{"title":"Congenital pancreas malformations: a clinical case report","authors":"Ana Bento, Hamilton Baptista, Fernando Oliveira","doi":"10.1016/S2255-4823(13)70427-2","DOIUrl":"https://doi.org/10.1016/S2255-4823(13)70427-2","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to review the congenital malformation known as agenesis of the dorsal pancreas (ADP) and other pancreatic birth defects, based on a rare and exemplary clinical case of pancreatic malformations. The intent was to review the latest information published in the national and international literature on pancreatic birth defects, and to investigate the diversity of clinical presentations of ADP and other congenital pancreas abnormalities. The purpose was to identify which situations have therapeutic indication, the most appropriate time to institute treatment, and the currently available medical or surgical treatment of pancreatic congenital malformations.</p></div><div><h3>Results</h3><p>ADP is a very rare malformation that occurs during organogenesis. In the last decades, a large volume of embryological and genetic information has been obtained, helping to understand the causes of pancreatic malformations, which must be studied and understood as a whole.</p></div><div><h3>Conclusion</h3><p>Pancreatic malformations are infrequently studied causes of acute and chronic pancreatitis in adults. The possibility of pancreatic malformations should always be considered in patients with acute or chronic pancreatitis with no evident cause.</p></div>","PeriodicalId":101100,"journal":{"name":"Revista da Associa??o Médica Brasileira (English Edition)","volume":"59 1","pages":"Pages 35-39"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70427-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91764977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychiatric co-morbidities in Crohn's disease: an often overlooked aspect","authors":"Shailendra Kapoor","doi":"10.1016/S2255-4823(13)70437-5","DOIUrl":"https://doi.org/10.1016/S2255-4823(13)70437-5","url":null,"abstract":"","PeriodicalId":101100,"journal":{"name":"Revista da Associa??o Médica Brasileira (English Edition)","volume":"59 2","pages":"Page 100"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70437-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136496682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fausto Aloísio Pedrosa Pimenta , Maria Aparecida Camargos Bicalho , Marco Aurélio Romano-Silva , Edgar Nunes de Moraes , Nilton Alves de Rezende
{"title":"Chronic diseases, cognition, functional decline, and the Charlson index in elderly people with dementia","authors":"Fausto Aloísio Pedrosa Pimenta , Maria Aparecida Camargos Bicalho , Marco Aurélio Romano-Silva , Edgar Nunes de Moraes , Nilton Alves de Rezende","doi":"10.1016/S2255-4823(13)70483-1","DOIUrl":"https://doi.org/10.1016/S2255-4823(13)70483-1","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the association between chronic degenerative diseases and functional decline, cognition, and mortality prediction.</p></div><div><h3>Methods</h3><p>A cross-sectional study was conducted in a geriatrics service in Belo Horizonte, Brazil, involving 424 patients subdivided into two groups: control and dementia. The study analyzed socio-demographic and environmental data, chronic degenerative diseases, the Charlson index, and data on functional and cognitive dementia.</p></div><div><h3>Results</h3><p>After a univariate analysis, there was a greater frequency of cerebrovascular accident (CVA), urinary incontinence, constipation, and sleep disorder in the dementia group, while the multivariate analysis showed a greater number of environmental factors and sleep disorder. Regarding the Mini Mental State Examination (MMSE), patients with chronic obstructive pulmonary disease (COPD), CVA, and heart failure presented lower scores. There was a greater score in the dementia group with regarding the Charlson index.</p></div><div><h3>Conclusion</h3><p>These comorbidities were associated with the functional decline in elderly people with dementia.</p></div>","PeriodicalId":101100,"journal":{"name":"Revista da Associa??o Médica Brasileira (English Edition)","volume":"59 4","pages":"Pages 326-334"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70483-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137438544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rita Maria Rodrigues-Bastos, Estela Márcia Saraiva Campos, Luiz Cláudio Ribeiro, Róberti Uili Rodrigues Firmino, Maria Teresa Bustamante-Teixeira
{"title":"Hospitalizations for primary care-sensitive conditions in a Southern Brazilian municipality","authors":"Rita Maria Rodrigues-Bastos, Estela Márcia Saraiva Campos, Luiz Cláudio Ribeiro, Róberti Uili Rodrigues Firmino, Maria Teresa Bustamante-Teixeira","doi":"10.1016/S2255-4823(13)70444-2","DOIUrl":"10.1016/S2255-4823(13)70444-2","url":null,"abstract":"<div><h3>Objective</h3><p>To study the most frequent causes of hospitalizations for primary care-sensitive conditions (HPCSC) in the city of Juiz de Fora, Brazil, by age group and gender, over the periods of 2002 to 2005 and of 2006 to 2009.</p></div><div><h3>Methods</h3><p>This was a descriptive study, with data collected from the Hospital Information System of the Unified Health System (Sistema de Informação Hospitalar do Sistema Único de Saúde - SIH-SUS) and from population projections by the Brazilian Institute of Geography and Statistics (Instituto Brasileiro de Geografia e Estatística – IBGE). HPCSC rates were calculated for 1,000 inhabitants, and the most frequent causes were studied by gender and age group, comparing both periods.