Journal of Holistic Integrative Pharmacy最新文献

{"title":"The repair effect of α-ketoglutarate combined with mesenchymal stem cells on osteoarthritis via the hedgehog protein pathway","authors":"Liyan Li,&nbsp;Han Shen,&nbsp;Li Lu","doi":"10.1016/j.jhip.2025.02.003","DOIUrl":"10.1016/j.jhip.2025.02.003","url":null,"abstract":"<div><h3>Objective</h3><div>Mesenchymal stem cell (MSC) therapy represents a promising treatment strategy for osteoarthritis (OA). Nevertheless, the therapeutic efficacy of MSCs may be attenuated under conditions of cellular senescence or when the available clinical quantity is insufficient. α-Ketoglutarate (AKG) exerts beneficial effects on skeletal tissues and the activity of stem cells. Consequently, the present study was designed to explore the potential of AKG in augmenting the viability of MSCs and the potential of their combined utilization in the treatment of OA.</div></div><div><h3>Method<em>s</em></h3><div>MSCs with senescence induced by <em>in vitro</em> passaging served as the experimental subjects. The effects of AKG on the activity of senescent MSCs were investigated via morphological observation, scratch assay, and DAPI staining. Bioinformatics methods were employed to explore the action targets and pathways of AKG in the treatment of OA, providing a theoretical basis and experimental evidence for further experiments. The feasibility of this pathway was verified at the animal level. A rat model of OA was induced by intra-articular injection of sodium monoiodoacetate (MIA). Platelet-rich plasma (PRP), a representative drug for clinical OA treatment, was used as a positive control. The efficacy of combined high-dose and low-dose medications was evaluated through morphological observation and pathological section staining.</div></div><div><h3>Results</h3><div>The outcomes of the <em>in vitro</em> cellular experiments indicate that AKG is capable of decreasing the quantity of MSCs exhibiting senescent morphological features, enhancing the migratory capacity of MSCs, and suppressing the apoptotic process of MSCs. Consequently, AKG exerts a reparative influence on senescent MSCs. Bioinformatics analysis indicated that AKG exerts its repairing effect on OA by inhibiting the Hedgehog (HH) signaling pathway. Additionally, at the animal experiment level, we found that the synergistic effect of high-dose AKG combined with MSCs could more significantly alleviate the severity of OA. It enhances matrix synthesis, reduces endochondral ossification, and promotes cartilage repair through the HH pathway.</div></div><div><h3>Conclusion</h3><div>Our research indicates that AKG has a significant effect on enhancing the activity of MSCs. The combined treatment can promote the repair of articular cartilage in OA rats through the HH pathway, and it provides a novel approach for the treatment of OA.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 11-22"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143592942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of ginger oleoresin-enriched marshmallow candy as a nutraceutical for managing pediatric chemotherapy-induced nausea and vomiting","authors":"Marzooka Kazi-Chishti ,&nbsp;Umme Jasvi Kulsum ,&nbsp;Mohamed Hassan Dehghan ,&nbsp;Mohd Nazimuddin Chishti ,&nbsp;Kazi Bilal","doi":"10.1016/j.jhip.2025.02.002","DOIUrl":"10.1016/j.jhip.2025.02.002","url":null,"abstract":"<div><h3>Objective</h3><div>Chemotherapy-induced nausea and vomiting (CINV) significantly impact pediatric cancer patients, affecting treatment adherence and quality of life. This study aimed to develop gingerol-enriched marshmallow candy as a nutraceutical to alleviate CINV, offering a palatable and effective antiemetic formulation for children.</div></div><div><h3>Methods</h3><div>A central composite experimental design was employed to optimize the formulation. The various parameters, including textural attributes (hardness, springiness, and cohesiveness), weight variation, disintegration time, <em>in vitro</em> release, moisture content, water activity coefficient, and stability, of the marshmallows were evaluated to ensure the efficacy and quality of the product.