Journal of Holistic Integrative Pharmacy最新文献

{"title":"An integrative framework for precision medication in hypertension: Applying a dialectical perspective to traditional Chinese and Western medicine","authors":"Jinliang Liu ,&nbsp;Jiena Xiao ,&nbsp;Zhongwei Lin ,&nbsp;Mingzhu Xiao","doi":"10.1016/j.jhip.2025.09.001","DOIUrl":"10.1016/j.jhip.2025.09.001","url":null,"abstract":"<div><div>Hypertension is the most common cardiovascular disease. In terms of diagnosis and treatment, Traditional Chinese Medicine (TCM) and Western medicine each have their own strengths, but also have certain limitations. Affected by the combined effects of genetic and environmental factors, the pharmacotherapy of hypertension shows significant individual differences. Therefore, how to integrate the advantages of TCM and Western medicine to achieve precision medication has become an important research topic. A single diagnostic and therapeutic model is difficult to take into account both the characteristics of TCM's \"holistic regulation\" and Western medicine's \"precision intervention\": TCM focuses on holistic syndrome differentiation and the restoration of bodily balance, yet it is relatively vague in the analysis of disease mechanisms and the identification of drug targets; Western medicine excels in targeted therapy, but often overlooks the patient's overall physiological state and the holistic progression of the disease. In the current development of precision medication, the concept of integrative pharmacy provides important support. By systematically integrating multi-source knowledge and technical means, it is committed to combining the macro-holistic perspective with micro-precision intervention, and provides a practical framework for the integration and innovation of TCM and Western medicine. Against this background, TCM takes \"holistic concept\" and \"syndrome differentiation and treatment\" as its fundamentals, and devotes itself to maintaining the dynamic balance of human body functions; Western medicine, relying on advanced tools such as genomics and proteomics, emphasizes the precise identification of etiologies and targeted therapy. The two show a dialectical unity in concepts and methods, and jointly serve the realization of the goal of individualized treatment for hypertension. With \"principle, method, prescription, and medicine\" as the logical main line, this paper systematically explores the diagnostic and therapeutic ideas and practical strategies of TCM and Western medicine for hypertension, and expounds on how to take integrative pharmacy as a bridge to incorporate the holistic thinking of TCM into the modern precision medication system, thereby providing theoretical references and practical paths for promoting the integrated diagnosis and treatment of hypertension with TCM and Western medicine and the implementation of precise drug intervention.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 290-300"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative network pharmacology and transcriptomics suggest the mechanism of Buyang Huanwu Decoction in attenuating vascular aging via AMPK signaling pathway","authors":"Xuejuan Shen ,&nbsp;Jieyong Du ,&nbsp;Xiangyu Chen ,&nbsp;Xiaodie Chen ,&nbsp;Nan Xiao ,&nbsp;Danping Huang ,&nbsp;Yubin Yang ,&nbsp;Rong Chen ,&nbsp;Zunpeng Shu ,&nbsp;Li Zhang","doi":"10.1016/j.jhip.2025.09.004","DOIUrl":"10.1016/j.jhip.2025.09.004","url":null,"abstract":"<div><h3>Objective</h3><div>Vascular aging is a critical factor in cardiovascular diseases. Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, shows potential in delaying vascular aging, yet its mechanisms remain unclear. This study aims to explore BYHWD's pharmacological mechanisms through integrative network pharmacology and transcriptomics.</div></div><div><h3>Methods</h3><div>Network pharmacology identified BYHWD targets related to aging, followed by pathway enrichment analysis. Vascular histopathology was evaluated using HE, Masson, and EVG staining. Senescence biomarkers SA-<em>β</em>-gal, advanced glycation end products (AGEs), p16, p21, and p53 were determined. Oxidative-inflammatory markers were quantified via ELISA and RT-qPCR. Transcriptomic profiling used Illumina NovaSeq. AMP-activated protein kinase (AMPK) signaling pathway analysis employed immunohistochemistry.