Journal of Liver Transplantation最新文献

{"title":"Successful liver transplantation from a donor with Swyer–James Syndrome","authors":"Avery Wilson , Kenji Okumura , Ryosuke Misawa , Abhay Dhand , Hiroshi Sogawa , Gregory Veillette , Seigo Nishida","doi":"10.1016/j.liver.2024.100203","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100203","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100203"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000047/pdfft?md5=aaa21791e88d11ca05a5c5bb257fc2c2&pid=1-s2.0-S2666967624000047-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rousing drug-induced liver injury through cytochrome p450 isoenzyme overload leading to fulminant liver failure","authors":"Jose R. Russe-Russe , Islam Abdelhamid , Raphael Meier , Giorgeta Giblen , Anurag Maheshwari","doi":"10.1016/j.liver.2024.100207","DOIUrl":"10.1016/j.liver.2024.100207","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100207"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000084/pdfft?md5=a0b9b60d8c44b6ffa0555c51cc9945a7&pid=1-s2.0-S2666967624000084-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139888954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombocytopenia and platelet dysfunction after transplant- evaluation, implication, and management","authors":"Pathik M. Parikh","doi":"10.1016/j.liver.2024.100210","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100210","url":null,"abstract":"<div><p>Thrombocytopenia in transplant period is nearly universal. Platelets are believed to have a significant role in the regeneration of hepatocytes and persistent thrombocytopenia can affect the graft function adversely. This current review discusses, in brief, the aetiology, implications, evaluation, and management of thrombocytopenia in post liver transplant period.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100210"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000114/pdfft?md5=7ce5320e49d094cc86b14280675a010e&pid=1-s2.0-S2666967624000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139936987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming traditional barriers in living donor liver transplant","authors":"Reed T. Jenkins ,&nbsp;Al-Faraaz Kassam ,&nbsp;David J. Farhat ,&nbsp;Manuj M. Shah ,&nbsp;Damon Cooney ,&nbsp;Francis Tinney ,&nbsp;Ramy El-Diwany ,&nbsp;Shane E. Ottmann ,&nbsp;Andrew M. Cameron ,&nbsp;Ahmet Gurakar ,&nbsp;Russell N. Wesson ,&nbsp;Elizabeth King ,&nbsp;Benjamin Philosophe","doi":"10.1016/j.liver.2024.100212","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100212","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100212"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000138/pdfft?md5=4b404fd04ca6cc2c6d69447f60eb5993&pid=1-s2.0-S2666967624000138-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nivolumab as a bridge to liver transplantation in advanced hepatocellular carcinoma","authors":"Julie Sullivan,&nbsp;Steven Stanek,&nbsp;Richard Kalman","doi":"10.1016/j.liver.2024.100213","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100213","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266696762400014X/pdfft?md5=fb588bef7752b98ff65590fc4063ad61&pid=1-s2.0-S266696762400014X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139942045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital diseases with multi-organ expression as an indication for liver transplantation in children during the first years of life: Integrative approach to improve the outcomes","authors":"Marina Moguilevitch,&nbsp;Ingrid Fitz-james","doi":"10.1016/j.liver.2024.100216","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100216","url":null,"abstract":"<div><p>Pediatric liver transplantation has evolved since the first transplant was performed by Dr. Starzl more than 50 years ago. Innovations in surgical techniques, immunosuppression, and infection control have significantly improved patient outcomes, graft survival, and quality of life. However, further progress depends not only on the discovery of new treatment option but should rely upon the identification of the factors in the perioperative care which contribute to successful outcomes and guide our decision-making process.</p><p>Indications for pediatric liver transplantation can be divided into three major groups: cholestatic liver conditions, liver based metabolic disorders, and others represented by acute liver failure of different etiologies, tumors, inherited autoimmune diseases, and multiple infectious causes.</p><p>Many of these conditions manifest themselves with multi organ pathologic expression, requiring earlier interventions to treat acute liver failure or chronic cholestasis leading to failure to thrive. Containment of patient pathology and maintenance of optimal neurologic and extra-hepatic visceral organ function is paramount during the pre - transplant period.</p><p>Multidisciplinary management of comorbid conditions in complex pediatric liver transplant candidates during the perioperative period with the emphases on optimization and patient selection has never been summarized in the literature. Thant is why this review focuses on a comprehensive, multidisciplinary preoperative evaluation of pediatric patients in whom progressive liver disfunction manifests early in life and eventually requires liver transplantation. We will address multi-organ system involvement, preoperative optimization in anticipation of the complexity of intraoperative care, as well as short- and long-term postoperative management.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100216"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000175/pdfft?md5=fb2348a21ad25fe272d50c01e1849aa6&pid=1-s2.0-S2666967624000175-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak systolic velocity at arterial Doppler ultrasound in pediatric liver transplantation: A predictor of acute severe complications","authors":"Ana Coma ,&nbsp;Maria Victoria Fasano ,&nbsp;Alba Anton-Jimenez ,&nbsp;Jose Andres Molino ,&nbsp;Jesus Quintero ,&nbsp;Maria Margaret Mercadal-Hally ,&nbsp;Mercedes Perez ,&nbsp;Juan Ortega ,&nbsp;Jose Miguel Escudero-Fernandez ,&nbsp;Ernest Hidalgo ,&nbsp;Ramon Charco","doi":"10.1016/j.liver.2024.100218","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100218","url":null,"abstract":"<div><p>The diagnosis of arterial complications in children after Liver Transplantation (LT) urges prompt diagnosis and treatment. This study aims to determine whether hepatic artery Doppler Ultrasound (DUS) parameters can predict arterial complications in the immediate period after LT in children.