Chinese Chemical Letters最新文献

{"title":"Advancements in nanophotonics and smart nanomaterials integrated with artificial intelligence-driven gene editing: A paradigm shift in cancer diagnosis and therapeutic","authors":"Bakr Ahmed Taha ,&nbsp;Ali J. Addie ,&nbsp;Luai Farhan Zghair Kolie ,&nbsp;Saba Talib Wahhab ,&nbsp;Sinan Adnan Abdulateef ,&nbsp;Adawiya J. Haider ,&nbsp;Khalid Ibnaouf ,&nbsp;Norhana Arsad","doi":"10.1016/j.cclet.2025.111955","DOIUrl":"10.1016/j.cclet.2025.111955","url":null,"abstract":"<div><div>Traditional cancer therapies are limited by side effects and damage to healthy tissues, while modern targeted treatments face challenges such as drug resistance and restricted applicability across cancer types. Early diagnosis also remains difficult, as many methods lack the sensitivity and specificity needed to reliably detect small, early-stage tumors. This review explores hybrid nanomaterial-based delivery systems, such as lipid–gold nanoparticle composites combined with polymeric nanocarriers, to improve the precision and efficacy of gene therapy. Advances in nanotechnology are highlighted for their ability to augment gene-editing tools including RNA interference and clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9), supported by techniques like optical tweezers, plasmonics, fluorescence imaging, and metamaterials. Nanophotonics in particular offers ultra-sensitive molecular imaging and real-time biomarker detection, underscoring its value for early cancer diagnosis. Artificial intelligence further strengthens these approaches by optimizing nanocarrier design, predicting therapeutic outcomes, and guiding personalized treatment strategies. Machine learning and deep learning platforms enable efficient analysis of complex genomic and clinical datasets, improving predictive accuracy and therapeutic customization. The review also outlines molecular mechanisms of gene therapy, from editing to expression, and addresses barriers to clinical translation, such as data integration, model validation, and regulatory considerations. Combining nanotechnology, artificial intelligence (AI), and gene-editing advances holds promise for more effective, targeted, and minimally invasive cancer treatments. These integrated strategies support earlier detection, enhance therapeutic precision, and provide a framework for translating experimental breakthroughs into clinical applications that better align with the goals of personalized medicine.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111955"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Au-reinforced chemo-photodynamic therapy of lanthanide-doped nanoplatforms with upconversion-downshifting luminescence via catalytic amplification","authors":"Ruohao Zhang ,&nbsp;Yifei Zhou ,&nbsp;Yu Lu ,&nbsp;Xudong Sun ,&nbsp;Jitong Gong ,&nbsp;Kehong Lv ,&nbsp;Xinyu Fu ,&nbsp;Yukai Cheng ,&nbsp;Jing Feng ,&nbsp;Hongjie Zhang","doi":"10.1016/j.cclet.2025.111144","DOIUrl":"10.1016/j.cclet.2025.111144","url":null,"abstract":"<div><div>The vast majority of lanthanide-doped nanoparticles (LnNPs) exhibit a single mode of upconversion luminescence (UCL) or downshifting luminescence (DSL) for photodynamic therapy (PDT) or diagnostic imaging of tumors, respectively. In order to achieve both UCL and DSL, it is often necessary to dope the luminescent ions in different shell layers to prevent their luminescence quenching, resulting in tedious synthesis steps. Herein, upconversion-downshifting nanoparticles (UDNPs) co-doped with Er³⁺ and Ho³⁺ enable the simultaneous dual-wavelength DSL for <em>in vivo</em> near-infrared (NIR)-II fluorescence imaging of tumors. On the other hand, the UCL of UDNPs could activate merocyanine photosensitizers (MC 540), resulting in the generation of reactive oxygen species (ROS) and the achievement of PDT. Importantly, Au NPs with glucose oxidase-like properties could consume glucose and promote H₂O₂ accumulation in tumor cells. Au-catalyzed UDNPs modified with Fe-tannic acid (FeTA) (UDNP-MC/Au-FeTA) could not only enhance