Journal of Liver Transplantation最新文献

{"title":"Editorial of the article of Furey G","authors":"Daniel Eyraud","doi":"10.1016/j.liver.2024.100231","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100231","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100231"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000321/pdfft?md5=681759b4d21517561a731893e7d28dd9&pid=1-s2.0-S2666967624000321-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141264094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Field in Transition: A Scoping Review and Thematic Network Map of Qualitative Health Research in Liver Transplantation","authors":"Selena Zhang ,&nbsp;Chloe Wong-Mersereau ,&nbsp;Ani Orchanian-Cheff ,&nbsp;Maryam Makki ,&nbsp;Shikha Gandhi ,&nbsp;Kelly Fritsch ,&nbsp;Mamatha Bhat ,&nbsp;Suze Berkhout","doi":"10.1016/j.liver.2024.100233","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100233","url":null,"abstract":"<div><h3>BACKGROUND</h3><p>In liver transplantation, qualitative methodologies can offer important insights from a range of perspectives into the meaning and impact of health experiences. This review aims to characterize the existing qualitative research in liver transplantation to understand how this work has evolved over time, its contribution to understanding clinical issues, and to conceptualize under-developed areas for future research.</p></div><div><h3>METHODS</h3><p>Studies from MEDLINE, Embase, Cochrane Database of Systematic Reviews, CENTRAL, CINAHL, and Web of Science were searched from database inception to January 2024. All English language studies focused on a liver transplant population with qualitative methodological components were included. Using VOSviewer network mapping software we constructed a visualization of the thematic networks within included studies.</p></div><div><h3>RESULTS</h3><p>Our initial search yielded 9092 studies from which 229 were included in the final review. Data extraction revealed significant increases in the publication of qualitative studies since 2015, predominantly utilizing interviews and focus groups. The thematic network map we constructed placed “social support” as a dominant and central concept across many different studies, with related themes tending to cluster within four domains of research: <em>Care of the Organ &amp; Patienthood; Identity, Embodiment, Adjustment; Relational &amp; Ethical Issues; Existential Themes</em>. Medicalized subject such as “self-management” were less well-networked with identity-related, ethical, and existential topics.</p></div><div><h3>DISCUSSION</h3><p>There is a growing body of rich qualitative research in liver transplantation. Future research would benefit from more longitudinal approaches as well as increased attention to the interrelation between “clinical” issues (adherence, quality of life) and ethical, relational, and existential ones.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000345/pdfft?md5=90219842834346a9477c0d9c9686c126&pid=1-s2.0-S2666967624000345-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience with Epstein barr virus and Cytomegalovirus infection in pediatric liver transplant recipients: A 2014–2017 study","authors":"Paola Marsela Pérez Camacho ,&nbsp;Jaime Alberto Patiño-Niño ,&nbsp;Lina María Jaimes ,&nbsp;María Camila López-Girón ,&nbsp;Laura Torres-Canchala ,&nbsp;Víctor García-Montoya ,&nbsp;Camila Ariza-Insignares ,&nbsp;Lina M. Sandoval-Calle ,&nbsp;Inés E. Gómez ,&nbsp;Mario Bustos-Paz ,&nbsp;Luis Armando Caicedo ,&nbsp;Verónica Botero-Osorio","doi":"10.1016/j.liver.2024.100222","DOIUrl":"10.1016/j.liver.2024.100222","url":null,"abstract":"<div><h3>Introduction</h3><p>This study presents our experience with Epstein Barr virus (EBV) and Cytomegalovirus (CMV) infections in the pediatric liver transplant population and their potential association with the development of the post-transplant lymphoproliferative syndrome (PTLD).</p></div><div><h3>Patients and methods</h3><p>This retrospective descriptive study covers the period from 2014 to 2017 and includes pediatric liver transplanted recipients who underwent viral load monitoring for EVB and CMV during the first-year post-transplant.</p></div><div><h3>Results</h3><p>A total of 89 patients were included in the study, with a median age of 0.68 years (RIQ 0.31–0.96) (10.8 months RIQ 8.4–25.2). The most common underlying pathology leading to transplantation was biliary atresia, observed in 55 (61.6 %) cases. Regarding EBV viral loads, values exceeding 10,000 copies/ml were observed in 9 (8 %) patients at 3 months, 33 (29.3 %) at 6 months, 31 (27.6 %) at 9 months and 25 (22.3 %) at 12 months post-transplantation. The probability of developing EBV infection within one-year post-transplantation was 81.3 %, while the probability of CMV infection was 29 %. A total of 8 (8.9 %) biopsy-confirmed graft rejections occurred, only 1 was EBV and CMV-negative. The likelihood of graft rejection in patients with EBV infection was 21.5 %, and for CMV it was 20.8 %. Importantly, only one case of PTLD was documented during 12 months follow-up.