Medicine Advances最新文献

{"title":"Alone in the Mind: Review of Research Examining the Link Between Loneliness and Dementia","authors":"Ahmed Hussein Al-Samiry,&nbsp;Samer Imad Mohammed,&nbsp;Ahmed Majid Hammed,&nbsp;Tayf M. Maryoosh","doi":"10.1002/med4.70005","DOIUrl":"https://doi.org/10.1002/med4.70005","url":null,"abstract":"<p>This narrative review focused on research investigating the impact of loneliness on the prevalence of dementia and its relationship with other risk factors. A comprehensive and rigorous search was conducted using a variety of scientific databases with specific keywords to identify all prior studies that examined the correlation between dementia and loneliness. The inquiry was confined to articles published in English from January 2017 to March 2024. The narrative review identified a consensus regarding the role of loneliness in enhancing the risk of all-cause dementia, with a particular emphasis on the subjective perception of loneliness. This phenomenon may be caused by the sensations of exclusion, discrimination, and alienation that are typically associated with low self-esteem and low life satisfaction, which may contribute to cognitive impairment and depressive symptoms. This finding was obtained despite the absence of robust evidence regarding the involvement of loneliness in the pathogenesis of dementia. Existing research has not yet identified a correlation between hereditary factors that influence the development of dementia and feelings of loneliness. However, loneliness is strongly associated with depression, which is a potential risk factor for dementia. Previous studies have reported a moderate correlation between depression and loneliness, as individuals who are isolated and lack a sense of community exhibit higher levels of depression. Meditation, social cognitive training, and social support are three strategies that have been implemented to address loneliness and are reported to be the most effective interventions. A strong correlation exists between dementia and loneliness. Although such strategies are unlikely to impede the progression of the disease if cognitive deterioration is already underway, understanding these associations can assist in the development of strategies to alleviate the effects of loneliness on vulnerable individuals.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"20-27"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diacerein's Role in Alleviating Inflammation and Synovial Effusion in Knee Osteoarthritis: A Novel Therapeutic Approach","authors":"Saim Mahmood Khan,&nbsp;Marium Amjad,&nbsp;Rida Shakil,&nbsp;Eisha Shoaib,&nbsp;Dong Hwi Kim,&nbsp;Jawairya Muhammad Hussain","doi":"10.1002/med4.70004","DOIUrl":"https://doi.org/10.1002/med4.70004","url":null,"abstract":"<p>Diacerein, an anthraquinone derivative, has gained interest in recent years as a potential therapeutic agent in the management of knee osteoarthritis (KOA), particularly the inflammatory subtype effusion synovitis. This commentary evaluates the effect of diacerein on KOA symptoms and functional outcomes of recent parts of a multicenter randomized controlled trial. The clinical trial of diacerein as a monotherapy for effusion synovitis concluded that not only was there no overall significant change in the knee joint's moisture content after a 24-week therapy but also there was no evidence of symptomatic or functional improvement. Furthermore, problems like diarrhea and colored urine raised questions about its safety and user-friendly profile; therefore, these findings were contentious. These outcomes highlight the need for greater investigation of diacerein, including in combination therapies where its benefits are amplified and adverse effects diminished. Further research should help to define diacerein's role in KOA treatment and increase the understanding of its actions regarding effusion synovitis, focusing on side effects.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"54-56"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zelsuvmi Berdazimer—A Novel New Therapy for Molluscum Contagiosum—Efficacy, Safety, and Future Considerations","authors":"Jawairya Muhammad Hussain,&nbsp;Sameen Suhail,&nbsp;Saim Mahmood Khan,&nbsp;Abdul Wasio","doi":"10.1002/med4.70003","DOIUrl":"https://doi.org/10.1002/med4.70003","url":null,"abstract":"<p>Berdazimer sodium, marketed as Zelsuvmi, is an antiviral medication used to treat a viral infection called molluscum contagiosum (MC). MC is a common skin infection caused by a poxvirus, resulting in round, stiff, but painless papules in various places on the body. Zelsuvmi's antiviral activity is associated with the release of nitric oxide, which exhibits potent antiviral properties. Zelsuvmi is used topically by patients or caregivers to treat this extremely contagious viral skin infection at home or in medical facilities. On January 5, 2024, the U.S. Food and Drug Administration approved Zelsuvmi for treating this infection in target populations, including adults and patients aged 1 year and above. Other therapies for MC, such as retinoic acid, benzoyl peroxide, and cryotherapy, are quite painful, while Zelsuvmi is less painful. The purpose of this article is to highlight the clinical importance and potential benefits of Zelsuvmi in the treatment of MC worldwide.