</div></div><div><h3>Results</h3><div>Network pharmacology identified 103 key targets, including SIRT1 and AMPK, related to oxidative stress and inflammation. In the D-galactose-induced aging model rats, BYHWD treatment significantly reduced vascular media thickness by 28% in the medium-dose group, collagen deposition, and markers of senescence, such as SA-<em>β</em>-gal, AGEs, p16, p21, and p53. Transcriptomics revealed AMPK signaling pathway enrichment, and further experiments revealed that BYHWD mediates its effects involving activation of the AMPK/Sirt1/Foxo3a axis, a key regulator of vascular homeostasis.</div></div><div><h3>Conclusion</h3><div>BYHWD may attenuate vascular aging by AMPK-mediated regulation of oxidative stress and inflammation, providing a novel multi-target strategy against age-related cardiovascular diseases. The underlying molecular mechanism still needs to be further clarified.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 276-289"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian randomization analysis establishes a causal relationship between COVID-19 and cardiometabolic diseases","authors":"Haibo Chen ,&nbsp;Lizhen Liao ,&nbsp;Zezhi Ke ,&nbsp;Xu Zhang ,&nbsp;Xiaodong Zhuang ,&nbsp;Xin Gao ,&nbsp;Litao Pan","doi":"10.1016/j.jhip.2025.08.001","DOIUrl":"10.1016/j.jhip.2025.08.001","url":null,"abstract":"<div><h3>Objective</h3><div>The causal impacts of COVID-19 on cardiometabolic diseases remained uncertain. This study utilized the two-sample Mendelian randomization (MR) method to evaluate causal relationships between COVID-19 (susceptibility and severity) and four primary cardiometabolic diseases (type 2 diabetes, coronary heart disease, ischemic stroke, and heart failure).</div></div><div><h3>Methods</h3><div>MR analysis was conducted using genome-wide association study (GWAS) results. Susceptibility and severity were defined as COVID-19-positive and COVID-19-hospitalization, respectively. Data from the COVID-19 Host Genetics Initiative were used for susceptibility and severity analysis. Consortium data from Spracklen CN, Nikpay, Malik R, and Neale lab were employed for type 2 diabetes, coronary heart disease, ischemic stroke, and heart failure, respectively.</div></div><div><h3>Results</h3><div>For COVID-19 susceptibility, the inverse variance weighted (IVW) method showed the odds ratio (OR) (95% confidence interval [CI], <em>P</em>-value) for type 2 diabetes was 1.719 (1.510–1.956, <em>P</em> ​= ​0.000). For COVID-19 severity, the IVW method estimate indicated that the OR (95% CI, P-value) for ischemic stroke was 1.051 (1.008–1.095, <em>P</em> ​= ​0.020). Moreover, the OR for heart failure was slightly higher in the hospitalized population than in the control population (1.001, 95% CI 1.000–1.002, <em>P</em> ​= ​0.010). The remaining results were negative.</div></div><div><h3>Conclusion</h3><div>This MR study establishes that genetically predicted COVID-19 susceptibility causally increases type 2 diabetes risk, while severe infection shows suggestive causal links with ischemic stroke and heart failure, redefining COVID-19 as an independent cardiometabolic risk factor.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 301-307"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking artemisinin's potential in polycystic ovary syndrome treatment: A call for controlled human trials","authors":"Osama Ahmad ,&nbsp;Komal Zulfiqar","doi":"10.1016/j.jhip.2025.09.009","DOIUrl":"10.1016/j.jhip.2025.09.009","url":null,"abstract":"","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 322-323"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Holistic insights of 6D printing in healthcare","authors":"Jatin Tekawade,&nbsp;Rohan Barse,&nbsp;Vijay Jagtap","doi":"10.1016/j.jhip.2025.09.003","DOIUrl":"10.1016/j.jhip.2025.09.003","url":null,"abstract":"<div><div>Additive manufacturing has recently demonstrated significant progress in healthcare. Six-dimensional (6D) printing is an emerging field that holds great promise through the rapid, layer-by-layer creation of complex objects capable of changing over time in response to external stimuli, resulting in dynamic and adaptable products. 