</p></div><div><h3>Conclusion</h3><p>Characterizing this pediatric liver transplant population and monitoring EBV and CMV viral loads enables timely interventions, potentially reducing the risk of PTLD and graft rejection.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100222"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000230/pdfft?md5=00810a014ce1cf6e44bb8b74f7d65ddf&pid=1-s2.0-S2666967624000230-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141056522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation for polycystic liver disease: How feasible is this option?","authors":"Mahmoudreza Moein ,&nbsp;Michael Guenoun ,&nbsp;Fatemeh Moosaie ,&nbsp;Gursimran Mavi ,&nbsp;Amin Bahreini ,&nbsp;Reza Saidi","doi":"10.1016/j.liver.2024.100230","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100230","url":null,"abstract":"<div><h3>Background</h3><p>Polycystic liver disease is a rare hereditary disease that can occur as an isolated disease. Because of its benign nature, polycystic liver disease rarely needs treatment. If treatment is needed, there are no standard guidelines, but usually, a liver resection or medical therapy is performed. A liver transplant is the last resort when all other possibilities have been exhausted, or complications arise. However, the risks and benefits must be carefully weighed.</p></div><div><h3>Methods and materials</h3><p>A retrospective registry analysis of the SRTR database was done for liver transplants performed in the United States from January 2001 to May 2023.</p></div><div><h3>Results</h3><p>The analysis of the data indicated a notable improvement in 5-year graft survival rates between the 2001–2010 group (mean of 92 %) and the 2011–2023 group (mean of 97 %) (<em>P</em> &lt; .001). The 2011–2023 group had a higher proportion of simultaneous kidney and liver transplants, more than 3 times, from 106 cases to 374 cases (57.7 % vs. 42.3 %, <em>P</em> = .001). The type of transplant was also considered when analyzing the 5-year survival of grafts. Patients who underwent both kidney and liver transplants simultaneously had a slightly better outcome. It was found that the only hazard affecting LT graft survival in the cohort was the cold ischemic time (HR: 2.80, <em>P</em> = .03).</p></div><div><h3>Conclusion</h3><p>With all the surgical techniques and post-operation improvements, a liver transplant can be a feasible option for polycystic liver disease when the medical treatments are not sufficient to eliminate the symptoms.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696762400031X/pdfft?md5=4a70a03b4cf6e9a1e9565951b8c59090&pid=1-s2.0-S266696762400031X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141097862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigation of cardiac disease during liver transplantation through concomitant cardiac surgery and liver transplant: Pushing the boundaries of acceptable surgical candidacy","authors":"George Furey,&nbsp;David Moros,&nbsp;Michael Zhen-Yu Tong","doi":"10.1016/j.liver.2024.100229","DOIUrl":"10.1016/j.liver.2024.100229","url":null,"abstract":"<div><h3>Introduction</h3><p>The prevalence of cardiac disease is high in patients with liver cirrhosis, making it one of the leading causes of death in this population. However, the presence of cardiac diseases (coronary artery disease and valvular heart disease) often leads to disqualification of potential liver transplantation (LT) candidates, resulting in limited treatment options available for these complex patients. In recent years, some medical centers, including Cleveland Clinic, have provided concomitant cardiac surgery (CS) and LT to carefully selected patients.</p></div><div><h3>Methods</h3><p>A comprehensive literature review was conducted, compiling our experience and that of other medical centers performing concomitant CS and LT. We highlight Cleveland Clinic's approach for LT candidates with cardiac diseases. This includes a description of our initial evaluation, designed to detect cardiac diseases, followed by an explanation of our patient selection criteria and intraoperative strategies for concomitant CS and LT.