</p><p>A retrospective review of the pediatric liver database at our tertiary-care pediatric hospital was performed. The study included 70 pediatric patients who underwent a liver transplantation from 2016 to 2021. Clinical, laboratory and Doppler findings were recorded daily the first 5 days after transplantation, with special attention given to post-anastomotic Peak Systolic Velocity (PSV) and Resistive Index (RI).</p><p>Patients with hepatic artery complications, including acute thrombosis and stenosis, had lower PSV values after surgery compared to the group with non-complications, with a statistical significance (&lt; 0.001). Receiver operating characteristic (ROC) curve analysis determined an optimal cut-off value of PSV less than 29 cm/s the 2nd day after LT, 25.2 cm/s the 3rd day, 28.5 cm/s the 4th day and 29.4 cm/s the 5th day, to discriminate children with and without hepatic arterial complications. Notably, these cut-off values are lower than those proposed in adults.</p><p>Optimal PSV cutt-off values in children in the immediate period after LT are presented. Knowledge of these cutt-off values improves the interpretation of DUS measurements and thereby, may help to accurately guide the clinical management.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100218"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000199/pdfft?md5=b0b504b7f877ad0272187a56db35fab6&pid=1-s2.0-S2666967624000199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140347068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous Subdural hematomas must remain a can't-miss diagnosis in patients who have undergone orthotopic liver transplantation with no history of trauma","authors":"Pranvera Sulejmani ,&nbsp;Morgan Sturgis ,&nbsp;Nathalie Sela","doi":"10.1016/j.liver.2024.100215","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100215","url":null,"abstract":"","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100215"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000163/pdfft?md5=ab53591d76228ca2bf0152a19c336083&pid=1-s2.0-S2666967624000163-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral antiviral therapy for treatment of COVID-19 in solid organ transplant recipients: Is the practice meeting the promise?","authors":"Abhay Dhand ,&nbsp;Kenji Okumura ,&nbsp;Seigo Nishida","doi":"10.1016/j.liver.2024.100209","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100209","url":null,"abstract":"<div><p>Solid organ transplant recipients (SOTRs) remain at high risk of progression to severe disease and hospitalization from Coronavirus disease 2019 (COVID-19). Regardless of vaccination status, burden of severe COVID-19 among SOTRs remains high and treatment of COVID-19 remains the main mitigating factor in preventing its progression. Oral antiviral therapies offer a convenient outpatient treatment option for mild-moderate COVID-19, and when used early may decrease the risk of progression of disease. Oral anti-viral therapies retain activity against all the currently known viral variants. Early diagnosis with prompt treatment and monitoring for drug-drug interactions is the key to optimal use of oral antiviral agents for COVID-19. Despite the promise to decrease morbidity and mortality from COVID-19, utilization of these medications among SOTRs remains low with existence of many barriers in their use.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000102/pdfft?md5=c7b2a80d150bb666764e80bfd89315ff&pid=1-s2.0-S2666967624000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139726825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of 50 years or older donors in septuagenarian recipients for liver transplantation: Potential to expand the donor pool","authors":"Kenji Okumura,&nbsp;Bima J. Hasjim,&nbsp;Abhay Dhand,&nbsp;Ryosuke Misawa,&nbsp;Hiroshi Sogawa,&nbsp;Gregory Veillette,&nbsp;Seigo Nishida","doi":"10.1016/j.liver.2024.100208","DOIUrl":"https://doi.org/10.1016/j.liver.2024.100208","url":null,"abstract":"<div><h3>Background</h3><p>While younger donors have better liver transplant (LT) outcomes, the median age of both the donor and recipient pools is rising. The impact of using donors ≥50 years on the LT outcomes of septuagenarians is unknown.</p></div><div><h3>Methods</h3><p>From 2011–2021, outcomes in septuagenarian LT recipients from donor livers &lt;50 year-old (DON&lt;50) and donor livers ≥50 year-old (DON≥50) were analyzed using the United Network for Organ Sharing database. Post-LT survival analysis was performed with the Kaplan-Meier method and multivariable Cox proportional-hazards model. A propensity score was utilized to conduct one-to-one matching using 14 recipient variables (1230-pairs).</p></div><div><h3>Results</h3><p>There were 2797 septuagenarian deceased-donor LT recipients during the study period. Of these, 1487 (53.2 %) were DON &lt;50 with median age of 34 years and 1310 (46.8 %) were DON ≥50 with median age of 60 years. The number of LT for septuagenarians has increased over the last decade. The causes of donor and recipient deaths were different between two groups. Post-LT one-year survival (DON&lt;50: 89.3 % vs. DON≥50: 88.3 %) and five-year survival (DON&lt;50: 41.4 % vs DON≥50: 42.8 %) were comparable. Multivariable Cox proportional-hazards model showed that donor age ≥50 years is not associated with increased mortality after LT in the matched cohort (HR: 1.04, 95 % CI: 0.88–1.24, <em>P</em> = 0.63).</p></div><div><h3>Conclusions</h3><p>The utilization of carefully selected donor livers older than 50 years may be a viable option for septuagenarian LT candidates by lowering their waitlist time and can maximize the organ utilization without compromising the outcomes.</p></div>","PeriodicalId":100799,"journal":{"name":"Journal of Liver Transplantation","volume":"14 ","pages":"Article 100208"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666967624000096/pdfft?md5=7298162ded61af49c36eb84246b64c6b&pid=1-s2.0-S2666967624000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139733056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}