6D printing represents a superimposition of 4D and 5D printing, combining the stimuli-responsiveness of 4D printing with the structural robustness of 5D printing. It uniquely enables autonomous, adaptive drug delivery systems by utilizing smart materials such as shape-memory alloys, responsive polymers, and hydrogels that react to environmental triggers. This review explores the evolution, mechanisms, significance, and innovations of 6D printing, which has made notable strides toward patient-centered medical approaches. Future developments in 6D printing may involve the use of material panels that adapt to stimuli varying over time under physiological conditions, offering new possibilities for advanced medical applications and solutions.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 263-275"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145120857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on clinical diagnosis, pathogenesis and therapeutic strategies of drug-induced liver injury","authors":"Xinxin Tan ,&nbsp;Jiajia Gao ,&nbsp;Chao Wang","doi":"10.1016/j.jhip.2025.09.002","DOIUrl":"10.1016/j.jhip.2025.09.002","url":null,"abstract":"<div><div>Drug-induced liver injury (DILI) is a severe adverse reaction caused by various drugs and their metabolites, with complex clinical manifestations, and severe cases may progress to acute liver failure (ALF) or even death. Currently, the pathogenesis of DILI has not been fully elucidated, and specific diagnostic indicators and effective therapeutic strategies are lacking, so it is crucial to deeply analyze its pathogenesis and develop precise intervention strategies. This review explores key pathogenic mechanisms in the development of DILI, with a focus on mitochondrial dysfunction, ferroptosis, immune responses and the gut-liver axis. It further systematically summarizes the clinical diagnostic approaches for DILI, including common diagnostic methods and potential biomarkers. Additionally, the review discusses therapeutic strategies for DILI, encompassing western medical treatments, ethnomedical treatments and non-pharmacological treatments. Although N-acetylcysteine (NAC) remains the FDA-approved standard treatment for acetaminophen (APAP) overdose, superior therapeutic options for DILI need to be explored urgently due to its therapeutic limitations and side effects. In the future, the prevention and treatment strategy of DILI will rely on deeper mechanistic investigations, development of novel biomarkers, and further exploration of multi-targeted traditional Chinese medicine (TCM) therapies.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 308-321"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential small-molecule compounds and targets for Alzheimer's disease: Integrating bioinformatics analysis and in vitro verification","authors":"Jiaorong Zheng ,&nbsp;Deti Peng ,&nbsp;Zhigao Liao ,&nbsp;Min Hong ,&nbsp;Weiqu Yuan ,&nbsp;Danping Huang","doi":"10.1016/j.jhip.2025.09.005","DOIUrl":"10.1016/j.jhip.2025.09.005","url":null,"abstract":"<div><h3>Objective</h3><div>Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by progressive memory decline and cognitive dysfunction. The specific pathogenesis of AD remains unclear. This study aimed to explore the crucial genes and therapeutic small-molecule compounds in AD via integrated bioinformatics analysis, molecular docking, and <em>in vitro</em> verification.</div></div><div><h3>Methods</h3><div>The gene dataset GSE122063, including 12 samples from patients with AD and 11 non-demented control samples, was downloaded from the Gene Expression Omnibus (GEO) database. The online tool GEO2R was used to analyze differentially expressed genes (DEGs). Functional enrichment analysis of the DEGs was performed using DAVID and ClueGo databases. A protein-protein interaction network was constructed using the STRING database and visualized in Cytoscape. Potential small-molecule compounds for AD therapy were screened using the Connectivity map database. The crucial genes in a rat model of AD were confirmed by RT-PCR. Molecular docking of the screened crucial genes and small-molecule compounds was further performed to identify potential therapeutic drugs for AD.