Revista del Laboratorio Clínico最新文献_第4页

Transient monoclonal gammopathy and hypercalcemia in a male patient with Systemic Lupus Erythematosus 男性系统性红斑狼疮患者的一过性单克隆伽玛病和高钙血症

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/J.LABCLI.2018.07.005

Carlos Quintero, Judith Corona, M. Ponce, A. Aviles, O. Gutiérrez, M. Candelaria

引用次数: 1

Farmacogenómica: la medicina personalizada 药物基因组学:个性化医疗

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/j.labcli.2018.07.004

María Pierna Álvarez , Elena Marcos-Vadillo , Belén García-Berrocal , María Isidoro-García

引用次数: 1

About the correct definition of acanthocytes for their use as markers of glomerular haematuria 关于棘细胞作为肾小球血尿标志物的正确定义

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/J.LABCLI.2019.02.004

S. Zaera, Noa Villar-Mallo, Marta González Vilanova, María Carmen Díaz Lozano, Juan J. Garrido-Sánchez, Lola Máiz Suárez

引用次数: 1

Recomendaciones preanalíticas para la obtención y análisis de ADN circulante a partir de sangre periférica. Recomendación (2018) 从外周血中获取和分析循环dna的分析前建议。建议(2018年)

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/j.labcli.2018.11.002

Álvaro González , Clara Pérez Barrios , Hada Macher , Marta Sánchez-Carbayo , Antonio Barco Sánchez , Antonio Fernández Suárez , Antonio Martínez Peinado , Blanca Ortiz Muñoz , Jaume Trapé Pujol , José Diego Santotoribio Camacho , Josep María Augé Fradera , María Jesús Gaspar Blázquez , Rosa Carbonell Muñoz , Xavier Filella Pla , Comité Científico de la Sociedad Española de Medicina de Laboratorio (SEQCML)

{"title":"Recomendaciones preanalíticas para la obtención y análisis de ADN circulante a partir de sangre periférica. Recomendación (2018)","authors":"Álvaro González , Clara Pérez Barrios , Hada Macher , Marta Sánchez-Carbayo , Antonio Barco Sánchez , Antonio Fernández Suárez , Antonio Martínez Peinado , Blanca Ortiz Muñoz , Jaume Trapé Pujol , José Diego Santotoribio Camacho , Josep María Augé Fradera , María Jesús Gaspar Blázquez , Rosa Carbonell Muñoz , Xavier Filella Pla , Comité Científico de la Sociedad Española de Medicina de Laboratorio (SEQCML)","doi":"10.1016/j.labcli.2018.11.002","DOIUrl":"https://doi.org/10.1016/j.labcli.2018.11.002","url":null,"abstract":"<div><p>Cell-free DNA analysis in peripheral blood has been shown to be useful in oncology, organ transplantation, and prenatal screening. For its introduction into the clinical laboratory, it is necessary to ensure appropriate, reproducible and standardised pre-analytical protocols are in place. The aim of this document is to provide pre-analytical recommendations for obtaining of cell free DNA from peripheral blood. These recommendations include the type of sample and extraction tube, the method of centrifugation, the method for cell free DNA extraction, and measurement and storage conditions.</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.labcli.2018.11.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91682720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Farmacogenómica: la medicina personalizada 药物基因组学:个性化医疗

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/J.LABCLI.2018.07.004

María Pierna Álvarez, Elena Marcos-Vadillo, Belén García-Berrocal, M. Isidoro-García

引用次数: 1

Transient monoclonal gammopathy and hypercalcemia in a male patient with Systemic Lupus Erythematosus 男性系统性红斑狼疮患者的一过性单克隆伽玛病和高钙血症

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/j.labcli.2018.07.005

Carlos Quintero , Judith Corona , Mayra Ponce , Alejandro Avilés , Olga Gutierrez , Myrna Candelaria

{"title":"Transient monoclonal gammopathy and hypercalcemia in a male patient with Systemic Lupus Erythematosus","authors":"Carlos Quintero , Judith Corona , Mayra Ponce , Alejandro Avilés , Olga Gutierrez , Myrna Candelaria","doi":"10.1016/j.labcli.2018.07.005","DOIUrl":"https://doi.org/10.1016/j.labcli.2018.07.005","url":null,"abstract":"<div><p><span><span><span>Systemic Lupus Erythematosus (SLE) as an autoimmune disorder, is characterized by a profound </span>B cell activation<span>, however, the association of this disease with a monoclonal gammopathy has been infrequently reported, while </span></span>hypercalcemia is associated with Hypercalcemia-Lymphadenopathy Syndrome (HL-SLE). We report the case of a 45-year-old man, with anemia, </span>hypoalbuminemia<span><span>, hypergammaglobulinemia, hypercalcemia, and bone marrow infiltrated with plasma cells. He was diagnosed as Monoclonal Gammopathy of Undetermined Significance (MGUS), one year later he attended with erythematous macules on both arms, at this time the </span>electrophoresis<span> reported a polyclonal hypergammaglobulinemia. Immunologic panel reported ANA 1:2560, mitochondrial ANA 1:80, anti-double-stranded DNA IgG 15.3 and hipocomplementemia. We confirmed SLE and treatment was initiated. In our patient we ruled out MGUS, γHCD (γ-heavy-chain disease) and hypercalcemia related to HL-SLE. To our knowledge, the findings of monoclonal gammopathy and hypercalcemia as the onset of SLE have never been reported and the role of clinical laboratory was very important in the approach to establish a definitive diagnosis.</span></span></p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.labcli.2018.07.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91682719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recomendaciones para la elaboración de un cuadro de mando integral para la gestión de pruebas en el lugar de asistencia del paciente (POCT). Recomendación (2017) 为患者护理场所(POCT)的检测管理开发综合仪表板的建议。建议(2017年)