</div></div><div><h3>Results</h3><div>The study identified an optimal formulation comprising ginger powder extract (4% w/w), gelatin (6% w/w), gum acacia (2.5% w/w), and agar (2.5% w/w). This composition demonstrated excellent textural characteristics, rapid disintegration, and efficient gingerol release in simulated conditions. The marshmallow candy also exhibited high acceptability in terms of stability and potential usability as a pediatric nutraceutical.</div></div><div><h3>Conclusion</h3><div>The ginger oleoresin-enriched marshmallow candy presents a novel and appealing delivery system for managing CINV in pediatric patients. Its favorable sensory and functional properties could improve compliance and enhance the overall treatment experience for children undergoing chemotherapy.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 1-10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the pharmacological effects of Alpinia offiinarum Hance and its active ingredients","authors":"Jiahui He,&nbsp;Yanfen Chen,&nbsp;Chaoyan Yang","doi":"10.1016/j.jhip.2025.03.006","DOIUrl":"10.1016/j.jhip.2025.03.006","url":null,"abstract":"<div><div><em>Alpinia officinarum</em> Hance (<em>A. officinarum</em>), as an important interior-warming herb in traditional Chinese medicine, is used to warm interior and disperse cold, regulate <em>Qi</em> and relieve pain. Modern research has found that <em>A. officinarum</em> has various active components and pharmacological effects. With the deepening of related studies, more attention has been focused to <em>A. officinarum</em>. This article reviews and summarizes the active components and pharmacological effects of <em>A. officinarum</em> by searching recent domestic and international literature, in order to provide a reference for the research on the mechanisms of action of <em>A. officinarum</em> and its active components, as well as for further clinical applications and new drug development.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 74-82"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on application and development of pharmacogenomics of adverse drug reactions","authors":"Hongyu Bi ,&nbsp;Jun Zhu ,&nbsp;Yuanxuan Cai ,&nbsp;Xiaofang Shangguan ,&nbsp;Zherui Chen ,&nbsp;Maimoon Shihab Ahmed ,&nbsp;Rui Huang","doi":"10.1016/j.jhip.2025.03.005","DOIUrl":"10.1016/j.jhip.2025.03.005","url":null,"abstract":"<div><div>Adverse drug reactions (ADRs) are a significant public health issue, contributing substantially to patient morbidity and mortality. The growing accessibility of genomic technologies has greatly advanced our understanding of the genetics underlying ADRs. Pharmacogenomics, which investigates how genetic polymorphisms influence individual responses to drug therapy on a genome-wide scale, plays a pivotal role in this field. The article summarizes the relationship between ADRs and genes, outlines the current applications and advancements of pharmacogenomics in the prediction, diagnosis, prevention, regulation, and personalized treatment of ADRs, and reviews cutting-edge research methods and large-scale international studies. These insights aim to provide a reference for the future development of pharmacogenomics in ADR research.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 105-116"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of TPM–NCs–gel and its effect on subcutaneous abscess caused by Staphylococcus aureus","authors":"Quanwei Xie ,&nbsp;Feirong Zhou ,&nbsp;Runan He ,&nbsp;Lianbao Ye ,&nbsp;Zonghao Lin ,&nbsp;Xiangyu Nie ,&nbsp;Yuanzheng Wei ,&nbsp;Chuqin Yu","doi":"10.1016/j.jhip.2025.02.004","DOIUrl":"10.1016/j.jhip.2025.02.004","url":null,"abstract":"<div><h3>Objective</h3><div>The insoluble compound 1,1′-(2,4,6-trihydroxy-1,3-phenylene)bis(3-methylbutan-1-one) (TPM) is used in preparing a TPM nanocrystals gel (TPM–NCs–gel), and its <em>in vitro</em> antibacterial activity and therapeutic effect on subcutaneous abscesses caused by <em>Staphylococcus aureus</em> were evaluated.</div></div><div><h3>Methods</h3><div>The effect of a prescription technology on the particle size of a TPM–NCs suspension was investigated using a single factor, and the TPM–NCs prescription was optimized using a Box–Behnken design. A TPM–NCs–gel was prepared using hydroxyethyl cellulose–HHX (HEC–HHX) as a gel matrix and characterized. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of TPM–NCs–gel were determined with the microdilution method. The susceptibility of <em>Staphylococcus aureus</em> to mupirocin ointment, TPM–NCs–gel, and TPM–gel was evaluated by the disk diffusion method. The efficacy of the TPM–NCs–gel for subcutaneous abscess caused by <em>Staphylococcus aureus</em> was evaluated using a mouse model.</div></div><div><h3>Results</h3><div>The optimized TPM–NCs prescription consisted of Tween 80 and TPGS (2.47%), TPM (1.24%) and mannitol (2.32%). The size of the TPM–NCs was 98.2 ​± ​3.9 ​nm, and the polydispersion coefficient (PDI) was 0.235 ​± ​0.023. The particle size and PDI of the TPM–NCs–gel were 112.4 ​± ​7.3 ​nm and 0.148 ​± ​0.068, respectively. The MIC and MBC were both 2.98 ​μg/mL. After 12 days of administration, the bacteria in the abscess site of 2% TPM–NCs–gel experimental group were cleared, the inflammatory cells were reduced, and the skin structure was remodeled.</div></div><div><h3>Conclusion</h3><div>After TPM was prepared into TPM–NCs–gel, the antibacterial activity was enhanced, <em>Staphylococcus aureus</em> at the site of abscess was effectively removed, and wound healing was promoted.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 41-49"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of carbamazepine loaded ethosomal nasal in-situ gel for brain targeted drug delivery","authors":"Arjun Bilapatte ,&nbsp;Anjali More ,&nbsp;Kranti Satpute ,&nbsp;Shoaeb Mohammad Syed","doi":"10.1016/j.jhip.2025.03.002","DOIUrl":"10.1016/j.jhip.2025.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to develop a novel intranasal drug delivery system for carbamazepine, an antiepileptic drug, to enhance its therapeutic efficacy through targeted and sustained delivery. The goal was to evaluate the suitability of various polymers and excipients for formulating an effective and mucoadhesive nasal gel.</div></div><div><h3>Methods</h3><div>Ethosomes were prepared using the cold method and evaluated for particle size, zeta potential, entrapment efficiency, and drug release. Gels were formulated using poloxamer 407 and carbopol 934 and characterized for their physicochemical properties. The optimized ethosomal gel was further assessed for mucoadhesive properties and <em>in vitro</em> drug release. Nasal in-situ gels were also prepared using carbopol and HPMC k 100, and their spreadability and drug release profiles were compared.</div></div><div><h3>Results</h3><div>The optimized ethosomal batch (ET3) exhibited a particle size of 200.7 ​nm, a zeta potential of −54.8 ​mV, and a high drug entrapment efficiency of 93%. The <em>in vitro</em> drug release from ET3 was 88.64%. Among the nasal in-situ gels, the carbopol-based batches demonstrated better spreadability compared to HPMC k 100. The optimized in-situ gel batch (G2) showed a gelation temperature of 33.7 ​°C and an <em>in vitro</em> drug release of 94.05%.</div></div><div><h3>Conclusion</h3><div>The developed ethosomal gel and in-situ gel formulations demonstrated sustained drug release, enhanced mucoadhesion, and targeted delivery, making them promising alternatives for the treatment of epilepsy. This intranasal delivery system could improve patient compliance and therapeutic outcomes by providing a non-invasive and effective route for carbamazepine administration.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 57-63"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the factors affecting the competitiveness of biopharmaceutical industry cluster: Evidence from Guangdong and Zhejiang of China","authors":"Qiu Zhang ,&nbsp;Mandong Huang ,&nbsp;Xiaoxin Huang ,&nbsp;Lu Gan ,&nbsp;Yiling Li ,&nbsp;Huiying Huang","doi":"10.1016/j.jhip.2025.03.004","DOIUrl":"10.1016/j.jhip.2025.03.004","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to analyze factors affecting the competitiveness of China's biopharmaceutical industry cluster, offering insights for policymakers and stakeholders, while providing Chinese experience and theoretical support for sustainable development of global biopharmaceutical industry clusters.</div></div><div><h3>Methods</h3><div>Based on relevant data from Guangdong and Zhejiang Provinces in China, the entropy value method was used to evaluate the comprehensive competitiveness of biopharmaceutical industry clusters in Guangdong and Zhejiang provinces respectively, and the principal component regression method was applied to respectively examine factors affecting the competitiveness of biopharmaceutical industry clusters in Guangdong and Zhejiang provinces.