Journal of Liver Transplantation最新文献

{"title":"Investigating Ineligibility of Potential Living Liver Donors for Transplantation: Experience from a Large Liver Transplant Center in Pakistan","authors":"Abdullah Khalid ,&nbsp;Bilal Ahmed Khan ,&nbsp;Imran Ali Syed ,&nbsp;Touseef Ahmed ,&nbsp;Faisal Saud Dar ,&nbsp;Sohail Rashid ,&nbsp;Ihsan-ul-Haq ,&nbsp;Yasir Khan","doi":"10.1016/j.liver.2023.100163","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100163","url":null,"abstract":"<div><h3>Background</h3><p>Living Donor Liver Transplantation (LDLT) is common in Pakistan, where the deceased organ donation is lacking. However, not all potential living donors are suitable for the procedure due to various medical, technical, psychosocial, and ethical reasons. This study aims to investigate the reasons for the ineligibility of potential living liver donors in Pakistan.</p></div><div><h3>Methods</h3><p>Between June 2022 and March 2023, 530 potential living liver donors were assessed for liver transplant recipients at the Pakistan Kidney and Liver Institute &amp; Research center (PKLI&amp;RC). Potential donors were evaluated in three steps, including laboratory tests imaging, and consultations. Prospectively maintained data on all potential donors were examined and retrospectively assessed to identify the causes of donor rejection.</p></div><div><h3>Results</h3><p>Of the 530 potential living donors evaluated, 364 of the potential donors were considered ineligible (68.67% of donors were rejected). From these rejected donors, 193 (53%) were males, and 171 (47%) were females. The mean age of the rejected donors was 26 years old. The most common reason for disqualifying potential living liver donors was a withdrawal of consent (65 cases, 17.9%). Other factors contributing to ineligibility included fatty liver infiltration reflected by a liver attenuation index (LAI) &lt; 0, future liver remnant (FLR) &lt; 28%, and a graft-to-recipient weight ratio (GRWR) &lt; 0.6. Medical issues, such as abnormal liver function tests and positive hepatitis serology, also resulted in disqualification.</p></div><div><h3>Conclusion</h3><p>This study highlights the importance of meticulous assessment of potential living liver donors to ensure their safety and the success of the transplant. The high rate of withdrawal of consent and the prevalence of medical issues indicates the need for addressing ethical concerns and improving public education on the donation process. This study also emphasizes the importance of a deceased organ donation in developing countries like Pakistan to ensure the availability of organs for transplantation.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49881983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iatrogenic hypervitaminosis A: An underrecognized complication in the liver transplant recipient","authors":"Raimund H Pichler,&nbsp;Lydia S Sun,&nbsp;Cary H Paine,&nbsp;Renuka Bhattacharya,&nbsp;Lei Yu,&nbsp;Scott W Biggins,&nbsp;Lena Sibulesky","doi":"10.1016/j.liver.2023.100162","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100162","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49882609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Operative risk assessment in liver transplant candidates: an important step to improve the prognosis","authors":"Daniel Eyraud","doi":"10.1016/j.liver.2023.100166","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100166","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100166"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49882502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A revealing scandal: The German transplant scandal between structural failures, moralizing rules, and ambivalent manipulations","authors":"Julia Rehsmann","doi":"10.1016/j.liver.2023.100168","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100168","url":null,"abstract":"<div><h3>Introduction</h3><p>In 2012, the German transplant scandal was uncovered and reported in the national and international media. This article offers an anthropological analysis of the scandal and examines its ‘scandalous’ characteristics by taking a close look at its extraordinary and ordinary features.</p></div><div><h3>Methods</h3><p>The article is based on ethnographic research using multiple methods including participant observation, interviewing as well as media and document analysis.</p></div><div><h3>Results</h3><p>The transplant scandal in Germany revealed systemic ‘scandalous’ features of the national transplant system. From a significant lack of transparency in decision making, a weak legal framework for accountability, adherence to moralizing rules about alcohol and abstinence, to media coverage that individualized the scandal.</p></div><div><h3>Conclusions</h3><p>Looking at extraordinary events such as transplant scandals from an anthropological perspective offers an analysis that goes beyond the singular, scandalous event. An anthropological analysis allows to highlight the ordinary and ambivalent ‘scandalous’ features of transplant medicine It examines transplant medicine at the intersection of biomedicine, politics, and morality.