Medicine Advances最新文献

{"title":"Chinese collaborative study of survival analysis in 980 patients with AL amyloidosis","authors":"Hokhim Yau,&nbsp;Liye Zhong,&nbsp;Sheng Li,&nbsp;Weiting He,&nbsp;Yaxi Zhu,&nbsp;Pengjun Liao,&nbsp;Jianteng Xie,&nbsp;Hongwen Fei,&nbsp;Liwen Li,&nbsp;Hui Liu,&nbsp;Jie Li,&nbsp;Wenjian Wang","doi":"10.1002/med4.53","DOIUrl":"https://doi.org/10.1002/med4.53","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The prognosis of patients with light-chain amyloidosis (AL) has improved markedly in the past decade in China; whether the current staging systems are suitable to predict the overall survival (OS) of the patients remains undetermined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Based on 980 biopsy-proved AL patients with 5-year follow-up from China Registration Network for Light-chain Amyloidosis, we evaluated the efficacy of existing staging systems and developed a new stratification model. This involved analyzing parameters such as N-terminal pro-brain natriuretic peptide (NT-proBNP) thresholds and estimated glomerular filtration rate (eGFR).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that 30% patients were classified as stage I, 25% as stage II, 26% as stage III, and 19% as stage IV disease using the Mayo 2012 staging system, with varying median OS values. However, the observed median OS values were notably higher than previously reported. By incorporating NT-proBNP thresholds and eGFR values, we developed a four-stage score system. With this new model, 41.6% patients were reclassified to stage I, 34.3% to stage II, 17.8% to stage III, and 6.3% to stage IV disease, with adjusted median OS values.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The new stratification model exhibited improved consistency compared to traditional staging systems. It effectively identified patients with the best and worst prognoses, even among those receiving comprehensive treatment. Specifically, NT-proBNP levels exceeding 9000 pg/mL combined with an eGFR less than 60 mL/min/1.73 m² proved superior in prognosticating patient outcomes. Overall, the median OS of AL amyloidosis patients in China has significantly improved, underscoring the need for tailored prognostic models in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.53","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of causal association between cheese intake and risk of peripheral vascular diseases: A two-sample Mendelian randomization study","authors":"Song Wen,&nbsp;Zehan Huang,&nbsp;Guodong He,&nbsp;Bin Zhang,&nbsp;Yuqing Huang","doi":"10.1002/med4.48","DOIUrl":"10.1002/med4.48","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous observational studies have yielded inconclusive findings regarding the potential association between cheese intake and peripheral vascular diseases (PVDs). We sought to systematically investigate the causal link between cheese intake and PVDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A two-sample Mendelian randomization (MR) investigation was undertaken to evaluate the causal link between cheese intake and PVDs. This MR analysis relied on summary statistics derived from published genome-wide associations studies (GWAS). GWAS summary statistics for cheese intake (<i>N</i> = 451,486), peripheral artery disease (PAD) (<i>N</i> = 361,194), PVD (<i>N</i> = 463,010), pulmonary embolism (PE) (<i>N</i> = 463,010), and deep vein thrombosis (DVT) (<i>N</i> = 6795) were derived from the UK Biobank. GWAS summary statistics for peripheral angiopathy (<i>N</i> = 162,394), aortic dissection (<i>N</i> = 218,792), aortic aneurysm (AA) (<i>N</i> = 218,792), other PVDs (<i>N</i> = 218,792), and arterial embolism and thrombosis of lower extremity artery (<i>N</i> = 218,792) were extracted from the FinnGen. Primary analysis was performed using an inverse variance weighted method. Sensitivity analyses included weighted median, MR Egger, and weighted mode analyses. Results are shown as odd ratio (OR) and 95% confidence interval (CI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Genetically predicted cheese intake was not associated with PAD (OR = 1.00, 95% CI: 1.00–1.00, <i>p</i> = 0.953), PVD (OR = 1.00, 95% CI: 0.99–1.00, <i>p</i> = 0.265), peripheral angiopathy (OR = 0.56, 95% CI: 0.09–3.66, <i>p</i> = 0.566), aortic dissection(OR = 0.69, 95% CI: 0.19–2.55, <i>p</i> = 0.583), AA(OR = 0.92, 95% CI: 0.46–1.82, <i>p</i> = 0.809), other PVDs (OR = 0.99, 95% CI: 0.44–2.21, <i>p</i> = 0.979), PE (OR = 1.00, 95% CI:1.00–1.00, <i>p</i> = 0.635), DVT (OR = 0.83, 95% CI: 0.62–1.12, <i>p</i> = 0.229), and arterial embolism and thrombosis of lower extremity artery (OR = 0.69, 95% CI: 0.21–2.29, <i>p</i> = 0.5413).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on the results of our two-sample MR analysis, we found no significant association between cheese intake and the risk of PVDs. We firmly believed that these findings had the potential to enhance the efficacy of prevention strategies for PVDs, at both the national and clinical level, by improving our understanding of the risk factors involved in their development. Low-sugar, low-salt and low-fat cheese may be a good choice for people at high risk of PVDs.