</p></div><div><h3>Results</h3><p>HPCSP showed rates of 7.74/1,000 between 2002 and 2005 and 8.81/1,000 between 2006 and 2009. The main causes were heart failure, cerebrovascular diseases, angina pectoris, pulmonary diseases, and kidney and urinary tract infections, which together represented 4.9/1,000 in the first period and 5.6/1,000 in the second period. The evolution of the rates between both periods occurred differently by age group and gender.</p></div><div><h3>Conclusion</h3><p>The study did not exhibit any remarkable differences in HPCSC rates between the periods. Regarding the most frequent causes, reduced hospitalization rates for gastroenteritis, asthma, high blood pressure, and cerebrovascular diseases were observed, as well as increased hospitalizations for heart failure, pulmonary diseases, epilepsies, and kidney and urinary tract infections; these hospitalizations occurred differently by gender and age group. The results showed that a deep reflection regarding the determinants of hospitalizations for avoidable causes is needed.</p></div>","PeriodicalId":101100,"journal":{"name":"Revista da Associa??o Médica Brasileira (English Edition)","volume":"59 2","pages":"Pages 120-127"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70444-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76372642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The life and legacy of William Ernest Miles (1869–1947): a tribute to an admirable surgeon","authors":"Fábio Guilherme Campos","doi":"10.1016/S2255-4823(13)70453-3","DOIUrl":"https://doi.org/10.1016/S2255-4823(13)70453-3","url":null,"abstract":"<div><p>The present article aimed to review some important aspects regarding the work and life of the legendary English surgeon William Ernest Miles. His masterwork began at the beginning of the 20<sup>th</sup> century, when he devised the first radical procedure that aimed to control rectal cancer, after analyzing the poor outcomes of perineal resections for the disease. The famous 1908 publication, focusing on the technique and early results of abdominoperineal excision influenced numerous surgeons for decades, at a time when most rectal tumors were managed through rectal amputation, regardless of their location. Miles was recognized as a brilliant, fast, and skilled surgeon, and his fame attracted many surgeons to watch him at work in London at that time. He was also recognized as a gentle and kind man who became a trusted leader in coloproctology. In this context, he also made various contributions in the field of anorectal diseases, such as hemorrhoids, anal fistula, anal fissure, and rectal procidentia. Thus, he deserves the honors as the pioneer in the elaboration and refinement of a surgical technique that allowed a significant decrease in tumor recurrence and mortality. Furthermore, the Miles operation shifted the perspectives of rectal cancer, and for that his name will always be regarded as one of the giants in the history of colorectal surgery.</p></div>","PeriodicalId":101100,"journal":{"name":"Revista da Associa??o Médica Brasileira (English Edition)","volume":"59 2","pages":"Pages 181-185"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70453-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136551114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Allex Jardim da Fonseca , Luiz Carlos de Lima Ferreira , Giacomo Balbinotto Neto
{"title":"Cost-effectiveness of the vaccine against human papillomavirus in the Brazilian Amazon region","authors":"Allex Jardim da Fonseca , Luiz Carlos de Lima Ferreira , Giacomo Balbinotto Neto","doi":"10.1016/S2255-4823(13)70503-4","DOIUrl":"https://doi.org/10.1016/S2255-4823(13)70503-4","url":null,"abstract":"<div><h3>Objective</h3><p>To assess the cost-utility of the human papillomavirus (HPV) vaccination on the prevention of cervical cancer in the Brazilian Amazon region.</p></div><div><h3>Methods</h3><p>A Markov cohort model was developed to simulate the natural evolution of HPV and its progress to cervical cancer, considering the current preventive programs and treatment costs. The one-year transition probabilities were mainly based on empirical data of local and national studies. The model evaluated the addition of the vaccine to three cervical cancer-screening scenarios (0, 3 or 10 exams throughout life).</p></div><div><h3>Results</h3><p>The scenario of three Pap tests resulted in satisfactory calibration (base case). The addition of HPV vaccination would reduce by 35% the incidence of cervical cancer (70% vaccination coverage). The incremental cost-effectiveness ratio was US$ 825 for each quality-adjusted life year gained. The sensitivity analysis confirms the robustness of this result, and duration of immunity was the parameter with greater variation in incremental cost-effectiveness ratio.</p></div><div><h3>Conclusion</h3><p>Vaccination has a favorable profile in terms of cost-utility, and its inclusion in the immunization schedule would result in a substantial reduction in incidence and mortality of invasive cervical cancer in the Brazilian Amazon region.</p></div>","PeriodicalId":101100,"journal":{"name":"Revista da Associa??o Médica Brasileira (English Edition)","volume":"59 5","pages":"Pages 442-451"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70503-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72283495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}