Journal of Liver Transplantation最新文献

{"title":"Stress pathways driving ischemia–reperfusion injury in the aged liver and consequences for post-transplant outcomes","authors":"Yizhen Li, Jian You, Can Lei, Xiaoli Fan","doi":"10.1016/j.liver.2026.100369","DOIUrl":"10.1016/j.liver.2026.100369","url":null,"abstract":"<div><h3>Background</h3><div>Cold ischemia time (CIT) represents a pivotal, potentially modifiable determinant of ischemia–reperfusion injury (IRI) and early allograft dysfunction. Its influence is particularly pronounced in extended-criteria and older donor livers, yet the mechanistic links have not been examined in an age- and CIT-focused integrative manner.</div></div><div><h3>Objective</h3><div>To integrate clinical and experimental evidence to clarify how prolonged CIT amplifies IRI in the aged liver, to delineate convergent and interacting molecular pathways, and to summarize therapeutically actionable strategies with translational potential.</div></div><div><h3>Review Scope and Search Strategy</h3><div>To ensure transparency in this narrative review, a structured literature search was conducted across PubMed/MEDLINE and Web of Science from database inception to March 2026 for English-language publications. The search strategy utilized Boolean combinations of MeSH terms and keywords: (1) \"liver transplantation\", \"hepatic transplantation\", or \"liver graft\"; (2) \"aging\", \"aged donor\", \"elderly donor\", or \"extended criteria donor\" intersected with \"cold ischemia time\", \"CIT\", \"ischemia-reperfusion injury\", or \"IRI\"; and (3) \"ferroptosis\", \"mitochondrial dysfunction\", \"endoplasmic reticulum stress\", \"ERS\", \"UPR\", \"machine perfusion\", \"HOPE\", or \"NMP\".</div></div><div><h3>Inclusion and Exclusion Criteria</h3><div>Peer-reviewed original research was eligible if it investigated: (i) hepatic IRI in the context of donor aging or prolonged CIT; (ii) convergent ferroptosis, mitochondrial collapse, or ERS-UPR axes; or (iii) post-transplant outcomes (EAD, biliary complications, graft survival). Non-English papers, case reports (<em>n</em> < 5), conference abstracts, and pediatric-only studies or models were excluded.</div></div><div><h3>Data Integration</h3><div>Retrieved evidence was categorized into two complementary streams within this narrative framework: preclinical studies (<em>in vitro</em> and <em>in vivo</em> models) mapped molecular cross-talk and organelle interactions, while clinical registries and cohorts defined operational risk thresholds, collectively aligning molecular vulnerability with clinical risk stratification. The literature identification and screening process is summarized in a PRISMA-style flow diagram (Supplementary Fig. S1).</div></div><div><h3>Results</h3><div>Longer CIT is linked to higher early allograft dysfunction and worse short-term outcomes, with larger effects in older and other extended-criteria grafts. Prolonged CIT promotes lipid peroxidation and iron dysregulation with impaired antioxidant defenses (Nrf2–SLC7A11–GSH–GPX4), disrupts mitochondrial energetics and quality control with excess ROS and mitophagy imbalance, and sustains maladaptive ERS–UPR signaling. These pathways amplify each other, driving cell death, microcirculatory failure, and sterile inflammation. HOPE/NMP and solution optimization may reduce","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"23 ","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Absent portal venous flow after liver transplantation: think abdominal compartment syndrome","authors":"Sofia Natalia Gamboa Miño,&nbsp;Claudia Riboldi,&nbsp;Magdalena Gonzalez Ferrari,&nbsp;Nicolás Dominguez,&nbsp;Grover Hinojosa Guzmán,&nbsp;Fernando Cairo,&nbsp;Emilio Gastón Quiñonez,&nbsp;Francisco Juan Mattera","doi":"10.1016/j.liver.2026.100370","DOIUrl":"10.1016/j.liver.2026.100370","url":null,"abstract":"<div><div>Introduction: Abdominal compartment syndrome (ACS) is an uncommon but potentially life-threatening complication after liver transplantation that may lead to graft hypoperfusion and multiorgan dysfunction. Prompt recognition and timely intervention are essential to prevent irreversible graft injury.</div><div>Case presentation: We report the case of a 36-year-old woman who underwent liver retransplantation and developed abdominal distension, oliguria, and progressive hemodynamic deterioration within the first postoperative day. Doppler ultrasound demonstrated complete absence of portal venous flow without evidence of portal thrombosis or technical vascular complications. Intravesical pressure measurement revealed intra-abdominal hypertension (20mmHg), supporting the diagnosis of ACS-associated portal hypoperfusion. Decompressive laparotomy was performed, resulting in immediate restoration of portal flow and clinical improvement.</div><div>Conclusion: ACS should be considered a potentially reversible cause of low portal flow in the immediate postoperative period after liver transplantation. Doppler ultrasound may be used as an extra tool to diagnose complications when ACS occurs post liver transplant.