Medicine Advances最新文献

{"title":"Nucleic Acid Based Detection and Prevalence of Yellow Fever Viral RNA Among Mosquitoes in Bayelsa State, Nigeria: An Environmental Epithet of Emerging Water-Inhabiting Insects","authors":"Bright E. Igere,&nbsp;Felix O. Onoriasakpobare,&nbsp;Temitope C. Ekundayo","doi":"10.1002/med4.70028","DOIUrl":"https://doi.org/10.1002/med4.70028","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Yellow fever (YF) viral transmission, spread, and prevalence has recently become a global concern and there is a need to screen for YF among inter-country travellers. This has been exacerbated by reports on the proliferation of aqua/water-breeding and inhabiting-insects (mosquitoes) and the potential viral transmission route. This study molecularly detected YF virus and its prevalence among mosquitoes in Bayelsa State, Nigeria, which is an environmental epithet of emerging water-inhabiting insects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An hour exposure of empty rooms to white-sheet and clean-water-spray technique was applied to collect adult mosquitoes in 100 empty rooms/houses that were located within the bushy/water-log study environment. This technique was applied to estimate the density of virus-harbouring mosquitoes and harvest structurally-intact mosquitoes for entomological identification by viral RNA extraction/detection from mosquito tissue using a Qiagen min-spin kit and reverse-transcriptase polymerase chain reaction (RT-PCR). A total of 400 adult male and female mosquitoes were harvested and entomologically described from the study region (Bayelsa State) between January 2021 and December 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Recovered mosquitoes included <i>Anopheles gambiae</i>, <i>An</i>. <i>nilli</i>, <i>Aedes aegypti</i>, <i>Ae</i>. <i>africanus</i>, <i>Ae</i>. <i>luteocephalus</i>, and <i>Ae</i>. <i>vittatus</i>. RT-PCR showed 27 positive complementary DNA amplicons at an expected size of 253 bp, which were detected by agarose gel electrophoresis at a prevalence rate of 6.75%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This result indicates that mosquitoes, which are water-inhabiting-insects, are a potential vector/carrier of YF viral RNA, which may be responsible for the transmission and distribution of the YF virus. These results also indicated the need for adequate research-based surveillance/monitoring of the study area, a mosquito eradication programme, appropriate drainage systems, and proper waste disposal.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"209-217"},"PeriodicalIF":0.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting Mitogen-Activated Protein Kinase-Activating Death Domain Protein of Brugia malayi for Construction of a Multi-Epitope Subunit Vaccine Against Lymphatic Filariasis","authors":"Paa Kwesi Anfu,&nbsp;Gifty Madjitey,&nbsp;Jennifer Afreh,&nbsp;Arnold Abakah,&nbsp;Prince Dunyo,&nbsp;Prince Manu,&nbsp;Kweku Foh Gyasi,&nbsp;Priscilla Osei-Poku,&nbsp;Alexander Kwarteng","doi":"10.1002/med4.70027","DOIUrl":"https://doi.org/10.1002/med4.70027","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lymphatic filariasis (LF) is a disease caused by parasitic worms that can lead to a debilitating condition known as elephantiasis. According to the World Health Organization, 657 million people across 39 countries are at risk of contracting LF. Eliminating LF remains a challenge despite ongoing efforts, primarily due to the ineffectiveness of existing treatments and the rise of drug resistance. Currently, no vaccines are available for LF. The main objective of this study was to design a vaccine that targets the MAP kinase-activating death domain (MADD) protein of <i>Brugia malayi</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Employing an in silico approach, we screened proteins to identify B- and T-cell epitopes and assess their safety. These epitopes were combined with adjuvants and linkers to design a multi-epitope vaccine. The six resulting vaccine models were refined using the GalaxyRefine tool to determine the most stable vaccine candidate, which was further validated through molecular dynamic simulations. Immune simulations were carried out using the final selected vaccine candidate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Here, we show significant stimulation of humoral and cell-mediated immune responses resulting in the production of numerous memory B cells and T cells and a substantial increase in the production of the IgG1 antibody. These antibodies are crucial in clearing microfilariae from the peripheral circulation of infected individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings highlight MADD protein as a promising vaccine candidate to target LF.