</p></div><div><h3>Conclusion</h3><p>In patients with liver cirrhosis who are candidates for LT but also present cardiac diseases, a cautious evaluation by a multidisciplinary team is required to determine the feasibility of performing concomitant CS and LT. Available evidence suggests that this combined approach is a potential treatment option, offering acceptable postoperative outcomes and overall survival, despite the often perceived high-risk nature of this complex patient population.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100229"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000308/pdfft?md5=0adf8a9d310275d6527fee9f36b6f391&pid=1-s2.0-S2666967624000308-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious complications in pediatric patients after liver transplantation in the first 3 months at the Fundación Valle del Lili, a Latin American transplant center","authors":"Paola Marsela Pérez Camacho ,&nbsp;Verónica Botero Osorio ,&nbsp;Daniel Fernando Carvajal Cárdenas ,&nbsp;María Alejandra Acevedo García ,&nbsp;Eliana Manzi Tarapués ,&nbsp;Laura Torres-Cánchala ,&nbsp;Inés Elvira Gómez Hernández ,&nbsp;Lina M. Sandoval-Calle ,&nbsp;Luis Armando Caicedo Rusca ,&nbsp;Jaime A. Patiño Niño","doi":"10.1016/j.liver.2024.100221","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100221","url":null,"abstract":"<div><h3>Introduction</h3><p>In pediatric patients undergoing liver transplantation, infections are one of the primary complications. The etiology varies depending on the time elapsed post-transplant, with early presentations of bacterial and fungal infections, followed by viral and parasitic infections. There is limited literature describing the prevalence of infectious complications in this group of patients in Colombia.</p></div><div><h3>Objective</h3><p>To describe infectious complications in patients undergoing liver transplantation within the first 3 months post-procedure at the Fundación Valle del Lili, Cali, Colombia.</p></div><div><h3>Methods</h3><p>A case series of 165 pediatric liver transplant patients during the period 2011–2017. A descriptive analysis of all entered data was conducted. Survival analysis using the Kaplan-Meier method was performed, with an exploratory analysis comparing patient survival based on the presence of infection, censored for death related to postoperative complications.</p></div><div><h3>Results</h3><p>The primary diagnosis at the time of transplantation was biliary atresia in 65% of cases. A total of 215 infectious episodes were recorded in 92 pediatric liver transplants. The most frequent microorganisms were <strong><em>Klebsiella pneumoniae</em></strong> (21%), <strong><em>Cytomegalovirus</em></strong> (CMV) (7%), <strong><em>Pseudomonas aeruginosa</em></strong> (7%), <strong><em>Escherichia coli</em></strong> (6%), and <strong><em>Epstein Barr Virus</em></strong> (EBV) (6%). Three-month patient survival was 92% for infection-related mortality.</p></div><div><h3>Discussion</h3><p>Infectious complications within the first three months post-pediatric liver transplantation were predominantly bacterial in origin. Bacterial and fungal infections manifested earlier, while viral infections appeared later. Infectious complications did not impact the three-month patient survival in this group.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100221"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000229/pdfft?md5=566e4e366f3123fb8806b1804f48184e&pid=1-s2.0-S2666967624000229-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140843590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Success of high-flow nasal cannula oxygen therapy for the treatment of severe hypoxemia after liver transplantation in a patient with severe hepatopulmonary syndrome","authors":"Moustapha Hussein ,&nbsp;Agathe Chenal ,&nbsp;Edouard Virot ,&nbsp;Camille Besch ,&nbsp;Guillaume Martin ,&nbsp;Matthieu Canuet ,&nbsp;Romain Kessler ,&nbsp;Marianne Riou","doi":"10.1016/j.liver.2024.100234","DOIUrl":"10.1016/j.liver.2024.100234","url":null,"abstract":"<div><p>Hepatopulmonary syndrome (HPS) is a rare pulmonary complication of cirrhosis for which the only curative treatment is liver transplantation (LT). Patients with severe HPS prior to LT are at high risk of postoperative complications and mortality, and may develop refractory HPS after LT. To date, no therapeutic strategy has been validated for these patients. To our knowledge, we describe the first case of successful use of high-flow nasal cannula oxygen therapy for severe post-LT hypoxemia in a 23-year-old adult.