Results in Materials最新文献

{"title":"Adsorption and release profile analysis of oxytetracycline drug on functionalized graphene oxide nanoparticles","authors":"Wesam R. Kadhum ,&nbsp;Marianna Budai ,&nbsp;Lívia Budai ,&nbsp;Ehsan kianfar","doi":"10.1016/j.rinma.2025.100711","DOIUrl":"10.1016/j.rinma.2025.100711","url":null,"abstract":"<div><div>In this study graphite particles were converted to graphene oxide (GO) via Hummer's method. Synthesized graphene oxide was used for studying adsorption and release of oxytetracycline in dog's simulated gastric. This material the synthesized GO was functionalized with epichlorohydrin and Cibacron blue. Due to the relatively high-water solubility of oxytetracycline, it can be easily dissolved in body fluids without sufficient absorption and storage time. Drugs which are soluble in water, easily dissolve in body fluids and won't store in body well enough according to their ease of solubility in water. Therefore, the drug is likely to be eliminated via kidney and urinary system without adequate adsorption and satisfactory therapeutic effect. won't have convenient effect. In order to overcome the rapid elimination of oxytetracycline prolonged drug release was considered. Oxytetracycline is an antibiotic. antibiotics are generally linked with bacterial ribosomal unit and thus inhibit protein synthesis in bacteria. In this study optimum pH for drug was investigated firstly and according to results obtain acidic environment has the best adsorption for the studied drug. First, the optimal pH value for the drug was investigated. Based on the results obtained the acidic environment provided the best adsorption conditions for oxytetracycline. According to studies dog's digestive system is acidic and drugs and food remains in it for approximately 8 h. Experiments demonstrated that oxytetracycline GO nanoparticles show the highest drug release in the first 2 h making the investigation of drug release in the intestines unnecessary. Finally, the accuracy of synthesis, adsorption and release were investigated by UV–Vis experiments. The obtained adsorption isotherm fits Langmuir and Temkin models well, and the theoretical maximum of adsorption capacity calculated by Langmuir model is 495 mg/g.The adsorption capacities of tetracycline oxytetracycline on GO decreased with increasing pH. The adsorption isotherms of oxytetracycline on graphene oxide were discussed and compared. The aim of this study is to make and modify graphene oxide in order to make a pharmaceutical adsorbent for the slow adsorption and release of the drug oxytetracycline in the simulated environment of the dog's body and the release of oxytetracycline was modified and enhanced by epichlorohydrin and Cibacron Blue and was investigated.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100711"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid pharmacophore-based design of novel 5-lipoxygenase inhibitors: Molecular docking and dynamics simulation studies","authors":"Jia Chern Pang ,&nbsp;Kit-Kay Mak ,&nbsp;Mallikarjuna Rao Pichika ,&nbsp;Vasudeva Rao Avupati","doi":"10.1016/j.rinma.2025.100709","DOIUrl":"10.1016/j.rinma.2025.100709","url":null,"abstract":"<div><div>5-Lipoxygenase (5-LO) is a fatty acid oxygenase, that catalyses the biosynthesis of leukotrienes (LT). Evidence shows that triggering 5-LO expression underlying pathogenesis for various diseases. Therefore it was identified as one of the potential target to develop drugs against inflammatory related disorders. We used hybrid pharmacophore design (HPD) approach to design a series of molecules scaffolds (HPD A to F) based on a set of chemical pharmacophores such as (benzothiophene, chalcone, benzothiazole, thiazolidinedione, and sulfonylurea) which earlier reported to possess 5-LO inhibitory potential. These HPD A to HPD F scaffolds were further subjected to the chemical enumeration at designed positions to develop a database of virtual chemical libraries. Subsequently, molecular docking simulations were performed to identify the potential hit molecules using crystallographic target binding site of 5-LO (PDB ID: 3V99), the top three ranked hits were evaluated to assess their drug-like properties. In addition, the most stable ligand conformation of the best pose for each molecular scaffold was selected for molecular dynamics study. Based on the results, compound F1 was found possess most stable binding conformation at the catalytic binding interaction with Phe 177.