the effect of PDT but also realize chemodynamic therapy (CDT) by reacting with Fe²⁺ generated from slightly acidic decomposition of FeTA to accelerate hydroxyl radical (^•OH) generation. The combination of long- and short-acting dual-dynamic therapy could mutually reinforce and compensate for the lack of therapeutic efficacy resulting from luminescence quenching caused by co-doping luminescent ions. Therefore, UDNP-MC/Au-FeTA guided by NIR-II fluorescence imaging could achieve efficient synergistic dual-dynamic therapy of tumors through differentially expressed genes associated with apoptosis and oxidative stress-related pathways. NIR-II fluorescence imaging diagnostic and dual-dynamic therapeutic strategy, which employs Au-catalyzed lanthanide co-doped UDNPs represents a dexterous design concept for promising anti-tumor applications.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111144"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of novel isosorbide-based polycarbonates by melt chain extension method","authors":"Xiafeng Yang ,&nbsp;Wushan Sun ,&nbsp;Chen Li ,&nbsp;Wei Bai ,&nbsp;Qingyin Wang ,&nbsp;Gongying Wang","doi":"10.1016/j.cclet.2025.111674","DOIUrl":"10.1016/j.cclet.2025.111674","url":null,"abstract":"<div><div>The melt-transesterification polycondensation method necessitates elevated reaction temperatures and protracted reaction times in the copolymerization of modified isosorbide-based polycarbonates. This results in a decline in molecular weight and color degradation of the copolymerized IS-PC. In this paper, the process of polyethylene glycol (PEG) modification was introduced in the synthesis of isosorbide-based copolycarbonate (PE_XHDC_YC) by means of a melt chain extension method. As demonstrated by experimental findings, this method has the capacity to reduce the reaction temperature and shorten the reaction time. Additionally, it has been observed to enhance the molecular weight and overall properties of the material. Through the optimization of reaction conditions, a series of PE_XHDC_YC with weight average molecular weight (<em>M</em>_w) ranging from 19,004 g/mol to 73,294 g/mol were synthesized. The results demonstrated that the glass transition temperature (<em>T</em>_g) of PE_XHDC_YC decreased in conjunction with an increase in the PEG₁₀₀₀ content. It is noteworthy that the PE_XHDC_YC synthesized by this method exhibits an exceptional elongation at break, reaching up to 135.45 % ± 24 %. Furthermore, PE_XHDC_YC demonstrates superior optical properties in comparison to bisphenol A polycarbonate (BPA-PC).</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111674"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Support engineering of single-atom electrocatalysis: Mechanism analysis and application expansion","authors":"Mingying Chen ,&nbsp;Junjie Ma ,&nbsp;Xiyong Chen ,&nbsp;Qian Liu ,&nbsp;Yanhong Feng ,&nbsp;Xijun Liu","doi":"10.1016/j.cclet.2025.111637","DOIUrl":"10.1016/j.cclet.2025.111637","url":null,"abstract":"<div><div>Electrocatalysis stands as a cornerstone in the pursuit of clean energy conversion and environmental sustainability, with single-atom catalysts (SACs) emerging as a transformative paradigm for enhancing electrocatalytic efficiency. In the architectural design of SACs, supports transcend conventional roles as mere supports, actively governing catalytic performance <em>via</em> robust metal-support interactions (SMSI). This review comprehensively analyses the key role of support engineering in modulating SACs performance. The study begins with a systematic assessment of currently popular SACs synthesis strategies, critically comparing their advantages and limitations. Through a hierarchical analysis, it reveals the impact of various support materials, such as carbon-based materials, metal oxides, MXenes, and metal-organic frameworks (MOFs), on the catalytic performance of SACs, with emphasis on their structural characteristics, electronic properties, and interaction mechanisms with active sites. The review further explores applications in energy conversion/storage and environmental remediation, while addressing current challenges and proposing future research directions for SACs development. By providing actionable insights, this work aims to guide the design of next-generation SACs and advance sustainable electrocatalysis.