</div></div><div><h3>Results</h3><div>A total of 1145 DEGs were identified, which were enriched in intracellular protein transport, cell cycle, establishment of protein localization to membrane, and so on. Eight hub genes, including <em>RPS29</em>, <em>CREBBP</em>, <em>ANAPC10</em>, <em>ANAPC4</em>, <em>MAGOHB</em>, <em>TCEB2</em>, <em>RPL10A</em>, and <em>SEC61A1</em>, were identified in the protein-protein interaction network. The MAPK signaling pathway was closely related to AD. Furthermore, increased expression of <em>CREBBP</em> was confirmed in the rat model of AD, and molecular docking revealed that CREBBP exhibited the strongest binding affinity with prochlorperazine.</div></div><div><h3>Conclusion</h3><div><em>CREBBP</em> was identified as a crucial hub gene and might serve as a potential target for AD. Prochlorperazine, which exhibited strong binding to CREBBP, showed potential as a therapeutic drug in AD.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 324-332"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical profiles, biological activities and medicinal importance of Aloe vera L.: A review","authors":"Suchhanda Nandi,&nbsp;Golak Majumdar,&nbsp;Shyamapada Mandal","doi":"10.1016/j.jhip.2025.07.001","DOIUrl":"10.1016/j.jhip.2025.07.001","url":null,"abstract":"<div><div><em>Aloe vera</em> (Av) is revered in Ayurveda as the \"wand of heaven\" or \"heaven's blessing\" and precisely the \"silent healer\". This herbaceous plant belongs to Asphodelaceae family, previously classified as Liliaceae. In Traditional Chinese Medicine (TCM), Av is acknowledged for its abundant bioactive substances that have considerable therapeutic value. Therefore, the objective of this review is to analyze Av's bioactive compounds, highlighting its medicinal potential in drug development. An extensive literature review is performed utilizing databases such as PubMed, Web of Science, SpringerLink, and more until October 2024. The research investigates the bioactive compounds of Av and their <em>in vivo</em>, <em>in vitro</em>, and <em>in silico</em> effects on infections (bacterial, fungal, viral, and protozoan infections), along with their medicinal properties and significance in drug development. The most investigated active constituents of Av are aloin, emodin, acemannan, and aloesin. Av contains more than 100 potentially active components from six different classes: anthraquinone, chromone, phenylpropanoids, coumarins, phenylpyrone, and phytosterols, focusing on its anti-infective, anti-cancer, anti-diabetic, anti-oxidant, anti-inflammatory, immuno-modulatory activity and impact on neural diseases as well, based on peer-reviewed scientific data. By deepening the understanding of Av's medicinal value, this study may provide a reference for its future research and the development of new bioactive drug molecules from Av.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 3","pages":"Pages 251-262"},"PeriodicalIF":0.0,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144771652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology","authors":"Zhanhao Ye ,&nbsp;Dongmin Cao ,&nbsp;Wenxing Ao ,&nbsp;Ting Li ,&nbsp;Minghua Xian ,&nbsp;Shumei Wang","doi":"10.1016/j.jhip.2025.05.002","DOIUrl":"10.1016/j.jhip.2025.05.002","url":null,"abstract":"<div><h3>Objective</h3><div>Gastrointestinal complications (GITC) are a major cause of increased morbidity and mortality in stroke patients, significantly impairing recovery by triggering systemic inflammation and hindering brain healing. Raw Rhubarb (RR) is a commonly used traditional Chinese medicine with significant potential in treating GITC of ischemic stroke (IS). However, its therapeutic mechanisms remain largely unknown. This study aims to investigate the therapeutic effects and potential mechanisms of RR on GITC in IS through an integrated analysis of gut microbiota, metabolomics, and network pharmacology.</div></div><div><h3>Methods</h3><div>Male Sprague-Dawley rats were subjected to middle cerebral artery occlusion/reperfusion (MCAO/R) to induce IS. The rats were divided into six groups: sham, model, nimodipine-treated, and three different dose groups for RR. Neuroprotective efficacy was assessed using infarct size measurement, neurological scoring, and histopathological analysis. Gut microbiota composition was analyzed through 16S rRNA gene sequencing, while metabolomic profiling of brain and colon tissues was performed using UPLC-Q-Orbitrap HRMS/MS. Multivariate statistical methods were employed to identify the key metabolites and pathways affected by RR treatment. Correlation analysis was conducted to establish links between gut microbiota alterations and differential metabolites. Additionally, network pharmacology, molecular docking analysis, and Western blot assays were utilized to explore the molecular mechanisms underlying RR's treatment of GITC in IS.