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100709"},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Kelvin Probe Force Microscopy and optical properties of F8BT polymer incorporated with ZnONR/AgNP nanocomposite","authors":"Ishaq Musa","doi":"10.1016/j.rinma.2025.100707","DOIUrl":"10.1016/j.rinma.2025.100707","url":null,"abstract":"<div><div>The optical properties and work function of poly(9,9-dioctylfluorene-co-benzothiadiazole) (F8BT) and its nanocomposites with ZnO nanorods (ZnONRs) and silver nanoparticles (AgNPs) were extensively studied using techniques such as Scanning Probe Microscopy (SPM) and optical spectroscopy. Kelvin Probe Force Microscopy (KPFM) measurements revealed significant differences in contact potential and a work function of around 4.484 eV for pure F8BT. Furthermore, optical absorption measurements showed increased absorbance and noticeable changes in bandgap when AgNPs and ZnONRs were added, indicating improved light-absorbing properties of the nanocomposites. The band gap of F8BT is typically around 2.50 eV, but the introduction of ZnO nanorods increases it to 2.63 eV. This could be due to the interaction between F8BT and ZnONRs. Additionally, the incorporation of silver nanoparticles (AgNPs) further raises the band gap to 2.66 eV. Analysis of the Photoluminescence (PL) spectra reveals a significant increase in emission intensity for the F8BT/AgNP/ZnONR combination, attributed to exciton recombination and the impact of localized surface Plasmon resonance in the nanocomposites.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100707"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimisation of plastic injection moulding parameters for biopolymer composite using Taguchi L9 method and mould flow analysis","authors":"Jibrilla Abdulrahman ,&nbsp;Williams S. Ebhota ,&nbsp;Pavel Y. Tabakov","doi":"10.1016/j.rinma.2025.100705","DOIUrl":"10.1016/j.rinma.2025.100705","url":null,"abstract":"<div><div>The production of bio-polymer composites through the injection moulding process often results in defects that can compromise product quality, especially when optimal parameters are not used for new materials. This paper addresses this issue by using a design of experiment and engineering software to simulate and optimise two cavities of a plastic injection mould for producing a biopolymer composite reinforced with banana fibre and high-density polyethylene (HDPE). The Taguchi L9 design of the experiment was employed to determine the optimal parameters, with each parameter simulated using the SolidWorks plastic injection to examine cavity filling, fibre degradation and sink marks. Three fibre particle sizes with different fibre aspect ratios were considered for simulation. The results showed that the temperature at the end of fill simulations was less than the degradation temperature of natural fibre. Moreover, the analysis using the Taguchi L9 alongside plastic flow simulation results, and the optimum parameters to produce a biopolymer composite were obtained. Specimens produced with these parameters exhibited good physical properties, as no sink marks or warpage were observed. The fibre aspect ratio plays an important role in the processing behaviour, mechanical properties, and final performance of biopolymer composites.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100705"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption, thermodynamic and corrosion study of enalapril malate pharmaceutical drug as corrosion inhibitor for carbon steel in saline solution","authors":"Haider Abdulkareem Almashhadani","doi":"10.1016/j.rinma.2025.100706","DOIUrl":"10.1016/j.rinma.2025.100706","url":null,"abstract":"<div><div>Unused and expired pharmaceutical drugs are a novel type of organic corrosion inhibitor. They are less expensive, more effective, and less harmful than conventional organic corrosion inhibitors. This study investigated the effects of concentration, adsorption mechanism and thermodynamic parameters of enalapril malate (ENAP) as a corrosion inhibitor for carbon steel in a saline solution (3.5 % NaCl). The polarization method was used to determine the corrosion rate and inhibition efficiency. Field emission scanning electron microscopy (FE-SEM) and atomic force spectroscopy (AFM) were used to investigate the surface morphology and topography of carbon steel after immersion in both uninhibited and inhibited media for 24 h. Fourier transform infrared spectroscopy (FTIR) was used to confirm the adsorption of ENAP inhibitor on the surface of the carbon steel. The results showed that the inhibition efficacy (IE%) reached 89.74 % when the corrosive solution was inhibited by 1200 ppm of ENAP at 298 K. The results also revealed a strong linear relationship between C_inh/θ and C_inh, which best fitted the Langmuir isotherm model. Thermodynamic and kinetic studies indicated that the ENAP inhibitor underwent physical adsorption on an energetically homogenous adsorbent surface. The apparent activation energies (E_a∗) of the inhibited process were higher compared to the uninhibited process at all concentrations. FE-SEM analysis showed significantly reduce in the corrosion of carbon steel in the 3.5 % NaCl inhibited by ENAP compared with free saline solution.