un papel central. Sin embargo, existen otras vías alternativas o no canónicas que emplean mediadores diferentes. Los resultados de diversos estudios clínicos y experimentales indican que la vía Wnt modula la diferenciación y la actividad de las células óseas y está implicada en diferentes trastornos esqueléticos, como la osteoporosis, la artrosis, el mieloma o las metástasis. Por tanto, una mejor comprensión de esta vía puede permitir desarrollar nuevas dianas terapéuticas para esos procesos. En este trabajo pretendemos hacer una breve puesta al día de los principales mediadores implicados en la vía Wnt, y en particular de su papel en las enfermedades óseas.</p></div><div><p>The participation of the Wnt pathway in bone metabolism has been the subject of many studies in recent years. This signal pathway is complex and is made up of many components, including ligands, membrane receptors, intracellular effectors and antagonists. The best known mechanisms of Wnt ligand signal transmission are included in the so-called canonical pathway, in which the β-catenin plays a central role. However, there are other alternative or noncanonical pathways that use different mediators. The results of different clinical and experimental studies indicate that the Wnt pathway modulates the differentiation and activity of the bone cells and is involved in different skeletal disorders, such as osteoporosis, arthrosis, myeloma or metastases. Thus, better understanding of this pathway may make it possible to develop new therapeutic targets for these diseases. In this work, we aim to make a brief up-date of the principal mediators involved in the Wnt pathway and especially in its role in bone diseases.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 1","pages":"Pages 5-9"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71131-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115585068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quiste hidatídico óseo","authors":"M.Á. Contreras Blasco","doi":"10.1016/S1132-8460(08)71133-4","DOIUrl":"10.1016/S1132-8460(08)71133-4","url":null,"abstract":"","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"17 1","pages":"Pages 15-16"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(08)71133-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133860748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tomografía por emisión de positrones y metástasis óseas","authors":"J.M. Olmos Martínez,&nbsp;J. Martínez García,&nbsp;J. González Macías","doi":"10.1016/S1132-8460(07)73513-4","DOIUrl":"10.1016/S1132-8460(07)73513-4","url":null,"abstract":"<div><p>Se describe el caso de un paciente de 76 años con disfonía y un nódulo pulmonar solitario, en el que la realización de una tomografía por emisión de positrones (PET) reveló la existencia de una captación sugestiva de malignidad en el nódulo pulmonar, así como la presencia de diseminación metastásica ósea, ganglionar y hepática.</p></div><div><p>We describe the case of a 76-year-old patient with dysphonia and a solitary pulmonary nodule; the uptake at positron emission tomography suggested the pulmonary nodule was malignant and revealed bone, lymph-node, and liver metastases.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"16 6","pages":"Pages 133-135"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(07)73513-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115051485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capacidad predictiva de la densitometría de calcáneo en mujeres climatéricas","authors":"J. Quiles Izquierdo ,&nbsp;F.J. Nohales Alfonso ,&nbsp;J. Castelló ,&nbsp;J.V. Carmona Moral ,&nbsp;J. Más Ribas ,&nbsp;A.M. Fullana Montoro","doi":"10.1016/S1132-8460(07)73510-9","DOIUrl":"10.1016/S1132-8460(07)73510-9","url":null,"abstract":"<div><h3>Material y métodos</h3><p>Estudio de la capacidad predictiva del PIXI Lunar^® en el calcáneo derecho con respecto al densitómetro DXA-Lunar^®, a través de las mediciones practicadas en 100 mujeres entre 46 y 70 años. La validez y seguridad se ha obtenido mediante la estimación de la sensibilidad, especificidad, precisión y valores predictivos para la categorización de la muestra como osteoporosis (OP) y baja masa ósea (BMO).</p></div><div><h3>Resultados</h3><p>La precisión estimada para el PIXI como predictor de OP y BMO ha sido del 72,7% (intervalo de confianza [IC] 95%: 62,7-81,0) con referencia a la densitometría de doble energía de rayos X (DXA) de columna y del 73% (IC 95%: 63,0-81,2) y 75% (IC 95%: 65,2-82,9) para la DXA de cadera, respectivamente.</p><p>La máxima sensibilidad se observó para la BMO comparada con la DXA de fémur, 93,7% (IC 95%: 81,8-98,4) y la máxima especificidad se obtuvo para OP con respecto a DXA de columna, 75,6% (IC 95%: 64,6-84,1).</p></div><div><h3>Conclusiones</h3><p>La categorización realizada con el PIXI de calcáneo se corresponde mejor a la DXA de fémur. Su uso puede servir para clasificar una población según su densidad mineral ósea.</p></div><div><h3>Material and methods</h3><p>We conducted a study of the predictive capacity of PIXI Lunar^® in the right calcaneus with respect to DXA-Lunar^® densitometry through measurements carried out in 100 women between 46 and 70 years of age. Validity and safety were assessed by measuring the sensitivity, specificity, accuracy, and predictive values for the classification of the sample as osteoporosis (OP) and low bone mass (LBM).</p></div><div><h3>Results</h3><p>The estimated accuracy of PIXI as a predictor of OP and LBM was 72.7% (95% CI: 62.7-81.0) with respect to spinal DXA and 73% (95% CI: 63.0-81.2) and 75% (95% CI: 65.2-82.9), respectively for hip DXA.</p><p>The maximum sensitivity was observed for LBM as compared to DXA of the femur, 93.7% (95% CI:81.8-98.4) and the maximum specificity was obtained for OP with respect to spinal DXA, 75.6% (95% CI: 64.6-84.1).</p></div><div><h3>Conclusions</h3><p>Classification using PIXI of the calcaneus corresponds best to DXA of the femur. PIXI can be used to classify a population according to its bone mineral density.</p></div>","PeriodicalId":101109,"journal":{"name":"Revista Espa?ola de Enfermedades Metabólicas óseas","volume":"16 6","pages":"Pages 119-123"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1132-8460(07)73510-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"96890151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}