</div></div><div><h3>Results</h3><div>RR showed significant neuroprotective effects, reducing infarct volume, improving neurological scores, and restoring intestinal function compared to the model group. In addition, gut microbiota analysis revealed that RR administration reversed gut microbiota dysbiosis in MCAO/R rats by increasing the abundance of <em>Bifidobacterium</em> and <em>Lactobacillus</em> while decreasing the abundance of <em>Escherichia-Shigella</em>. Metabolomics analysis indicated that RR reversed the metabolic disturbances in MCAO/R rats by modulating arachidonic acid (AA) metabolism. Correlation analysis showed that AA and its metabolites, such as PGE2, were closely associated with <em>Bifidobacterium</em> and <em>Lactobacillus</em>. Combining metabolomics, network pharmacology, and molecular docking analysis suggested that RR might regulate AA metabolism through the PI3K/mTOR signaling pathway to treat GITC in IS. Finally, Western blot validation confirmed that RR modulates the PI3K/mTOR signaling pathway.</div></div><div><h3>Conclusion</h3><div>These findings indicate that RR holds significant promise as a therapeutic strategy for addressing GITC of IS. The protective effects mediated by RR are associated with the improvement of gut microbiota dysbiosis and metabolic disturbances.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 2","pages":"Pages 136-149"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of five selected underutilized medicinal plants of Sri Lanka: Focusing on ethnobotany, phytochemistry and bioactivities, and evaluation of their potential for novel herbal product development","authors":"Isuru Sakbo Uyangoda ,&nbsp;Mayuri Munasinghe","doi":"10.1016/j.jhip.2025.06.005","DOIUrl":"10.1016/j.jhip.2025.06.005","url":null,"abstract":"<div><div><em>Ageratum conyzoides</em> L., <em>Artocarpus gomezianus</em> Wall. ex Trécul, <em>Euphorbia hirta</em> L., <em>Plectranthus zeylanicus</em> Benth., and <em>Piper sarmentosum</em> Roxb. have long been utilized in traditional medical practices, particularly across South and Southeast Asia. Despite their significant ethnopharmacological potential to treat various disorders, these plants remain underutilized in Sri Lanka. This review aims to evaluate the habit, propagation, ethnomedicinal uses, phytochemistry, and pharmacological properties of these five underutilized medicinal plants to promote their sustainable utilization in the herbal products industry of Sri Lanka. The plants were selected based on data from pharmacopeias and interviews with traditional medical practitioners. Scientific information on their ethnomedicinal uses, phytochemical compositions, and pharmacological properties was gathered from key scientific databases, including PubMed, Scopus, ScienceDirect, and Google Scholar, as well as web references and books. This information was analyzed to assess the factors contributing to their underutilization and their potential for novel herbal product development in Sri Lanka. All five plants possess a wide range of ethnomedicinal uses and are rich in bioactive compounds, including alkaloids, terpenoids, stilbenoids, and polyphenolic compounds. These bioactive compounds have been scientifically validated for their pharmacological properties, making these plants strong candidates for the development of novel pharmaceuticals and cosmeceuticals. However, their full potential remains largely untapped, primarily due to the lack of detailed phytochemical characterization and bioactive studies specific to Sri Lanka. Further preclinical and clinical research is needed to evaluate their therapeutic outcomes within the local context. The findings of this scoping review will guide future research and encourage broader use of these underutilized plants. Promoting their use will provide a sustainable alternative to the overexploitation of commonly used medicinal plants and support effective biodiversity conservation and resource management.</div></div>","PeriodicalId":100787,"journal":{"name":"Journal of Holistic Integrative Pharmacy","volume":"6 2","pages":"Pages 209-223"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}