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100706"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143860009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of metakaolin and acetic acid on sodium silicate-based inorganic bonded wood composites for additive manufacturing","authors":"Alexandra M. Lehman-Chong ,&nbsp;James L. Setters ,&nbsp;Armando G. McDonald ,&nbsp;Michael R. Maughan","doi":"10.1016/j.rinma.2025.100708","DOIUrl":"10.1016/j.rinma.2025.100708","url":null,"abstract":"<div><div>Aluminosilicates such as geopolymers show promise as formaldehyde-free binders for inorganic-bonded wood composites. Understanding the curing behavior, mechanical properties, and wet performance of these composites is necessary to advance inorganic-bonded wood composites for construction additive manufacturing (AM) applications. This study examined the effects of metakaolin content, curing temperature, and acetic acid treatment on the dry and wet properties of wood-sodium silicate composites for AM. Wood-sodium silicate-metakaolin composite (WSSMC) formulations with 50 wt% wood fiber and 50 wt% binder we prepared with varying sodium silicate to metakaolin content (0, 5, 10 wt%). Dynamic rheology demonstrated suitable shear-thinning behavior and extrudability for formulations containing up to 10 wt% metakaolin. These composites displayed glass transition temperatures ranging between 181 and 201 °C (peak of <em>Eʹʹ</em>), and true densities increased with increasing curing temperature. Cold-pressed and extruded composites were subjected to acetic acid treatment and subsequent water soaking. Composites after acid treatment displayed changes to aluminosilicate bonds identified using Fourier transform infrared spectroscopy. Acid treated composites exhibited higher flexural (3–10 MPa) and compressive strengths (9–23 MPa) and lower weight gain and thickness swelling after water soaking compared to untreated composites. Flexural and compressive strengths were highest for dry, untreated composites (8–13 MPa and 12–34 MPa, respectively), especially when cured at lower temperatures (60 °C and 105 °C). This work provides insight into the use of acetic acid to improve the wet performance of inorganic bonded wood composites and demonstrates the potential for using metakaolin in inorganic bonded wood composites for novel wood composite additive manufacturing for construction.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100708"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular insights into functionalized carbon nanotubes for the adsorption of therapeutic peptides","authors":"Fatemeh Talaei,&nbsp;Farzaneh Farzad,&nbsp;Asma Yaghobi","doi":"10.1016/j.rinma.2025.100704","DOIUrl":"10.1016/j.rinma.2025.100704","url":null,"abstract":"<div><div>Peptides are considered effective therapeutic agents in medicine, but it is crucial to understand how to use and apply them properly. Carbon nanotubes (CNT), due to their exceptional properties, can serve as effective carriers for peptides. The current research examines the adsorption behavior of peptides EGAGAGAE (EGA), GGGGGGGG (GGG), RGAGAGAR (RGA), and TSHMSNT (TSH) on the surface of pristine and functionalized carbon nanotubes using molecular dynamics (MD) simulation. The calculation results show that all four peptides can be well adsorbed on the CNT surface. With the functionalization of CNT, the amount of interactions between peptides and the substrate increases, and peptides show considerable interaction with the functional group. Evaluation of the calculated adsorption energies, ranging from −103 to −264 kJ/mol, suggests that Lennard-Jones interactions play a significant role in the adsorption process. In addition, the assessment of various parameters showed that RGA and TSH peptides adsorb on the CNT surface better than the other two peptides.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100704"},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical and chemical effect of an electrospun nanocomposite of gelatin/polyvinyl alcohol loaded with heparin","authors":"Paola Orozco ,&nbsp;Yuliet Montoya ,&nbsp;Alejandra García-García ,&nbsp;John Bustamante","doi":"10.1016/j.rinma.2025.100703","DOIUrl":"10.1016/j.rinma.2025.100703","url":null,"abstract":"<div><div>The field of materials has focused on developing fibrillar, porous, laminar, or hybrid structures for applications in the biochemical, biophysical, and biological areas at the micro and nanoscale. Said biomaterials can be of protein and synthetic origin, seeking to imitate the morphological characteristics of native tissues. Fibrillar scaffolds composed of polyvinyl alcohol and gelatin with heparin incorporation at concentrations of 5 % and 20 % v/v were developed by the electrospinning technique. The scaffolds were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, contact angle, thermogravimetric analysis, and mechanical tests. The MTT assay and cell adhesion were carried out in interaction with an <em>in vitro</em> model of RL-14 cardiomyocytes.