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49881982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the patient perspective of weight management while on the liver transplant waitlist","authors":"Ariana Chirban ,&nbsp;Anushi Shah ,&nbsp;Taylor M Coe ,&nbsp;Heidi Yeh ,&nbsp;Jennie Galpern ,&nbsp;Jessica Witchey ,&nbsp;Lorraine Castaldo ,&nbsp;Nahel Elias ,&nbsp;Angela Fitch ,&nbsp;Leigh Anne Dageforde","doi":"10.1016/j.liver.2023.100159","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100159","url":null,"abstract":"<div><h3>Introduction</h3><p>Obesity-associated comorbidities increase risks for patients undergoing liver transplant. In this study, we explore patient perspectives and motivation for healthy weight management among patients on the liver transplant waiting list.</p></div><div><h3>Methods</h3><p>This is a cross-sectional, observational, electronic survey-based study. A survey on weight management was administered to patients on the liver transplant waiting list. Demographic and clinical data were collected from patients’ medical records. Data was analyzed using Pearson's chi-squared, Fisher's exact, and Student's t-tests.</p></div><div><h3>Results</h3><p>Respondents had a mean age of 54.4 years, were predominately male (62.0%) with a mean BMI of 29.2 kg/m² with alcoholic cirrhosis as the leading etiology of liver disease (33.9%). Among patients with a BMI≥30 kg/m², 59.0% perceived that they were overweight and 23.1% believed they were underweight. Among patients with BMI≥30 kg/m² who perceived they were overweight, 39.1% were actively trying to lose weight and 60.9% were trying to keep from gaining weight. Regardless of current weight, there was a median increase in BMI for patients who categorized themselves as having lost weight or maintained weight since being waitlisted.</p></div><div><h3>Conclusion</h3><p>Many patients with a BMI≥30 kg/m² did not perceive themselves as overweight and were not actively trying to lose weight. Weight perception was not consistent with actual weight change while waitlisted for liver transplant. Further research is needed to understand how weight awareness and weight perception impacts motivation for weight loss.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49882498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic monitoring in liver Transplantation patients in the third millennium","authors":"Giorgio Della Rocca ,&nbsp;Alessandra Della Rocca","doi":"10.1016/j.liver.2023.100156","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100156","url":null,"abstract":"<div><p>In patients undergoing orthotopic liver transplantation (OLTx) surgery, the intraoperative hemodynamic monitoring technique that is most utilized is still the pulmonary artery catheter (PAC). The popularity of transesophageal echocardiography (TEE) is increasing, so today's updated issue is the following: should the use of PAC and/or volumetric monitoring with transpulmonary thermodilution and/or advanced volumetric PAC be limited in clinical practice, only for some high risk patients? Could we use the TEE, if necessary, in less critical ill patients undergoing OLTx surgery?</p><p>We can integrate all of the aforementioned monitoring techniques in an increasing modular step wise monitoring concept. But in an uncertain hemodynamic situation, transthoracic and/or transoesophageal echocardiographic evaluation represents a cornerstone.</p><p>The use of echocardiography during OLTx is more and more common with several benefits demonstrated particularly by the TEE in this patient population.</p><p>To achieve and maintain adequate tissue perfusion becomes difficult in case of major bleeding, an event quite possible to occur during OLTx, affecting the immediate and the late outcome.</p><p>All the clinicians agree that bleeding interfere with the choice of hemodynamic monitoring and or vice versa.</p><p>A reasonable compromise is to find a balance between the need to extend monitoring in high-risk surgical patients and the average consumption of blood products that characterizes each individual transplant center. This is also in line with what is shown in literature in terms of Maximum Surgical Blood Ordering Schedule (MSBOS).</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49882503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative management of severe portopulmonary hypertension in a paediatric living donor liver transplantation using pulmonary vasodilators","authors":"Annu Sarin Jolly,&nbsp;Vidyadhar Metri,&nbsp;Sanjay K. Goja,&nbsp;Nandini Dave,&nbsp;Ashok Thorat,&nbsp;Vaibhav,&nbsp;Manoj Singh","doi":"10.1016/j.liver.2023.100158","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100158","url":null,"abstract":"<div><p>Portopulmonary hypertension (PoPH) is a rare but serious disorder carrying a very poor prognosis. PoPH is defined as the presence of pulmonary arterial hypertension (PAH) associated with portal hypertension, with or without underlying liver disease. We are reporting our institutional experience of anaesthetic management of an 8-year old female child weighing 20 kg with severe PoPH who underwent liver transplantation (LT). The use of pulmonary vasodilators in the perioperative period along with a carefully planned anaesthetic strategy was critical in the successful outcome of this potentially lethal disorder.