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"177-192"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Causal Inflammatory Factors With Gene Mediators and Potential Drugs for Bronchiectasis","authors":"Wanzhe Liao,&nbsp;Haobin Zhou,&nbsp;Zhuofeng Wen,&nbsp;Weixuan Liang,&nbsp;Chongde Pan,&nbsp;Zhiyi Zhou,&nbsp;Jingzhang Sun,&nbsp;Chang Liu,&nbsp;Xiangdong Zhou,&nbsp;Naijun Yuan,&nbsp;Qi Li,&nbsp;Chuiguo Huang","doi":"10.1002/med4.70025","DOIUrl":"https://doi.org/10.1002/med4.70025","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bronchiectasis is a chronic respiratory disease characterized by irreversible dilation of the bronchi. Despite advancements in diagnostic techniques and therapeutic strategies, the underlying etiological factors driving bronchiectasis pathogenesis remain unclear. The purpose of this study was to explore the potential causal relationship between inflammatory factors and bronchiectasis to better understand the disease's molecular mechanisms and identify possible therapeutic targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Genome-wide data were utilized to conduct two-sample Mendelian randomization (MR) focusing on the causal relationships between 41 inflammatory factors and bronchiectasis. The reliability of the results was validated by sensitivity tests. Summary data-based MR, coloc, and intermediary MR were utilized to determine latent upstream genes and estimate indirect effects. Molecular docking was applied to identify existing effective drugs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four inflammatory factors with potential causal effects on bronchiectasis were identified: macrophage migration inhibitory factor, interleukin-4, interferon-gamma (IFN-γ), and basic fibroblast growth factor (bFGF). Additional sensitivity tests tended to support the directional consistency of the IFN-γ and bFGF estimates. RP11-589P10.5 reduced the risk of bronchiectasis mediated by the IFN-γ concentration. Metronidazole, ibuprofen, methotrexate, pioglitazone, and ciprofloxacin were identified as effective therapeutic drugs, whereas simvastatin was predicted to be harmful. Ciprofloxacin and lansoprazole were also identified as potentially therapeutic and harmful drugs with the strongest binding activities, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides strong evidence for the causal effects of macrophage migration inhibitory factor, interleukin-4, IFN-γ and bFGF in bronchiectasis, especially the latter two inflammatory factors. RP11-589P10.5 latently decreased the risk of bronchiectasis mediated by IFN-γ. Methotrexate, lansoprazole, and pioglitazone were predicted to have potential therapeutic values.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"158-170"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Burden and Trends of Soft Tissue and Extraosseous Sarcomas in China: An Observational Study From 1990 to 2021","authors":"Zhaoqi Wu,&nbsp;Zhenle Su,&nbsp;Jun Huang,&nbsp;Martin Gluchman,&nbsp;Chenyu Zhao","doi":"10.1002/med4.70032","DOIUrl":"https://doi.org/10.1002/med4.70032","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Soft tissue and extraosseous sarcomas (STS) are rare malignancies of mesenchymal origin characterized by heterogeneous biological behavior, posing substantial diagnostic and therapeutic challenges. In China, the paucity of epidemiological data coupled with disparities in healthcare access has contributed to poorer prognoses, positioning STS as a critical public health concern. This study aimed to comprehensively analyze the epidemiological trends of STS in China over the past three decades and project its future burden, thereby providing evidence-based insights for public health strategies and clinical decision-making.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study used data from the Global Burden of Disease 2021 database to evaluate national trends in STS incidence, prevalence, mortality, and burden in China from 1990 to 2021. Statistical analyses included Joinpoint regression to identify temporal inflection points, age-period-cohort modeling to assess age and cohort effects, decomposition analysis to quantify demographic contributors to disease trends, and Bayesian age-period-cohort models to project incidence and mortality through 2036.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;From 1990 to 2021, the absolute number of STS cases in China increased, whereas age-standardized incidence rates exhibited a modest decline. While overall prevalence rose substantially in absolute terms, age-standardized prevalence rates decreased by five percentage points. Disability-adjusted life years attributable to STS declined by 18.13%. Significant age- and gender-related disparities were observed, with individuals aged &gt; 75 years experiencing the largest increases in both prevalence and mortality. Men consistently demonstrated higher incidence and mortality rates than women. Age-period-cohort models revealed that adults aged 36–60 years exhibited the most dynamic changes in incidence, with average annual increases ranging from 0.8% to 1.5%. Although overall mortality decreased, individuals born before 1960 contributed disproportionately to the disease burden. Projections for 2036 estimate age-standardized incidence rates of 0.107 and 0.108 per 100,000 for men and women, respectively, with corresponding increases anticipated in mortality rates.