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"50-53"},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Diagnostic Performance of [18F]PSMA-1007 With [68Ga]Ga-PSMA-11 in PET/CT Imaging and Staging of Recurrent Prostate Cancer","authors":"Negar Abdi,&nbsp;Miad Alsulami,&nbsp;Hamid Ghaznavi","doi":"10.1002/med4.70006","DOIUrl":"https://doi.org/10.1002/med4.70006","url":null,"abstract":"<p>PET/CT has become the reference standard imaging modality for diagnosing prostate cancer because of its ability to target prostate-specific membrane antigen (PSMA), a protein specific to prostate cells. [⁶⁸Ga]Ga-PSMA-11 was a major advance, but limitations such as a short lifespan and image blurring led to the introduction of [¹⁸F]PSMA-1007, which offers advantages such as a longer lifespan and clearer images. This study aimed to compare the effectiveness of [¹⁸F]PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 in the detection and staging of recurrent prostate cancer because there is currently insufficient evidence to conclude that one PSMA-radiotracer is better than the other. Both ⁶⁸Ga and ¹⁸F-labeled PSMA-radiotracers have similar detection rates in patients. Therefore, more investigation is required to authoritatively conclude which radiotracer results in optimal performance for diagnosing prostate cancer lesions on PET/CT. In this narrative review, we focus on comparing the effectiveness of [¹⁸F]PSMA-1007 with that of [⁶⁸Ga]Ga-PSMA-11 in the detection of recurrent prostate cancer and determination of its stage. We found that [¹⁸F]PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 showed similar diagnostic performance, with [¹⁸F]PSMA-1007 having slightly higher sensitivity for primary and metastatic recurrent prostate cancer. However, a lack of statistical significance in the differences between the two radiotracers indicates comparable diagnostic accuracy, enabling their interchangeable use based on availability and cost efficiency.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"9-19"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Adverse Effects of Combination Therapy of Mpox With Tecovirimat and Brincidofovir, and Individual Therapy With Tecovirimat","authors":"Muhammad Affan Abid,&nbsp;Abdul Ahad,&nbsp;Muhammad Faizan Shaikh,&nbsp;Kazim Raza","doi":"10.1002/med4.70007","DOIUrl":"https://doi.org/10.1002/med4.70007","url":null,"abstract":"<p>This study evaluates the safety profile of tecovirimat monotherapy compared to its combination with brincidofovir for mpox treatment Brincidofovir is associated with hepatic toxicity, raising concerns about its clinical use Tecovirimat demonstrates a favorable safety profile with minimal side effects, making it a strong candidate for standalone mpox treatment Combining tecovirimat with brincidofovir may increase hepatic toxicity risks and impair drug absorption, necessitating careful consideration A retrospective UK study found that brincidofovir-treated patients experienced liver enzyme abnormalities and prolonged hospitalization, while those on tecovirimat had no major adverse effects Tecovirimat remains the preferred option for mpox management, but further studies are required to establish safer and more effective treatment strategies.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"57-58"},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agentic Large Language Models for Healthcare: Current Progress and Future Opportunities","authors":"Han Yuan","doi":"10.1002/med4.70000","DOIUrl":"https://doi.org/10.1002/med4.70000","url":null,"abstract":"<p>Agentic large language models (LLMs) combine vanilla LLMs’ reasoning, planning, and reflecting acquired from vast pre-trained datasets with specialized tools to enhance problem-solving capabilities. To understand the current progress and future opportunities of agentic LLMs for healthcare, this commentary conducted a comprehensive literature search in PubMed and summarized key takeaways.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward the Comprehensive Evaluation of Medical Text Generation by Large Language Models: Programmatic Metrics, Human Assessment, and Large Language Models Judgment","authors":"Han Yuan","doi":"10.1002/med4.70002","DOIUrl":"https://doi.org/10.1002/med4.70002","url":null,"abstract":"<p>This commentary discusses three evaluation approaches for assessing large language models' generation in healthcare: programmatic metrics, human assessment, and large language models judgment. No single approach can address all challenges; however, the combination of these three methods provides a pipeline toward the comprehensive evaluation of medical text generation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"46-49"},"PeriodicalIF":0.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pioneering Multidisciplinary Innovation: A Year in Review and Vision for the Future","authors":"Xueqing Yu","doi":"10.1002/med4.90","DOIUrl":"https://doi.org/10.1002/med4.90","url":null,"abstract":"&lt;p&gt;&lt;i&gt;Medicine Advances&lt;/i&gt; is dedicated to driving multidisciplinary innovation and advancing global healthcare. Reflecting on our achievements in 2024 and looking ahead to the opportunities in 2025, we reaffirm our commitment to shaping the future of medicine through collaboration, innovation, and excellence.&lt;/p&gt;&lt;p&gt;In 2024, the journal achieved significant milestones. The share of international manuscripts rose to 40%, reflecting our growing global reach. Additionally, our indexation by the Directory of Open Access Journals (DOAJ) marked a pivotal step in enhancing accessibility to high-quality research. As we anticipate the release of our first Impact Factor in 2025, these accomplishments highlight our journal's expanding influence and dedication to advancing global medical science.&lt;/p&gt;&lt;p&gt;Healthcare is undergoing transformative changes, with interdisciplinary collaboration breaking traditional “silos” and enabling innovative solutions to complex medical challenges. The integration of engineering, computational sciences, and behavioral research is driving advancements in diagnostics and treatments. Multimodal frameworks that combine imaging, biomarkers, and clinical data empower clinicians to treat diseases with unprecedented precision and depth. Over the past year, we have embraced these trends, actively promoting interdisciplinary collaboration. Our upcoming special issue on cardio-renal syndrome reflects this approach, exploring the complexities of multidisciplinary medicine from a holistic perspective.&lt;/p&gt;&lt;p&gt;Similarly, the convergence of multi-omics and systems biology is reshaping precision medicine. By integrating genomics, proteomics, metabolomics, and epigenomics, we gain holistic insights into disease mechanisms and therapeutic targets. Multi-omics approaches are transforming oncology, enabling dynamic understanding of tumor heterogeneity and guiding adaptive treatments. &lt;i&gt;Medicine Advances&lt;/i&gt; is at the forefront of this transformation, prioritizing studies that bridge the gap between research and clinical care. To support this mission, we are preparing a special issue on multi-omics advancements, showcasing cutting-edge innovations.