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"23 ","pages":"Article 100370"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148656678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic signatures of organ viability during ex-situ normothermic machine perfusion in human donor livers","authors":"Meryl J. Copray,&nbsp;Martin Pabst,&nbsp;Puck C. Groen,&nbsp;Jorke Willemse,&nbsp;Jeroen de Jonge,&nbsp;Marcel Ottens","doi":"10.1016/j.liver.2026.100366","DOIUrl":"10.1016/j.liver.2026.100366","url":null,"abstract":"<div><div>Extended criteria donor (ECD) livers are increasingly used to mitigate organ shortage, yet they carry a higher risk of post-transplant complications. Normothermic machine perfusion (NMP) enables functional assessment, but current viability criteria cannot always distinguish transplantable from non-transplantable grafts. Here, we identify proteomic signatures and propose underlying mechanisms that determine ECD liver suitability during NMP. Using label-free shotgun proteomics, we analysed 72 perfusate samples collected during hypothermic oxygenated perfusion, controlled rewarming, and NMP of 24 human ECD livers. Non-transplanted grafts were consistently enriched in oxidative stress–related proteins, associated with disrupted glutathione metabolism and severe ischemia–reperfusion injury. In contrast, transplanted livers maintained balanced antioxidant responses and progressively upregulated functional and regenerative pathways. Oxidative stress proteins distinguished transplantable from non-transplantable grafts within 60 minutes of NMP (AUC≥0.94), while prolonged perfusion supported recovery in moderate livers. These findings propose a mechanistic basis for graft viability and demonstrate how oxidative stress and regeneration markers can refine organ assessment during machine perfusion.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"23 ","pages":"Article 100366"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is left hepatic artery division with middle hepatic artery preservation a viable strategy for right lobe graft procurement in living donor liver transplantation with complex arterial anatomy?","authors":"Sreekumar Sreejith,&nbsp;Subhash Gupta,&nbsp;Peush Sahni,&nbsp;Shaleen Agarwal,&nbsp;Ruchi Rastogi,&nbsp;Abhishek Agarwal","doi":"10.1016/j.liver.2026.100368","DOIUrl":"10.1016/j.liver.2026.100368","url":null,"abstract":"<div><div>Right lobe grafts typically have a single hepatic artery, although arterial variations are not uncommon. We encountered a rare and complex hepatic arterial anatomy during procurement of a modified right lobe graft (MRLG), in which the right hepatic artery (RHA) arose from the proximal common hepatic artery (CHA) and bifurcated into the right anterior hepatic artery (RAHA) and right posterior hepatic artery (RPHA). The left hepatic artery (LHA) originated from the RAHA, while the middle hepatic artery (MHA) arose from the distal CHA. Preserving the LHA would have resulted in short (7–10 mm) and small-calibre (1 mm) arterial stumps of both the RAHA and RPHA, potentially compromising arterial reconstruction. Following completion of parenchymal transection and right hepatic duct division, the main portal vein and LHA were temporarily clamped. No ischaemic demarcation developed in the remnant liver, indicating adequate intrahepatic collateral arterial communication between the MHA and LHA. The LHA was therefore divided, and satisfactory pulsatile back-bleeding confirmed preserved arterial inflow to the remnant liver. This strategy provided the MRLG with a single RHA stump measuring 3 mm in diameter and 2.5 cm in length, facilitating a technically favourable arterial reconstruction. Both donor and recipient had uneventful postoperative recoveries. In selected LDLT donors with complex arterial anatomy, division of the LHA may be considered only when preoperative imaging demonstrates robust intrahepatic arterial communications with the MHA, intraoperative assessment confirms adequate remnant liver perfusion, and a contingency plan for arterial reconstruction is available.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"23 ","pages":"Article 100368"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation for acute liver failure associated with secondary hemophagocytic lymphohistiocytosis in a postpartum patient with HSV-2 viremia","authors":"Flávio Falcão Lima de Souza,&nbsp;Mariana Dias de Campos,&nbsp;Letícia Góes Gitaí Fernandes,&nbsp;Rafael Fiacadori Silva,&nbsp;Renê Donizeti Ribeiro de Oliveira","doi":"10.1016/j.liver.2026.100363","DOIUrl":"10.1016/j.liver.2026.100363","url":null,"abstract":"<div><div>Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening hyperinflammatory syndrome associated with high mortality. We report a case of secondary HLH associated with herpes simplex virus type 2 (HSV-2) viremia in a 21-year-old postpartum woman who developed acute liver failure. The patient presented with fever, cytopenias, and extreme hyperferritinemia (&gt;30,000 ng/mL). Bone marrow examination demonstrated prominent hemophagocytosis. Despite treatment with dexamethasone, intravenous immunoglobulin (IVIG), and acyclovir, she developed fulminant hepatic failure with severe coagulopathy and encephalopathy, requiring urgent liver transplantation. Postoperatively, she developed refractory shock due to polymicrobial sepsis and died. The explanted liver showed massive hemorrhagic necrosis. This case highlights the diagnostic challenges of HLH presenting as acute liver failure in the postpartum period, emphasizes the importance of early recognition of HSV infection, and illustrates the substantial risks associated with liver transplantation during active hyperinflammation.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"23 ","pages":"Article 100363"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148641431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated liver transplantation for cirrhotic cholangiopathic liver disease in Jeune syndrome caused by a homozygous WDR60 mutation","authors":"Mehdi Bakkali,&nbsp;Raja Mroué,&nbsp;Stéphanie Patouraux,&nbsp;Albert Tran,&nbsp;Rodolphe Anty","doi":"10.1016/j.liver.2026.100367","DOIUrl":"10.1016/j.liver.2026.100367","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"23 ","pages":"Article 100367"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro evaluation of clotting time in rotational thromboelastometry after correction with platelet-rich plasma and fibrinogen in post–liver transplant patients: A case series","authors":"Amal Francis Sam ,&nbsp;Deepti Sachan ,&nbsp;Velure Mohan Jyotsnaa Grace ,&nbsp;Deepthi Krishna Gundrajukuppam ,&nbsp;Koustav Jana ,&nbsp;Akila Rajakumar ,&nbsp;Mohamed Rela","doi":"10.1016/j.liver.2026.100322","DOIUrl":"10.1016/j.liver.2026.100322","url":null,"abstract":"<div><div>In the post-liver transplant care unit, we observed several instances in which patients exhibited normal prothrombin time but disproportionately prolonged clotting time (CT), as measured by Rotational Thromboelastography (ROTEM). Hence, we conducted a case series in patients with reduced maximum clot firmness (MCF) in ROTEM. Platelets and fibrinogen concentrate were incrementally added to the blood samples in vitro in three tubes, with incremental doses from tubes 1 to 3, and ROTEM was repeated for each tube. Blood samples from six patients were analysed, with each patient undergoing one baseline ROTEM and three subsequent ROTEM tests following in vitro correction, resulting in a total of 24 observations (six baseline and 18 repeat ROTEM). Except for three instances, all repeat ROTEM values showed improvements in CT, along with Clot formation time (CFT) and MCF, from baseline to tube 3. Regression analysis of the 18 delta values suggested that for every 100-second increase in CFT, there was an associated 10-second increase in the CT. We conclude that a critically prolonged CFT and low MCF can result in falsely prolonged CT in ROTEM.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"22 ","pages":"Article 100322"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146174874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe acute pancreatitis in acute-on-chronic liver failure: An absolute contraindication for liver transplantation?","authors":"David Toapanta ,&nbsp;Gonzalo Crespo ,&nbsp;Annabel Blasi ,&nbsp;Jordi Colmenero ,&nbsp;Ernest Hidalgo ,&nbsp;Javier Fernández","doi":"10.1016/j.liver.2026.100323","DOIUrl":"10.1016/j.liver.2026.100323","url":null,"abstract":"<div><div>Acute pancreatitis in the context of acute-on-chronic liver failure (ACLF) is a rare but potentially severe complication that can jeopardize eligibility for liver transplantation (LT). We describe two ACLF patients listed for highly prioritized transplantation who developed acute pancreatitis during the late course of ACLF. In the first case, the patient developed necrosis of the pancreatic tail and a large pseudocyst; in the second, necrosis affected &gt;50% of the pancreatic body and tail. Both patients were delisted and died. While necrotizing pancreatitis was considered an absolute contraindication for LT in these two cases, recent reports suggest that transplantation may be feasible in highly selected patients. A case-by-case multidisciplinary assessment remains essential for appropriate decision-making in this complex scenario. Early LT could contribute to prevent this feared complication.