</p>\u0000 ","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.48","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life, adherence and knowledge of epileptic patients and the impact of a pharmacist-led educational intervention: A review","authors":"Zahraa Abbas Munaf,&nbsp;Samer Imad Mohammed","doi":"10.1002/med4.55","DOIUrl":"10.1002/med4.55","url":null,"abstract":"<p>Around 65 million individuals suffer from epilepsy worldwide, and when it is not properly treated, it is linked to higher rates of physical harm and mortality. Due to the requirement for long-term therapy and the side effects of many medications, medication compliance is a significant issue. The purpose of this review was to summarize the findings of previous studies examining the quality of life (QOL), adherence, patient education, and medication knowledge, as well as the impact of a pharmacist-led educational intervention. Additionally, to find out if these studies benefit epileptic patients, to find the appropriate method used to help them in all aspects of their lives, and to use these in future studies. A systematic and comprehensive search was conducted using specific keywords from PubMed, Google Scholar, and Research Gate. A significantly poorer QOL was linked to prolonged antiepileptic drug use or poor adherence as well as psychiatric problems. Neglect was the most frequent reason for nonadherence. The frequency of seizures was greatly reduced, and the adherence was significantly increased by patient education and medication understanding. Patient awareness, adherence, QOL, and seizure frequency were dramatically improved following the intervention. In the absence of optimal treatment, epilepsy is associated with increased rates of bodily injuries and mortality. It is crucial to increase patient education and knowledge about disease and treatment in order to improve adherence, and QOL. Intervention by a chemist is required to achieve these results.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.55","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoring system related to retrograde percutaneous coronary intervention for coronary chronic total occlusion","authors":"Song Wen,&nbsp;Jing Wang,&nbsp;Zehan Huang,&nbsp;Yuqing Huang,&nbsp;Feng Wang,&nbsp;Bin Zhang","doi":"10.1002/med4.54","DOIUrl":"10.1002/med4.54","url":null,"abstract":"<p>The retrograde approach is a principal procedure used in coronary chronic total occlusion percutaneous coronary intervention. However, the retrograde approach presents more challenges compared with the antegrade approach, as it is associated with a lower rate of success and a higher risk of complications. An accurate pre-procedural evaluation of the complexity of a lesion could aid in the planning of the procedure, in estimating the procedure's duration, or in determining whether the patient should be referred to another center specializing in CTO-PCI, as well as in a more precise evaluation of the risk-benefit ratio. In recent years, multiple scoring systems have been created to forecast the success and efficiency of the retrograde procedure. However, each scoring system was developed independently, and comparative studies were lacking. This article provides a review of these scoring systems, offers an overview of the current state of the retrograde approach, and aims to stimulate further discussion on this topic.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.54","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140229525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coffee and caffeine consumption and risk of periodontitis: National Health and Nutrition Examination Survey 2009–2014","authors":"Wan-Zhe Liao,&nbsp;Zhi-Yi Zhou,&nbsp;Xian-Nan Wu,&nbsp;Xiao-Feng Zhu,&nbsp;Song-An Li,&nbsp;Jun-Huang Zheng,&nbsp;Jia-Nuo Tan,&nbsp;Hao-Kai Chen,&nbsp;Ting-Yu Gu,&nbsp;Zhe Xu,&nbsp;Ya-Han Li,&nbsp;Xu-Guang Guo","doi":"10.1002/med4.50","DOIUrl":"10.1002/med4.50","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to evaluate whether coffee consumption and caffeine intake are independently associated with periodontitis infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Coffee consumption was categorized into binary and continuous variables, serving as the exposure factor alongside caffeine intake, with periodontitis infection as the outcome variable. Other covariables were regarded as potential confounders. The cross-sectional study was conducted based on the national health and nutrition examination survey, with multivariate regression models, subgroup analyses, smooth fitting curves, and threshold effect examinations conducted to pursue a definite correlation between exposures and the outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Negative associations were discovered between binary coffee consumption (OR = 0.81, 95% CI = (0.71, 0.92), <i>p</i>-value = 0.001) and caffeine intake (Q3: OR = 0.77, 95% CI = (0.66, 0.91), <i>p</i>-value = 0.002; Q4: OR = 0.76, 95% CI = (0.64, 0.90), <i>p</i>-value = 0.001) with periodontitis infection, respectively, with all confounders adjusted. In subgroup analyses stratified by gender, diabetes mellitus status, and hypertension status, interaction, and threshold effects were observed, which were intuitively revealed by smooth-fitting curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Significant negative associations between binary consumption and caffeine intake and periodontitis infection separately were indicated, with no evidence suggesting a credible correlation between continuous coffee consumption and infection risk of periodontitis. The benefits of the behavior of consuming coffee and caffeine were more obvious among males and individuals who did not suffer from diabetes or hypertension.