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100234"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000357/pdfft?md5=ec17cb95c6edb0283d2a127e81f46a57&pid=1-s2.0-S2666967624000357-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis B reactivation after solid organ transplantation: A single-center experience","authors":"Josiah D. McCain ,&nbsp;Rolland C. Dickson ,&nbsp;Jacqueline Cai ,&nbsp;Nan Zhang ,&nbsp;Surakit Pungpapong ,&nbsp;Bashar A. Aqel ,&nbsp;David M.H. Chascsa","doi":"10.1016/j.liver.2024.100227","DOIUrl":"10.1016/j.liver.2024.100227","url":null,"abstract":"<div><h3>Background</h3><p>The risk of HBV reactivation after solid organ transplantation and the strategies to prevent it are not well defined.</p></div><div><h3>Methods</h3><p>We reviewed patients who received liver, kidney, pancreas, or heart transplants at our center between September 2015 and November 2020. We collected recipient and donor data on HBV serologies, prophylactic strategies, and known risk factors that associate with HBV reactivation in post-transplant patients.</p></div><div><h3>Results</h3><p>In the study period, 2126 solid organs were transplanted into 1951 patients. The recipient (R), donor (D), or both were HBcAb(+)/HBsAg(-) in 360 transplants. Post-transplant HBV DNA developed in 0/10 heart, 0/3 pancreas-kidney, 2/1517 (0.1 %) kidney, and 10/430 (2.3 %) liver recipients. Both kidney recipients with HBV DNA tested negative on re-testing without treatment. HBV DNA developed in 17.5 % of liver recipients who were D+/R- for HBcAb (10/57). All 10 liver recipients developing HBV DNA received prophylaxis. 5 patients developed detectable HBV DNA while on prophylaxis at a median 886 days (range 139 to 2287) after transplant. 5 patients developed HBV DNA after prophylaxis was discontinued at a median 955 days (range 756 to 2003) after transplant and 596 days (395 to 1638) after discontinuation.</p></div><div><h3>Conclusion</h3><p>HBcAb is found in a significant portion of our solid organ transplant donors and recipients, and HBcAb(+)/HBsAg(-) liver allografts represent the primary risk factor for HBV post-transplant. HBV infection in non-liver solid organ transplant is minimal risk using current monitoring strategies. Infection can occur long after the transplant event. Monitoring and prophylaxis strategies in this group should be reassessed.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100227"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696762400028X/pdfft?md5=fe199cae55287c817f5efc9e5e1fc480&pid=1-s2.0-S266696762400028X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141142089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Abnormalities Pre- and Post-Liver Transplantation for Metabolic Dysfunction-Associated Steatohepatitis – Evidence and Special Considerations","authors":"Steven M. Elzein,&nbsp;Elizabeth W. Brombosz,&nbsp;Sudha Kodali","doi":"10.1016/j.liver.2024.100228","DOIUrl":"10.1016/j.liver.2024.100228","url":null,"abstract":"<div><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) has an alarmingly high global prevalence. Its progressive subtype, metabolic dysfunction-associated steatohepatitis (MASH), is the leading indication for liver transplantation overall. Although MASLD has been associated with increased risk for several cardiac abnormalities including cardiac arrhythmias, structural disease, heart failure, valvular disease, and coronary artery disease, little is known about the clinical course and effects of these abnormalities in post-liver transplant patients with MASH as an etiology of their cirrhosis. This narrative review presents clinical and mechanistic evidence for the association of MASLD with the aforementioned cardiac abnormalities, as well as characterizes what is known about their significance in the post-operative period for those undergoing liver transplantation for MASH. Additionally, this review emphasizes knowledge gaps and highlights areas for further study of the impact of cardiac abnormalities in patients undergoing liver transplantation for MASH.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"15 ","pages":"Article 100228"},"PeriodicalIF":0.0,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000291/pdfft?md5=b0a73ffdb2cc7b766ab50231d2e97b15&pid=1-s2.0-S2666967624000291-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141132576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding previously published articles","authors":"","doi":"10.1016/j.liver.2024.100217","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100217","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100217"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000187/pdfft?md5=02d4281e9d3936ef6a0c876ce962b74a&pid=1-s2.0-S2666967624000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140321202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}