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"22 ","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective evaluation of vibration-controlled transient elastography for guiding long-term protocol liver biopsies after liver transplantation","authors":"Bozon-Rivière Pauline ,&nbsp;Faure Stéphanie ,&nbsp;Ursic Bedoya José ,&nbsp;Meszaros Magdalena ,&nbsp;Rivière Benjamin ,&nbsp;Monet Clément ,&nbsp;Moulis Lionel ,&nbsp;Herrero Astrid ,&nbsp;Guiu Boris ,&nbsp;Pageaux Georges-Philippe ,&nbsp;Meunier Lucy","doi":"10.1016/j.liver.2025.100317","DOIUrl":"10.1016/j.liver.2025.100317","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Liver biopsy (LB) is the gold standard for diagnosing post-liver transplantation (LT) complications. Currently, there is no data on the value of vibration-controlled-transient elastography (VCTE) for medium- and long-term follow-up after LT compared to protocol LB in asymptomatic patients. This study aims to evaluate the correlation between VCTE-derived liver stiffness measurements (LSM) and histological abnormalities observed in protocol LB 5 to 10 years after LT, to determine the potential role of VCTE in long-term graft monitoring.</div></div><div><h3>Methods</h3><div>A prospective study was conducted at a liver transplantation center in Montpellier, France, involving adult LT recipients who underwent both VCTE and LB within 6 months between January 2022 and January 2024. Protocol LB were performed in the absence of clinical or laboratory evidence of post-LT complications. The primary endpoint was to determine the LSM threshold for predicting abnormal LB. Receiver operating characteristic (ROC) curve analysis and the Youden index were used to identify the optimal cutoff.</div></div><div><h3>Results</h3><div>Among 90 patients, 32% had abnormal LB findings, including fibrosis ≥ F1 (by Ishak) in 58.6% of abnormal biopsies. The mean LSM was significantly higher in patients with abnormal LB (12.6 ± 13.9 kPa) compared to those with normal LB (5.9 ± 1.6 kPa), <em>p</em> &lt; 0.001. LSM (area under the ROC curve [AUC]: 0.816) was the most accurate predictor of abnormal LB. The optimal LSM threshold to predict abnormal LB was 6.90 kPa (sensitivity [Se] = 0.69, specificity [Sp] = 0.84), while values ≤5.6 kPa and &gt;12.9 kPa respectively ruled out and predicted an abnormal LB.</div></div><div><h3>Conclusion</h3><div>These results underscore the relevance of VCTE in long-term follow-up of LT recipients to determine the need for LB. VCTE effectively predicts abnormal histology and can guide selective use of protocol liver biopsies, potentially reducing unnecessary procedures. Multicenter studies are needed to validate these findings.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"21 ","pages":"Article 100317"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined heart-liver transplantation and Acute Kidney Injury: Risk factors and outcomes from CARDHEPAT registry","authors":"Andre Cordeiro ,&nbsp;Pascal Lebray ,&nbsp;Romain Guillemain ,&nbsp;Samy Meriem ,&nbsp;Fabiano Perdigao ,&nbsp;Adrien Bougle ,&nbsp;Olivier Scatton ,&nbsp;Pascal Leprince ,&nbsp;Shaida Varnouss ,&nbsp;Eric Savier ,&nbsp;Alain Combes ,&nbsp;Geraldine Rousseau ,&nbsp;Bernard Cholley ,&nbsp;Bastien Genet ,&nbsp;Benjamin Granger ,&nbsp;Antoine Monsel ,&nbsp;Daniel Eyraud","doi":"10.1016/j.liver.2025.100305","DOIUrl":"10.1016/j.liver.2025.100305","url":null,"abstract":"<div><h3>Background</h3><div>Combined heart-liver transplantation (CHLT) offers new possibilities for patients with no other treatment options, yet it remains a rare and complex procedure. Despite an increase in its utilisation in recent years, data remain scarce, and many aspects of the procedure are not yet fully understood, particularly the causes of its significant perioperative morbidity, such as acute kidney injury. The CARDHEPAT study presents the first description of a French regional cohort of CHLT patients.</div></div><div><h3>Methods</h3><div>A retrospective analysis of the CARDHEPAT cohort examined 30 CHLTs performed at Assistance Publique - Hôpitaux de Paris (APHP) from January 1, 2002, to January 1, 2022. The aim of this study was to highlight the impact of postoperative KDIGO3 acute kidney injury (AKI) on recipient outcomes and its evolution.</div></div><div><h3>Results</h3><div>KDIGO3 AKI was observed in 50 % of cases and was associated with an excess mortality rate among patients undergoing CHLT. At Day-30 and -90, the survival rates with KDIGO3 AKI were 67 % and 53 %, respectively, compared to 100 % and 93 % in patients without (<em>p</em> = 0.04 and <em>p</em> = 0.03). Additionally, we found several intraoperative factors that were associated with the occurrence of postoperative KDIGO3 AKI, including durations of extracorporeal circulation and aortic clamping and level of intraoperative acidosis but also preoperative albuminemia</div></div><div><h3>Conclusion</h3><div>The incidence of KDIGO3 AKI is high after CHLT and seems to be associated with increased mortality, with results suggesting that the intraoperative phase is crucial for its occurrence.</div></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"21 ","pages":"Article 100305"},"PeriodicalIF":0.0,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145580513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}