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111637"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145915458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full-profile bioanalysis of polydisperse macromolecular hydroxyethyl starch 130/0.4 in rat plasma via LC-IS-CID coupled with MRM","authors":"Xin Xu ,&nbsp;Huan Yang ,&nbsp;Jiachong Chi ,&nbsp;Xiangjun Meng ,&nbsp;Jingkai Gu","doi":"10.1016/j.cclet.2025.111703","DOIUrl":"10.1016/j.cclet.2025.111703","url":null,"abstract":"<div><div>Hydroxyethyl starch 130/0.4 (HES130/0.4) is a macromolecular polysaccharide with polydispersity, which is widely used as a plasma expander. Full-profile bioanalysis of HES130/0.4 is required to characterize its plasma pharmacokinetics, yet current analytical technologies struggle with this task due to its complex structure and composition. To address this existing lacuna within the realm of analytical science, we propose a liquid chromatography-electrospray ionization mass spectrometry (LC-ESI-MS) methodology for the full-profile bioanalysis of HES130/0.4. Amide column separation with gradient optimization eluted polydisperse HES130/0.4 as a single symmetric peak. In-source collision-induced dissociation (IS-CID) converted the numerous precursor ions of HES130/0.4 into a limited number of characteristic fragment ions, from which <em>m/z</em> 597.4 was selected as the \"<em>pseudo</em>-precursor ion\" for MRM quantification. The ion transition <em>m/z</em> 597.4 → 435.3 was identified as the quantitative ion pair. The method demonstrated a linear calibration curve from 40 μg/mL to 4000 μg/mL, with accuracy and precision meeting acceptance criteria, confirming its reliability and reproducibility. Subsequently, the workflow was successfully applied to investigate the pharmacokinetics of HES130/0.4 in rat, revealing its large distribution volume and rapid elimination within 24 h. This work provides a straightforward approach for the full-profile quantification of HES130/0.4 in biological samples, overcoming the limitations of traditional methods in terms of poor specificity, low sensitivity and narrow linear range, and providing a reference for the <em>in vivo</em> full-profile bioanalysis of HES130/0.4 and other polysaccharides.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111703"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assembly of π-conjugated [B3O7] groups by unprecedented antiparallel triangles [ZnO3] to tailor a deep-UV zinc borate birefringent crystal","authors":"Ning Yang ,&nbsp;Huijian Zhao ,&nbsp;Wenli Zhao ,&nbsp;Yuheng She ,&nbsp;Ning Ye ,&nbsp;Zhanggui Hu ,&nbsp;Conggang Li","doi":"10.1016/j.cclet.2025.110825","DOIUrl":"10.1016/j.cclet.2025.110825","url":null,"abstract":"<div><div>Birefringent crystals have gained increasing attention for versatile optical devices due to their inherent ability to modulate light polarization. However, the rational design of structures that exhibit high birefringence and deep-ultraviolet (DUV) transparency remains a formidable challenge. Here, a novel zinc borate birefringent crystal, Na₂ZnB₆O₁₁ (NZBO), was identified by strategically assembling the <em>π</em>-conjugated [B₃O₇] functional units using the unprecedented antiparallel triangles formed by [ZnO₃] motifs. Remarkably, through a tailored motif approach and optimized arrangement, NZBO achieves the largest birefringence (0.094) in the visible wavelength range among the borate-based crystals containing [B₃O₇] units, exceeding that of commercially available birefringent crystal MgF₂ by approximately 8 times (0.012@532 nm). Furthermore, NZBO exhibits a notably short DUV absorption cutoff edge below 190 nm along with a wide band gap of 6.04 eV attributed to the elimination of dangling bonds. The origin of the optical anisotropy attributes of NZBO was elucidated through a combination of theoretical calculations and structural analyses. These findings highlight the good potential of NZBO in the manipulation of polarized light and offer valuable insights for tailoring new birefringent materials in the short-wave UV transparency region.