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Although the overall burden of STS in China has declined, pre-1960 birth cohorts remain at elevated risk. Population aging is expected to drive continued increases in both morbidity and mortality over the next 15 years, ","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"145-157"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of Evidence on the Safety Management of Non-Suicidal Self-Injury Behaviors in Adolescents in General Hospitals","authors":"Xiaoxia Jian,&nbsp;Chunlei Luo,&nbsp;Junjian Xiao,&nbsp;Yanyan Huang,&nbsp;Zhenyan Wei,&nbsp;Chen Fang,&nbsp;Zhen Yang,&nbsp;Liping Huang","doi":"10.1002/med4.70022","DOIUrl":"https://doi.org/10.1002/med4.70022","url":null,"abstract":"<p>The current study was conducted to summarize the evidence related to the safety management of non-suicidal self-injury behaviors in adolescents in general hospitals, providing a basis for clinical medical staff to carry out appropriate safety management practices. We systematically searched domestic and international databases and guideline websites for literature on the safety management of non-suicidal self-injury behaviors in adolescents. The search period was from the establishment of the database to April 2024. Three researchers independently conducted literature quality evaluation, evidence extraction, and summarization. A total of 11 articles were included, consisting of four guidelines, five systematic reviews, one meta-analysis, and one expert consensus. Evidence was summarized in five aspects: building a multidisciplinary safety team, assessing self-injury risk, ensuring the safety of the ward environment, safety intervention strategies, and health education, comprising 22 pieces of evidence. In conclusion, the best evidence-based practice for the safety management of non-suicidal self-injury behaviors in adolescents provides a reference for clinical practice. Proceeding with clinical transformation to improve nursing quality and ensure patient safety is recommended.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"134-144"},"PeriodicalIF":0.0,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70022","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Complication After Surgical Correction of Shepherd's Crook Deformity in a Young Woman: A Case Report and Literature Review","authors":"Rongjie Wu,&nbsp;Guangtao Fu","doi":"10.1002/med4.70024","DOIUrl":"https://doi.org/10.1002/med4.70024","url":null,"abstract":"<p>Cardiac events are rare, easily neglected, but potentially fatal complications of McCune–Albright syndrome. An 18-year-old woman underwent proximal femur osteotomy and intramedullary nail fixation for correction of shepherd's crook deformity at our institution. Unexpectedly, she developed acute heart failure on postoperative day 2. She had no preoperative cardiovascular abnormality and did not receive excessive fluids during the perioperative period. Pulmonary embolism was excluded based on spiral computed tomography pulmonary angiography. Her symptoms resolved on postoperative day 3. Genetic analysis of surgical tissue revealed that the patient had McCune–Albright syndrome.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"193-196"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could the Altmetric Score Be an Alternative Approach to Traditional Bibliometrics for Evaluating Influential Articles in Pediatric Robotic Surgery?","authors":"Boshen Shu","doi":"10.1002/med4.70026","DOIUrl":"https://doi.org/10.1002/med4.70026","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Traditional bibliometrics have been used to estimate the scientific impact of research across various fields. However, citation analysis is not without limitations. With the rapid development of social media, the Altmetric score has become popular for evaluating scientific work. This study aimed to determine whether the Altmetric score could replace traditional bibliometrics for assessing influential papers in pediatric robotic surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Web of Science database was searched for the 50 top-cited publications in pediatric robotic surgery, and the characteristics of each article were recorded and identified. Conventional bibliometric variables included the citation count and impact factor (IF) of the publishing journal. The Altmetric score database was used to identify the Altmetric score and details for each article. Statistical analysis, including Spearman's correlation coefficients, was performed using Microsoft Excel and GraphPad PRISM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The top 50 publications with the most citations were obtained and analyzed. A significant negative relationship was identified between the impact index and the Altmetric score (<i>r</i> = −0.42, <i>p</i> &lt; 0.01, <i>R</i>² = 0.18), and no correlations were observed for the number of citations (<i>r</i> = −0.12, <i>p</i> = 0.40, <i>R</i>² = 0.01) and IF (<i>r</i> = −0.09, <i>p</i> = 0.53, <i>R</i>² = 0.01). X/Twitter (68%) was the most popular social media source for Altmetric score details.