</div></div><div><h3>Results</h3><div>The competitiveness study showed that the comprehensive competitiveness scores of biopharmaceutical industry clusters in Guangdong and Zhejiang both show an upward trend from 2010 to 2020. From 2010 to 2020, the average value of Zhejiang's competitiveness was 0.53 and Guangdong's was 0.41. The influencing factor study showed that the top five factors affecting the competitiveness of biopharmaceutical industry clusters in Guangdong and Zhejiang were the same, namely, the ratio of general public service expenditure to regional GDP, ratio of regional road freight turnover to regional road mileage, proportion of R&amp;D expenditure to total industrial output, ratio of total healthcare expenditure to provincial consumption, and product sales rate.</div></div><div><h3>Conclusion</h3><div>The results suggested that core factors affecting the competitiveness of China's biopharmaceutical industry cluster center on four aspects: infrastructure, innovation resources, enterprise performance, and market environment. Therefore, the primary strategy is to strengthen infrastructure construction and investment in innovation resources, while balancing enterprise performance with market environment optimization. This study pioneered the research on factors influencing the competitiveness of China's biopharmaceutical industry cluster, providing a new perspective and reference framework for subsequent research in this field.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 117-123"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143760001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective potential of Carduus marianus extract against p-dimethylaminoazobenzene (pDAB) induced hepatocarcinogenesis in mice through apoptosis induction and antioxidant pathway","authors":"Saili Paul ,&nbsp;Anisur Rahman Khuda-Bukhsh","doi":"10.1016/j.jhip.2025.02.005","DOIUrl":"10.1016/j.jhip.2025.02.005","url":null,"abstract":"<div><h3>Objective</h3><div>In homeopathy, ethanolic extract of <em>Carduus marianus</em> (EECM)<em>,</em> is used against various liver disorders including cancer. This investigation aims at evaluating hepatoprotective potential of EECM, if any, against p-dimethylaminoazobenzene (pDAB)-induced hepatocarcinogenesis in mouse models <em>in vivo</em> and elucidating its possible underlying mechanism(s).</div></div><div><h3>Methods</h3><div>Randomized sets of inbred mice were chronically fed with different food regimens for varying periods of time and divided accordingly, 6 mice in each group, into control (Normal I and Alcohol II) and treated groups (III-V); group I: fed Normal diet, group II: Normal diet ​+ ​Alcohol, group III: pDAB ​+ ​Phenobarbital (PB), group IV: pDAB ​+ ​PB ​+ ​Alcohol, group V: pDAB ​+ ​PB ​+ ​EECM. They were sacrificed at day 30, 60, 90 and 120. All routine protocols were deployed for cytogenetical, enzymatic, and histopathological studies. Expressions of B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), Bcl-2 associated X protein (Bax), Cysteine aspartic acid protease-3 (Caspase-3), and Matrix metalloproteinase 9 (MMP-9) were evaluated at day 90 and 120 only. The DPPH free-radical scavenging activity of EECM was estimated to determine the antioxidant properties.</div></div><div><h3>Results</h3><div>No mice of groups I and II developed tumors in liver at any fixation intervals while all mice of groups (III-IV) developed liver tumors at three fixation intervals. But in group V mice, 4 each of 6 mice at 90 and 120 days, did not show tumor nodules in their livers, signifying that feeding of EECM could combat carcinogenesis. EECM reduced genotoxic effects and favorably modulated expression of Caspase 3 and MMP-9 as compared to control.</div></div><div><h3>Conclusion</h3><div>The treatment of EECM clearly demonstrated protective action against pDAB induced hepatocarcinogenesis in mice for delaying tumor progression, decreasing total tumor load and genotoxic effects, and also evidenced by favourable modulations of the apoptotic signal proteins like Bcl2, Bcl-xl. Bax, Caspase 3 and other marker enzymes AST (Aspartate amino transferase), ALT (Alanine amino transferase) etc. However, the molecular mechanism of this protective action still needs to be further elucidated.