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.50","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifying the electrical, optical, and magnetic properties of cancer cells: A comprehensive approach for cancer management","authors":"Rishav Sharma,&nbsp;Rishabha Malviya","doi":"10.1002/med4.51","DOIUrl":"10.1002/med4.51","url":null,"abstract":"<p>Despite the recent successes of cancer therapy, numerous obstacles remain. The medical community of the 16^th century believed that magnets might be used to cure or prevent illness. However, this concept has only recently been put into practice in the treatment of cancer. Cancers vary greatly not only at the patient, tissue, and cellular levels but also at the molecular level. Because of this multiscale heterogeneity, effective treatments that not only differentiate between cancerous and healthy tissues but also target a wide variety of tumor subclones are difficult to develop. Most treatments either take advantage of a specific biological characteristic shared by cancer cells (e.g., their propensity for rapid division) or indiscriminately eradicate every cell in an area of interest. In this article, we review the physical, chemical, electrical, optical, and magnetic properties of cancer cells, before discussing how these properties may be modulated by current and future cancer therapies.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.51","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salamanders aid research into mechanisms of non-canonical organ regeneration for clinical applications","authors":"Binxu Yin,&nbsp;Xiao Cui,&nbsp;Yanmei Liu,&nbsp;Ji-Feng Fei","doi":"10.1002/med4.49","DOIUrl":"10.1002/med4.49","url":null,"abstract":"<p>Salamanders possess remarkable regenerative capacities for organ regeneration among tetrapod vertebrates. Previous research has primarily focused on studying the regeneration of canonical tissues or organs such as limbs, tail, brain, spinal cord, heart, and lens. The advancements made in these areas have broader implications for understanding regeneration and developing therapeutic approaches for these organs, not only in salamanders but also in other vertebrates. In recent years, there has been an increasing interest in studying the regeneration of non-canonical organs in salamanders, such as the liver, lungs, kidneys, and pancreas. This diversification of research has opened up new avenues and provided potential solutions to challenging clinical problems. This review aims to summarize the progress made in the field of non-canonical organ regeneration in salamanders and provides an outlook on future research directions.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.49","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140263446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bullous pemphigoid is a rare autoimmune skin disease that affects the scalp: A case report","authors":"Salkapuram Sunil Kumar,&nbsp;Karthikeyan Elumalai,&nbsp;Navaneetha Krishnan Subramaniyan,&nbsp;Srinivasan Sivannan,&nbsp;Sivaneswari Srinivasan","doi":"10.1002/med4.47","DOIUrl":"10.1002/med4.47","url":null,"abstract":"<p>Pemphigoid, a rare autoimmune skin disease affecting the elderly, requires effective pharmacy management. This includes medication therapy, patient education, and counseling. Understanding pharmacokinetics and potential drug interactions are crucial for optimal treatment and minimizing adverse effects. In this case, the patient is a 65-year-old male who was diagnosed with pemphigoid 2 months ago. He is currently taking prednisone, an oral corticosteroid, to manage the symptoms. The pharmacist plays a crucial role in medication therapy by monitoring the patient's response to the medication and adjusting the dosage if necessary. Additionally, patient education is vital in ensuring that the patient understands the importance of adherence to the medication regimen and the potential side effects. The pharmacist can also provide counseling on lifestyle modifications and self-care measures to alleviate symptoms and improve the quality of life. Overall, effective pharmacy management is essential for optimizing treatment outcomes and promoting patient well-being in pemphigoid cases. The pharmacist's role in pemphigoid cases is crucial for effective medication management and patient education. They monitor the patient's response to treatment, make necessary adjustments, and empower them to take an active role in managing their condition. This approach ultimately improves the overall well-being of patients with pemphigoid.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.47","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140080918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Advances keeps track of new developments on the frontiers of medicine: The 1st founding anniversary of the Medical Advances","authors":"Xueqing Yu","doi":"10.1002/med4.52","DOIUrl":"https://doi.org/10.1002/med4.52","url":null,"abstract":"<p><i>Medicine Advances</i> is a platform dedicated to sharing cutting-edge research, insights, and advancements in the field of medicine. As the Editor-in-Chief, it is my privilege to guide this journal towards its mission of promoting knowledge, innovation, and excellence in healthcare.