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 110825"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A high-tap-density, particle-nested-bulk bismuth anode for fast-charging sodium-ion batteries","authors":"Xiaoling Qiu ,&nbsp;Ruijie Chen ,&nbsp;Keren Luo ,&nbsp;Xiaoran Wang ,&nbsp;Tuan Wang ,&nbsp;Pengcheng Shi ,&nbsp;Wenlong Cai ,&nbsp;Hao Wu","doi":"10.1016/j.cclet.2024.110792","DOIUrl":"10.1016/j.cclet.2024.110792","url":null,"abstract":"<div><div>The application of commercial hard carbon (HC) materials in sodium-ion batteries (SIBs) is limited by their inferior rate capability (&lt;5.0 A/g) and low tap density (&lt;1.0 g/cm³). Alloying-type bismuth (Bi) offers a high theoretical volumetric capacity of 3800 mAh/cm³ and superb rate capability but suffers from large volume expansion (∼244 %) and undesirable structural pulverization. Herein, a hectogram-scale Bi-inlaid carbon skeleton (GC-Bi) composite was synthesized through a facile precipitation-carbonization method using low-cost industrial-grade chemical reagents. The as-prepared GC-Bi composite features a unique particle-nested-bulk architecture, achieving a high tap-density of 3.33 g/cm³, which is approximately 4.16 times greater than that of commercial HC. Besides, the carbon sheath enhances the electronic conductivity and accommodates the substantial volume swelling of the embedded Bi particles, contributing to the formation of a thin and stable solid electrolyte interface on the electrode. Consequently, the GC-Bi anode achieves a high volumetric capacity (1123 mAh/cm³), impressive rate capability (207.8 mAh/g at 80 A/g), together with long cyclability retaining 96.5 % of its capacity after 5000 cycles in a Na//GC-Bi half-cell and 78 % after 800 cycles in a GC-Bi//Na₃V₂(PO₄)₃ full-cell.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 110792"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic interaction of ternary Pd−Cu−Ni confined in nanoparticles as pH-universal catalysts for enhanced hydrogen evolution reaction","authors":"Xiao Liu ,&nbsp;Haiyan Pang ,&nbsp;Xinrui Kou ,&nbsp;Zheng Tang ,&nbsp;Bing Cui ,&nbsp;Shihong Cen ,&nbsp;Yuechang Wei","doi":"10.1016/j.cclet.2025.111567","DOIUrl":"10.1016/j.cclet.2025.111567","url":null,"abstract":"<div><div>The development of a high-performance pH-universal electrocatalyst for hydrogen evolution reaction (HER) is a vital step toward hydrogen economy but remains a major challenge. Herein, the Pd, Cu, and Ni three elements were confined in a nanoparticle <em>via</em> the microemulsion method. Morphology and structural analysis reveal that PdCuNi nanoparticles are nearly spherical in shape with slight aggregation, and are mainly composed of metallic Pd and Cu, as well as Ni oxide. The electrochemical tests show that PdCuNi exhibits favorable HER catalytic activity in acid (<em>ŋ</em>₁₀: 45 mV; Tafel slopes: 33 mV/dec) and neutral (<em>ŋ</em>₁₀: 71 mV; Tafel slopes: 87 mV/dec) media, and alkaline (<em>ŋ</em>₁₀: 66 mV; Tafel slopes: 116 mV/dec) media. The mechanism analysis implies that the synergistic effect of Pd, Cu, and Ni can improve the inherent conductivity of the catalyst and accelerate the charge transfer process. Furthermore, over 30 h long-term stability has been achieved without significant attenuation. This work provides a strategy for developing versatile and robust multimetallic catalysts towards pH-universal HER.