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 64-73"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143686151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral pH-triggered colon-specific ketoprofen loaded microspheres for the better management of early morning symptoms associated with rheumatoid arthritis. Part II: Pharmacokinetic and pharmacodynamic assessment in rats","authors":"Krishna Sanka ,&nbsp;Prabhakar Reddy Veerareddy ,&nbsp;Rajeswara Rao Pragada","doi":"10.1016/j.jhip.2025.03.001","DOIUrl":"10.1016/j.jhip.2025.03.001","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the effectiveness of oral pH-triggered colon-specific ketoprofen-loaded microspheres (C-SKLMs) in managing early morning symptoms of rheumatoid arthritis (RA) through pharmacokinetic and pharmacodynamic assessments.</div></div><div><h3>Methods</h3><div>Pharmacokinetic parameters, including T_max, C_max, and mean residence time (MRT), were analyzed in animals treated with C-SKLMs and compared with pure ketoprofen. Pharmacodynamic evaluations assessed the ability of C-SKLMs to address early morning RA symptoms effectively by aligning drug release with the body's circadian rhythm.</div></div><div><h3>Results</h3><div>The T_max for the C-SKLMs group (9.33 ​± ​1.63 ​h) was significantly prolonged compared to pure ketoprofen (2 ​h), indicating delayed drug release tailored to circadian needs. The C_max for C-SKLMs (5.94 ​± ​1.20 ​μg/mL) was lower than that of pure ketoprofen (12.4 ​± ​3.00 ​μg/mL), demonstrating a controlled-release profile. Additionally, the MRT for C-SKLMs (12.96 ​± ​1.42 ​h) was approximately 1.4 times longer than for pure ketoprofen (9.44 ​± ​0.69 ​h), emphasizing extended drug release. Pharmacodynamic evaluations supported the superior effectiveness of C-SKLMs in managing early morning RA symptoms compared to pure ketoprofen.</div></div><div><h3>Conclusion</h3><div>C-SKLMs demonstrated significant potential to improve the management of early morning symptoms associated with RA through controlled, extended, and circadian-tailored drug release, making them a promising therapeutic approach.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 83-90"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine","authors":"Lin Yang ,&nbsp;Liang Wang ,&nbsp;Baofeng Yang ,&nbsp;Yue Zhang","doi":"10.1016/j.jhip.2025.03.003","DOIUrl":"10.1016/j.jhip.2025.03.003","url":null,"abstract":"<div><div>Mitochondria play a central role in cardiovascular diseases, primarily by providing cellular energy and facilitating various cardiac functions. Excessive fat accumulation, circadian rhythm disturbances, viral infections, and persistent inflammation can lead to myocarditis, fibrosis, and infarction, thereby exacerbating the progression of cardiovascular diseases. As essential organelles for energy production, mitochondria exhibit remarkable dynamic adaptability and can integrate diverse cellular signaling pathways, endowing myocardial cells with both bioenergetic and biosynthetic versatility. Consequently, targeting mitochondria for cardiovascular disease therapy has gained increasing attention and is applicable to various cardiovascular conditions. Numerous mitochondrial adaptive mechanisms, including dynamics, metabolic processes, and apoptosis regulation, have emerged as promising therapeutic targets. Nevertheless, contemporary investigations into mitochondrial biology have unveiled their intricate structural and functional characteristics, as well as their complex roles within cellular systems, which present obstacles to the clinical implementation of mitochondria-focused cardiovascular therapies. Recent studies have found that traditional Chinese medicine (TCM) possesses the potential to effectively address cardiovascular diseases while enhancing the structural integrity and functional capacity of mitochondria. This review aims to offer a comprehensive analysis of the modulatory effects of TCM on cardiac mitochondria and its therapeutic ramifications for cardiovascular conditions.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 1","pages":"Pages 91-104"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}