</p><p>The aim of <i>Medicine Advances</i> is to provide a platform for researcher, scholars, and practitioners in healthcare to communicate and share their scientific findings and innovations. The journal is committed to promoting new medical theories, exchanging new clinical technologies, presenting new medical products, and accelerating the pace of medical development. This journal is dedicated to publishing high-quality original research articles, review articles, survey articles, case reports, editorials, and short communications.</p><p>In 2023, we successfully launched the <i>Medicine Advances</i> and published 4 issues containing 37 high-quality articles. Among the published papers, the majority were original articles (19), accounting for 51%, followed by “review” and “case report” (8 and 2, respectively). Among these submissions, the proportion of Chinese authors is the highest (58%). But the manuscripts from India, Egypt, and the United States accounted for 32%.</p><p>We have successfully established a WeChat public account in China, enhancing our accessibility and outreach. A total of 37 WeChat public account articles were published, and the articles and the journal received effective publicity. At the same time, we also promote on some international social media sites, like Twitter, Linkedin and ResearchGate.</p><p>The continued publicity resulted in good downloads and citations. Our articles' readership and download rates have shown a consistent upward trend, which is a testament to our collective efforts. Together, these articles have amassed over 12,000 downloads and 5 citations.</p><p>The involvement of 87 globally renowned experts in various medical specialties as our editorial members has significantly elevated our influence abroad. Seventeen of the 37 articles were from the journal's editorial board. The editorial board has made great contributions to the development of the journal.</p><p>The enthusiastic reception of our special issues, “Application of Omics in Diseases” and “CardioRenal Research,” inspires us to delve even deeper into these critical fields, evidence of our journal's synergy with the scientific community's pulse.</p><p>The journal's progress has grown substantially since its inception. I would like to express my heartfelt gratitude to our authors, reviewers, and readers for their continuous support and dedication. Thank you for being a part of our journey. Your contributions are what make our journal thrive and evolve. Together, we can shape the future of medicine and healthcare, making a positive impact on the lives of millions.</p><p><b>Xueqing Yu</b>: Conceptualization; writing original draft; review; editing.</p><p>The auth","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.52","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IV ketamine infusion therapy for chronic pain: A systematic review and meta‐analysis","authors":"Peter Olujimi Odutola, Ruchir Gupta","doi":"10.1002/med4.45","DOIUrl":"https://doi.org/10.1002/med4.45","url":null,"abstract":"Chronic pain exerts a significant physical, emotional, and socioeconomic toll on millions of patients worldwide. Traditional pharmacological interventions are often inadequate in providing lasting and effective pain relief for patients suffering from severe chronic pain. However, in recent years, intravenous ketamine infusion therapy has emerged as a promising and alternative treatment modality. The effectiveness of intravenous ketamine infusion therapy in treating chronic pain has been investigated in various pain conditions, such as neuropathic pain, fibromyalgia, complex regional pain syndrome (CRPS), and phantom limb pain. However, varied patient demographics, different endpoints for measuring analgesia, and inconsistent numbers of patients in studies have led to conflicting results. The objective of the present inquiry is to undertake a contemporary updated meta‐analysis of the application of IV ketamine infusion therapy in the context of persistent pain.A search was conducted, adhering to the PRISMA guidelines, to compare the efficacy of IV Ketamine infusion versus control (placebo, midazolam, gabapentin, hydromorphone, and pregabalin) among individuals with chronic pain. During the analysis, Medline, Cochrane, and Embase were thoroughly searched. Two independent investigators identified randomized double‐blind and non‐randomized trials comparing IV Ketamine infusions with controls. Review Manager 5.4.1 was used to scrutinize the data, with the main focus on pain scores. Secondary outcomes such as quality of sleep, as well as side effects such as nausea, hallucinations, and sedation, were also analyzed. Sixteen studies were included involving 1080 patients.The pain score was significantly reduced by IV Ketamine (Mean difference −1.05; 95% CI −1.72, −0.39; p = 0.002), while the quality of sleep (Mean difference 0.00; 95% CI −0.12, 0.12; p = 1.00) was not significantly different between studies. Nausea (risk ratio 1.42; 95% CI 0.84, 2.39; p = 0.19), hallucinations (risk ratio 1.08; 95% CI 0.67, 1.76; p = 0.75), and sedation (risk ratio 1.05; 95% CI 0.24, 4.54; p = 0.95) outcomes were not significantly different among the studies.Our meta‐analysis indicates that IV Ketamine infusion is efficacious and safe in patients with chronic pain.","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}