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/j.labcli.2018.09.001

Alfonso J. Benítez-Estévez , Manuel Francisco Otero Santiago , Paloma Oliver Sáez , Javier Lirón Hernández , Fernando Rodríguez Cantalejo , Catalina Sánchez Mora , Imma Caballé Martín , José Luis Bedini Chesa , Ana M. García Raja , Antonio León Justel , Rafael Venta Obaya , Ana Isabel Quinteiro García , Montserrat Torra Puig

{"title":"Recomendaciones para la elaboración de un cuadro de mando integral para la gestión de pruebas en el lugar de asistencia del paciente (POCT). Recomendación (2017)","authors":"Alfonso J. Benítez-Estévez , Manuel Francisco Otero Santiago , Paloma Oliver Sáez , Javier Lirón Hernández , Fernando Rodríguez Cantalejo , Catalina Sánchez Mora , Imma Caballé Martín , José Luis Bedini Chesa , Ana M. García Raja , Antonio León Justel , Rafael Venta Obaya , Ana Isabel Quinteiro García , Montserrat Torra Puig","doi":"10.1016/j.labcli.2018.09.001","DOIUrl":"https://doi.org/10.1016/j.labcli.2018.09.001","url":null,"abstract":"<div><p>Technological development of <em>in vitro</em> diagnostics has led to a diversity of new tests for point-of-care testing (POCT) and at the same time provides quality in the process. Construction of a balanced scorecard is a useful tool for the success in the management of a cross-sectional, complex and interdisciplinary process, as well as to obtain reliable analytical results for immediately use with POCT systems. In constructing a balanced scorecard, four perspectives should be considered: Customer (patients, doctors), Financial (private or public investors), Operating procedures (systems, processes), and Professionals (organisational culture). The aim of this document is to establish the recommendations for the development of an adequate balanced scorecard to manage a point-of-care network in a healthcare system.</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.labcli.2018.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91637095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utilidad de los marcadores bioquímicos de preeclampsia 子痫前期生化标志物的应用

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/j.labcli.2018.06.001

M.a José Alcaine Villarroya , Eva M. Barrenechea Iparraguirre , Elena Casals , Concepción González Rodríguez , Inmaculada Martín Navas , Hada Macher Manzano , M. Concepción Martínez Camarasa , Daniel Morell García , Helena Méndez Sol , Irene Rosas Allende , Elvira Tejedor Hernández , Belén Prieto García

引用次数: 0

Interferencia por ácido 2,4-diamino-N10-metilpteroico en la determinación de metotrexato tras la administración de glucarpidasa

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/j.labcli.2018.08.003

Nazaret del Amo del Arco , Raquel Ramos Corral , Javier López Flores , Yessika M. Amezquita Orjuela , Alicia Roldán Pérez , Fernando Cava Valenciano

{"title":"Interferencia por ácido 2,4-diamino-N10-metilpteroico en la determinación de metotrexato tras la administración de glucarpidasa","authors":"Nazaret del Amo del Arco , Raquel Ramos Corral , Javier López Flores , Yessika M. Amezquita Orjuela , Alicia Roldán Pérez , Fernando Cava Valenciano","doi":"10.1016/j.labcli.2018.08.003","DOIUrl":"https://doi.org/10.1016/j.labcli.2018.08.003","url":null,"abstract":"<div><p>High-dose methotrexate (MTX) treatment involves close monitoring of drug level in order to confirm its proper elimination. One of the possible side effects of this therapy is renal failure, causing accumulation of the drug, and therefore is a mayor toxic effect. Glucarpidase (carboxypeptidase-G2 or CPDG2) is a recombinant enzyme used to reduce MTX serum levels in patients who develop acute renal failure during high-dose MTX treatment. The enzyme reduces MTX concentration by 95-99% within 15-30minutes after the dose. Glucarpidase cleaves MTX into glutamate and 2,4-diamino-N10-methylpteroic acid, a minor and non-active metabolite. Cross-reactivity of 2,4-diamino-N10-methylpteroic acid in immunological assays of MTX has been previously reported, and is said to cause an enormous overestimation in serum MTX analysis. However immunoassay is a widely used technique for MTX analysis, being the main method for its determination in most clinical laboratories.</p><p>An interference case report is presented and MTX analysis in serum samples by liquid chromatography coupled with Ultra-High Resolution Q-Time of Flight Mass Spectrometry (LC-UHR-QTOF) is described.</p></div>","PeriodicalId":101105,"journal":{"name":"Revista del Laboratorio Clínico","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91636461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Una aplicación app para el diagnóstico de los micetismos 一个诊断micetismos的应用程序

Revista del Laboratorio Clínico Pub Date : 2019-07-01 DOI: 10.1016/J.LABCLI.2019.01.005

Cristina Ruiz, Jaume-Miquel March-Amengual, Gerard Reches, Salvador Ventura, J. M. Queraltó

引用次数: 2