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49882548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of two-dimensional strain-echocardiography in patients with liver cirrhosis in Intensive care Unit. A prospective, observational Study","authors":"Sophia EL Boukili,&nbsp;Laurent Reydellet,&nbsp;Valery Blasco,&nbsp;Karim Harti,&nbsp;Jacques Albanese,&nbsp;Cyril Nafati","doi":"10.1016/j.liver.2023.100165","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100165","url":null,"abstract":"<div><h3>Purpose</h3><p>Cirrhotic cardiomyopathy (CCM) is a major comorbidity of cirrhosis. The diagnostic performance of conventional echocardiography is poor. Two-dimensional-strain echo-cardiography (2D-strain) detects myocardial dysfunction earlier than conventional echocardiography, with a significant prognostic value. The aim of our study is to assess whether the 2D-strain will allow a more relevant assessment of CCM in cirrhotic patients than conventional echocardiography. The secondary objective is to determine if altered strain or strain rate are associated with cirrhotic patient's outcome in intensive care unit (ICU).</p></div><div><h3>Methods</h3><p>Conventional echocardiography and 2D-strain were performed on 44 consecutive patients within 24 hours of admission to the ICU. Using 2D-strain, the global-longitudinal-strain (GLS) was assessed.</p></div><div><h3>Results</h3><p>GLS was impaired in 64% of patients. GLS was significantly higher in the patients who died compared with those who survived, using 28-day mortality rate (-17 vs -14 <em>p &lt;</em> 0.039). Regarding conventional echocardiography, no factor was associated with increased mortality.</p></div><div><h3>Conclusion</h3><p>GLS is correlated to cirrhotic patient's prognosis in intensive care, while conventional echocardiography shows no dysfunction.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100165"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49881979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impacts of in situ donor partial hepatectomy in pediatric liver transplantation","authors":"Z. Tremblay ,&nbsp;A. Kawaguchi ,&nbsp;A. Calderone ,&nbsp;M. Beaunoyer ,&nbsp;F. Alvarez ,&nbsp;M. Lallier ,&nbsp;P. Jouvet","doi":"10.1016/j.liver.2023.100157","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100157","url":null,"abstract":"<div><h3>Background</h3><p>Pediatric liver transplantation is performed with either whole, reduced, split livers depending on the technical aspects of the surgery and the discrepancy between donor and recipient body dimensions. The optimal method of partial hepatectomy for pediatric transplants remains debated to this day: either <em>in situ</em> (<em>i.e.</em> occurring before liver removal from the donor) or <em>ex situ</em> (<em>i.e.</em> taking place after liver removal). In 2007, our tertiary academic center changed its surgical protocol from <em>ex situ</em> to <em>in situ</em> partial hepatectomy in deceased donor mainly to decrease bleeding complication risk among other amendments. Our study aimed to evaluate the clinical impact of this major modification on the post-operative blood products volume transfusion.</p></div><div><h3>Methods</h3><p>A retrospective analysis of 104 patients who underwent liver transplantation at our pediatric center between 1998 and 2016 was performed. Patients receiving multiple organ transplantations or re-transplantation were excluded from the study. Differences in blood products transfusion volume, post-operative complications and mortality rates were compared between two periods implementing different surgical transplantation protocols: <em>ex situ</em> partial hepatectomy from 1998 to 2006 and <em>in situ</em> partial hepatectomy from 2007 to 2016.</p></div><div><h3>Results</h3><p>42 children from the original <em>ex situ</em> protocol group and 62 children from the modified <em>in situ</em> protocol group were included in the study. The median age and weight were 1.5 years (0.7–4.8 kg) and 11.1 kg (7.9–18.2), respectively. There were no significant differences in demographic data between groups. A significant decrease in liver transplant cold ischemia time was observed in the <em>in situ</em> group compared to the <em>ex situ</em> group (<em>p</em> &lt; 0.001). A significant increase in vasopressor use was observed for the <em>in situ</em> group (64% (IS) <em>vs</em>. 24% <em>ex situ</em> group (<em>p</em> &lt; 0.001)), as part of the protocol modifications. Median perioperative blood products transfusion volume was not significantly different between both groups: 275 ml/kg (76–497) <em>ex situ</em> group <em>vs</em>. 229 ml/kg (76–499) <em>in situ</em> group (<em>p</em> = 0.82). We observed a 28-day and 90-day mortality rate of 14.3% and 16.6%, respectively, for the <em>ex situ</em> group and 6.5% and 8.1%, respectively, for the <em>in situ</em> group. Hepatic artery thrombosis was found in the first 7 days in 7% of the <em>ex situ</em> group patients and 6% of the <em>in situ</em> group patients. There were no significant differences in post-operative mortality and morbidity rates observed between groups (p value of 0.29 and 0.28 for 28-days and 90-days mortality rates, respectively).</p></div><div><h3>Conclusions</h3><p>Although the median amount of transfusion was higher in the ex-situ group, our stud","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49882497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplant registries: Need, benefits and risks","authors":"James Neuberger","doi":"10.1016/j.liver.2023.100160","DOIUrl":"https://doi.org/10.1016/j.liver.2023.100160","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"11 ","pages":"Article 100160"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49882501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}