&lt;/p&gt;&lt;p&gt;The 2024 Nobel Prize, awarded for breakthroughs in artificial intelligence (AI) applied to protein design and structure prediction, underscores AI's transformative role in healthcare. By accelerating drug discovery, enhancing diagnostic accuracy in medical imaging, and enabling tailored treatment plans through personalized medicine, AI is reshaping the medical landscape. To delve deeper into these innovations, we are preparing a special issue on exploring the true color of AI in its role of supporting the medical imaging in cancer evolution. We aim to highlight AI's role in understanding cancer progression, improving diagnostic precision, and guiding personalized therapies. By bringing together insights from oncology, imaging technology, and computational science, the issue seeks to foster interdis","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 1","pages":"7-8"},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.90","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a local nomogram-based scoring system for predicting overall survival in idiopathic pulmonary fibrosis: A rural appalachian experience","authors":"Rowida Mohamed,&nbsp;Rahul G. Sangani,&nbsp;Khalid M. Kamal,&nbsp;Traci J. LeMaster,&nbsp;Toni Marie Rudisill,&nbsp;Virginia G. Scott,&nbsp;George A. Kelley,&nbsp;Sijin Wen","doi":"10.1002/med4.86","DOIUrl":"https://doi.org/10.1002/med4.86","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Accurate staging systems are essential for assessing the severity of idiopathic pulmonary fibrosis (IPF) and guiding clinical management. This study aimed to evaluate the prognostic value of pulmonary comorbidities and body mass index (BMI) in IPF, develop a nomogram predicting overall survival (OS), and create a nomogram-based survival prediction model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with IPF were identified from electronic medical records of the West Virginia hospital system. Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression analysis was used for variable selection, and a nomogram was constructed. Risk groups were defined based on the nomogram's probability tertiles. The performance of the nomogram-based model was evaluated using Harrell's concordance index (C-index) and the Hosmer–Lemeshow test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study included 152 patients with IPF. The majority of the patients were elderly, male, and had a BMI above 24 kg/m². The median survival duration was 7.6 years. The survival rates were 91% at 1 year, 78% at 3 years, and 68% at 5 years. LASSO regression selected carbon monoxide lung diffusion capacity percentage predicted (DLco%), BMI, pulmonary hypertension, pulmonary embolism, and sleep apnea as independent predictive variables. The nomogram demonstrated good discrimination (C-index = 0.71) and calibration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Pulmonary comorbidities and BMI have significant prognostic value in IPF, emphasizing the necessity for consistent screening, assessment, and management of these factors in IPF care. Furthermore, the nomogram-based staging system showed promising performance in predicting OS and represents an actionable staging system that could potentially improve clinical management in IPF. Further validation of the nomogram is warranted to confirm its utility in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"2 4","pages":"336-348"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.86","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143252856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical profiles in autism spectrum disorder: Enhancing diagnosis, treatment, and overall health outcomes","authors":"Tielle Machado Cruz","doi":"10.1002/med4.89","DOIUrl":"https://doi.org/10.1002/med4.89","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by significant challenges in communication, behavior, and social interaction. The prevalence of ASD is rising, with current estimates indicating that it affects 1 in 36 children in the United States. Traditional diagnostic methods often fail to capture the full complexity of ASD, leading to incomplete treatment approaches. This study aimed to enhance diagnostic and therapeutic approaches to ASD by identifying and categorizing 10 clinical profiles using precision medicine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study presents a new stratification model for ASD that classifies individuals based on prevalent comorbidities and underlying biological mechanisms. The model is based on a synthesis of existing literature, clinical observations, and expert insights. Data were collected from detailed clinical evaluations, patient histories, and laboratory tests, and the model was refined through iterative analysis. It integrates findings from genetic, neurological, and psychiatric research to develop a comprehensive approach for diagnosing and treating ASD-related comorbidities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study proposes 10 clinical profiles of ASD: syndromic, gastrointestinal, metabolic, mitochondrial, endocrine, bioaccumulative, infectious, immunological, inflammatory, and Neurological. Each profile is associated with specific symptoms and comorbidities influenced by genetic, environmental, and biological factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The stratification model proposed in this study enhances the diagnosis and treatment of ASD by recognizing its heterogeneity. By identifying specific clinical profiles, healthcare providers can develop personalized and integrated therapeutic strategies to improve the overall health outcomes of individuals with ASD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"2 4","pages":"384-401"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.89","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143252777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}