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study did not identify a statistically significant correlation between Altmetric scores and conventional bibliometric variables in the 50 top-cited publications. Furthermore, the Altmetric score is susceptible to manipulation because its calculation mechanism is unknown. Thus, the Altmetric score does not currently deliver an alternative approach to traditional bibliometrics. A combination of traditional bibliometrics and the Altmetric score can provide a more comprehensive method for evaluating influential articles in pediatric robotic surgery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"171-176"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of ResNet-18 and InceptionResNetV2 in Automated Detection of Diabetic Retinopathy","authors":"Akwasi Asare,&nbsp;Alvin Adjei Broni,&nbsp;Alex Kwasi Asare Dickson,&nbsp;Mary Sagoe,&nbsp;Joshua Makafui Cudjoe","doi":"10.1002/med4.70023","DOIUrl":"https://doi.org/10.1002/med4.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Diabetic retinopathy (DR) is a leading cause of blindness worldwide, particularly in diabetic individuals. Manual detection of DR by ophthalmologists is time-consuming and resource-intensive, making early automated detection essential for mitigating the risk of vision impairment. This study evaluates the effectiveness of two deep learning models, ResNet-18 and InceptionResNetV2, for detecting and classifying DR from retinal fundus images, with the aim of identifying the most suitable model for clinical application.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A dataset of 3662 retinal fundus images, divided into five DR severity classes, was used to train and test ResNet-18 and InceptionResNetV2. The key performance metrics used to assess classification across the DR stages included testing accuracy, precision, recall, specificity, <i>F</i>₁ score, and area under the curve (AUC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ResNet-18 achieved a testing accuracy of 83% and an AUC of 0.946, showing robust generalization across DR stages. InceptionResNetV2 achieved a testing accuracy of 70.4% and an AUC of 0.9305, with high precision in distinguishing “No DR” cases. However, it exhibited overfitting, particularly in “Mild” and “Proliferative DR” classifications, whereas ResNet-18 demonstrated a more stable performance across categories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results suggest that ResNet-18 holds significant potential as an automated DR detection tool, providing reliable classification and superior generalization across DR stages. Integrating deep learning models such as ResNet-18 into clinical workflows may enhance early DR diagnosis and timely intervention, reducing the risk of vision impairment among patients with diabetes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"231-241"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Challenges After Treatment for Colorectal and Anal Cancer: A Descriptive Study","authors":"Birthe Thing Oggesen,&nbsp;Jacob Rosenberg","doi":"10.1002/med4.70020","DOIUrl":"https://doi.org/10.1002/med4.70020","url":null,"abstract":"<p>Receiving a diagnosis of cancer can profoundly impact an individual's perception of life. It can significantly affect their daily functioning because of changes in work ability, treatment-related sequelae, and psychological distress. This prospective single center observational study aimed to identify psychosocial problems experienced by patients treated for colorectal or anal cancer. Patients were seen in an outpatient clinic for cancer sequelae treatment. During consultations, we documented the specific problems discussed and addressed with each patient. Patients with psychosocial problems were eligible for this study. Psychosocial challenges were defined from the patients' medical records. Of the 583 patients evaluated at our center, 107 patients experienced psychosocial issues that were discussed during consultations. The most prevalent issues included tiredness or sleep disturbance followed by challenges with returning to everyday life, existential dilemmas, work-related challenges, and bowel and stool problems. There were no correlations with age, gender, or tumor stadium.</p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"197-201"},"PeriodicalIF":0.0,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Peptides Versus Semaglutide: A Safer Approach to Obesity Management","authors":"Muhammad Affan Abid,&nbsp;Muhammad Babar Asad,&nbsp;Muhammad Junaid Razzak","doi":"10.1002/med4.70021","DOIUrl":"https://doi.org/10.1002/med4.70021","url":null,"abstract":"<p>This paper highlights that while semaglutide is effective for weight loss, it is associated with significant side effects, high cost, and muscle loss. In contrast, natural peptides such as BRP, BPC-157, and MOTS-c demonstrate promising anti-obesity effects with fewer adverse outcomes, improved safety profiles, and potential affordability making them attractive candidates for future therapeutic development.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100913,"journal":{"name":"Medicine Advances","volume":"3 3","pages":"202-204"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med4.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145196534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}