</div><div>It was found that the diameters of the fibers depended on the decrease in the proportion of gelatine and the increase in the concentration of heparin, responding to a hybrid morphology with diameters from 176 nm to 166 nm. Likewise, it was evidenced that the cross-linking effect using glutaraldehyde and ethanol increased the resistance to dissolution in aqueous media, due to the modifications induced in the secondary structures of the protein. On the other hand, it was found that as the concentration of heparin in the electrospun membranes increased, viability and cellular adhesion decreased. In addition, it was found that the incorporation of heparin induces a decrease in the stiffness and elasticity of the scaffold, and the cell viability is dependent on the concentration of the active principle. Therefore, scaffolds could be applied as a potential biomaterial in tissue engineering.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100703"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural, optical, and antioxidant properties of biocompatible CuO-MgO nanocomposites","authors":"B.V. Vamsi Krishna ,&nbsp;B. Durga Lakshmi ,&nbsp;P. Tirupathi Rao ,&nbsp;R.K. Ramachandra","doi":"10.1016/j.rinma.2025.100695","DOIUrl":"10.1016/j.rinma.2025.100695","url":null,"abstract":"<div><div>This study synthesized a CuO-MgO nanocomposite using Tinospora cordifolia (TC) leaf extract through co-precipitation. Characterization using XRD, UV–visible spectroscopy, FTIR, FESEM with EDAX, HRTEM, and DLS-Zeta potential analysis confirmed the formation and properties of the nanocomposite. XRD confirmed the coexistence of CuO and MgO phases. UV–visible spectroscopy showed SPR peaks at 209 nm and 232 nm (MgO), 281.5 nm, and 307 nm (CuO). Indirect and direct band gaps formed within the same nanocomposite were analyzed through the optical conductivity spectrum. FTIR indicated that phenolic and flavonoid groups from the leaf extract acted as capping and reducing agents. FESEM and HRTEM showed spherical morphology, with EDAX confirming the elemental composition. HRTEM micrographs revealed the core-shell structure of TC CuO-MgO NC and SAED bright-spot rings confirming the formation of two phases in the prepared nanocomposite. The average particle size was 49.129 ± 1.2622 nm through HRTEM findings, and DLS-Zeta potential analysis showed a size of 63.266 nm, polydispersity index of 0.137, and zeta potential of −22.8 mV. The nanocomposite demonstrated a hemolysis percentage of 0.5708 ± 0.0016 % at 100 μg/ml, indicating biocompatibility. Its IC₅₀ value for antioxidant activity was 20.8919 μg/ml, close to that of ascorbic acid. These findings suggest that TC CuO-MgO nanocomposite is suitable for optoelectronic, photodynamic therapy, and biomedical applications.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100695"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143785392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical modeling of coaxial wire-powder laser directed energy deposition process in dissimilar metal additive manufacturing","authors":"Stephanie B. Lawson ,&nbsp;Dongqing Yan ,&nbsp;Ali Tabei ,&nbsp;Brian K. Paul ,&nbsp;Somayeh Pasebani","doi":"10.1016/j.rinma.2025.100701","DOIUrl":"10.1016/j.rinma.2025.100701","url":null,"abstract":"<div><div>Coaxial wire-fed powder-fed directed energy deposition (CWP-DED), a single-step additive manufacturing process, offers the unique capability of producing tailored dissimilar metals by combining the high deposition rates of wire-based DED with the high resolution and complexity of powder-based DED. Modeling this process for its thermal profile and solidification morphology is crucial for understanding key outcomes such as dimensional accuracy and material composition. In this study, a CWP-DED system is simulated through the development of a computational fluid dynamics (CFD) numerical model. This model captures in-situ thermal profiling and heat transfer interactions within the process while simultaneously providing bead dimensions and weight percentages of the individual materials for wire and powder feedstocks. Simulation results demonstrated strong agreement with experimental data, indicating a robust understanding of the CWP-DED process for dissimilar metal additive manufacturing. These findings contribute to advancements in the synthesis, processing, joining and tailoring of dissimilar metal systems, offering new insights into the design of multi-materials systems.</div></div>","PeriodicalId":101087,"journal":{"name":"Results in Materials","volume":"26 ","pages":"Article 100701"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143850259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}