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111567"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron-based catalysts for NOx reduction: Reaction mechanism and anti-poisoning strategies","authors":"Zaisheng Jin ,&nbsp;Fuli Wang ,&nbsp;Yongjie Shen ,&nbsp;Xiaonan Hu ,&nbsp;Yanqi Chen ,&nbsp;Jin Zhang ,&nbsp;Ming Xie ,&nbsp;Penglu Wang ,&nbsp;Dengsong Zhang","doi":"10.1016/j.cclet.2025.111733","DOIUrl":"10.1016/j.cclet.2025.111733","url":null,"abstract":"<div><div>Iron-based metal oxide catalysts are widely used for selective catalytic reduction (SCR) of NO_x with NH₃ due to their excellent catalytic performance at medium and high temperatures, high nitrogen selectivity, robust resistance to sulfur dioxide poisoning, environmental sustainability and cost effectiveness. However, several challenges including sub-optimal low-temperature catalytic activity, narrow operating temperature range, poor resistance to alkali/alkaline earth metal poisoning, as well as insufficient thermal stability and H₂O/SO₂ resistance always hinder the further application of iron-based metal oxide catalysts, which is in urgent need of further improvement in practical applications. This review provides a comprehensive overview of the development, applications and challenges associated with different types of iron-based metal oxide catalysts and suggests corresponding modification strategies to address the as-mentioned issues. Iron oxide catalysts can promote low-temperature catalytic performance by adjusting crystal structures and exposing specific crystal faces; however, their thermal stability and resistance to SO₂/H₂O and alkali metals still have substantial room for improvement. Iron-based composite metal oxide catalysts can effectively increase the resistance to SO₂/H₂O by coupling multiple metals and modulating adjacent electronic sites. Iron-based acidic salt catalysts greatly enhance the resistance to alkali metal poisoning by enriching the surface acid sites and providing sacrificial sites. Supported iron-based metal oxide catalysts can significantly improve both catalytic performance and resistance by modulating reaction pathways and constructing core-shell structures. This review clarifies the important direction of further research on iron-based metal oxide catalysts, and provides scientific basis and design ideas for the development and application of high-efficiency low-temperature NO_x reduction catalysts.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 111733"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional nanoadjuvants-aided synergistic photothermal-immunotherapy of tumor","authors":"Kaiyue Yang ,&nbsp;Yifan Zhang ,&nbsp;Shamei Luo,&nbsp;Chenxi Yu,&nbsp;Lin Chen,&nbsp;Qingyu Yu,&nbsp;Chenlu Huang,&nbsp;Guilei Ma,&nbsp;Linhua Zhang,&nbsp;Dunwan Zhu","doi":"10.1016/j.cclet.2025.112324","DOIUrl":"10.1016/j.cclet.2025.112324","url":null,"abstract":"<div><div>Cancer persists as a major global health challenge, marked by high recurrence rates in aggressive malignancies such as melanoma. While immunotherapy has emerged as a promising approach, its clinical benefits are often limited by tumor immune escape mechanisms and an immunosuppressive tumor microenvironment (TME). These hurdles have driven the exploration of integrated approaches, with photothermal-immunotherapy gaining significant traction. In this study, we developed a multifunctional nanoadjuvant (MICN@PI) engineered with an acid-responsive calcium carbonate core, a hypoxia-alleviating MnO₂ component, a polydopamine shell for photothermal ablation, and co-loaded immunomodulators (imiquimod and indoximod). The MnO₂ in the nanoadjuvant catalytically converted the overexpressed H₂O₂ in the TME into O₂. Concurrently, the combined action of imiquimod and indoximod orchestrated a potent adaptive immune response. Upon near-infrared laser irradiation, MICN@PI achieved significant tumor ablation, inhibited recurrence, and prolonged survival in a murine melanoma model, offering a safe and effective synergistic photothermal-immunotherapy strategy for cancer treatment.</div></div>","PeriodicalId":10088,"journal":{"name":"Chinese Chemical Letters","volume":"37 4","pages":"Article 112324"},"PeriodicalIF":8.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145975190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}